fk 224 has been researched along with substance p in 22 studies
| Studies (fk 224) | Trials (fk 224) | Recent Studies (post-2010) (fk 224) | Studies (substance p) | Trials (substance p) | Recent Studies (post-2010) (substance p) |
|---|---|---|---|---|---|
| 44 | 3 | 0 | 17,289 | 277 | 2,010 |
| Protein | Taxonomy | fk 224 (IC50) | substance p (IC50) |
|---|---|---|---|
| Substance-P receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Substance-K receptor | Rattus norvegicus (Norway rat) | 0.2 | |
| Substance-K receptor | Homo sapiens (human) | 0.2455 | |
| Substance-P receptor | Homo sapiens (human) | 0.0011 | |
| Neuromedin-K receptor | Homo sapiens (human) | 0.125 | |
| Substance-K receptor | Mesocricetus auratus (golden hamster) | 0.148 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (90.91) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, T; Matsuda, A; Miyake, H; Morimoto, H; Yamashita, M | 1 |
| Fujii, T; Kiyotoh, S; Maeda, Y; Morimoto, H; Murai, M; Nishikawa, M; Yamaoka, M | 1 |
| Fujii, T; Kiyotoh, S; Maeda, Y; Morimoto, H; Murai, M; Nishikawa, M | 1 |
| Ezaki, M; Hashimoto, M; Hayashi, K; Imanaka, H; Kiyoto, S; Kohsaka, M; Nishikawa, M; Okuhara, M; Shigematsu, N; Yamashita, M | 1 |
| Fujii, T; Hashimoto, M; Hayashi, K; Imanaka, H; Kiyoto, S; Kohsaka, M; Murai, M; Nishikawa, M; Okuhara, M | 1 |
| Gomi, Y; Mizuno, K; Suzuki, N | 2 |
| Nakajima, Y; Sakamoto, T; Takahashi, Y | 1 |
| Ishihara, H; Nagaki, M; Sasaki, T; Shimura, S; Shirato, K; Takishima, T | 1 |
| Church, MK; Featherstone, R; Polak, JM; Salmon, M; Walsh, DA; Wharton, J | 1 |
| Barnes, PJ; Hirayama, Y; Lei, YH; Rogers, DF | 1 |
| Kiyoto, S | 1 |
| Mizuguchi, T; Shimoyama, N; Yamamoto, T | 1 |
| Fujimura, M; Matsuda, T; Matsushima, K; Mizuguchi, M; Nomura, M; Tsujiura, M | 1 |
| Arakawa, M; Goto, F; Katori, M; Majima, M; Nagai, K | 1 |
| Fujii, T; Itaba, M; Kagaya, M; Miura, M; Sano, M; Shindo, T; Shioya, T | 1 |
| Fujimura, M; Ishiura, Y; Matsuda, T; Myou, S; Tsujiura, M | 1 |
| Asakura, K; Kataura, A; Narita, S; Shirasaki, H; Watanabe, M | 1 |
| Ando, M; Fujii, K; Goto, E; Hamamoto, J; Hirata, N; Honda, I; Iwagoe, H; Kohrogi, H; Yamaguchi, T | 1 |
| Kraneveld, AD; Nijkamp, FP; Van Oosterhout, AJ | 1 |
| Bae, SJ; Hamazaki, Y; Katayama, I; Matsunaga, Y; Shimizu, K; Takenaka, M; Tanaka, Y | 1 |
| Ibuki, R; Kawashima, Y; Nakate, T; Ohike, A; Tokunaga, Y; Yoshida, H | 1 |
1 review(s) available for fk 224 and substance p
| Article | Year |
|---|---|
[Substance P receptor antagonist].
Topics: Amino Acid Sequence; Animals; Dactinomycin; In Vitro Techniques; Molecular Sequence Data; Muscle Contraction; Neprilysin; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet Aggregation; Receptors, Neurokinin-1; Substance P; Tachykinins | 1993 |
21 other study(ies) available for fk 224 and substance p
| Article | Year |
|---|---|
Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation.
Topics: Amino Acid Sequence; Animals; Capillary Permeability; Histamine; Male; Molecular Sequence Data; Neurokinin A; Nicotiana; Oligopeptides; Peptides, Cyclic; Plants, Toxic; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Smoke; Substance P; Tachykinins; Trachea | 1992 |
FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Cerebral Cortex; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1992 |
Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerve stimulation in guinea pigs.
Topics: Animals; Bronchoconstriction; Capsaicin; Constriction, Pathologic; Edema; Guinea Pigs; Histamine Antagonists; Injections, Intravenous; Male; Peptides, Cyclic; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1992 |
WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
Topics: Animals; Asthma; Fermentation; Guinea Pigs; In Vitro Techniques; Lactones; Microscopy, Electron, Scanning; Peptides, Cyclic; Streptomyces; Substance P; Tachykinins | 1992 |
WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. II. Biological and pharmacological properties of WS9326A and tetrahydro-WS9326A (FK224)
Topics: Animals; Dose-Response Relationship, Drug; Edema; Guinea Pigs; In Vitro Techniques; Injections, Intravenous; Lactones; Male; Muscle Contraction; Peptides, Cyclic; Streptomyces; Substance P; Tachykinins; Trachea | 1992 |
Neurogenic "off" contractions are mediated by NK2-receptors in the circular muscle of guinea pig ileum.
Topics: Animals; Atropine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Receptors, Neurokinin-2; Substance P | 1994 |
Dermatome mapping in the rat hindlimb by electrical stimulation of the spinal nerves.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Electric Stimulation; Hemorrhage; Hindlimb; Male; Nerve Fibers; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Scrotum; Skin; Spinal Nerves; Substance P | 1994 |
Tachykinin-induced contractions in the circular muscle of guinea pig ileum.
Topics: Animals; Atropine; Biphenyl Compounds; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptides, Cyclic; Rats; Structure-Activity Relationship; Substance P; Tachykinins; Tetrodotoxin | 1994 |
Tachykinins induce a [Ca2+]i rise in the acinar cells of feline tracheal submucosal gland.
Topics: Animals; Calcium; Cats; Exocrine Glands; Fura-2; Glycoproteins; In Vitro Techniques; Indicators and Reagents; Mucins; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-2; Substance P; Tachykinins; Trachea | 1994 |
Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung.
Topics: Animals; Autoradiography; Dipeptides; Guinea Pigs; Humans; Immunohistochemistry; In Vitro Techniques; Indoles; Iodine Radioisotopes; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptides, Cyclic; Pulmonary Artery; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Species Specificity; Substance P; Succinimides | 1994 |
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve | 1993 |
Effects of FK224, a novel cyclopeptide NK1 and NK2 antagonist, and CP-96,345, a nonpeptide NK1 antagonist, on development and maintenance of thermal hyperesthesia evoked by carrageenan injection in the rat paw.
Topics: Animals; Biphenyl Compounds; Carrageenan; Extremities; Hot Temperature; Hyperesthesia; Male; Neurokinin A; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Substance P | 1993 |
Sensory neuropeptides are not directly involved in bronchial hyperresponsiveness induced by interleukin-8 in guinea-pigs in vivo.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dipeptides; Guinea Pigs; Histamine; Indoles; Interleukin-8; Male; Neurokinin A; Peptides, Cyclic; Substance P | 1996 |
Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Bradykinin; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Piperidines; Substance P | 1996 |
Effect of a new dual neurokinin antagonist on airway smooth muscle in situ.
Topics: Animals; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-2; Respiratory System; Substance P; Trachea | 1995 |
Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin A; Peptides, Cyclic; Propranolol; Substance P | 1996 |
The effects of NK1 receptor antagonists (FK224 and FK888) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs.
Topics: Animals; Antigens; Capillary Permeability; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin-1 Receptor Antagonists; Nose; Ovalbumin; Peptides, Cyclic; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Substance P | 1997 |
Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction.
Topics: Acetylcholine; Adult; Aged; Bronchi; Capsaicin; Glycopeptides; Histamine; Humans; In Vitro Techniques; Leukotriene D4; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Protease Inhibitors; Receptors, Tachykinin; Substance P; Tachykinins | 1997 |
Role for neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dipeptides; Eosinophilia; Eosinophils; Guinea Pigs; Indoles; Interleukin-5; Leukocyte Count; Male; Peptides, Cyclic; Receptors, Neurokinin-2; Specific Pathogen-Free Organisms; Substance P | 1997 |
Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts.
Topics: Cells, Cultured; Cycloheximide; Dipeptides; Fibroblasts; Gene Expression; Glycopeptides; Humans; Immunohistochemistry; Indoles; Neprilysin; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Skin; Substance P; Tachykinins | 2002 |
Improvement of pulmonary absorption of cyclopeptide FK224 in rats by co-formulating with beta-cyclodextrin.
Topics: Absorption; Administration, Intranasal; Administration, Oral; Animals; Area Under Curve; beta-Cyclodextrins; Biological Availability; Chemistry, Pharmaceutical; Cyclodextrins; Excipients; Injections, Subcutaneous; Kinins; Lung; Male; Particle Size; Peptides, Cyclic; Pharmaceutical Solutions; Rats; Rats, Sprague-Dawley; Solubility; Substance P; Suspensions; Time Factors | 2003 |