flavin-adenine-dinucleotide has been researched along with anacardic-acid* in 1 studies
1 other study(ies) available for flavin-adenine-dinucleotide and anacardic-acid
| Article | Year |
|---|---|
Characterization of xanthine oxidase inhibition by anacardic acids.
Anacardic acid, 6[8(Z), 11(Z), 14-pentadecatrienyl]salicylic acid, inhibits generation of superoxide radicals by xanthine oxidase. This inhibition does not follow a hyperbolic inhibition, depends on anacardic acid concentrations, but follows a sigmoidal inhibition. The inhibition was analyzed by using a Hill equation, and slope factor and EC(50) were 4.3+/-0.5 and 53.6+/-5.1 microM, respectively. In addition, anacardic acid inhibited uric acid formation by xanthine oxidase cooperatively. Slope factor and EC(50) were 1.7+/-0.5 and 162+/-10 microM, respectively. The results indicate that anacardic acid binds to allosteric sites near the xanthine-binding domain in xanthine oxidase. Salicylic acid moiety and alkenyl side chain in anacardic acid are associated with the cooperative inhibition and hydrophobic binding, respectively. Topics: Anacardic Acids; Binding Sites; Enzyme Inhibitors; Flavin-Adenine Dinucleotide; Kinetics; Salicylates; Uric Acid; Xanthine; Xanthine Oxidase | 2004 |