fk-838 and piperidine

fk-838 has been researched along with piperidine* in 1 studies

Other Studies

1 other study(ies) available for fk-838 and piperidine

Article	Year
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist. Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14 Novel 3-(2-cycloalkyl and cycloalkenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazo lo [1,5-a]-pyridines were synthesized and evaluated for their adenosine A1 receptor binding activities. In this series, FR166124 (3) was found to be the most potent and selective adenosine A1 receptor antagonist, and the double bond of the cyclohexenyl acetic acid group was essential for selectivity of A1 receptor binding. Furthermore, the solubility in water of the sodium salt of FR 166124 was high. Topics: Antihypertensive Agents; Inhibitory Concentration 50; Molecular Structure; Piperidines; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Receptors, Purinergic P1; Solubility; Structure-Activity Relationship; Water; Xanthines	1999

Article

Year

Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.

Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

Novel 3-(2-cycloalkyl and cycloalkenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazo lo [1,5-a]-pyridines were synthesized and evaluated for their adenosine A1 receptor binding activities. In this series, FR166124 (3) was found to be the most potent and selective adenosine A1 receptor antagonist, and the double bond of the cyclohexenyl acetic acid group was essential for selectivity of A1 receptor binding. Furthermore, the solubility in water of the sodium salt of FR 166124 was high.

Topics: Antihypertensive Agents; Inhibitory Concentration 50; Molecular Structure; Piperidines; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Receptors, Purinergic P1; Solubility; Structure-Activity Relationship; Water; Xanthines

1999