flavin-adenine-dinucleotide and mitoquinone

Mitochondrial dysfunction is a core feature of acute pancreatitis, a severe disease in which oxidative stress is elevated. Mitochondrial targeting of antioxidants is a potential therapeutic strategy for this and other diseases, although thus far mixed results have been reported. We investigated the effects of mitochondrial targeting with the antioxidant MitoQ on pancreatic acinar cell bioenergetics, adenosine triphosphate (ATP) production and cell fate, in comparison with the non-antioxidant control decyltriphenylphosphonium bromide (DecylTPP) and general antioxidant

Topics: Acetylcysteine; Acinar Cells; Adenosine Triphosphate; Animals; Antioxidants; Cell Death; Cell Lineage; Cell Survival; Energy Metabolism; Flavin-Adenine Dinucleotide; Mice, Inbred C57BL; Mitochondria; NAD; Onium Compounds; Organophosphorus Compounds; Oxidation-Reduction; Pancreas; Ubiquinone