fleroxacin and cefotaxime

fleroxacin has been researched along with cefotaxime in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (12.50)	18.7374
1990's	19 (79.17)	18.2507
2000's	2 (8.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Albrecht, HA; Beskid, G; Christenson, JG; Durkin, JW; Fallat, V; Georgopapadakou, NH; Keith, DD; Konzelmann, FM; Lipschitz, ER; McGarry, DH	1
Albrecht, HA; Beskid, G; Chan, KK; Christenson, JG; Cleeland, R; Deitcher, KH; Georgopapadakou, NH; Keith, DD; Pruess, DL; Sepinwall, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Edelstein, MA; Edelstein, PH	1
Bodey, GP; Ho, DH; LeBlanc, B; Nguyen, HT; Rolston, KV	1
Bertasso, A; Georgopapadakou, NH; Pace, J	1
Beskid, G; Chan, K; Cleeland, R; Keith, DD; McGarry, CM; Siebelist, J	1
Chan, KK; Christenson, JG; Cleeland, R; Dix-Holzknecht, B; Farrish, HH; Patel, IH; Specian, A	1
Gu, JW; Neu, HC	1
Krcméry, V	1
Barry, AL; Jones, RN; Thornsberry, C	1
Bertasso, A; Chan, KK; Chapman, JS; Cleeland, R; Cummings, LM; Dix, BA; Georgopapadakou, NH; Keith, DD	1
Beskid, G; Chan, K; Cleeland, R; Fallat, V; Keith, DD; Lipschitz, ER; McGarry, DH; Unowsky, J	1
Bertasso, A; Chapman, JS; Cummings, LM; Georgopapadakou, NH	1
Jones, RN; Sanchez, ML	1
Georgopapadakou, NH; McCaffrey, C	1
Cunha, BA; Qadri, SM; Saldin, H; Ueno, Y	1
Blain, RW; Szuna, AJ	1
Barry, AL; Fuchs, PC; Pfaller, MA	1
Appelbaum, PC; Jacobs, MR; Pankuch, GA; Spangler, SK	1
Cunningham, B; Nickerson, B; Scypinski, S	1
Barreca, GS; Berlinghieri, MC; Focà, A; Foti, F; Matera, G	1
Agneter, E; Burgdorff, T; Eichler, HG; Georgopoulos, A; Haag, O; Jansen, B; Müller, M; Pehamberger, H; Stanek, G; Weninger, W	1

Trials

1 trial(s) available for fleroxacin and cefotaxime

Article	Year
Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:12 Topics: Adipose Tissue; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cefotaxime; Cefpirome; Cellulitis; Cephalosporins; Erythromycin; Female; Fleroxacin; Humans; Macrolides; Male; Microdialysis; Muscle, Skeletal; Skin	1996

Other Studies

23 other study(ies) available for fleroxacin and cefotaxime

Article	Year
Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones. Journal of medicinal chemistry, 1991, Volume: 34, Issue:2 Topics: Animals; Bacterial Infections; Cephalosporins; Chemical Phenomena; Chemistry; Mice; Microbial Sensitivity Tests; Quinolones; Structure-Activity Relationship	1991
Cephalosporin 3'-quinolone esters with a dual mode of action. Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: Animals; Anti-Infective Agents; Cefotaxime; Cephalosporins; Chemical Phenomena; Chemistry; Ciprofloxacin; Enterobacter; Escherichia coli Infections; Fleroxacin; Fluoroquinolones; Hydrolysis; Mice; Molecular Structure; Pneumococcal Infections; Prodrugs; Quinolones; Rats; Staphylococcus aureus; Structure-Activity Relationship	1990
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
In vitro activity of Ro 23-9424 against clinical isolates of Legionella species. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11 Topics: Animals; Anti-Infective Agents; Cefotaxime; Colony Count, Microbial; Culture Media; Erythromycin; Extracellular Space; Fleroxacin; Fluoroquinolones; Guinea Pigs; Intracellular Fluid; Legionella; Macrophages, Alveolar; Microbial Sensitivity Tests	1992
In vitro activity of Ro 23-9424, a dual-action antibacterial agent, against bacterial isolates from cancer patients compared with those of other agents. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:4 Topics: Anti-Infective Agents; Bacteria; Cefotaxime; Fleroxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Neoplasms	1992
Escherichia coli resistant to cephalosporins and quinolones is still susceptible to the cephalosporin-quinolone ester Ro 23-9424. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:5 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; beta-Lactamases; Carrier Proteins; Cefotaxime; Cell Membrane Permeability; Cephalosporins; Ciprofloxacin; Coliphages; DNA Replication; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Fleroxacin; Fluoroquinolones; Gene Expression Regulation, Bacterial; Hexosyltransferases; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Mutation; Penicillin-Binding Proteins; Peptidyl Transferases; Porins	1991
In vivo evaluation of a dual-action antibacterial, Ro 23-9424, compared to cefotaxime and fleroxacin. Chemotherapy, 1990, Volume: 36, Issue:2 Topics: Animals; Anti-Infective Agents; Bacterial Infections; Cefotaxime; Ciprofloxacin; Drug Evaluation, Preclinical; Enterobacteriaceae; Fleroxacin; Fluoroquinolones; Klebsiella pneumoniae; Meningitis; Mice; Neutropenia; Penicillin Resistance; Pneumonia; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; Time Factors	1990
Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:10 Topics: Animals; Anti-Infective Agents; Cefotaxime; Chromatography, High Pressure Liquid; Ciprofloxacin; Dogs; Fleroxacin; Fluoroquinolones; Humans; Injections, Intravenous; Mice; Papio; Rats; Species Specificity	1990
In vitro activity of Ro 23-9424, a dual-action cephalosporin, compared with activities of other antibiotics. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Bacterial Infections; Cefotaxime; Ciprofloxacin; Drug Resistance, Microbial; Fleroxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests	1990
[Dual cephalosporins--a return of fixed combinations of antibiotics?]. Casopis lekaru ceskych, 1990, Jul-20, Volume: 129, Issue:29 Topics: Anti-Infective Agents; Bacteria; Cefotaxime; Ciprofloxacin; Drug Combinations; Fleroxacin; Fluoroquinolones	1990
Antimicrobial activity of Ro 23-9424, a novel ester-linked codrug of fleroxacin and desacetylcefotaxime. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:6 Topics: Anti-Infective Agents; Bacteria; Cefotaxime; Ciprofloxacin; Drug Combinations; Drug Resistance, Microbial; Fleroxacin; Fluoroquinolones; Gram-Negative Aerobic Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests	1989
Mode of action of the dual-action cephalosporin Ro 23-9424. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:7 Topics: Anti-Infective Agents; Bacterial Proteins; beta-Lactamases; Carrier Proteins; Cefotaxime; Cephalosporins; Ciprofloxacin; DNA Replication; DNA, Bacterial; Enterobacter; Escherichia coli; Fleroxacin; Fluoroquinolones; Hexosyltransferases; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; Staphylococcus aureus	1989
In vitro activities of a dual-action antibacterial agent, Ro 23-9424, and comparative agents. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:7 Topics: Anti-Bacterial Agents; Bacteria; Cefotaxime; Cephalosporins; Ciprofloxacin; Enterobacteriaceae; Fleroxacin; Fluoroquinolones; Gram-Positive Bacteria; Microbial Sensitivity Tests; Pseudomonas	1989
Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:2 Topics: Anti-Infective Agents; Cefotaxime; Drug Resistance, Microbial; Escherichia coli; Fleroxacin; Fluoroquinolones; Microbial Sensitivity Tests	1995
Antimicrobial activity of a new antipseudomonal dual-action drug, Ro 25-0534. Diagnostic microbiology and infectious disease, 1994, Volume: 18, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cefotaxime; Ceftazidime; Cephalosporins; Ciprofloxacin; Enterobacteriaceae; Fleroxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Molecular Structure	1994
beta-Lactamase hydrolysis of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:5 Topics: Amines; Anti-Infective Agents; beta-Lactamases; Carbamates; Cefotaxime; Esters; Fleroxacin; Fluoroquinolones; Hydrolysis; Kinetics; Plasmids	1994
In vitro activity of Ro 23-9424, a dual-acting cephalosporin-quinolone antimicrobial agent. Journal of clinical pharmacology, 1993, Volume: 33, Issue:10 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Cefotaxime; Fleroxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Saudi Arabia	1993
Determination of a new antibacterial agent (Ro 23-9424) by multidimensional high-performance liquid chromatography with ultraviolet detection and direct plasma injection. Journal of chromatography, 1993, Oct-29, Volume: 620, Issue:2 Topics: Anti-Infective Agents; Cefotaxime; Chromatography, Gel; Chromatography, High Pressure Liquid; Drug Stability; Fleroxacin; Fluoroquinolones; Humans; Hydrolysis; Molecular Structure; Reproducibility of Results; Spectrophotometry, Ultraviolet	1993
RO 23-9424, a new cephalosporin 3'-quinolone: in-vitro antimicrobial activity and tentative disc diffusion interpretive criteria. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:1 Topics: Anti-Infective Agents; Bacteria; Bacteriological Techniques; Cefotaxime; Fleroxacin; Fluoroquinolones; Microbial Sensitivity Tests; Regression Analysis	1993
Susceptibility of 170 penicillin-susceptible and penicillin-resistant pneumococci to six oral cephalosporins, four quinolones, desacetylcefotaxime, Ro 23-9424 and RP 67829. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:2 Topics: Anti-Infective Agents; Cefotaxime; Cephalosporins; Culture Media; Fleroxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Penicillin Resistance; Penicillins; Pneumococcal Infections; Streptococcus pneumoniae	1993
The use of capillary electrophoresis to monitor the stability of a dual-action cephalosporin in solution. Journal of pharmaceutical and biomedical analysis, 1995, Volume: 14, Issue:1-2 Topics: Anti-Infective Agents; Cefotaxime; Cephalosporins; Drug Stability; Electrophoresis, Capillary; Fleroxacin; Fluoroquinolones; Half-Life; Kinetics; Solutions; Water	1995
Effect of RO 23-9424, cefotaxime and fleroxacin on functions of human polymorphonuclear cells and cytokine production by human monocytes. The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:5 Topics: Anti-Infective Agents; Cefotaxime; Cephalosporins; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Fleroxacin; Fluoroquinolones; Humans; Interleukin-1; Interleukin-8; Lipopolysaccharides; Monocytes; Neutrophils; Phagocytosis; Superoxides; Tumor Necrosis Factor-alpha	1996