fk 888 has been researched along with fk 224 in 14 studies
| Studies (fk 888) | Trials (fk 888) | Recent Studies (post-2010) (fk 888) | Studies (fk 224) | Trials (fk 224) | Recent Studies (post-2010) (fk 224) |
|---|---|---|---|---|---|
| 97 | 2 | 3 | 44 | 3 | 0 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (92.86) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Church, MK; Featherstone, R; Polak, JM; Salmon, M; Walsh, DA; Wharton, J | 1 |
| Buckley, TL; Koster, AS; Kraneveld, AD; Nijkamp, FP; van Heuven-Nolsen, D; van Schaik, Y | 1 |
| Barnes, PJ; Hirayama, Y; Lei, YH; Rogers, DF | 1 |
| Fujii, T | 1 |
| Fujimura, M; Matsuda, T; Matsushima, K; Mizuguchi, M; Nomura, M; Tsujiura, M | 1 |
| Amemiya, T; Fujimura, M; Matsuda, T; Mizuguchi, M; Nishi, K; Ohka, T | 1 |
| Fujimura, M; Ishiura, Y; Matsuda, T; Myou, S; Tsujiura, M | 1 |
| Asakura, K; Kataura, A; Narita, S; Shirasaki, H; Watanabe, M | 1 |
| Ferrell, WR; Karimian, SM; Lockhart, JC | 1 |
| Kraneveld, AD; Nijkamp, FP; Van Oosterhout, AJ | 1 |
| Katahashi, T; Konno, A | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Matsuda, T; Mizuguchi, M; Myou, S; Sasaki, S | 1 |
| Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ | 1 |
| Bae, SJ; Hamazaki, Y; Katayama, I; Matsunaga, Y; Shimizu, K; Takenaka, M; Tanaka, Y | 1 |
1 review(s) available for fk 888 and fk 224
| Article | Year |
|---|---|
[Discovery and pharmacological properties of selective neurokinin-receptor antagonists, FK224 and FK888].
Topics: Animals; Bronchoconstriction; Cricetinae; Dipeptides; Humans; Indoles; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Rats; Receptors, Neurokinin-2; Receptors, Neurokinin-3 | 1995 |
13 other study(ies) available for fk 888 and fk 224
| Article | Year |
|---|---|
Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung.
Topics: Animals; Autoradiography; Dipeptides; Guinea Pigs; Humans; Immunohistochemistry; In Vitro Techniques; Indoles; Iodine Radioisotopes; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptides, Cyclic; Pulmonary Artery; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Species Specificity; Substance P; Succinimides | 1994 |
Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade.
Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Hypersensitivity, Delayed; Indoles; Intestine, Small; Isoindoles; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Neuropeptides; Peptides, Cyclic | 1995 |
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve | 1993 |
Sensory neuropeptides are not directly involved in bronchial hyperresponsiveness induced by interleukin-8 in guinea-pigs in vivo.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dipeptides; Guinea Pigs; Histamine; Indoles; Interleukin-8; Male; Neurokinin A; Peptides, Cyclic; Substance P | 1996 |
Involvement of NK2 receptors rather than NK1 receptors in bronchial hyperresponsiveness induced by allergic reaction in guinea-pigs.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Capsaicin; Dipeptides; Glycopeptides; Guinea Pigs; Histamine; Indoles; Male; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Hypersensitivity | 1996 |
Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin A; Peptides, Cyclic; Propranolol; Substance P | 1996 |
The effects of NK1 receptor antagonists (FK224 and FK888) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs.
Topics: Animals; Antigens; Capillary Permeability; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin-1 Receptor Antagonists; Nose; Ovalbumin; Peptides, Cyclic; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Substance P | 1997 |
Tachykinin regulation of basal synovial blood flow.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Hindlimb; Indoles; Joints; Laser-Doppler Flowmetry; Male; Microscopy, Electron; Nerve Fibers; Peptides, Cyclic; Phenoxybenzamine; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Tachykinin; Regional Blood Flow; Synovial Membrane; Tachykinins; Vasoconstriction | 1997 |
Role for neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dipeptides; Eosinophilia; Eosinophils; Guinea Pigs; Indoles; Interleukin-5; Leukocyte Count; Male; Peptides, Cyclic; Receptors, Neurokinin-2; Specific Pathogen-Free Organisms; Substance P | 1997 |
Effects of tachykinin receptor antagonists, FK224 and FK888, in a guinea-pig model of nasal allergy.
Topics: Airway Resistance; Animals; Antigens; Capillary Permeability; Dipeptides; Female; Guinea Pigs; Indoles; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Hypersensitivity; Sneezing; Statistics, Nonparametric | 1997 |
Role of tachykinins in distilled water-induced bronchoconstriction in guinea-pigs.
Topics: Animals; Bronchoconstriction; Capsaicin; Dipeptides; Disease Models, Animal; Glycopeptides; Guinea Pigs; Indoles; Killer Cells, Natural; Male; Nebulizers and Vaporizers; Ovalbumin; Peptides, Cyclic; Respiration; Tachykinins; Water | 1998 |
Effects of airway inflammation on cough response in the guinea pig.
Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1998 |
Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts.
Topics: Cells, Cultured; Cycloheximide; Dipeptides; Fibroblasts; Gene Expression; Glycopeptides; Humans; Immunohistochemistry; Indoles; Neprilysin; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Skin; Substance P; Tachykinins | 2002 |