Compounds > fleroxacin

fleroxacin and probenecid

fleroxacin has been researched along with probenecid in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (9.09)	18.7374
1990's	4 (36.36)	18.2507
2000's	2 (18.18)	29.6817
2010's	4 (36.36)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Abath Filho, L; Belli, L; Lassus, A; Santos Júnior, MF	1
Hori, S; Kaji, M; Kaneko, S; Kusajima, H; Miyahara, T; Ooie, T; Saito, A; Saito, S; Shiba, K; Shimada, J	1
Dell, D; Lücker, PW; Partos, C; Portmann, R; Suter, K; Weidekamm, E	1
Ooie, T; Sugiyama, Y; Suzuki, H; Terasaki, T	2

Trials

2 trial(s) available for fleroxacin and probenecid

Article	Year
Comparison of fleroxacin and penicillin G plus probenecid in the treatment of acute uncomplicated gonococcal infections. Genitourinary medicine, 1992, Volume: 68, Issue:5 Topics: Acute Disease; Adolescent; Adult; Drug Therapy, Combination; Fleroxacin; Gonorrhea; Humans; Male; Middle Aged; Penicillin G; Probenecid; Treatment Outcome; Urethral Diseases	1992
Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:12 Topics: Administration, Oral; Biological Availability; Ciprofloxacin; Drug Interactions; Fleroxacin; Humans; Infusions, Intravenous; Male; Probenecid	1987

Other Studies

9 other study(ies) available for fleroxacin and probenecid

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Renal handling of fleroxacin in rabbits, dogs, and humans. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:1 Topics: Adult; Animals; Blood Proteins; Ciprofloxacin; Creatinine; Dogs; Fleroxacin; Glomerular Filtration Rate; Humans; Kidney; Kinetics; Male; Probenecid; Protein Binding; Rabbits; Species Specificity	1990
Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus. Pharmaceutical research, 1996, Volume: 13, Issue:4 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anti-Infective Agents; Binding, Competitive; Biological Transport, Active; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Choroid Plexus; Enzyme Inhibitors; Fleroxacin; Ion Transport; Isotope Labeling; Male; Ouabain; Penicillin G; Penicillins; Probenecid; Rats; Rats, Wistar; Renal Agents; Rotenone; Sulfhydryl Reagents; Uncoupling Agents	1996
Kinetics of quinolone antibiotics in rats: efflux from cerebrospinal fluid to the circulation. Pharmaceutical research, 1996, Volume: 13, Issue:7 Topics: 4-Quinolones; Animals; Anti-Infective Agents; Biological Transport; Choroid Plexus; Fleroxacin; Fluoroquinolones; Injections, Intraventricular; Male; Pefloxacin; Probenecid; Quinolones; Rats; Rats, Wistar	1996