Compounds > fk 888
Page last updated: 2024-09-02

fk 888 and 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one

fk 888 has been researched along with 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one in 5 studies

Compound Research Comparison

Studies
(fk 888)		Trials
(fk 888)		Recent Studies (post-2010)
(fk 888)		Studies
(7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one)		Trials
(7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one)		Recent Studies (post-2010) (7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one)
9723217016

Protein Interaction Comparison

ProteinTaxonomyfk 888 (IC50)7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one (IC50)
Substance-P receptorHomo sapiens (human)0.03
Substance-P receptorCavia porcellus (domestic guinea pig)0.032

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gether, U; Schwartz, TW; Zoffmann, S1
Goso, C; Manzini, S; Potier, E; Szallasi, A1
Buckley, TL; Koster, AS; Kraneveld, AD; Nijkamp, FP; van Heuven-Nolsen, D; van Schaik, Y1
Brelière, JC; Emonds-Alt, X; Fujii, T; Garret, C; Gether, U; Hagiwara, D; Johansen, TE; Pradier, L; Schwartz, TW1
Ngan, MP; Rudd, JA; Wai, MK1

Other Studies

5 other study(ies) available for fk 888 and 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one

ArticleYear
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
    FEBS letters, 1993, Dec-28, Volume: 336, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection

1993
Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding.
    European journal of pharmacology, 1994, Mar-21, Volume: 254, Issue:3

    Topics: Astrocytoma; Biphenyl Compounds; Dipeptides; Humans; Indoles; Isoindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured

1994
Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade.
    British journal of pharmacology, 1995, Volume: 114, Issue:7

    Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Hypersensitivity, Delayed; Indoles; Intestine, Small; Isoindoles; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Neuropeptides; Peptides, Cyclic

1995
Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.
    Molecular pharmacology, 1994, Volume: 45, Issue:3

    Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Dipeptides; Gene Transfer Techniques; Indoles; Inositol Phosphates; Isoindoles; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3

1994
Inhibition of emesis by tachykinin NK1 receptor antagonists in Suncus murinus (house musk shrew).
    European journal of pharmacology, 1999, Feb-05, Volume: 366, Issue:2-3

    Topics: Animals; Antiemetics; Copper Sulfate; Dipeptides; Dose-Response Relationship, Drug; Emetics; Female; Ganglionic Stimulants; Indoles; Infusions, Parenteral; Isoindoles; Male; Motion Sickness; Neurokinin-1 Receptor Antagonists; Nicotine; Physalaemin; Piperidines; Shrews; Stereoisomerism; Vomiting

1999