flesinoxan has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (9.62) | 18.7374 |
| 1990's | 41 (78.85) | 18.2507 |
| 2000's | 5 (9.62) | 29.6817 |
| 2010's | 1 (1.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Rabin, RA; Winter, JC | 1 |
| Buisson-Defferier, S; Van den Buuse, M | 1 |
| Kelder, D; Ross, SB | 1 |
| Motevalian, M; Parsons, AA; Whalley, ET | 1 |
| Dreteler, GH; Ramage, AG; Saxena, PR; Wouters, W | 1 |
| Fischer, G; Grohs, JG; Huber, S; Raberger, G | 1 |
| Dreteler, GH; Jansen, JA; Saxena, PR; Toorop, GP; Wouters, W | 1 |
| Ahlenius, S; Larsson, K; Wijkström, A | 1 |
| Ahlenius, S; Hillegaart, V; Wijkström, A | 1 |
| Beller, KD; Boer, R; Sanders, KH; Walter, B | 1 |
| Mos, J; Olivier, B; Slangen, JL; Ybema, CE | 1 |
| Dreteler, GH; Saxena, PR; Wouters, W | 2 |
| Connor, HE; Higgins, GA | 2 |
| Fozard, JR; Hof, RP | 1 |
| Ramage, AG; Wilkinson, SJ | 1 |
| Kalkman, HO | 1 |
| Avgustinovich, DF; Kolpakov, VG; Kulikov, AV; Popova, NK; Vishnivetskaia, GB | 1 |
| Groenink, L; Maes, RA; Mos, J; Olivier, B; Van der Gugten, J | 1 |
| Kolpakov, VG; Kozintsev, I; Kulikov, AV; Maslova, GB; Popova, NK | 1 |
| Buisson-Defferier, S; Hibert, M; van den Buuse, M | 1 |
| Bervoets, K; Canton, H; Gobert, A; Millan, MJ; Rivet, JM; Veiga, S | 1 |
| Boeijinga, PH; Galvan, M; Leishman, DJ | 1 |
| Lucot, JB | 1 |
| Olivier, B; Slangen, JL; Ybema, CE | 1 |
| Critchley, DJ; Dourish, CT; Foden, ND; Liddle, CW; Middlefell, VC | 1 |
| Ahlenius, S; Hillegaart, V; Salmi, P; Wijkström, A | 1 |
| Leysen, JE; Pauwels, PJ; Van Gompel, P | 1 |
| Dakshinamurti, K; Lal, KJ | 1 |
| Gommans, J; Hijzen, TH; Maes, RA; Mos, J; Olivier, B | 1 |
| Blier, P; de Montigny, C; Dennis, T; Hadrava, V; Ortemann, C | 1 |
| Bosker, FJ; de Winter, TY; Klompmakers, AA; Westenberg, HG | 1 |
| IJzerman, AP; Kruse, CG; Kuipers, W; Spek, AL; Standaar, PJ; Tulp, MT; van Wijngaarden, I; Veldman, N | 1 |
| Bosker, F; Klompmakers, A; Vrinten, D; Westenberg, H | 1 |
| Gommans, J; Hijzen, TH; Joordens, RJ; King, CM; Maes, RA; Olivier, B | 1 |
| Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A | 1 |
| Haensel, SM; Slob, AK | 1 |
| Colpaert, FC; Dupuis, DS; Palmier, C; Pauwels, PJ | 1 |
| Bueno, L; Fioramonti, J; Rouzade, ML | 1 |
| Faccidomo, S; Hussain, S; Miczek, KA | 1 |
| Hijzen, TH; Joordens, RJ; Olivier, B | 1 |
| Ronken, E; Soudijn, W; van Steen, BJ; van Wijngaarden, I | 1 |
| Amstislavskaia, TG; Ivanova, EA; Kucheriavyĭ, SA; Popova, NK | 1 |
| Cryan, JF; Kelliher, P; Kelly, JP; Leonard, BE | 1 |
| Dulawa, SC; Geyer, MA; Gross, C; Hen, R; Stark, KL | 1 |
| Chidlow, G; Melena, J; Osborne, NN | 1 |
| Bruins Slot, LA; Colpaert, FC; Dupuis, DS; Koek, W | 1 |
| Jantos, H; Monti, D; Monti, JM | 1 |
| Colpaert, FC; Pauwels, PJ; Wurch, T | 1 |
| Gulinello, M; Li, Y; Olivier, B; Oosting, RS; Pehrson, AL; Sanchez, C | 1 |
52 other study(ies) available for flesinoxan and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Isoindoles; Male; Piperazines; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Yohimbine | 1992 |
Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Buspirone; Dioxins; Heart Rate; Hypertension; Male; Pindolol; Piperazines; Rats; Rats, Inbred SHR; Receptors, Serotonin; Serotonin Receptor Agonists; Spiro Compounds; Vasodilator Agents | 1992 |
Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Corticosterone; Drug Interactions; Hydrocortisone; Injections; Male; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Serotonin Receptor Agonists; Time Factors | 1992 |
Contractile effects of 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan in human isolated basilar artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Antihypertensive Agents; Basilar Artery; Humans; In Vitro Techniques; Indoles; Methiothepin; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Sulfonamides; Sumatriptan; Tetrahydronaphthalenes; Vasoconstrictor Agents | 1991 |
Pressor effects following microinjection of 5-HT1A receptor agonists into the raphe obscurus of the anaesthetized rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Electric Stimulation; Glutamates; Glutamic Acid; Heart Rate; Male; Methiothepin; Microinjections; Phrenic Nerve; Pindolol; Piperazines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1991 |
Alpha 1-adrenoceptor blockade and/or 5-HT1A agonism during treadmill exercise in dogs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dogs; Heart Rate; Hemodynamics; Physical Exertion; Piperazines; Receptors, Serotonin; Sympathetic Nervous System; Tetrahydronaphthalenes; Vagus Nerve | 1991 |
Systemic and regional hemodynamic effects of the 5-hydroxytryptamine1A receptor agonists flesinoxan and 8-hydroxy-2(di-N-propylamino)tetralin in the conscious rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Hemodynamics; Male; Microspheres; Piperazines; Rats; Rats, Inbred SHR; Receptors, Serotonin; Tetrahydronaphthalenes | 1991 |
Behavioral and biochemical effects of the 5-HT1A receptor agonists flesinoxan and 8-OH-DPAT in the rat.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Biogenic Monoamines; Carboxy-Lyases; Dihydroxyphenylalanine; Male; Motor Activity; Piperazines; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Sexual Behavior, Animal; Tetrahydronaphthalenes | 1991 |
Increased dopamine turnover in the ventral striatum by 8-OH-DPAT administration in the rat.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biotransformation; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Male; Methoxydimethyltryptamines; Naphthalenes; Piperazines; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes | 1990 |
Is blockade of alpha 1-adrenoceptors favourable in hypotension induced by stimulation of serotonin1A receptors in conscious dogs?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Rate; Male; Piperazines; Prazosin; Rats; Receptors, Serotonin; Stimulation, Chemical; Swine; Tetrahydronaphthalenes | 1990 |
Discriminative stimulus properties of flesinoxan.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Discrimination, Psychological; Generalization, Stimulus; Male; Naphthalenes; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1990 |
Comparison of the cardiovascular effects of the 5-HT1A receptor agonist flesinoxan with that of 8-OH-DPAT in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Antihypertensive Agents; Atropine; Blood Pressure; Decerebrate State; Heart Rate; Hemodynamics; Imidazoles; In Vitro Techniques; Male; Naphthalenes; Ondansetron; Piperazines; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Tetrahydronaphthalenes | 1990 |
Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Atropine Derivatives; Behavior, Animal; Catheterization; Hemodynamics; Injections; Injections, Intravenous; Male; Pindolol; Piperazines; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
Systemic and regional hemodynamic effects of the putative 5-HT1A receptor agonist flesinoxan in the cat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Blood Gas Analysis; Blood Pressure; Cardiac Output; Cats; Clonidine; Female; Heart Rate; Hemodynamics; Male; Piperazines; Receptors, Serotonin; Regional Blood Flow; Tetrahydronaphthalenes | 1989 |
Cardiovascular effects following injection of 8-OH-DPAT and flesinoxan into the dorsal raphe nucleus of conscious rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Heart Rate; Hemodynamics; Injections; Male; Naphthalenes; Piperazines; Raphe Nuclei; Rats; Tetrahydronaphthalenes | 1989 |
8-OH-DPAT, flesinoxan and guanfacine: systemic and regional haemodynamic effects of centrally acting antihypertensive agents in anaesthetized rabbits.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Guanfacine; Guanidines; Hemodynamics; Microspheres; Naphthalenes; Phenylacetates; Piperazines; Rabbits; Regional Blood Flow; Tetrahydronaphthalenes | 1989 |
Evidence that different regional sympathetic outflows vary in their sensitivity to the sympathoinhibitory actions of putative 5-HT1A and alpha 2-adrenoceptor agonists in anaesthetized cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Anesthesia; Animals; Cats; Clonidine; Hemodynamics; Imidazoles; Male; Piperazines; Receptors, Serotonin; Sympathetic Nervous System; Tetrahydronaphthalenes | 1989 |
Beta-adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Male; Motor Activity; Pindolol; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1989 |
[Participation of brain 5-HT1A serotonin receptors in regulating hereditary catalepsy].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Catalepsy; Cerebral Cortex; Corpus Striatum; Male; Mice; Mice, Inbred C57BL; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin | 1994 |
The corticosterone-enhancing effects of the 5-HT1A receptor antagonist, (S)-UH301, are not mediated by the 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Blood Glucose; Corticosterone; Male; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists | 1995 |
Effect of selective 5-HT1A agonists and 5-HT2 antagonists on inherited catalepsy in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Catalepsy; Dose-Response Relationship, Drug; Ketanserin; Male; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Differential cardiovascular effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), flesinoxan, 5-methyl-urapidil and MDL 75,608A in conscious spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiovascular System; Dioxanes; Heart Rate; Hypertension; Injections, Intraventricular; Male; Phenylephrine; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Serotonin Receptor Agonists; Spiro Compounds | 1993 |
5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Corticosterone; Drug Interactions; Eyelids; Hypothermia; Male; Models, Biological; Pain Measurement; Piperazines; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Tail | 1994 |
Differential effects of centrally-active antihypertensives on 5-HT1A receptors in rat dorso-lateral septum, rat hippocampus and guinea-pig hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antihypertensive Agents; Electrophysiology; Guinea Pigs; Hippocampus; Male; Neurons; Piperazines; Prosencephalon; Pyramidal Cells; Rats; Receptors, Serotonin; Serotonin; Signal Transduction; Tetrodotoxin; Tryptamines | 1994 |
Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antiemetics; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Injections, Subcutaneous; Motion Sickness; Piperazines; Propranolol; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Vomiting; Xylazine | 1994 |
Discriminative stimulus effect of flesinoxan: effect of 5-HT1A antagonists and PCPA.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Discrimination Learning; Fenclonine; Male; Pindolol; Piperazines; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Effects of the selective 5-HT1A receptor antagonist WAY100135 and its enantiomers on 8-OH-DPAT-induced hyperglycaemia in conscious rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Glucose; Dose-Response Relationship, Drug; Hyperglycemia; Male; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism | 1994 |
Effects of 5-HT1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biogenic Monoamines; Brain; Buspirone; Hydrazines; Male; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin | 1993 |
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Colforsin; Cyclic AMP; HeLa Cells; Humans; Indoles; Lysergic Acid Diethylamide; Models, Biological; Pindolol; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Transfection | 1993 |
Hypotensive action of 5-HT receptor agonists in the vitamin B6-deficient hypertensive rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Blood Pressure; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Riboflavin Deficiency; Serotonin; Serotonin Receptor Agonists; Yohimbine | 1993 |
Discriminative stimulus properties of flesinoxan: effects of enantiomers, (S)-UH301 and WAY-100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Analgesics, Opioid; Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Fentanyl; Generalization, Psychological; Injections, Subcutaneous; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Serotonin Antagonists; Stereoisomerism | 1995 |
Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Hippocampus; Hypothermia; Male; Piperazines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Time Factors | 1995 |
Flesinoxan dose-dependently reduces extracellular 5-hydroxytryptamine (5-HT) in rat median raphe and dorsal hippocampus through activation of 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Male; Microdialysis; Neurons; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1996 |
5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Brain; CHO Cells; Cricetinae; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Piperazines; Protein Binding; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiperone; Structure-Activity Relationship | 1997 |
The effects of a 5-HT1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: a microdialysis study with flesinoxan and WAY 100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Indoles; Male; Microdialysis; Piperazines; Potassium Chloride; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin | 1997 |
Effects of 5-HT1A receptor ligands in a modified Geller-Seifter conflict model in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alprazolam; Animals; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; Ligands; Male; Piperazines; Pyridines; Quinpirole; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists | 1997 |
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 1997 |
Flesinoxan: a prosexual drug for male rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ejaculation; Male; Piperazines; Rats; Rats, Wistar; Reaction Time; Serotonin Receptor Agonists; Sexual Behavior, Animal | 1997 |
Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain Chemistry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Hippocampus; Male; Oxadiazoles; Piperazines; Raphe Nuclei; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Septal Nuclei; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tryptamines | 1998 |
Decrease in gastric sensitivity to distension by 5-HT1A receptor agonists in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Male; Pain Threshold; Piperazines; Pyridines; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Stomach; Yohimbine | 1998 |
Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
The effects of 5-HT1A receptor agonists, 5-HT1A receptor antagonists and their interaction on the fear-potentiated startle response.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Fear; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex, Startle; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 1998 |
Functional characteristics of a series of N4-substituted 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazines as 5-HT1A receptor ligands. Structure-activity relationships.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; CHO Cells; Cricetinae; Frontal Lobe; Humans; Ligands; Models, Chemical; Piperazines; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship | 1998 |
[Effects of 5-HT1a serotonin receptor agonists on sex motivation in male mice].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Estrus; Female; Male; Mice; Mice, Inbred CBA; Motivation; Piperazines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Sexual Behavior, Animal; Testosterone | 1999 |
Comparative effects of serotonergic agonists with varying efficacy at the 5-HT(1A) receptor on core body temperature: modification by the selective 5-HT(1A) receptor antagonist WAY 100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dose-Response Relationship, Drug; Hypothermia; Male; Piperazines; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Female; Habituation, Psychophysiologic; Indoles; Mice; Mice, Knockout; Neural Inhibition; Piperazines; Piperidines; Pyridines; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex, Startle; Serotonin Receptor Agonists | 2000 |
Blockade of voltage-sensitive Na(+) channels by the 5-HT(1A) receptor agonist 8-OH-DPAT: possible significance for neuroprotection.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Batrachotoxins; Calcium; Neuroprotective Agents; omega-Conotoxins; Piperazines; Pyridines; Rats; Saxitoxin; Serotonin Receptor Agonists; Sodium; Sodium Channel Blockers | 2000 |
Memory of an operant response and of depressed mood retained in activation states of 5-HT(1A) receptors: evidence from rodent models.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Depression; Disease Models, Animal; Heterotrimeric GTP-Binding Proteins; Hippocampus; In Vitro Techniques; Ligands; Male; Memory; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2000 |
Increased REM sleep after intra-dorsal raphe nucleus injection of flesinoxan or 8-OHDPAT: prevention with WAY 100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Injections, Intraventricular; Male; Microinjections; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Sleep, REM; Stereotaxic Techniques; Wakefulness | 2002 |
Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Calcium; CHO Cells; Cricetinae; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Humans; Ligands; Mutation; Phosphorylation; Piperazines; Protein Kinase C; Pyridines; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Tetradecanoylphorbol Acetate; Transfection | 2003 |
A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Autoradiography; Dose-Response Relationship, Drug; Female; Male; Piperazines; Rats; Rats, Wistar; Reaction Time; Receptors, Serotonin; RNA-Binding Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Sex Characteristics; Sexual Behavior, Animal; Sulfides; Time Factors; Vortioxetine | 2017 |