Page last updated: 2024-09-02

fk 888 and cp 96345

fk 888 has been researched along with cp 96345 in 8 studies

Compound Research Comparison

Studies
(fk 888)
Trials
(fk 888)
Recent Studies (post-2010)
(fk 888)
Studies
(cp 96345)
Trials
(cp 96345)
Recent Studies (post-2010) (cp 96345)
9723403116

Protein Interaction Comparison

ProteinTaxonomyfk 888 (IC50)cp 96345 (IC50)
Substance-P receptorHomo sapiens (human)0.0028
Substance-P receptorCavia porcellus (domestic guinea pig)0.0004

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gether, U; Schwartz, TW; Zoffmann, S1
Gerard, NP; Gether, U; Jensen, CJ; Schwartz, TW1
Goso, C; Manzini, S; Potier, E; Szallasi, A1
Mizuguchi, T; Shimoyama, N; Yamamoto, T1
Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Ziche, M1
Amerini, S; Ledda, F; Maggi, CA; Parenti, A; Zawieja, D; Ziche, M1
Boudon, A; Fauchère, JL; Jacoby, E; Kucharczyk, N; Michel, A1
Sakashita, Y; Yamamoto, T1

Other Studies

8 other study(ies) available for fk 888 and cp 96345

ArticleYear
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
    FEBS letters, 1993, Dec-28, Volume: 336, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection

1993
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.
    Molecular pharmacology, 1994, Volume: 45, Issue:2

    Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Cell Line; Dipeptides; Humans; Indoles; Molecular Sequence Data; Mutation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P

1994
Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding.
    European journal of pharmacology, 1994, Mar-21, Volume: 254, Issue:3

    Topics: Astrocytoma; Biphenyl Compounds; Dipeptides; Humans; Indoles; Isoindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured

1994
Effects of intrathecal FK888, a novel dipeptide NK1 receptor antagonist, on the formalin test in the rat.
    Neuroscience letters, 1993, Oct-14, Volume: 161, Issue:1

    Topics: Animals; Behavior, Animal; Biphenyl Compounds; Dipeptides; Escape Reaction; Formaldehyde; Indoles; Injections, Spinal; Male; Movement; Nociceptors; Pain; Rats; Rats, Sprague-Dawley

1993
The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:5

    Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cell Adhesion; Cell Movement; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet-Derived Growth Factor; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Skin; Substance P

1996
Effect of the non-peptide blocker (+/-) CP 96,345 on the cellular mechanism involved in the response to NK1 receptor stimulation in human skin fibroblasts.
    Neuropeptides, 1996, Volume: 30, Issue:4

    Topics: Biphenyl Compounds; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Cytosol; Dipeptides; Fibroblasts; Humans; Hydrolysis; Indoles; Neurokinin-1 Receptor Antagonists; Phosphatidylinositols; Physalaemin; Receptors, Neurokinin-1; Skin; Stimulation, Chemical; Substance P

1996
A structural rationale for the design of water soluble peptide-derived neurokinin-1 antagonists.
    Journal of receptor and signal transduction research, 1997, Volume: 17, Issue:6

    Topics: Animals; Biphenyl Compounds; Dipeptides; Drug Design; Humans; In Vitro Techniques; Indoles; Models, Chemical; Models, Molecular; Molecular Mimicry; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Solubility; Substance P; Tetrazoles; Tryptophan; Water

1997
The role of the spinal opioid receptor like1 receptor, the NK-1 receptor, and cyclooxygenase-2 in maintaining postoperative pain in the rat.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:5

    Topics: Animals; Benzenesulfonates; Biphenyl Compounds; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatologic Surgical Procedures; Dipeptides; Hindlimb; Hyperalgesia; Indoles; Isoenzymes; Male; Neurokinin-1 Receptor Antagonists; Nitrobenzenes; Nociceptin; Nociceptin Receptor; Opioid Peptides; Oxazoles; Pain Threshold; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Sulfonamides

1999