fk 224 has been researched along with capsaicin in 11 studies
| Studies (fk 224) | Trials (fk 224) | Recent Studies (post-2010) (fk 224) | Studies (capsaicin) | Trials (capsaicin) | Recent Studies (post-2010) (capsaicin) |
|---|---|---|---|---|---|
| 44 | 3 | 0 | 11,238 | 661 | 3,410 |
| Protein | Taxonomy | fk 224 (IC50) | capsaicin (IC50) |
|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | 0.019 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 0.6 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 3 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 2.6755 | |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | 0.008 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (90.91) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, T; Kiyotoh, S; Maeda, Y; Morimoto, H; Murai, M; Nishikawa, M | 1 |
| Buckley, TL; Koster, AS; Kraneveld, AD; Nijkamp, FP; van Heuven-Nolsen, D; van Schaik, Y | 1 |
| Barnes, PJ; Hirayama, Y; Lei, YH; Rogers, DF | 1 |
| Akao, N; Fujimura, M; Kondo, K; Matsuda, T; Ogawa, H; Saito, M | 1 |
| Ando, M; Fujii, K; Hamamoto, J; Hirata, N; Iwagoe, H; Kawano, O; Kohrogi, H; Yamaguchi, T | 1 |
| Amemiya, T; Fujimura, M; Matsuda, T; Mizuguchi, M; Nishi, K; Ohka, T | 1 |
| Arakawa, M; Goto, F; Katori, M; Majima, M; Nagai, K | 1 |
| Ando, M; Fujii, K; Goto, E; Hamamoto, J; Hirata, N; Honda, I; Iwagoe, H; Kohrogi, H; Yamaguchi, T | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Matsuda, T; Mizuguchi, M; Myou, S; Sasaki, S | 1 |
| Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ | 1 |
| Fujimura, M; Nakao, S; Nishitsuji, M; Oribe, Y | 1 |
11 other study(ies) available for fk 224 and capsaicin
| Article | Year |
|---|---|
Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerve stimulation in guinea pigs.
Topics: Animals; Bronchoconstriction; Capsaicin; Constriction, Pathologic; Edema; Guinea Pigs; Histamine Antagonists; Injections, Intravenous; Male; Peptides, Cyclic; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1992 |
Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade.
Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Hypersensitivity, Delayed; Indoles; Intestine, Small; Isoindoles; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Neuropeptides; Peptides, Cyclic | 1995 |
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve | 1993 |
The effect of the neurokinin antagonist FK-224 on the cough response to inhaled capsaicin in a new model of guinea-pig eosinophilic bronchitis induced by intranasal polymyxin B.
Topics: Administration, Inhalation; Administration, Intranasal; Animals; Bronchial Provocation Tests; Bronchitis; Bronchoalveolar Lavage Fluid; Capsaicin; Cough; Eosinophilia; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Polymyxin B; Tachykinins | 1994 |
Evidence that PGF2 alpha-induced contraction of isolated guinea pig bronchi is mediated in part by release of tachykinins.
Topics: Animals; Bronchi; Bronchoconstriction; Capsaicin; Dinoprost; Glycopeptides; Guinea Pigs; In Vitro Techniques; Male; Peptides, Cyclic; Protease Inhibitors; Tachykinins; Tetrodotoxin | 1995 |
Involvement of NK2 receptors rather than NK1 receptors in bronchial hyperresponsiveness induced by allergic reaction in guinea-pigs.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Capsaicin; Dipeptides; Glycopeptides; Guinea Pigs; Histamine; Indoles; Male; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Hypersensitivity | 1996 |
Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Bradykinin; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Piperidines; Substance P | 1996 |
Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction.
Topics: Acetylcholine; Adult; Aged; Bronchi; Capsaicin; Glycopeptides; Histamine; Humans; In Vitro Techniques; Leukotriene D4; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Protease Inhibitors; Receptors, Tachykinin; Substance P; Tachykinins | 1997 |
Role of tachykinins in distilled water-induced bronchoconstriction in guinea-pigs.
Topics: Animals; Bronchoconstriction; Capsaicin; Dipeptides; Disease Models, Animal; Glycopeptides; Guinea Pigs; Indoles; Killer Cells, Natural; Male; Nebulizers and Vaporizers; Ovalbumin; Peptides, Cyclic; Respiration; Tachykinins; Water | 1998 |
Effects of airway inflammation on cough response in the guinea pig.
Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1998 |
A guinea pig model for cough variant asthma and role of tachykinins.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cough; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Peptides, Cyclic; Procaterol; Tachykinins | 2004 |