fk 888 has been researched along with cp 96345 in 8 studies
| Studies (fk 888) | Trials (fk 888) | Recent Studies (post-2010) (fk 888) | Studies (cp 96345) | Trials (cp 96345) | Recent Studies (post-2010) (cp 96345) |
|---|---|---|---|---|---|
| 97 | 2 | 3 | 403 | 1 | 16 |
| Protein | Taxonomy | fk 888 (IC50) | cp 96345 (IC50) |
|---|---|---|---|
| Substance-P receptor | Homo sapiens (human) | 0.0028 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 0.0004 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gether, U; Schwartz, TW; Zoffmann, S | 1 |
| Gerard, NP; Gether, U; Jensen, CJ; Schwartz, TW | 1 |
| Goso, C; Manzini, S; Potier, E; Szallasi, A | 1 |
| Mizuguchi, T; Shimoyama, N; Yamamoto, T | 1 |
| Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Ziche, M | 1 |
| Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Zawieja, D; Ziche, M | 1 |
| Boudon, A; Fauchère, JL; Jacoby, E; Kucharczyk, N; Michel, A | 1 |
| Sakashita, Y; Yamamoto, T | 1 |
8 other study(ies) available for fk 888 and cp 96345
| Article | Year |
|---|---|
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection | 1993 |
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.
Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Cell Line; Dipeptides; Humans; Indoles; Molecular Sequence Data; Mutation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P | 1994 |
Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding.
Topics: Astrocytoma; Biphenyl Compounds; Dipeptides; Humans; Indoles; Isoindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1994 |
Effects of intrathecal FK888, a novel dipeptide NK1 receptor antagonist, on the formalin test in the rat.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Dipeptides; Escape Reaction; Formaldehyde; Indoles; Injections, Spinal; Male; Movement; Nociceptors; Pain; Rats; Rats, Sprague-Dawley | 1993 |
The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture.
Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cell Adhesion; Cell Movement; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet-Derived Growth Factor; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Skin; Substance P | 1996 |
Effect of the non-peptide blocker (+/-) CP 96,345 on the cellular mechanism involved in the response to NK1 receptor stimulation in human skin fibroblasts.
Topics: Biphenyl Compounds; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Cytosol; Dipeptides; Fibroblasts; Humans; Hydrolysis; Indoles; Neurokinin-1 Receptor Antagonists; Phosphatidylinositols; Physalaemin; Receptors, Neurokinin-1; Skin; Stimulation, Chemical; Substance P | 1996 |
A structural rationale for the design of water soluble peptide-derived neurokinin-1 antagonists.
Topics: Animals; Biphenyl Compounds; Dipeptides; Drug Design; Humans; In Vitro Techniques; Indoles; Models, Chemical; Models, Molecular; Molecular Mimicry; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Solubility; Substance P; Tetrazoles; Tryptophan; Water | 1997 |
The role of the spinal opioid receptor like1 receptor, the NK-1 receptor, and cyclooxygenase-2 in maintaining postoperative pain in the rat.
Topics: Animals; Benzenesulfonates; Biphenyl Compounds; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatologic Surgical Procedures; Dipeptides; Hindlimb; Hyperalgesia; Indoles; Isoenzymes; Male; Neurokinin-1 Receptor Antagonists; Nitrobenzenes; Nociceptin; Nociceptin Receptor; Opioid Peptides; Oxazoles; Pain Threshold; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Sulfonamides | 1999 |