fk 888 has been researched along with capsaicin in 25 studies
| Studies (fk 888) | Trials (fk 888) | Recent Studies (post-2010) (fk 888) | Studies (capsaicin) | Trials (capsaicin) | Recent Studies (post-2010) (capsaicin) |
|---|---|---|---|---|---|
| 97 | 2 | 3 | 11,238 | 661 | 3,410 |
| Protein | Taxonomy | fk 888 (IC50) | capsaicin (IC50) |
|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | 0.019 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 0.6 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 3 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 2.6755 | |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | 0.008 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (76.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aikawa, T; Sasaki, H; Sekizawa, K; Ujiie, Y | 1 |
| Fukushima, T; Jin, Y; Morikawa, M; Nakazawa, H; Sasaki, H; Sekizawa, K | 1 |
| Kawaguchi, M; Maehara, K; Maruyama, Y; Saito, T; Sato, E; Yaoita, H | 1 |
| Barthó, L; Maggi, CA; Patacchini, R; Wilhelm, M | 1 |
| Buckley, TL; Koster, AS; Kraneveld, AD; Nijkamp, FP; van Heuven-Nolsen, D; van Schaik, Y | 1 |
| Barnes, PJ; Hirayama, Y; Lei, YH; Rogers, DF | 1 |
| Fujii, T; Hagiwara, D; Ikari, N; Maeda, Y; Matsuo, M; Miyake, H; Murai, M | 1 |
| Fujii, T; Hagiwara, D; Maeda, Y; Matsuo, M; Miyake, H; Murai, M; Yamaoka, M | 1 |
| Ebihara, T; Nakazawa, H; Ohrui, T; Sasaki, H; Sekizawa, K | 1 |
| Matsuda, H; Miyatake, K; Nagata, S; Ohmori, F; Uematsu, M | 1 |
| Ichinose, M; Ishikawa, J; Kageyama, N; Miura, M; Sasaki, Y; Shirato, K; Tomaki, M; Yamauchi, H | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 1 |
| Amemiya, T; Fujimura, M; Matsuda, T; Mizuguchi, M; Nishi, K; Ohka, T | 1 |
| Fujita, H; Kageyama, M; Kanai, A; Nakata, K; Shirasawa, E | 1 |
| Fujita, H; Goto, W; Kageyama, M; Kanai, A; Nakata, K; Shirasawa, E | 1 |
| Fujiwara, R; Izushi, K; Kamei, C; Ohishi, H; Sugimoto, Y; Takada, M; Yamaji, M | 1 |
| Evangelista, S; Giachetti, A; Manzini, S; Paoli, S | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Matsuda, T; Mizuguchi, M; Myou, S; Sasaki, S | 1 |
| Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ | 1 |
| Hayashi, I; Kamijo, Y; Majima, M; Ohwada, T; Soma, K | 1 |
| Beirith, A; Calixto, JB; Santos, AR | 1 |
| Calixto, JB; El Sayah, M | 1 |
| Calixto, JB; Ferreira, J; Medeiros, R; Trichês, KM | 1 |
| Andrade, EL; Calixto, JB; Ferreira, J; Luiz, AP | 1 |
| Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Tsuchida, H; Yamashita, M | 1 |
25 other study(ies) available for fk 888 and capsaicin
| Article | Year |
|---|---|
Evidence for substance P as an endogenous substance causing cough in guinea pigs.
Topics: Aerosols; Animals; Capsaicin; Cough; Dipeptides; Dose-Response Relationship, Drug; Glycopeptides; Guinea Pigs; Indoles; Male; Neprilysin; Smoking; Substance P; Tachykinins | 1993 |
Capsaicin desensitization inhibits swallowing reflex in guinea pigs.
Topics: Acetylcholine; Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Deglutition; Dipeptides; Dose-Response Relationship, Drug; Electromyography; Guinea Pigs; Indoles; Lidocaine; Nerve Fibers; Premedication; Reflex; Substance P | 1994 |
Nonadrenergic noncholinergic nerves regulate basal coronary flow via release of capsaicin-sensitive neuropeptides in the rat heart.
Topics: Adenosine; Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Circulation; Coronary Vessels; Dipeptides; Heart; Hemodynamics; Immunohistochemistry; In Vitro Techniques; Indoles; Male; Myocardium; Neuropeptides; Oxygen Consumption; Rats; Substance P; Ventricular Function, Left | 1994 |
Tachykinin NK1 and NK2 receptors mediate atropine-resistant ileal circular muscle contractions evoked by capsaicin.
Topics: Amino Acid Sequence; Animals; Atropine; Capsaicin; Dipeptides; Drug Resistance; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Ruthenium Red; Substance P; Tetrodotoxin | 1994 |
Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade.
Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Hypersensitivity, Delayed; Indoles; Intestine, Small; Isoindoles; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Neuropeptides; Peptides, Cyclic | 1995 |
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve | 1993 |
Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.
Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1993 |
The pharmacological properties of FK888, a novel dipeptide NK1 antagonist.
Topics: Animals; Bronchoconstriction; Capsaicin; Cell Membrane; Dipeptides; Edema; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indoles; Kinetics; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-1; Substance P | 1993 |
Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs.
Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Capsaicin; Cilazapril; Citrates; Citric Acid; Cough; Cyclic AMP; Danazol; Dipeptides; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Guinea Pigs; Indoles; Procaterol; Reflex; Sex Factors; Substance P; Trachea | 1996 |
Different modes of sensory neuropeptides and nitric oxide involvement in relaxation of guinea-pig vessels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin Endoperoxides, Synthetic; Receptors, Neurotransmitter; Substance P; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Involvement of endogenous tachykinins in LTD4-induced airway responses.
Topics: Administration, Inhalation; Animals; Bronchi; Bronchoconstriction; Capsaicin; Cell Membrane Permeability; Chromones; Dipeptides; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Leukotriene D4; Male; Neurokinin-1 Receptor Antagonists; Respiratory System; Tachykinins | 1996 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Involvement of NK2 receptors rather than NK1 receptors in bronchial hyperresponsiveness induced by allergic reaction in guinea-pigs.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Capsaicin; Dipeptides; Glycopeptides; Guinea Pigs; Histamine; Indoles; Male; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Hypersensitivity | 1996 |
Effects of the immunosuppressant cyclosporin A on neurotransmitter release from peripheral non-adrenergic, non-cholinergic nerves.
Topics: Animals; Atropine; Calcium Channel Blockers; Capsaicin; Cyclosporine; Dipeptides; Immunosuppressive Agents; Indoles; Iris; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Rabbits; Sodium Channel Blockers; Substance P | 1997 |
FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release.
Topics: Animals; Calcium Channel Blockers; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Immunosuppressive Agents; Indoles; Iris; Male; Muscle Contraction; Muscle, Smooth; Polyenes; Rabbits; Receptors, Tachykinin; Sirolimus; Synaptic Transmission; Tachykinins; Tacrolimus | 1997 |
Role of substance P in experimental allergic conjunctivitis in guinea pigs.
Topics: Animals; Capillary Permeability; Capsaicin; Conjunctiva; Conjunctivitis, Allergic; Dipeptides; Disease Models, Animal; Guinea Pigs; Histamine; Indoles; Male; Mast Cells; Ovalbumin; p-Methoxy-N-methylphenethylamine; Serine Proteinase Inhibitors; Substance P; Tears | 1997 |
Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.
Topics: Animals; Antigens; Blood Proteins; Capsaicin; Dextrans; Dipeptides; Extravasation of Diagnostic and Therapeutic Materials; Fluorescein-5-isothiocyanate; Glycopeptides; Guinea Pigs; Indoles; Male; Nasal Mucosa; Neurokinin A; Neurokinin-1 Receptor Antagonists; Olfactory Receptor Neurons; Peptide Fragments; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rhinitis; Substance P | 1997 |
Role of tachykinins in distilled water-induced bronchoconstriction in guinea-pigs.
Topics: Animals; Bronchoconstriction; Capsaicin; Dipeptides; Disease Models, Animal; Glycopeptides; Guinea Pigs; Indoles; Killer Cells, Natural; Male; Nebulizers and Vaporizers; Ovalbumin; Peptides, Cyclic; Respiration; Tachykinins; Water | 1998 |
Effects of airway inflammation on cough response in the guinea pig.
Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1998 |
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P | 2001 |
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.
Topics: Animals; Benzamides; Bradykinin Receptor Antagonists; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Edema; Foot; Glutamic Acid; Indoles; Male; Mice; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 2003 |
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Calcium Channels; Capsaicin; Carbazoles; Conotoxins; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indoles; Iris; Maleimides; Muscle Contraction; Nicardipine; omega-Agatoxin IVA; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Tachykinins | 2003 |
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.
Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Antibodies; Behavior, Animal; Blotting, Western; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Chelating Agents; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Guanethidine; Indoles; Male; Mice; Nociceptors; Pain; Pain Measurement; Peptide Fragments; Propranolol; Protein Kinase C; Ruthenium Red; Salicylates; Sympatholytics; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Pronociceptive response elicited by TRPA1 receptor activation in mice.
Topics: Analgesics; Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Isothiocyanates; Male; Mice; Pain; Pain Measurement; Ruthenium Red; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2008 |
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses.
Topics: Animals; Bronchi; Capillary Permeability; Capsaicin; Chlorocebus aethiops; Citric Acid; COS Cells; Cough; Cyclic S-Oxides; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Inositol Phosphates; Male; Molecular Sequence Data; Morpholines; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea | 2008 |