fk 888 has been researched along with histamine in 7 studies
| Studies (fk 888) | Trials (fk 888) | Recent Studies (post-2010) (fk 888) | Studies (histamine) | Trials (histamine) | Recent Studies (post-2010) (histamine) |
|---|---|---|---|---|---|
| 97 | 2 | 3 | 37,718 | 1,372 | 3,457 |
| Protein | Taxonomy | fk 888 (IC50) | histamine (IC50) |
|---|---|---|---|
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | 0.1585 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.1585 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, T; Hagiwara, D; Ikari, N; Maeda, Y; Matsuo, M; Miyake, H; Morimoto, H; Murai, M; Yamaoka, M | 1 |
| Fujii, T; Hagiwara, D; Maeda, Y; Matsuo, M; Miyake, H; Murai, M; Yamaoka, M | 1 |
| Fujimura, M; Matsuda, T; Matsushima, K; Mizuguchi, M; Nomura, M; Tsujiura, M | 1 |
| Amemiya, T; Fujimura, M; Matsuda, T; Mizuguchi, M; Nishi, K; Ohka, T | 1 |
| Endoh, N; Ichinose, M; Ishikawa, J; Kageyama, N; Miura, M; Ohuchi, Y; Shirato, K; Tomaki, M | 1 |
| Esteve, H; Hsieh, L; Knippenberg, R; Kudlacz, E; Logan, D; Maynard, G; Olsen, K; Shatzer, S | 1 |
| Fujiwara, R; Izushi, K; Kamei, C; Ohishi, H; Sugimoto, Y; Takada, M; Yamaji, M | 1 |
7 other study(ies) available for fk 888 and histamine
| Article | Year |
|---|---|
Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888.
Topics: Administration, Oral; Animals; Cerebral Cortex; Dipeptides; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Injections, Intravenous; Kinetics; Lung; Male; Membranes; Pulmonary Edema; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Membranes | 1992 |
The pharmacological properties of FK888, a novel dipeptide NK1 antagonist.
Topics: Animals; Bronchoconstriction; Capsaicin; Cell Membrane; Dipeptides; Edema; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indoles; Kinetics; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-1; Substance P | 1993 |
Sensory neuropeptides are not directly involved in bronchial hyperresponsiveness induced by interleukin-8 in guinea-pigs in vivo.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dipeptides; Guinea Pigs; Histamine; Indoles; Interleukin-8; Male; Neurokinin A; Peptides, Cyclic; Substance P | 1996 |
Involvement of NK2 receptors rather than NK1 receptors in bronchial hyperresponsiveness induced by allergic reaction in guinea-pigs.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Capsaicin; Dipeptides; Glycopeptides; Guinea Pigs; Histamine; Indoles; Male; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Hypersensitivity | 1996 |
Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators.
Topics: Aminoquinolines; Animals; Arginine; Asthma; Capillary Permeability; Coloring Agents; Dipeptides; Enzyme Inhibitors; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guanylate Cyclase; Guinea Pigs; Histamine; Indoles; Inflammation Mediators; Injections, Intravenous; Leukotriene D4; Lung; Male; Microcirculation; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Organometallic Compounds; Substance P | 1997 |
A role for histamine and substance P in immediate allergic responses in guinea pig airways: characterization of MDL 108,207DA, a dual H1/NK-1 receptor antagonist.
Topics: Animals; Benzimidazoles; Bronchi; Capillary Permeability; CHO Cells; Cricetinae; Dipeptides; Drug Combinations; Guinea Pigs; Histamine; Histamine H1 Antagonists; Indoles; Inositol Phosphates; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Ovalbumin; Pyrilamine; Pyrrolidines; Radioligand Assay; Receptors, Histamine H1; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Skin Tests; Substance P; Trachea; Tumor Cells, Cultured | 1998 |
Role of substance P in experimental allergic conjunctivitis in guinea pigs.
Topics: Animals; Capillary Permeability; Capsaicin; Conjunctiva; Conjunctivitis, Allergic; Dipeptides; Disease Models, Animal; Guinea Pigs; Histamine; Indoles; Male; Mast Cells; Ovalbumin; p-Methoxy-N-methylphenethylamine; Serine Proteinase Inhibitors; Substance P; Tears | 1997 |