flecainide and isoproterenol

flecainide has been researched along with isoproterenol in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's5 (23.81)18.2507
2000's4 (19.05)29.6817
2010's9 (42.86)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cockrell, JL; Griffin, JC; Helmy, I; Langberg, JJ; Lee, MA; Scheinman, MM; Titus, C1
Griffin, JC; Helmy, I; Herre, JM; Scheinman, MM; Sharkey, H1
Estes, NA; Manolis, AS1
Admant, P; Brembilla-Perrot, B; Le Helloco, A; Pernot, C1
Martin, CL; Mcmahon, EG; Palomo, MA1
Cragun, KT; Johnson, SB; Packer, DL1
Biffi, M; Boriani, G; Branzi, A; Bronzetti, G; Capucci, A; Magnani, B1
Fan, L; Friedman, DM; Ovadia, M; Rifkind, AB1
Avelino-Cruz, JE; Boyden, PA; Coetzee, WA; Denegri, M; Liu, N; Napolitano, C; Negri, S; Perissi, A; Priori, SG; Ruan, Y1
Chang, CJ; Chen, SA; Chen, YC; Chen, YH; Chen, YJ; Kao, YH; Lin, YK; Lu, YY; Tsai, WC; Yang, LY1
Bögeholz, N; Bogossian, H; Dechering, DG; Eckardt, L; Fehr, M; Frommeyer, G; Kaese, S; Milberg, P; Pott, C; Sterneberg, M1
Chau, S; Miyamoto, SD; Nau, S; Phillips, EK; Stauffer, BL; Sucharov, CC; Tompkins, C; Wilson, CE; Woulfe, KC; Zang, S1
Hoang, P; Jacquir, S; Lemus, S; Ma, Z1
Fletcher, S; Gharanei, M; James, RS; Maddock, H; Wallis, R1

Reviews

1 review(s) available for flecainide and isoproterenol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for flecainide and isoproterenol

ArticleYear
Electrophysiologic effects of isoproterenol in patients with atrioventricular reentrant tachycardia treated with flecainide.
    Journal of the American College of Cardiology, 1990, Volume: 16, Issue:7

    Topics: Cardiac Pacing, Artificial; Electrophysiology; Flecainide; Heart Conduction System; Humans; Isoproterenol; Tachycardia, Atrioventricular Nodal Reentry

1990

Other Studies

19 other study(ies) available for flecainide and isoproterenol

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Safety and efficacy of oral flecainide therapy in patients with atrioventricular re-entrant tachycardia.
    Annals of internal medicine, 1991, Feb-01, Volume: 114, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Pacing, Artificial; Child; Electric Stimulation; Female; Flecainide; Follow-Up Studies; Heart Diseases; Humans; Isoproterenol; Male; Middle Aged; Prospective Studies; Tachycardia, Atrioventricular Nodal Reentry

1991
Reversal of electrophysiologic effects of flecainide on the accessory pathway by isoproterenol in the Wolff-Parkinson-White syndrome.
    The American journal of cardiology, 1989, Jul-15, Volume: 64, Issue:3

    Topics: Adolescent; Adult; Electrophysiology; Female; Flecainide; Follow-Up Studies; Humans; Isoproterenol; Male; Middle Aged; Monitoring, Physiologic; Propranolol; Wolff-Parkinson-White Syndrome

1989
Loss of efficacy of flecainide in the Wolff-Parkinson-White syndrome after isoproterenol administration.
    European heart journal, 1985, Volume: 6, Issue:12

    Topics: Adult; Anti-Arrhythmia Agents; Electrocardiography; Female; Flecainide; Heart Block; Heart Conduction System; Heart Rate; Humans; Isoproterenol; Piperidines; Wolff-Parkinson-White Syndrome

1985
Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Flecainide; Guinea Pigs; Heart Atria; Isoproterenol; Male; Phenethylamines; Piperidines; Sulfonamides

1996
Beta-adrenergic augmentation of flecainide-induced conduction slowing in canine Purkinje fibers.
    Circulation, 1997, Oct-21, Volume: 96, Issue:8

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Dogs; Female; Flecainide; Isoproterenol; Male; Membrane Potentials; Neural Conduction; Potassium; Protein Kinase C; Purkinje Fibers; Receptors, Adrenergic, beta; Sodium Channels

1997
Electrophysiological effects of flecainide and propafenone on atrial fibrillation cycle and relation with arrhythmia termination.
    Heart (British Cardiac Society), 1999, Volume: 82, Issue:2

    Topics: Adrenergic beta-Agonists; Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Flecainide; Humans; Isoproterenol; Male; Middle Aged; Propafenone; Prospective Studies; Signal Processing, Computer-Assisted; Stimulation, Chemical

1999
Ventricular preexcitation sensitive to flecainide in late stage chick embryo ECGs: 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs inotropic but not chronotropic or dromotropic responses to isoproterenol and confers resistance to flecainide.
    Toxicology and applied pharmacology, 2000, Jul-01, Volume: 166, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Chick Embryo; Drug Interactions; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Isoproterenol; Myocardial Contraction; Polychlorinated Dibenzodioxins; Teratogens; Ventricular Function

2000
Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.
    Circulation research, 2011, Jul-22, Volume: 109, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Calcium Signaling; Disease Models, Animal; Extracellular Space; Flecainide; Gene Knock-In Techniques; Isoproterenol; Mice; Mice, Mutant Strains; Myocytes, Cardiac; Patch-Clamp Techniques; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sodium Channels; Sympathomimetics; Tachycardia, Ventricular

2011
Ablation of androgen receptor gene triggers right ventricular outflow tract ventricular tachycardia.
    International journal of cardiology, 2015, Jun-15, Volume: 189

    Topics: Action Potentials; Adenosine; Animals; Caffeine; Calcium; Flecainide; Gene Knockdown Techniques; Gene Knockout Techniques; Isoproterenol; Male; Mice; Mice, Knockout; Receptors, Androgen; Tachycardia, Ventricular; Ventricular Dysfunction, Left

2015
Effective suppression of atrial fibrillation by the antihistaminic agent antazoline: First experimental insights into a novel antiarrhythmic agent.
    Cardiovascular therapeutics, 2017, Volume: 35, Issue:2

    Topics: Acetylcholine; Action Potentials; Animals; Antazoline; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Drug Discovery; Electrocardiography; Electrophysiologic Techniques, Cardiac; Flecainide; Heart Rate; Histamine H1 Antagonists; Isolated Heart Preparation; Isoproterenol; Rabbits; Refractory Period, Electrophysiological; Time Factors

2017
Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs.
    American journal of physiology. Heart and circulatory physiology, 2018, 10-01, Volume: 315, Issue:4

    Topics: Action Potentials; Age Factors; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Disease Models, Animal; Female; Flecainide; Guinea Pigs; Heart Rate; Heart Ventricles; Isoproterenol; Male; Oxidation-Reduction; Phosphorylation; Ryanodine Receptor Calcium Release Channel; Time Factors; Ventricular Function, Left

2018
Quantification of Contractile Dynamic Complexities Exhibited by Human Stem Cell-Derived Cardiomyocytes Using Nonlinear Dimensional Analysis.
    Scientific reports, 2019, 10-11, Volume: 9, Issue:1

    Topics: Cells, Cultured; Electric Stimulation; Flecainide; Humans; Induced Pluripotent Stem Cells; Isoproterenol; Kinetics; Myocardial Contraction; Myocytes, Cardiac; Quinazolines

2019
The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles.
    Scientific reports, 2020, 03-24, Volume: 10, Issue:1

    Topics: Animals; Anthropometry; Atenolol; Cardiotonic Agents; Digoxin; Dobutamine; Electric Stimulation; Flecainide; In Vitro Techniques; Isometric Contraction; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Verapamil

2020