Page last updated: 2024-09-02

fk 888 and substance p

fk 888 has been researched along with substance p in 59 studies

Compound Research Comparison

Studies (fk 888)	Trials (fk 888)	Recent Studies (post-2010) (fk 888)	Studies (substance p)	Trials (substance p)	Recent Studies (post-2010) (substance p)
97	2	3	17,289	277	2,010
97	2	3	85	0	12

Protein Interaction Comparison

Protein	Taxonomy	substance p (IC50)
Substance-P receptor	Rattus norvegicus (Norway rat)	0.0005
Substance-K receptor	Rattus norvegicus (Norway rat)	0.2
Substance-K receptor	Homo sapiens (human)	0.2455
Substance-P receptor	Homo sapiens (human)	0.0011
Neuromedin-K receptor	Homo sapiens (human)	0.125
Substance-K receptor	Mesocricetus auratus (golden hamster)	0.148

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	47 (79.66)	18.2507
2000's	12 (20.34)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fujii, T; Hagiwara, D; Ikari, N; Maeda, Y; Matsuo, M; Miyake, H; Morimoto, H; Murai, M; Yamaoka, M	1
Aikawa, T; Sasaki, H; Sekizawa, K; Ujiie, Y	1
Gether, U; Schwartz, TW; Zoffmann, S	1
Fukushima, T; Jin, Y; Morikawa, M; Nakazawa, H; Sasaki, H; Sekizawa, K	1
Kupryszewski, G; Maggi, CA; Patacchini, R; Quartara, L; Rolka, K; Zboinska, J	1
Gerard, NP; Gether, U; Jensen, CJ; Schwartz, TW	1
Ichinose, M; Igarashi, A; Inoue, H; Miura, M; Nakajima, N; Shirato, K; Takahashi, T; Takishima, T; Yamauchi, H	1
Goso, C; Manzini, S; Potier, E; Szallasi, A	1
Fujii, T; Hagiwara, D; Igari, N; Karino, M; Maeda, Y; Matsuo, M; Miyake, H	1
Kawaguchi, M; Maehara, K; Maruyama, Y; Saito, T; Sato, E; Yaoita, H	1
Barthó, L; Maggi, CA; Patacchini, R; Wilhelm, M	1
Aramori, I; Iwami, M; Kojo, H; Morikawa, N; Nakanishi, S; Notsu, Y; O'Donnell, N; Okuhara, M; Ono, S; Zenkoh, J	1
Giuliani, S; Holzer, P; Maggi, CA	1
Ebihara, T; Sasaki, H; Sekizawa, K	1
Church, MK; Featherstone, R; Polak, JM; Salmon, M; Walsh, DA; Wharton, J	1
Giuliani, S; Maggi, CA; Zagorodnyuk, V	1
Haga, N; Inatomi, N; Itoh, Z; Mizumoto, A; Shiba, Y; Yamamoto, O	1
Barnes, PJ; Hirayama, Y; Lei, YH; Rogers, DF	1
Fujii, T; Hagiwara, D; Ikari, N; Maeda, Y; Matsuo, M; Miyake, H; Murai, M	1
Barnes, PJ; Mak, JC; Miyayasu, K; Nishikawa, M	1
Ferrell, WR; Lam, FY; Scott, DT	1
Fujii, T; Hagiwara, D; Igari, N; Matsuo, M; Miyake, H; Morimoto, H; Murai, M; Murano, K	1
Fujii, T; Hagiwara, D; Maeda, Y; Matsuo, M; Miyake, H; Murai, M; Yamaoka, M	1
Ebihara, T; Nakazawa, H; Ohrui, T; Sasaki, H; Sekizawa, K	1
Calixto, JB; Campos, AH; Cechinel Filho, V; Dias, MA; Yunes, RA	1
Matsuda, H; Miyatake, K; Nagata, S; Ohmori, F; Uematsu, M	1
Fujimura, M; Matsuda, T; Matsushima, K; Mizuguchi, M; Nomura, M; Tsujiura, M	1
Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Ziche, M	1
Inoue, H; Koshihara, Y; Nagata, N	1
Calixto, JB; De Lima, TC; Rae, GA; Ribeiro, SJ; Santos, AR; Teixeira, RM	1
Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Zawieja, D; Ziche, M	1
Fukuuchi, Y; Kobari, M; Takao, M; Tanahashi, N; Tomita, M; Yokoyama, M	1
Fujimura, M; Ishiura, Y; Matsuda, T; Myou, S; Tsujiura, M	1
Endoh, N; Ichinose, M; Ishikawa, J; Kageyama, N; Miura, M; Ohuchi, Y; Shirato, K; Tomaki, M	1
Asakura, K; Kataura, A; Narita, S; Shirasaki, H; Watanabe, M	1
El-Shazly, AE; Eura, M; Ishikawa, T; Masuyama, K	1
Kraneveld, AD; Nijkamp, FP; Van Oosterhout, AJ	1
Fujita, H; Kageyama, M; Kanai, A; Nakata, K; Shirasawa, E	1
Boudon, A; Fauchère, JL; Jacoby, E; Kucharczyk, N; Michel, A	1
Barnhart, DC; Kimball, BC; Mulholland, MW; Sarosi, GA; Zhang, W	1
Esteve, H; Hsieh, L; Knippenberg, R; Kudlacz, E; Logan, D; Maynard, G; Olsen, K; Shatzer, S	1
Fujiwara, R; Izushi, K; Kamei, C; Ohishi, H; Sugimoto, Y; Takada, M; Yamaji, M	1
Manzini, S; Palma, C	1
Evangelista, S; Giachetti, A; Manzini, S; Paoli, S	1
Cirillo, R; Conte, B; Lopez, G; Maggi, CA; Manzini, S; Parlani, M	1
Esposito, V; Griffiths, NM; Linard, C; Mathe, D; Wysocki, J	1
Manzini, S; Nardelli, F; Palma, C	1
Lam, FF; Yip, AL	1
Ando, M; Fujii, K; Hamamoto, J; Hirata, N; Iwagoe, H; Kawano, O; Kohrogi, H	1
Hayashi, I; Kamijo, Y; Majima, M; Ohwada, T; Soma, K	1
Bae, SJ; Hamazaki, Y; Katayama, I; Matsunaga, Y; Shimizu, K; Takenaka, M; Tanaka, Y	1
Canteras, NS; De Lima, TC; Gavioli, EC	1
Hamada, K; Hanioka, N; Imazumi, K; Maeda, Y; Manda, T; Matsuo, M; Mutoh, S; Yamamoto, T	1
De lima, TC; Teixeira, RM	1
De Lima, TC; Duarte, FS; Testolin, R	1
Coutinho, E; Malde, A; Prabhu, A; Srivastava, S	1
Goto, T; Gunjigake, KK; Kido, MA; Kobayashi, S; Nakao, K; Tanaka, T	1
Calixto, AV; De Lima, TC; Duarte, FS; Duzzioni, M	1
Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Tsuchida, H; Yamashita, M	1

Other Studies

59 other study(ies) available for fk 888 and substance p

Article	Year
Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. British journal of pharmacology, 1992, Volume: 107, Issue:3 Topics: Administration, Oral; Animals; Cerebral Cortex; Dipeptides; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Injections, Intravenous; Kinetics; Lung; Male; Membranes; Pulmonary Edema; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Membranes	1992
Evidence for substance P as an endogenous substance causing cough in guinea pigs. The American review of respiratory disease, 1993, Volume: 148, Issue:6 Pt 1 Topics: Aerosols; Animals; Capsaicin; Cough; Dipeptides; Dose-Response Relationship, Drug; Glycopeptides; Guinea Pigs; Indoles; Male; Neprilysin; Smoking; Substance P; Tachykinins	1993
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P. FEBS letters, 1993, Dec-28, Volume: 336, Issue:3 Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection	1993
Capsaicin desensitization inhibits swallowing reflex in guinea pigs. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1 Topics: Acetylcholine; Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Deglutition; Dipeptides; Dose-Response Relationship, Drug; Electromyography; Guinea Pigs; Indoles; Lidocaine; Nerve Fibers; Premedication; Reflex; Substance P	1994
Effect of scyliorhinin I and synthetic scyliorhinin I derivatives at mammalian tachykinin NK1, NK2 and NK3 receptors. European journal of pharmacology, 1993, Dec-07, Volume: 250, Issue:2 Topics: Amino Acid Sequence; Animals; Cricetinae; Dipeptides; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mesocricetus; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Rabbits; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins	1993
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors. Molecular pharmacology, 1994, Volume: 45, Issue:2 Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Cell Line; Dipeptides; Humans; Indoles; Molecular Sequence Data; Mutation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P	1994
Bradykinin-induced airway inflammation. Contribution of sensory neuropeptides differs according to airway site. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:3 Pt 1 Topics: Animals; Asthma; Atropine; Bradykinin; Capillary Permeability; Dipeptides; Evans Blue; Guinea Pigs; Indoles; Indomethacin; Inflammation; Male; Neurons, Afferent; Premedication; Propranolol; Substance P; Tachykinins	1994
Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding. European journal of pharmacology, 1994, Mar-21, Volume: 254, Issue:3 Topics: Astrocytoma; Biphenyl Compounds; Dipeptides; Humans; Indoles; Isoindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured	1994
Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and Journal of medicinal chemistry, 1994, Jun-24, Volume: 37, Issue:13 Topics: Animals; Binding Sites; Dipeptides; Guinea Pigs; Indoles; Male; Pulmonary Edema; Radioligand Assay; Structure-Activity Relationship; Substance P	1994
Nonadrenergic noncholinergic nerves regulate basal coronary flow via release of capsaicin-sensitive neuropeptides in the rat heart. Circulation research, 1994, Volume: 75, Issue:4 Topics: Adenosine; Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Circulation; Coronary Vessels; Dipeptides; Heart; Hemodynamics; Immunohistochemistry; In Vitro Techniques; Indoles; Male; Myocardium; Neuropeptides; Oxygen Consumption; Rats; Substance P; Ventricular Function, Left	1994
Tachykinin NK1 and NK2 receptors mediate atropine-resistant ileal circular muscle contractions evoked by capsaicin. European journal of pharmacology, 1994, Jul-01, Volume: 259, Issue:2 Topics: Amino Acid Sequence; Animals; Atropine; Capsaicin; Dipeptides; Drug Resistance; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Ruthenium Red; Substance P; Tetrodotoxin	1994
Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors. European journal of pharmacology, 1994, Oct-14, Volume: 269, Issue:2 Topics: Animals; Base Sequence; CHO Cells; Clone Cells; Cloning, Molecular; Cricetinae; Dipeptides; DNA, Complementary; Haplorhini; Humans; Indoles; Ligands; Molecular Sequence Data; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Tachykinin; Species Specificity; Substance P; Transfection	1994
Effect of omega-conotoxin on cholinergic and tachykininergic excitatory neurotransmission to the circular muscle of the guinea-pig colon. Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 350, Issue:5 Topics: Acetylcholine; Animals; Atropine; Calcium Channel Blockers; Colon; Dipeptides; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Methacholine Chloride; Motor Neurons; Neurokinin A; Oligopeptides; omega-Conotoxin GVIA; Peptides; Substance P; Tachykinins	1994
Role of substance P in cough during bronchoconstriction in awake guinea pigs. American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:3 Pt 1 Topics: Animals; Bronchial Provocation Tests; Bronchoconstriction; Consciousness; Cough; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Indoles; Male; Procaterol; Substance P	1995
Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung. British journal of pharmacology, 1994, Volume: 113, Issue:4 Topics: Animals; Autoradiography; Dipeptides; Guinea Pigs; Humans; Immunohistochemistry; In Vitro Techniques; Indoles; Iodine Radioisotopes; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptides, Cyclic; Pulmonary Artery; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Species Specificity; Substance P; Succinimides	1994
Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon. Neuroscience, 1994, Volume: 63, Issue:4 Topics: Action Potentials; Animals; Atropine; Autonomic Nervous System; Colon; Dipeptides; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuromuscular Junction; Nifedipine; Oligopeptides; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission	1994
Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs. Gastroenterology, 1995, Volume: 109, Issue:5 Topics: Animals; Anti-Bacterial Agents; Atropine; Dipeptides; Dogs; Dopamine; Eating; Erythromycin; Hexamethonium; Indoles; Motilin; Muscle Contraction; Naloxone; Ondansetron; Serotonin Antagonists; Stomach; Substance P	1995
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo. British journal of pharmacology, 1993, Volume: 108, Issue:3 Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve	1993
Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin. European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1 Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea	1993
Characterization of guinea pig pulmonary neurokinin type 1 receptors using a novel antagonist ligand, [3H]FK888. Molecular pharmacology, 1993, Volume: 44, Issue:3 Topics: Animals; Autoradiography; Binding, Competitive; Dipeptides; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Indoles; Lung; Male; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P	1993
Substance P-induced inflammation in the rat knee joint is mediated by neurokinin 1 (NK1) receptors. Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2 Topics: Animals; Dipeptides; Indoles; Inflammation; Joints; Male; Rats; Rats, Wistar; Receptors, Neurokinin-2; Regional Blood Flow; Substance P; Vasodilation; Vasodilator Agents	1993
Design of a novel dipeptide substance P antagonist FK888. Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2 Topics: Amino Acid Sequence; Animals; Dipeptides; Drug Design; Indoles; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Oligopeptides; Receptors, Neurokinin-1; Substance P	1993
The pharmacological properties of FK888, a novel dipeptide NK1 antagonist. Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2 Topics: Animals; Bronchoconstriction; Capsaicin; Cell Membrane; Dipeptides; Edema; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indoles; Kinetics; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-1; Substance P	1993
Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs. American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:2 Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Capsaicin; Cilazapril; Citrates; Citric Acid; Cough; Cyclic AMP; Danazol; Dipeptides; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Guinea Pigs; Indoles; Procaterol; Reflex; Sex Factors; Substance P; Trachea	1996
Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:10 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzamides; Dipeptides; Ethanol; Female; Guinea Pigs; In Vitro Techniques; Indoles; Ion Channels; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Plant Extracts; Plants, Medicinal; Receptors, Tachykinin; Substance P; Urinary Bladder	1995
Different modes of sensory neuropeptides and nitric oxide involvement in relaxation of guinea-pig vessels. Journal of the autonomic nervous system, 1995, Oct-05, Volume: 55, Issue:1-2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin Endoperoxides, Synthetic; Receptors, Neurotransmitter; Substance P; Thromboxane A2; Vasoconstrictor Agents	1995
Sensory neuropeptides are not directly involved in bronchial hyperresponsiveness induced by interleukin-8 in guinea-pigs in vivo. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1996, Volume: 26, Issue:3 Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dipeptides; Guinea Pigs; Histamine; Indoles; Interleukin-8; Male; Neurokinin A; Peptides, Cyclic; Substance P	1996
The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture. Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:5 Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cell Adhesion; Cell Movement; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet-Derived Growth Factor; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Skin; Substance P	1996
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:6 Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P	1996
Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. European journal of pharmacology, 1996, Sep-05, Volume: 311, Issue:1 Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Postural Balance; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P	1996
Effect of the non-peptide blocker (+/-) CP 96,345 on the cellular mechanism involved in the response to NK1 receptor stimulation in human skin fibroblasts. Neuropeptides, 1996, Volume: 30, Issue:4 Topics: Biphenyl Compounds; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Cytosol; Dipeptides; Fibroblasts; Humans; Hydrolysis; Indoles; Neurokinin-1 Receptor Antagonists; Phosphatidylinositols; Physalaemin; Receptors, Neurokinin-1; Skin; Stimulation, Chemical; Substance P	1996
Intravascular substance P dilates cerebral parenchymal vessels through a specific tachykinin NK1 receptor in cats. European journal of pharmacology, 1996, Dec-19, Volume: 317, Issue:2-3 Topics: Animals; Blood Pressure; Blood Volume; Carotid Arteries; Cats; Cerebrovascular Circulation; Dipeptides; Dose-Response Relationship, Drug; Indoles; Injections, Intra-Arterial; Microcirculation; Receptors, Neurokinin-1; Substance P; Vasodilator Agents	1996
Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1996, Volume: 26, Issue:12 Topics: Adrenergic beta-Antagonists; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin A; Peptides, Cyclic; Propranolol; Substance P	1996
Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators. The European respiratory journal, 1997, Volume: 10, Issue:1 Topics: Aminoquinolines; Animals; Arginine; Asthma; Capillary Permeability; Coloring Agents; Dipeptides; Enzyme Inhibitors; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guanylate Cyclase; Guinea Pigs; Histamine; Indoles; Inflammation Mediators; Injections, Intravenous; Leukotriene D4; Lung; Male; Microcirculation; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Organometallic Compounds; Substance P	1997
The effects of NK1 receptor antagonists (FK224 and FK888) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:1 Topics: Animals; Antigens; Capillary Permeability; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin-1 Receptor Antagonists; Nose; Ovalbumin; Peptides, Cyclic; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Substance P	1997
Immunoregulatory effect of substance P in human eosinophil migratory function. Immunological investigations, 1996, Volume: 25, Issue:3 Topics: Adjuvants, Immunologic; Chemotaxis, Leukocyte; Dipeptides; Eosinophils; Humans; Hypersensitivity; In Vitro Techniques; Indoles; Inflammation; Interleukin-5; Male; Neurokinin-1 Receptor Antagonists; Platelet Activating Factor; Recombinant Proteins; Substance P	1996
Role for neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs. American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:2 Pt 1 Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dipeptides; Eosinophilia; Eosinophils; Guinea Pigs; Indoles; Interleukin-5; Leukocyte Count; Male; Peptides, Cyclic; Receptors, Neurokinin-2; Specific Pathogen-Free Organisms; Substance P	1997
Effects of the immunosuppressant cyclosporin A on neurotransmitter release from peripheral non-adrenergic, non-cholinergic nerves. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:3 Topics: Animals; Atropine; Calcium Channel Blockers; Capsaicin; Cyclosporine; Dipeptides; Immunosuppressive Agents; Indoles; Iris; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Rabbits; Sodium Channel Blockers; Substance P	1997
A structural rationale for the design of water soluble peptide-derived neurokinin-1 antagonists. Journal of receptor and signal transduction research, 1997, Volume: 17, Issue:6 Topics: Animals; Biphenyl Compounds; Dipeptides; Drug Design; Humans; In Vitro Techniques; Indoles; Models, Chemical; Models, Molecular; Molecular Mimicry; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Solubility; Substance P; Tetrazoles; Tryptophan; Water	1997
Tachykinin neuropeptide-evoked intracellular calcium transients in cultured guinea pig myenteric neurons. Peptides, 1998, Volume: 19, Issue:1 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Dipeptides; Fluorometry; Guinea Pigs; Indoles; Lanthanum; Myenteric Plexus; Neurokinin A; Nickel; Nifedipine; Peptide Fragments; Peptides, Cyclic; Receptors, Tachykinin; Substance P; Tachykinins; Virulence Factors, Bordetella	1998
A role for histamine and substance P in immediate allergic responses in guinea pig airways: characterization of MDL 108,207DA, a dual H1/NK-1 receptor antagonist. International archives of allergy and immunology, 1998, Volume: 115, Issue:2 Topics: Animals; Benzimidazoles; Bronchi; Capillary Permeability; CHO Cells; Cricetinae; Dipeptides; Drug Combinations; Guinea Pigs; Histamine; Histamine H1 Antagonists; Indoles; Inositol Phosphates; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Ovalbumin; Pyrilamine; Pyrrolidines; Radioligand Assay; Receptors, Histamine H1; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Skin Tests; Substance P; Trachea; Tumor Cells, Cultured	1998
Role of substance P in experimental allergic conjunctivitis in guinea pigs. Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:9 Topics: Animals; Capillary Permeability; Capsaicin; Conjunctiva; Conjunctivitis, Allergic; Dipeptides; Disease Models, Animal; Guinea Pigs; Histamine; Indoles; Male; Mast Cells; Ovalbumin; p-Methoxy-N-methylphenethylamine; Serine Proteinase Inhibitors; Substance P; Tears	1997
Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells. Journal of neuroimmunology, 1998, Volume: 81, Issue:1-2 Topics: Astrocytoma; Brain Neoplasms; Cytokines; Dipeptides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Indoles; Interleukin-6; Interleukin-8; Leukemia Inhibitory Factor; Lymphokines; Neoplasm Proteins; Neurokinin-1 Receptor Antagonists; Protein Kinase C; Receptors, Neurokinin-1; RNA, Messenger; RNA, Neoplasm; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1998
Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways. Neuropeptides, 1997, Volume: 31, Issue:1 Topics: Animals; Antigens; Blood Proteins; Capsaicin; Dextrans; Dipeptides; Extravasation of Diagnostic and Therapeutic Materials; Fluorescein-5-isothiocyanate; Glycopeptides; Guinea Pigs; Indoles; Male; Nasal Mucosa; Neurokinin A; Neurokinin-1 Receptor Antagonists; Olfactory Receptor Neurons; Peptide Fragments; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rhinitis; Substance P	1997
Inflammatory and motor responses by tachykinins in the guinea-pig oesophageal sphincter. Journal of autonomic pharmacology, 1998, Volume: 18, Issue:5 Topics: Animals; Dipeptides; Diphenhydramine; Dose-Response Relationship, Drug; Esophagogastric Junction; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P	1998
A substance P receptor antagonist (FK 888) modifies gut alterations induced by ionizing radiation. International journal of radiation biology, 1998, Volume: 74, Issue:5 Topics: Animals; Dipeptides; Ileum; Indoles; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P	1998
Correlation between binding characteristics and functional antagonism in human glioma cells by tachykinin NK1 receptor antagonists. European journal of pharmacology, 1999, Jun-25, Volume: 374, Issue:3 Topics: Binding, Competitive; Cyclohexylamines; Dipeptides; Glioma; Humans; Indoles; Inositol Phosphates; Interleukin-6; Kinetics; Neurokinin-1 Receptor Antagonists; Radioligand Assay; Receptors, Neurokinin-1; Substance P; Time Factors; Tritium; Tumor Cells, Cultured	1999
Unique gradual and sustained vasodilator response to substance P in the rabbit knee joint. European journal of pharmacology, 2000, Jul-21, Volume: 400, Issue:2-3 Topics: Administration, Topical; Animals; Benzamides; Cyclooxygenase Inhibitors; Dipeptides; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Flurbiprofen; Hindlimb; Indoles; Injections, Intra-Articular; Joints; Neurokinin-1 Receptor Antagonists; Piperidines; Rabbits; Receptors, Neurokinin-2; Regional Blood Flow; Substance P; Vasodilation	2000
The role of substance P release in the lung with esophageal acid. The American journal of medicine, 2001, Dec-03, Volume: 111 Suppl 8A Topics: Animals; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Esophagus; Extravasation of Diagnostic and Therapeutic Materials; Glycopeptides; Guinea Pigs; Hydrochloric Acid; Indoles; Lung; Reference Values; Sensitivity and Specificity; Substance P; Vagotomy	2001
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction. Life sciences, 2001, Nov-21, Volume: 70, Issue:1 Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P	2001
Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts. International archives of allergy and immunology, 2002, Volume: 127, Issue:4 Topics: Cells, Cultured; Cycloheximide; Dipeptides; Fibroblasts; Gene Expression; Glycopeptides; Humans; Immunohistochemistry; Indoles; Neprilysin; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Skin; Substance P; Tachykinins	2002
The role of lateral septal NK1 receptors in mediating anxiogenic effects induced by intracerebroventricular injection of substance P. Behavioural brain research, 2002, Aug-21, Volume: 134, Issue:1-2 Topics: Animals; Anxiety; Dipeptides; Grooming; Indoles; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Posture; Rats; Rats, Wistar; Receptors, Neurokinin-1; Septum of Brain; Substance P	2002
Contribution of tachykinin receptor subtypes to micturition reflex in guinea pigs. European journal of pharmacology, 2003, Sep-23, Volume: 477, Issue:3 Topics: Animals; Brain; Catheterization; CHO Cells; Cricetinae; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Indoles; Injections, Intravenous; Iodine Radioisotopes; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Spinal Cord; Substance P; Succinimides; Tetrazoles; Tissue Extracts; Transfection; Urinary Bladder; Urination	2003
Involvement of tachykinin NK1 receptor in the behavioral and immunological responses to swimming stress in mice. Neuropeptides, 2003, Volume: 37, Issue:5 Topics: Animals; Anxiety; Behavior, Animal; Dipeptides; Indoles; Injections, Intraventricular; Leukocyte Count; Maze Learning; Mice; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Stress, Physiological; Substance P; Swimming	2003
Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats. Behavioural brain research, 2004, Oct-05, Volume: 154, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Indoles; Injections, Intraventricular; Male; Maze Learning; Microinjections; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P; Thiorphan; Time Factors	2004
Solution conformation of Substance P antagonists-[D-Arg1, D-Trp7,9, Leu11]-SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-SP and [D-Pro2, D-Trp7,9]-SP by CD, NMR and MD simulations. Peptides, 2005, Volume: 26, Issue:5 Topics: Circular Dichroism; Computer Simulation; Dipeptides; Indoles; Magnetic Resonance Spectroscopy; Protein Structure, Secondary; Recombinant Proteins; Solutions; Substance P	2005
Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors. Neuropeptides, 2007, Volume: 41, Issue:1 Topics: Animals; Bone Development; Cell Differentiation; Collagen; Dipeptides; DNA Primers; Indoles; Osteoblasts; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; RNA, Messenger; Substance P	2007
Modulation of anxiety in rats evaluated in the elevated T-maze: evidence of the relationship between substance P and diazepam. Behavioural brain research, 2008, Feb-11, Volume: 187, Issue:1 Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Diazepam; Dipeptides; Fear; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Memory; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P	2008
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses. European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3 Topics: Animals; Bronchi; Capillary Permeability; Capsaicin; Chlorocebus aethiops; Citric Acid; COS Cells; Cough; Cyclic S-Oxides; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Inositol Phosphates; Male; Molecular Sequence Data; Morpholines; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea	2008