Page last updated: 2024-09-02

fk 888 and capsaicin

fk 888 has been researched along with capsaicin in 25 studies

Compound Research Comparison

Studies
(fk 888)
Trials
(fk 888)
Recent Studies (post-2010)
(fk 888)
Studies
(capsaicin)
Trials
(capsaicin)
Recent Studies (post-2010) (capsaicin)
972311,2386613,410

Protein Interaction Comparison

ProteinTaxonomyfk 888 (IC50)capsaicin (IC50)
Transient receptor potential cation channel subfamily V member 1Rattus norvegicus (Norway rat)0.019
Lysine-specific histone demethylase 1AHomo sapiens (human)0.6
Bile salt export pumpHomo sapiens (human)10
Cytochrome P450 1A2Homo sapiens (human)3
Prostaglandin G/H synthase 1Homo sapiens (human)2.6755
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)0.008

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's19 (76.00)18.2507
2000's6 (24.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aikawa, T; Sasaki, H; Sekizawa, K; Ujiie, Y1
Fukushima, T; Jin, Y; Morikawa, M; Nakazawa, H; Sasaki, H; Sekizawa, K1
Kawaguchi, M; Maehara, K; Maruyama, Y; Saito, T; Sato, E; Yaoita, H1
Barthó, L; Maggi, CA; Patacchini, R; Wilhelm, M1
Buckley, TL; Koster, AS; Kraneveld, AD; Nijkamp, FP; van Heuven-Nolsen, D; van Schaik, Y1
Barnes, PJ; Hirayama, Y; Lei, YH; Rogers, DF1
Fujii, T; Hagiwara, D; Ikari, N; Maeda, Y; Matsuo, M; Miyake, H; Murai, M1
Fujii, T; Hagiwara, D; Maeda, Y; Matsuo, M; Miyake, H; Murai, M; Yamaoka, M1
Ebihara, T; Nakazawa, H; Ohrui, T; Sasaki, H; Sekizawa, K1
Matsuda, H; Miyatake, K; Nagata, S; Ohmori, F; Uematsu, M1
Ichinose, M; Ishikawa, J; Kageyama, N; Miura, M; Sasaki, Y; Shirato, K; Tomaki, M; Yamauchi, H1
Inoue, H; Koshihara, Y; Nagata, N1
Amemiya, T; Fujimura, M; Matsuda, T; Mizuguchi, M; Nishi, K; Ohka, T1
Fujita, H; Kageyama, M; Kanai, A; Nakata, K; Shirasawa, E1
Fujita, H; Goto, W; Kageyama, M; Kanai, A; Nakata, K; Shirasawa, E1
Fujiwara, R; Izushi, K; Kamei, C; Ohishi, H; Sugimoto, Y; Takada, M; Yamaji, M1
Evangelista, S; Giachetti, A; Manzini, S; Paoli, S1
Amemiya, T; Fujimura, M; Ishiura, Y; Matsuda, T; Mizuguchi, M; Myou, S; Sasaki, S1
Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ1
Hayashi, I; Kamijo, Y; Majima, M; Ohwada, T; Soma, K1
Beirith, A; Calixto, JB; Santos, AR1
Calixto, JB; El Sayah, M1
Calixto, JB; Ferreira, J; Medeiros, R; Trichês, KM1
Andrade, EL; Calixto, JB; Ferreira, J; Luiz, AP1
Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Tsuchida, H; Yamashita, M1

Other Studies

25 other study(ies) available for fk 888 and capsaicin

ArticleYear
Evidence for substance P as an endogenous substance causing cough in guinea pigs.
    The American review of respiratory disease, 1993, Volume: 148, Issue:6 Pt 1

    Topics: Aerosols; Animals; Capsaicin; Cough; Dipeptides; Dose-Response Relationship, Drug; Glycopeptides; Guinea Pigs; Indoles; Male; Neprilysin; Smoking; Substance P; Tachykinins

1993
Capsaicin desensitization inhibits swallowing reflex in guinea pigs.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1

    Topics: Acetylcholine; Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Deglutition; Dipeptides; Dose-Response Relationship, Drug; Electromyography; Guinea Pigs; Indoles; Lidocaine; Nerve Fibers; Premedication; Reflex; Substance P

1994
Nonadrenergic noncholinergic nerves regulate basal coronary flow via release of capsaicin-sensitive neuropeptides in the rat heart.
    Circulation research, 1994, Volume: 75, Issue:4

    Topics: Adenosine; Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Circulation; Coronary Vessels; Dipeptides; Heart; Hemodynamics; Immunohistochemistry; In Vitro Techniques; Indoles; Male; Myocardium; Neuropeptides; Oxygen Consumption; Rats; Substance P; Ventricular Function, Left

1994
Tachykinin NK1 and NK2 receptors mediate atropine-resistant ileal circular muscle contractions evoked by capsaicin.
    European journal of pharmacology, 1994, Jul-01, Volume: 259, Issue:2

    Topics: Amino Acid Sequence; Animals; Atropine; Capsaicin; Dipeptides; Drug Resistance; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Ruthenium Red; Substance P; Tetrodotoxin

1994
Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade.
    British journal of pharmacology, 1995, Volume: 114, Issue:7

    Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Hypersensitivity, Delayed; Indoles; Intestine, Small; Isoindoles; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Neuropeptides; Peptides, Cyclic

1995
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
    British journal of pharmacology, 1993, Volume: 108, Issue:3

    Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve

1993
Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.
    European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1

    Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea

1993
The pharmacological properties of FK888, a novel dipeptide NK1 antagonist.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Animals; Bronchoconstriction; Capsaicin; Cell Membrane; Dipeptides; Edema; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indoles; Kinetics; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-1; Substance P

1993
Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs.
    American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:2

    Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Capsaicin; Cilazapril; Citrates; Citric Acid; Cough; Cyclic AMP; Danazol; Dipeptides; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Guinea Pigs; Indoles; Procaterol; Reflex; Sex Factors; Substance P; Trachea

1996
Different modes of sensory neuropeptides and nitric oxide involvement in relaxation of guinea-pig vessels.
    Journal of the autonomic nervous system, 1995, Oct-05, Volume: 55, Issue:1-2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin Endoperoxides, Synthetic; Receptors, Neurotransmitter; Substance P; Thromboxane A2; Vasoconstrictor Agents

1995
Involvement of endogenous tachykinins in LTD4-induced airway responses.
    The European respiratory journal, 1996, Volume: 9, Issue:3

    Topics: Administration, Inhalation; Animals; Bronchi; Bronchoconstriction; Capsaicin; Cell Membrane Permeability; Chromones; Dipeptides; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Leukotriene D4; Male; Neurokinin-1 Receptor Antagonists; Respiratory System; Tachykinins

1996
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:6

    Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P

1996
Involvement of NK2 receptors rather than NK1 receptors in bronchial hyperresponsiveness induced by allergic reaction in guinea-pigs.
    British journal of pharmacology, 1996, Volume: 117, Issue:3

    Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Capsaicin; Dipeptides; Glycopeptides; Guinea Pigs; Histamine; Indoles; Male; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Hypersensitivity

1996
Effects of the immunosuppressant cyclosporin A on neurotransmitter release from peripheral non-adrenergic, non-cholinergic nerves.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:3

    Topics: Animals; Atropine; Calcium Channel Blockers; Capsaicin; Cyclosporine; Dipeptides; Immunosuppressive Agents; Indoles; Iris; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Rabbits; Sodium Channel Blockers; Substance P

1997
FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release.
    European journal of pharmacology, 1997, Aug-27, Volume: 333, Issue:2-3

    Topics: Animals; Calcium Channel Blockers; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Immunosuppressive Agents; Indoles; Iris; Male; Muscle Contraction; Muscle, Smooth; Polyenes; Rabbits; Receptors, Tachykinin; Sirolimus; Synaptic Transmission; Tachykinins; Tacrolimus

1997
Role of substance P in experimental allergic conjunctivitis in guinea pigs.
    Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:9

    Topics: Animals; Capillary Permeability; Capsaicin; Conjunctiva; Conjunctivitis, Allergic; Dipeptides; Disease Models, Animal; Guinea Pigs; Histamine; Indoles; Male; Mast Cells; Ovalbumin; p-Methoxy-N-methylphenethylamine; Serine Proteinase Inhibitors; Substance P; Tears

1997
Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.
    Neuropeptides, 1997, Volume: 31, Issue:1

    Topics: Animals; Antigens; Blood Proteins; Capsaicin; Dextrans; Dipeptides; Extravasation of Diagnostic and Therapeutic Materials; Fluorescein-5-isothiocyanate; Glycopeptides; Guinea Pigs; Indoles; Male; Nasal Mucosa; Neurokinin A; Neurokinin-1 Receptor Antagonists; Olfactory Receptor Neurons; Peptide Fragments; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rhinitis; Substance P

1997
Role of tachykinins in distilled water-induced bronchoconstriction in guinea-pigs.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1998, Volume: 28, Issue:7

    Topics: Animals; Bronchoconstriction; Capsaicin; Dipeptides; Disease Models, Animal; Glycopeptides; Guinea Pigs; Indoles; Killer Cells, Natural; Male; Nebulizers and Vaporizers; Ovalbumin; Peptides, Cyclic; Respiration; Tachykinins; Water

1998
Effects of airway inflammation on cough response in the guinea pig.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:5

    Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases

1998
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
    Life sciences, 2001, Nov-21, Volume: 70, Issue:1

    Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P

2001
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.
    Brain research, 2003, Apr-18, Volume: 969, Issue:1-2

    Topics: Animals; Benzamides; Bradykinin Receptor Antagonists; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Edema; Foot; Glutamic Acid; Indoles; Male; Mice; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2

2003
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
    Peptides, 2003, Volume: 24, Issue:7

    Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Calcium Channels; Capsaicin; Carbazoles; Conotoxins; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indoles; Iris; Maleimides; Muscle Contraction; Nicardipine; omega-Agatoxin IVA; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Tachykinins

2003
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Antibodies; Behavior, Animal; Blotting, Western; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Chelating Agents; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Guanethidine; Indoles; Male; Mice; Nociceptors; Pain; Pain Measurement; Peptide Fragments; Propranolol; Protein Kinase C; Ruthenium Red; Salicylates; Sympatholytics; Tetradecanoylphorbol Acetate; Time Factors

2005
Pronociceptive response elicited by TRPA1 receptor activation in mice.
    Neuroscience, 2008, Mar-18, Volume: 152, Issue:2

    Topics: Analgesics; Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Isothiocyanates; Male; Mice; Pain; Pain Measurement; Ruthenium Red; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel

2008
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses.
    European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3

    Topics: Animals; Bronchi; Capillary Permeability; Capsaicin; Chlorocebus aethiops; Citric Acid; COS Cells; Cough; Cyclic S-Oxides; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Inositol Phosphates; Male; Molecular Sequence Data; Morpholines; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea

2008