flecainide and mexiletine

flecainide has been researched along with mexiletine in 88 studies

Research

Studies (88)

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (32.95)	18.7374
1990's	25 (28.41)	18.2507
2000's	15 (17.05)	29.6817
2010's	17 (19.32)	24.3611
2020's	2 (2.27)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Sen, S; Sinha, N	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Belardinelli, L; Corkey, B; Desai, MC; Dhalla, AK; El-Bizri, N; Elzein, E; Graupe, M; Guerrero, J; Hirakawa, R; Hu, L; Jiang, H; Kahlig, K; Kalla, R; Kobayashi, T; Koltun, DO; Lepist, EI; Li, CH; Li, X; Li, XJ; Liu, G; Lu, Y; Martinez, R; Mollova, N; Murray, B; Notte, GT; Osier, M; Parkhill, EQ; Perry, J; Perry, T; Rajamani, S; Rhodes, G; Saunders, O; Soohoo, D; Strickley, R; Venkataramani, C; Wang, WQ; Xie, C; Zablocki, JA	1
Cappiello, E; Dalla Vecchia, L; Lombardi, F; Sandrone, G; Torzillo, D	1
Jung, W; Lüderitz, B; Manz, M	1
Arita, M; Kiyosue, T; Sato, T; Wu, B	1
Kato, R; Koide, M; Miyahara, T; Sotobata, I; Toyama, J; Ukai, M; Yasui, S; Yokota, M	1
Ikeda, N; Kamiya, K	1
Kanno, M; Nakaya, H; Oyama, Y; Shishido, Y	1
Baĭer, T; Brakhmann, I; Khilbel, T; Kiubler, V; Shmitt, K; Valdeker, B	1
Doran, TC; Lensmeyer, GL; Wiebe, DA	1
Cappiello, E; Castelli, A; Dalla Vecchia, L; Finocchiaro, ML; Lombardi, F; Pastine, J; Rech, R	1
Bass, P; Bielefeldt, K	1
Clement, DL; Jordaens, LJ; Robbens, E; Tavernier, R; Vanmeerhaeghe, X	1
Balducelli, M; Boriani, G; Capucci, A; Carini, G; Carozzi, A; Di Pasquale, G; Finzi, A; Frabetti, L; Magnani, B; Pinelli, G	1
Gullberg, B; Hansen, O; Johansson, BW	1
Fukami, M; Hashimoto, T; Itoh, Y; Koike, H; Kumakura, S; Miyake, S; Mizuno, H; Shiga, H; Shimoji, Y; Yorikane, R	1
Delpón, E; Tamargo, J; Valenzuela, C	1
Kawamura, T; Kodama, I; Toyama, J	1
Desai, DM; Gal, J; Meyer-Lehnert, S	1
Hayashi, H; Kawamura, T; Kodama, I; Saito, H; Toyama, J; Yamada, K	1
Kates, RE; Liem, LB	1
Grauer, K; Gums, J; Skluth, H	1
James, MA; Jones, JV; Papouchado, P	1
Somberg, J	1
Roden, DM; Siddoway, LA; Woosley, RL	1
Roy, D	1
Morganroth, J; Nestico, PF	2
Huang, SK; Marcus, FI	1
Horowitz, LN; Morganroth, J	1
Hammill, SC; Kreeger, RW	1
Bonazzi, O; Facchini, M; Priori, SG; Schwartz, PJ; Varisco, T	1
Lanza, GA; Lucente, M; Mondello Malvestiti, FM; Rebuzzi, AG; Tamburi, S	1
Pepper, GA	1
Podrid, PJ	2
Collignon, P; Legrand, V	1
Sanna, GP	1
Hillis, WS; Whiting, B	1
Somberg, JC	1
Duff, HJ; Oates, JA; Roden, DM; Woosley, RL	1
Fabry, E; Klempt, HW; Nayebagha, A	1
Block, PJ; Winkle, RA	1
Pottage, A	1
Harrison, DC; Mead, RH	1
Hellestrand, KJ	1
Luck, JC; Mann, DE; Pratt, CM; Wyndham, CR	1
Bhamra, RK; Flanagan, RJ; Holt, DW	1
Atallah, G; Kirkorian, G; Moleur, P; Touboul, P	1
Jung, W; Lüderitz, B; Manz, M; Mletzko, R; Nitsch, J	1
Ajiki, K; Inoue, H; Kuo, TT; Murakawa, Y; Nakajima, T; Oikawa, N; Sezaki, K; Sugimoto, T; Usui, M; Yamashita, T	1
Arita, M; Kiyosue, T; Sato, T; Wang, DW	1
Adgey, AA; Allen, JD; Devine, AB; Stewart, AJ	1
Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F	1
Imagawa, N; Sato, S	1
Arita, J; Aye, NN; Hashimoto, K; Xue, YX	1
Aihara, N; Antzelevitch, C; Kamakura, S; Kurita, T; Shimizu, W; Sunagawa, K; Suyama, K; Taguchi, A; Takaki, H	1
Atkins, DL; Geletka, RC; Moss, AJ; Windle, JR; Zareba, W	1
Moczydlowski, E; Wang, G; Wang, SY	1
Carr, DB; Challapalli, V; Lau, J; McNicol, ED; Tremont-Lukats, IW	1
Aoike, F; Sakoda, S; Takahashi, MP	1
Ai, T; Cheng, J; Li, Z; Merkle, EM; Razavi, M; Shuraih, M; Sohma, Y; Taylor, E; Towbin, JA; Vatta, M; Xi, Y	1
Chen, YW; Cheng, KI; Chu, CC; Chu, KS; Huang, KL; Tzeng, JI; Wang, JJ	1
Aziz, PF; Pass, RH; Shah, MJ; Tanel, RE; Vetter, VL; Vogel, RL; Wieand, TS; Zelster, IJ	1
Bruno, C; Conte Camerino, D; Costanza, T; Desaphy, JF; Dipalma, A; Franchini, C; George, A; Lentini, G	1
Chen, YC; Chen, YW; Chu, CC; Leung, YM; Wang, JJ	1
Cros, C; Lainee, P; Moors, J; Skinner, M; Valentin, JP	1
Chung, WK; Jean, JC; Kass, RS; Keller, G; Kotton, DN; Lu, JT; Omari, A; Pass, RH; Sampson, KJ; Terrenoire, C; Tung, KW; Wang, K	1
Ermakov, S; Gerstenfeld, EP; Hoffmayer, KS; Scheinman, MM	1
Osadchii, OE	1
Carbonara, R; Conte Camerino, D; Costanza, T; Desaphy, JF	1
Johnson-Davis, KL; Slawson, MH	1
Carbonara, R; Conte Camerino, D; D'Amico, A; Desaphy, JF; Imbrici, P; Lo Monaco, M; Lucchiari, S; Modoni, A; Pagliarani, S; Roussel, J	1
Li, SY; Lv, TT; Yang, Y; Zhang, P	1
Iwamoto, M; Kawada, A; Kawai, S; Nakano, Y; Shimizu, T; Wakamiya, T; Watanabe, S	1

Reviews

19 review(s) available for flecainide and mexiletine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Update: cardiac antiarrhythmic drugs. Comprehensive therapy, 1989, Volume: 15, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Mexiletine; Piperidines; Propafenone; Propanolamines	1989
Ventricular arrhythmias. An assessment of newer therapeutic agents. Postgraduate medicine, 1989, May-01, Volume: 85, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide; United States	1989
Antiarrhythmic drug therapy. Recent advances and current status. Cardiology, 1985, Volume: 72, Issue:5-6 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil	1985
Clinical pharmacology of old and new antiarrhythmic drugs. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide	1985
Antiarrhythmic drugs. Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 2 Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1986
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment. Cardiology clinics, 1986, Volume: 4, Issue:2 Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil	1986
Antiarrhythmic drug therapy of ventricular arrhythmias. Current problems in cardiology, 1986, Volume: 11, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil	1986
Antiarrhythmic agents for chronic ventricular arrhythmias. Comprehensive therapy, 1987, Volume: 13, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine; Tocainide	1987
New antiarrhythmic drugs: tocainide, mexiletine, flecainide, encainide, and amiodarone. Mayo Clinic proceedings, 1987, Volume: 62, Issue:11 Topics: Administration, Oral; Amiodarone; Anilides; Anti-Arrhythmia Agents; Drug Interactions; Encainide; Flecainide; Heart Conduction System; Humans; Lidocaine; Mexiletine; Tachycardia; Tocainide	1987
Antiarrhythmic drug therapy (Part 2). Benefits and hazards. Chest, 1985, Volume: 88, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide	1985
Hemodynamic effects of antiarrhythmic drugs. The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6 Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide	1983
Clinical profiles of newer class I antiarrhythmic agents--tocainide, mexiletine, encainide, flecainide and lorcainide. The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6 Topics: Administration, Oral; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Lidocaine; Mexiletine; Piperidines; Tocainide	1983
Therapy with investigational antiarrhythmic drugs. The Medical clinics of North America, 1984, Volume: 68, Issue:5 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Tocainide	1984
Comparison of the efficacy of newly developed antiarrhythmic drugs in the treatment of ventricular tachyarrhythmias. European heart journal, 1984, Volume: 5 Suppl B Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Coronary Disease; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Piperidines; Tachycardia; Tocainide; Ventricular Fibrillation	1984
Investigational antiarrhythmic drugs for the treatment of ventricular rhythm disturbances. Cardiology clinics, 1984, Volume: 2, Issue:1 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Tocainide	1984
[New antiarrythmic drugs: mexiletine, tocainide, lorcainide, encainide, flecainide, propafenone, cipralan, sotalol]. Annales de cardiologie et d'angeiologie, 1982, Volume: 31, Issue:7 Topics: Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Sotalol; Tocainide	1982
Systemic administration of local anesthetic agents to relieve neuropathic pain. The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4 Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; Mexiletine; Nervous System Diseases; Pain; Randomized Controlled Trials as Topic; Tocainide	2005
Sodium channel blockers in the management of long QT syndrome types 3 and 2: A system review and meta-analysis. Journal of cardiovascular electrophysiology, 2021, Volume: 32, Issue:11 Topics: Adrenergic beta-Antagonists; Electrocardiography; Flecainide; Humans; Long QT Syndrome; Mexiletine; Ranolazine; Sodium Channel Blockers	2021

Trials

6 trial(s) available for flecainide and mexiletine

Article	Year
A double-blind crossover comparison of flecainide and slow-release mexiletine in the treatment of stable premature ventricular complexes. International journal of clinical pharmacology research, 1991, Volume: 11, Issue:1 Topics: Cardiac Complexes, Premature; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Female; Flecainide; Half-Life; Humans; Male; Mexiletine; Middle Aged	1991
Combined anti-arrhythmic therapy with class 1 and class 3 drugs. Postgraduate medical journal, 1989, Volume: 65, Issue:766 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Disopyramide; Drug Therapy, Combination; Electrocardiography; Female; Flecainide; Humans; Male; Mexiletine; Middle Aged; Randomized Controlled Trials as Topic; Single-Blind Method	1989
Selection of an antiarrhythmic drug for a sudden-death-prevention trial. American heart journal, 1982, Volume: 103, Issue:4 Pt 2 Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Encainide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Moricizine; Morpholines; Phenothiazines; Piperidines; Tocainide; Verapamil	1982
[Antiarrhythmic efficacy of mexiletine, propafenone and flecainide in ventricular premature beats. A comparative study in patients after myocardial infarction (author's transl)]. Zeitschrift fur Kardiologie, 1982, Volume: 71, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Coronary Disease; Electrocardiography; Flecainide; Half-Life; Heart Rate; Heart Ventricles; Humans; Mexiletine; Middle Aged; Myocardial Infarction; Piperidines; Propafenone; Propiophenones	1982
Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. Journal of cardiovascular electrophysiology, 2000, Volume: 11, Issue:12 Topics: Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Disopyramide; Electrocardiography; Flecainide; Heart Rate; Humans; Infusions, Intravenous; Male; Mexiletine; Middle Aged; Sodium; Sodium Channel Blockers; Sodium Channels; Syndrome; Ventricular Dysfunction; Ventricular Fibrillation	2000
Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2001, Volume: 6, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Child; Child, Preschool; Drug Monitoring; Electrocardiography; Flecainide; Follow-Up Studies; Heart Rate; Humans; Long QT Syndrome; Male; Mexiletine; Middle Aged; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Pilot Projects; Sodium Channels; Treatment Outcome; Ventricular Function	2001

Other Studies

63 other study(ies) available for flecainide and mexiletine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Journal of medicinal chemistry, 2016, Oct-13, Volume: 59, Issue:19 Topics:	2016
Autonomic effects of antiarrhythmic drugs and their importance. European heart journal, 1992, Volume: 13 Suppl F Topics: Adult; Autonomic Nervous System; Cardiac Complexes, Premature; Electrocardiography; Female; Flecainide; Heart Rate; Humans; Male; Mexiletine; Middle Aged; Propafenone; Tachycardia, Ventricular; Ventricular Fibrillation	1992
[Combination anti-arrhythmic drug therapy]. Zeitschrift fur Kardiologie, 1992, Volume: 81 Suppl 4 Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography, Ambulatory; Encainide; Flecainide; Humans; Mexiletine; Sotalol; Tachycardia; Tocainide	1992
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs. Cardiovascular research, 1992, Volume: 26, Issue:11 Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines	1992
[Pharmacokinetics and pharmacodynamics of class I antiarrhythmic agents after a single oral administration]. Japanese circulation journal, 1992, Volume: 56 Suppl 5 Topics: Administration, Oral; Anti-Arrhythmia Agents; Aprindine; Flecainide; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone	1992
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration]. Japanese circulation journal, 1992, Volume: 56 Suppl 5 Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function	1992
Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Mexiletine; Microelectrodes; Neuromuscular Depolarizing Agents; Papillary Muscles; Piperidines; Propylamines; Pyridines; Quinidine; Sodium Channels	1992
[Anti-arrhythmia agents in heart failure]. Kardiologiia, 1992, Volume: 32, Issue:4 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Flecainide; Humans; Mexiletine; Middle Aged; Propafenone; Quinidine	1992
Application of the Empore solid-phase extraction membrane to the isolation of drugs from blood: II. Mexiletine and flecainide. Therapeutic drug monitoring, 1992, Volume: 14, Issue:5 Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flecainide; Humans; Membranes, Artificial; Mexiletine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Verapamil	1992
Effects of mexiletine, propafenone and flecainide on signal-averaged electrocardiogram. European heart journal, 1992, Volume: 13, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Electrocardiography, Ambulatory; Female; Flecainide; Heart Diseases; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Propafenone; Signal Processing, Computer-Assisted; Tachycardia	1992
Sodium channel blockers alter slow-wave frequency of the rat stomach in vivo. Digestion, 1991, Volume: 48, Issue:1 Topics: Animals; Electrodes, Implanted; Flecainide; Gastrointestinal Motility; Male; Mexiletine; Muscle, Smooth; Rats; Rats, Inbred Strains; Sodium Channels	1991
Combination of flecainide and mexiletine for the treatment of ventricular tachyarrhythmias. Pacing and clinical electrophysiology : PACE, 1990, Volume: 13, Issue:9 Topics: Aged; Cardiac Pacing, Artificial; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Flecainide; Follow-Up Studies; Humans; Male; Mexiletine; Tachycardia; Time Factors; Ventricular Fibrillation	1990
Metabolic, hemodynamic, and electrocardiographic responses to increased circulating adrenaline: effects of pretreatment with class 1 antiarrhythmics. Angiology, 1991, Volume: 42, Issue:12 Topics: Adult; Analysis of Variance; Blood Pressure; Disopyramide; Electrocardiography; Epinephrine; Flecainide; Heart Rate; Humans; Magnesium; Male; Mexiletine; Myocardial Infarction; Potassium	1991
Antiarrhythmic and cardiovascular profiles of the fused indole compound (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydrox yisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate. Arzneimittel-Forschung, 1991, Volume: 41, Issue:11 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbazoles; Chloroform; Disopyramide; Dogs; Female; Flecainide; Heart; Heart Conduction System; Hemodynamics; Isoquinolines; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Myocardial Contraction; Ouabain	1991
Electrophysiological effects of the combination of mexiletine and flecainide in guinea-pig ventricular fibres. British journal of pharmacology, 1991, Volume: 103, Issue:2 Topics: Action Potentials; Animals; Drug Interactions; Electric Stimulation; Electrophysiology; Female; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Male; Mexiletine; Myocardium; Papillary Muscles	1991
Effects of combined use of class I antiarrhythmic agents on Vmax of guinea-pig ventricular muscles. Cardiovascular drugs and therapy, 1991, Volume: 5 Suppl 4 Topics: Action Potentials; Animals; Disopyramide; Drug Interactions; Electric Stimulation; Female; Flecainide; Guinea Pigs; Male; Mexiletine; Papillary Muscles	1991
Reversed-phase LC resolutions of chiral antiarrhythmic agents via derivatization with homochiral isothiocyanates. Chirality, 1990, Volume: 2, Issue:1 Topics: Anti-Arrhythmia Agents; Chromatography, Liquid; Flecainide; Humans; Indicators and Reagents; Lidocaine; Male; Mexiletine; Propafenone; Thiocyanates; Tocainide	1990
Combined application of class I antiarrhythmic drugs causes "additive", "reductive", or "synergistic" sodium channel block in cardiac muscles. Cardiovascular research, 1990, Volume: 24, Issue:11 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Male; Mexiletine; Myocardium; Sodium Channels	1990
Second generation antiarrhythmic agents: have we reached antiarrhythmic Nirvana? Journal of the American College of Cardiology, 1987, Volume: 9, Issue:2 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide	1987
Antiarrhythmic efficacy of penticainide and comparison with disopyramide, flecainide, propafenone and mexiletine by acute oral drug testing. The American journal of cardiology, 1987, Nov-01, Volume: 60, Issue:13 Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Disopyramide; Drug Administration Schedule; Electrocardiography; Electrophysiology; Female; Flecainide; Humans; Male; Mexiletine; Middle Aged; Propafenone; Propylamines; Pyridines	1987
[Worsening of ventricular arrhythmia in the dynamic ECG in patients treated with anti-arrhythmia drugs]. Cardiologia (Rome, Italy), 1988, Volume: 33, Issue:6 Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Therapy, Combination; Electrocardiography; Female; Flecainide; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Propafenone	1988
New antiarrhythmic agents. The Nurse practitioner, 1986, Volume: 11, Issue:7 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Flecainide; Humans; Kinetics; Mexiletine; Patient Education as Topic; Piperidines	1986
Aggravation of ventricular arrhythmia. A drug-induced complication. Drugs, 1985, Volume: 29 Suppl 4 Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography; Encainide; Flecainide; Humans; Mexiletine; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine	1985
Haemodynamic effects of class I antiarrhythmic agents. Drugs, 1985, Volume: 29 Suppl 4 Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1985
New drugs in the management of ventricular arrhythmias. Giornale italiano di cardiologia, 1984, Volume: 14, Issue:10 Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Drug Interactions; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide	1984
Antiarrhythmic drugs. British medical journal (Clinical research ed.), 1983, Apr-23, Volume: 286, Issue:6374 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil	1983
New directions in antiarrhythmic drug therapy. The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil	1984
High-performance liquid chromatographic method for the measurement of mexiletine and flecainide in blood plasma or serum. Journal of chromatography, 1984, May-11, Volume: 307, Issue:2 Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Flecainide; Humans; Mexiletine; Piperidines; Propylamines; Spectrometry, Fluorescence	1984
Efficacy and safety of combination therapy with amiodarone and type I agents for treatment of inducible ventricular tachycardia. Pacing and clinical electrophysiology : PACE, 1993, Volume: 16, Issue:4 Pt 1 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Drug Therapy, Combination; Electrocardiography; Encainide; Female; Flecainide; Humans; Male; Mexiletine; Middle Aged; Prospective Studies; Stroke Volume; Tachycardia, Ventricular	1993
Prolongation of intraventricular conduction time associated with fatal [correction of fetal] impairment of defibrillation efficiency during treatment with class I antiarrhythmic agents. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Defibrillators, Implantable; Disopyramide; Dogs; Electrophysiology; Female; Flecainide; Heart; Heart Conduction System; Male; Mexiletine; Myocardium; Ventricular Fibrillation	1995
Comparison of the effects of class I anti-arrhythmic drugs, cibenzoline, mexiletine and flecainide, on the delayed rectifier K+ current of guinea-pig ventricular myocytes. Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Flecainide; Guinea Pigs; Imidazoles; Ion Transport; Mexiletine; Patch-Clamp Techniques; Potassium; Ventricular Function	1996
Effects of blockade of fast and slow inward current channels on ventricular fibrillation in the pig heart. Heart (British Cardiac Society), 1996, Volume: 76, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Flecainide; Lidocaine; Mexiletine; Models, Biological; Sodium-Potassium-Exchanging ATPase; Swine; Ventricular Fibrillation; Verapamil	1996
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle. General pharmacology, 1997, Volume: 29, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley	1997
Effects of lidocaine and mexiletine on defibrillation energy requirements in animals treated with flecainide. Resuscitation, 1998, Volume: 36, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Flecainide; Lidocaine; Mexiletine; Ventricular Fibrillation	1998
Effects of an antiarrhythmic drug A-2545 on canine ventricular arrhythmia models; comparison with mexiletine and flecainide. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 358, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Flecainide; Heart Rate; Mexiletine; Models, Biological; Molecular Structure; Pyrroles	1998
Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells. Receptors & channels, 2004, Volume: 10, Issue:3-4 Topics: Anti-Arrhythmia Agents; Batrachotoxins; Electrophysiology; Flecainide; Humans; Membrane Potentials; Mexiletine; Muscle Proteins; Muscle, Skeletal; Mutation; NAV1.4 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Point Mutation; Sodium; Sodium Channels; Transfection	2004
Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation. European journal of pharmacology, 2006, Feb-17, Volume: 532, Issue:1-2 Topics: Anti-Arrhythmia Agents; Cell Line; Dose-Response Relationship, Drug; Flecainide; Humans; Ion Channel Gating; Membrane Potentials; Mexiletine; Muscle, Skeletal; Myotonia; Patch-Clamp Techniques; Sodium Channel Blockers; Sodium Channels	2006
A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:4 Topics: Anti-Arrhythmia Agents; Cells, Cultured; Flecainide; Genetic Variation; Humans; Ion Channel Gating; Mexiletine; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Quinidine; Sodium Channels	2007
The cutaneous analgesic effect of class I antiarrhythmic drugs. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Analgesics; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Bupivacaine; Dose-Response Relationship, Drug; Flecainide; Injections, Subcutaneous; Lidocaine; Male; Mexiletine; Pain Measurement; Pain Threshold; Quinidine; Rats; Rats, Sprague-Dawley; Reflex; Skin; Sodium Channel Blockers; Time Factors	2007
Congenital long QT syndrome and 2:1 atrioventricular block: an optimistic outcome in the current era. Heart rhythm, 2010, Volume: 7, Issue:6 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Atrioventricular Block; Child; Child, Preschool; Cohort Studies; Defibrillators, Implantable; Female; Flecainide; Genotype; Humans; Infant; Infant, Newborn; Long QT Syndrome; Male; Mexiletine; Multivariate Analysis; Prognosis; Propanolamines; Propranolol; Retrospective Studies; Risk Assessment; Risk Factors; Torsades de Pointes; Treatment Outcome	2010
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide. British journal of pharmacology, 2010, Volume: 160, Issue:6 Topics: Brain; Cell Line; Flecainide; Heart; Humans; Lidocaine; Mexiletine; Muscle Proteins; Muscle, Skeletal; NAV1.1 Voltage-Gated Sodium Channel; NAV1.4 Voltage-Gated Sodium Channel; NAV1.5 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Patch-Clamp Techniques; Sodium Channel Blockers; Sodium Channels	2010
Spinal blockades of class I antiarrythmic drugs with bupivacaine by isobolographic analysis in rats. Neuroscience letters, 2012, Oct-18, Volume: 528, Issue:1 Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Bupivacaine; Dose-Response Relationship, Drug; Flecainide; Injections, Spinal; Male; Mexiletine; Quinidine; Rats; Rats, Sprague-Dawley	2012
Detecting drug-induced prolongation of the QRS complex: new insights for cardiac safety assessment. Toxicology and applied pharmacology, 2012, Dec-01, Volume: 265, Issue:2 Topics: Animals; CHO Cells; Cricetinae; Dogs; Electrocardiography; Flecainide; Heart Rate; Male; Mexiletine; Patch-Clamp Techniques; Quinidine; Telemetry; Voltage-Gated Sodium Channel Blockers	2012
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. The Journal of general physiology, 2013, Volume: 141, Issue:1 Topics: Anti-Arrhythmia Agents; Biophysical Phenomena; Cell Communication; Cells, Cultured; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Flecainide; Humans; Infant, Newborn; Long QT Syndrome; Male; Mexiletine; Mutation; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Pharmacogenetics; Pluripotent Stem Cells; Sodium Channels; Treatment Outcome	2013
Combination drug therapy for patients with intractable ventricular tachycardia associated with right ventricular cardiomyopathy. Pacing and clinical electrophysiology : PACE, 2014, Volume: 37, Issue:1 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Chronic Disease; Drug Therapy, Combination; Female; Flecainide; Humans; Male; Mexiletine; Retrospective Studies; Sotalol; Tachycardia, Ventricular; Treatment Failure; Treatment Outcome	2014
Effects of Na+ channel blockers on extrasystolic stimulation-evoked changes in ventricular conduction and repolarization. Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiological Phenomena; Female; Flecainide; Guinea Pigs; Heart Ventricles; Lidocaine; Mexiletine; Quinidine; Sodium Channel Blockers; Tachycardia, Ventricular	2014
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs. Experimental neurology, 2014, Volume: 255 Topics: Animals; Carbamazepine; Disease Models, Animal; Flecainide; HEK293 Cells; Humans; Mexiletine; Muscle, Skeletal; Myotonia Congenita; Orphenadrine; Piperidines; Propafenone; Rats; Rats, Wistar; Riluzole; Sodium Channel Blockers; Thiazoles	2014
Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Methods in molecular biology (Clifton, N.J.), 2016, Volume: 1383 Topics: Amiodarone; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Flecainide; Humans; Mexiletine; Propafenone; Tandem Mass Spectrometry	2016
Translational approach to address therapy in myotonia permanens due to a new SCN4A mutation. Neurology, 2016, May-31, Volume: 86, Issue:22 Topics: Cell Line; Child; Diagnosis, Differential; Female; Flecainide; Humans; Mexiletine; Mutation; Myotonia Congenita; NAV1.4 Voltage-Gated Sodium Channel; Pharmacogenomic Testing; Precision Medicine; Translational Research, Biomedical; Voltage-Gated Sodium Channel Blockers	2016
Combined mexiletine and flecainide for severe long QT syndrome type 3. Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1 Topics: Anti-Arrhythmia Agents; Cardiac Conduction System Disease; Electrocardiography; Flecainide; Humans; Long QT Syndrome; Mexiletine	2023