Page last updated: 2024-09-02

fingolimod hydrochloride and sphingosine kinase

fingolimod hydrochloride has been researched along with sphingosine kinase in 93 studies

Compound Research Comparison

Studies (fingolimod hydrochloride)	Trials (fingolimod hydrochloride)	Recent Studies (post-2010) (fingolimod hydrochloride)	Studies (sphingosine kinase)	Trials (sphingosine kinase)	Recent Studies (post-2010) (sphingosine kinase)
2,771	157	2,062	1,660	4	978

Research

Studies (93)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	27 (29.03)	29.6817
2010's	60 (64.52)	24.3611
2020's	6 (6.45)	2.80

Authors

Authors	Studies
Albert, R; Baumruker, T; Brinkmann, V; Bruns, C; Cottens, S; Davis, MD; Foster, CA; Heise, CE; Hiestand, P; Hof, R; Lynch, KR; Prieschl, E; Zollinger, M	1
Brinkmann, V; Claffey, K; Estrada-Hernandez, T; Hla, T; Paik, JH; Sanchez, T; Venkataraman, K; Wu, MT	1
Baumruker, T; Billich, A; Bornancin, F; Dévay, P; Mechtcheriakova, D; Urtz, N	1
Barbour, SE; Milstien, S; Paugh, SW; Payne, SG; Spiegel, S	1
Butler, J; LaMontagne, K; Lana, D; Round, O	1
Djanani, AM; Feistritzer, C; Kaneider, NC; Lindner, J; Mosheimer, BA; Sturn, DH; Wiedermann, CJ	1
Allende, ML; Hajdu, R; Kawai, H; Keohane, CA; Mandala, S; Mi, Y; Olivera, A; Proia, RL; Rosenbach, M; Sasaki, T; Spiegel, S; van Echten-Deckert, G	1
Lee, WJ; Lee, YM; Lim, JS; Oh, S; Suh, PG; Yoo, HS	1
Burcin, TL; Engelhard, VH; Kharel, Y; Lee, S; Ley, K; Lynch, KR; Macdonald, TL; Morris, MA; Pearson-White, S; Setiady, Y; Sheasley-O'neill, SL; Snyder, AH; Tung, KS; Zhu, R; Zigler, MA	1
Baumruker, T; Billich, A; Bornancin, F; Kinzel, B; Mechtcheriakova, D; Müller, M; Reuschel, R; Urtz, N; Zemann, B	1
Baumruker, T; Billich, A; Ettmayer, P; Guerini, D; Mechtcheriakova, D; Nussbaumer, P; Streiff, MB	1
Kihara, A	1
Huwiler, A; Pfeilschifter, J	2
Don, AS; Martinez-Lamenca, C; Proia, RL; Roberts, E; Rosen, H; Webb, WR	1
Chun, J	1
Bittman, R; Coelho, RP; Payne, SG; Sato-Bigbee, C; Spiegel, S	1
Karliner, JS; Kelley, M; Li, L; Tao, R; Vessey, DA; Zhang, J	1
Kennedy, PC; Kharel, Y; Lynch, KR; Macdonald, TL; Schaffter, L; Snyder, AH; Sun, Q; Zhu, R	1
Billich, A; Högenauer, K; Nussbaumer, P; Pally, C; Streiff, M; Wagner, T; Welzenbach, K	1
Fujita, T; Nagaoka, Y; Otsuki, K; Uesato, S	1
Milstien, S; Paugh, SW; Spiegel, S; Takabe, K	1
Awad, AS; Bajwa, A; Jo, SK; Kharel, Y; Lynch, KR; Okusa, MD; Vergis, AL; Ye, H	1
Berdyshev, EV; Bittman, R; Dudek, SM; Garcia, JG; Gorshkova, I; Lu, X; Mirzapoiazova, T; Natarajan, V; Skobeleva, A	1
Arita, N; Fujino, T; Kamada, K; Miyazaki, T; Nose, M; Soga, Y; Takubo, N; Tsubaki, T; Yamamoto, H	1
Gidday, JM; Park, TS; Wacker, BK	1
Brinkmann, V	1
Adamowicz, JJ; Berdyshev, EV; Diab, KJ; Garrison, J; Gu, Y; Hubbard, WC; Kamocki, K; Petrache, I; Rajashekhar, G; Rush, NI; Schweitzer, KS; Skobeleva, A	1
Coolen, C; Jones, C; Lopez, AF; Ma, Y; Pham, D; Pitson, SM; Woodcock, JM	1
Bittman, R; Lim, KG; Long, J; Loveridge, C; Pitson, SM; Pyne, NJ; Pyne, S; Tigyi, G; Tonelli, F	1
Bohler, T; Brizuela, L; Cuvillier, O; Doumerc, N; Golzio, M; Malavaud, B; Pchejetski, D; Salunkhe, V; Sauer, L; Teissié, J; Waxman, J	1
Lai, WQ; Leung, BP; Wong, WS	1
Claas, RF; Ferreirós, N; Hegen, B; Huwiler, A; Labocha, S; Meyer Zu Heringdorf, D; Pfeilschifter, J; Ter Braak, M; van Echten-Deckert, G	1
Bode, C; Gräler, M; Heusch, G; Keul, P; Levkau, B; Lucke, S; von Wnuck Lipinski, K	1
Awad, AS; Bolton, WK; Huang, L; Khutsishvili, K; Lynch, KR; Okusa, MD; Rouse, MD	1
Bittman, R; Li, Z; Lim, KG; Lu, X; Pyne, NJ; Pyne, S; Tonelli, F	1
Bittman, R; Lim, KG; Pyne, NJ; Pyne, S; Sun, C	1
Milstien, S; Nagahashi, M; Spiegel, S; Stevenson, CE; Takabe, K	1
Czech-Zechmeister, B; Foerch, C; Huwiler, A; Koch, A; Mirceska, A; Pfeilschifter, J; Pfeilschifter, W; Rami, A; Steinmetz, H; Sujak, M	1
Böhler, T; Pchejetski, D; Stebbing, J; Waxman, J	1
Bittman, R; Pyne, NJ; Pyne, S	1
Bissel, P; Kharel, Y; Knott, K; Lynch, KR; Raje, MR; Santos, WL	1
Alewijnse, AE; Peters, SL; Spijkers, LJ	1
Kharel, Y; Knott, K; Lynch, KR; Raje, MR; Santos, WL	1
Abeynaike, LD; Bonder, CS; Escarbe, S; Hickey, MJ; Pitson, SM; Smith, CD; Sun, WY	1
Nakamura, S; Okada, T	1
Lopez, AF; Pitman, MR; Pitson, SM; Woodcock, JM	1
Alossaimi, M; Bittman, R; Chan, E; Pyne, NJ; Pyne, S; Tate, RJ; Tonelli, F; Watson, DG; Williamson, L	1
Bianco, R; Carlomagno, C; D'Amato, C; D'Amato, V; Damiano, V; De Placido, S; De Stefano, A; Del Vecchio, S; Formisano, L; Greco, A; Malapelle, U; Marciano, R; Marfè, G; Nappi, L; Rosa, R; Troncone, G; Veneziani, BM; Zannetti, A	1
Allegood, JC; Avni, D; Hait, NC; Harikumar, KB; Huang, WC; Kim, EY; Kordula, T; Liang, J; Milstien, S; Nagahashi, M; Price, MM; Spiegel, S; Takabe, K; Yamada, A	1
Baek, DJ; Bittman, R; MacRitchie, N; Pyne, NJ; Pyne, S	1
Abassi, T; Berdyshev, E; Bittman, R; Dudek, SM; Garcia, JG; Huang, LS; Jacobson, JR; Mathew, B; Moreno-Vinasco, L; Natarajan, V; Wang, L; Weichselbaum, R; Zhao, Y	1
Honbo, N; Imhof, I; Karliner, JS; Li, L; Vessey, DA	1
Ihlefeld, K; Pfeilschifter, J; Zu Heringdorf, DM	1
Ebinuma, I; Isshiki, H; Iwatsubo, T; Osawa, S; Sasaki, T; Takasugi, N; Takeo, K; Tomita, T	1
Ferrer, F; Hla, T; Li, MH	1
Huwiler, A; Pfeilschifter, J; Schwalm, S	1
Altay, O; Hasegawa, Y; Rolland, W; Suzuki, H; Zhang, JH	1
Amico, E; Castrataro, R; Di Pardo, A; Favellato, M; Fucile, S; Maglione, V; Squitieri, F	1
Bittman, R; Ohotski, J; Pyne, NJ; Pyne, S; Rosen, H	1
Allegood, JC; Avni, D; Hait, NC; Knapp, PE; Lichtman, AH; Lu, J; Luo, C; Miles, MF; Milstien, S; O'Brien, M; Reeves, TM; Spiegel, S; Wise, LE	1
Danhof, M; Luttringer, O; Ploeger, BA; Snelder, N; Stanski, DR	1
Banno, Y; Fujine, E; Ishitsuka, A; Kanoh, H; Mizutani, Y; Seishima, M; Tawada, C	1
Amor, S; Beyer, C; Clarner, T; Kipp, M; Schmidt, T; Slowik, A	1
Beak, DJ; Bertaina, A; Bittman, R; Chiarini, F; Evangelisti, C; Falconi, M; Locatelli, F; Martelli, AM; McCubrey, JA; Melchionda, F; Pession, A; Pyne, NJ; Pyne, S; Teti, G	1
Ahmadiani, A; Asle-Rousta, M; Dargahi, L; Kolahdooz, Z; Nasoohi, S	1
Chi, M; Guo, ST; Jiang, CC; Jin, L; Liu, X; Tay, KH; Tseng, HY; Verrills, NM; Zhang, XD	1
Ding, LH; Liu, BC; Liu, D; Liu, H; Lv, LL; Ma, KL; Tang, RN; Wen, Y; Wu, M; Xu, M	1
Bae, DS; Cho, YJ; Choi, CH; Choi, JJ; Do, IG; Jeon, HK; Kim, BG; Kim, TJ; Lee, JW; Lee, YY; Ryu, JY; Song, SY; Yoon, G	1
Angioni, C; Arlt, O; Huwiler, A; Pfeilschifter, JM; Radeke, HH; Schmidt, H; Schröder, M; Schwiebs, A	1
Bae, DS; Cho, YJ; Choi, CH; Choi, JJ; Kim, BG; Kim, HS; Kim, TJ; Lee, JW; Lee, YY; Ryu, JY; Song, SY; Yoon, G	1
Choi, JW; Chun, J; Han, JE; Jeon, S; Moon, E; Ryu, JH	1
Gao, E; He, Y; Lee, Y; Tao, L; Wang, W; Xia, Y; Xin, C; Yan, W; Zhang, F; Zhang, H; Zhang, L; Zhao, S; Zhou, F; Zhu, D	1
Grüner, S; Mayer, CA; Ottenlinger, F; Pfarr, K; Pfeilschifter, JM; Radeke, HH; Schwiebs, A; Wagner, A	1
Barnawi, J; Davies, LT; Haberberger, R; Hamon, R; Hodge, G; Hodge, S; Pitson, SM; Reynolds, PN; Roscioli, E; Tran, HB; Ween, M	1
Bonder, CS; Dimasi, DP; Grimbaldeston, MA; Heddle, R; Pitman, MR; Pitson, SM; Sun, WY; Zhuang, Y	1
Herr, DR; Ibrahim, MH; Johnson, SP; Lai, SL; Lopes, V; Murray, PG; Narayanaswamy, P; Panja Bernam, S; Paterson, IC; Patmanathan, SN; Torta, F; Wei, W; Wenk, MR; Yap, LF	1
Adams, BJ; Allegood, JC; Aoyagi, T; Huang, WC; Milstien, S; Miyazaki, H; Nagahashi, M; Rashid, OM; Spiegel, S; Takabe, K; Terracina, KP; Tsuchida, J; Wakai, T; Yamada, A	1
Ader, I; Cuvillier, O; Gstalder, C	1
Li, J; Li, N; Li, W; Ni, B; Ruan, Z; Tian, Z; Wang, H; Wang, Y; Zhang, K	1
Adams, DH; Frampton, J; Haldar, D; Henderson, NC; Houlihan, DD; Kalia, N; Kavanagh, D; King, A; Luu, N; Newsome, PN; Owen, A; Penny, J; Ramachandran, P; Reynolds, G; Sumption, H; Suresh, S; Than, NN	1
Baxter, RC; Boyle, FM; de Silva, HC; Julovi, SM; Lin, MZ; Martin, JL	1
Hait, NC; Katsuta, E; Lyon, DE; Nagahashi, M; Rashid, OM; Raza, A; Sturgill, JL; Takabe, K; Yan, L	1
Chen, F; Lin, L; Pan, Y; Wang, L; Xiong, X	1
Boguszewski, PM; Kosson, P; Motyl, J; Przykaza, Ł; Strosznajder, JB	1
Hu, JP; Li, Y; Yang, S	1
Blanchard, F; Bougault, C; Briolay, A; Brizuela, L; El Jamal, A; Le Goff, B; Magne, D; Mebarek, S	1
Choi, JW; Gaire, BP	1
Adams, DR; Pyne, NJ; Pyne, S	1
Chen, CP; Chew, WS; Chua, XY; Herr, DR; Ho, LTY; Lai, MKP; Lam, BWS; Ong, WY; Xiang, P	1
Hirata, N; Kanda, Y; Ono, A; Yamada, S; Yanagida, S	1
Bu, YH; Chen, FY; Deng, R; Dong, XT; Gan, PR; Ke, JT; Wang, RH; Wu, H	1
Ando, H; Ishida, T; Ishima, Y; Kusumoto, K; Ogawa, M; Okuhira, K; Shimizu, T; Tachibana, K	1

Reviews

16 review(s) available for fingolimod hydrochloride and sphingosine kinase

Article	Year
[Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics]. Seikagaku. The Journal of Japanese Biochemical Society, 2006, Volume: 78, Issue:8 Topics: Animals; Biological Transport; Cell Membrane; Drug Design; Fingolimod Hydrochloride; Humans; Immune System; Immunosuppressive Agents; Lysophospholipids; Membrane Proteins; Neovascularization, Physiologic; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Saccharomyces cerevisiae Proteins; Signal Transduction; Sphingosine	2006
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochemical pharmacology, 2008, May-15, Volume: 75, Issue:10 Topics: Animals; Fingolimod Hydrochloride; Humans; Lysophospholipids; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Sphingosine; Sulfhydryl Compounds; Thiazolidines; Thiophenes	2008
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacological reviews, 2008, Volume: 60, Issue:2 Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Enzyme Activation; Fingolimod Hydrochloride; Humans; Hypersensitivity; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sulfhydryl Compounds	2008
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system. British journal of pharmacology, 2009, Volume: 158, Issue:5 Topics: Animals; Astrocytes; Brain; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Gap Junctions; Humans; Immune System; Inflammation; Lymph Nodes; Lysophospholipids; Multiple Sclerosis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes	2009
Sphingosine kinase and sphingosine 1-phosphate in asthma. Bioscience reports, 2011, Volume: 31, Issue:2 Topics: Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Humans; Inflammation; Lung; Lysophospholipids; Mast Cells; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine	2011
Targeting sphingosine-1-phosphate in hematologic malignancies. Anti-cancer agents in medicinal chemistry, 2011, Volume: 11, Issue:9 Topics: Animals; Fingolimod Hydrochloride; Hematologic Neoplasms; Humans; Immunosuppressive Agents; Lysophospholipids; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2011
Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer. Nature reviews. Urology, 2011, Sep-13, Volume: 8, Issue:10 Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Male; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostatic Neoplasms; Signal Transduction; Sphingosine	2011
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. Cancer research, 2011, Nov-01, Volume: 71, Issue:21 Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mice; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Sphingosine; Vinyl Compounds	2011
[Role of S1P acting both inside and outside the cells]. Seikagaku. The Journal of Japanese Biochemical Society, 2012, Volume: 84, Issue:2 Topics: Adaptive Immunity; Animals; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunity, Innate; Immunosuppressive Agents; Lysophospholipids; Membrane Microdomains; Nervous System Physiological Phenomena; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Second Messenger Systems; Sphingolipids; Sphingosine	2012
Molecular targets of FTY720 (fingolimod). Current molecular medicine, 2012, Volume: 12, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Lysophospholipids; Multiple Sclerosis; Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2012
Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:1 Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Biomarkers; Capillary Permeability; Fingolimod Hydrochloride; Humans; Lung; Lysophospholipids; Membrane Proteins; Nerve Tissue Proteins; Phosphotransferases (Alcohol Group Acceptor); Pneumonia; Propylene Glycols; Receptors, Lysosphingolipid; Sepsis; Sphingosine; Transferases (Other Substituted Phosphate Groups); Translational Research, Biomedical	2013
Pharmacology of the sphingosine-1-phosphate signalling system. Handbook of experimental pharmacology, 2013, Issue:215 Topics: Aldehyde-Lyases; Animals; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2013
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:1 Topics: Animals; Cell Proliferation; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Glomerulonephritis; Humans; Inflammation; Kidney Failure, Chronic; Lysophospholipids; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2014
Sphingosine 1-Phosphate Receptors in Cerebral Ischemia. Neuromolecular medicine, 2021, Volume: 23, Issue:1 Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Neovascularization, Physiologic; Nerve Tissue Proteins; Neuroprotective Agents; Phosphotransferases (Alcohol Group Acceptor); Rats; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors	2021
Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases. Cellular signalling, 2020, Volume: 76 Topics: Animals; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Ligands; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Sphingosine 1 Phosphate Receptor Modulators	2020
Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment. Neuromolecular medicine, 2021, Volume: 23, Issue:1 Topics: Aldehyde-Lyases; Alzheimer Disease; Animals; Cerebrovascular Disorders; Clinical Trials as Topic; Dementia, Vascular; Drug Delivery Systems; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Mice; Mice, Knockout; Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors	2021

Other Studies

77 other study(ies) available for fingolimod hydrochloride and sphingosine kinase

Article	Year
The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of biological chemistry, 2002, Jun-14, Volume: 277, Issue:24 Topics: Animals; Apoptosis; Cell Line; Cell Membrane; Chemotaxis; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Insecta; Kidney; Lipid Metabolism; Lymphocytes; Lymphopenia; Mice; Models, Chemical; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Inbred Lew; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Recombinant Proteins; Signal Transduction; Sphingosine; Time Factors	2002
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. The Journal of biological chemistry, 2003, Nov-21, Volume: 278, Issue:47 Topics: Adherens Junctions; Animals; Capillary Permeability; Cell Survival; Cells, Cultured; Drug Antagonism; Endothelial Cells; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Umbilical Veins; Vascular Endothelial Growth Factor A	2003
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. The Journal of biological chemistry, 2003, Nov-28, Volume: 278, Issue:48 Topics: Animals; Blotting, Northern; Cell Line; Cloning, Molecular; DNA, Complementary; Endothelial Cells; Fingolimod Hydrochloride; Genetic Variation; Genome, Human; Humans; Immunosuppressive Agents; Kinetics; Mice; Mice, Inbred BALB C; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Isoforms; Protein Structure, Tertiary; Rats; Rats, Wistar; Sphingosine; Tissue Distribution	2003
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS letters, 2003, Nov-06, Volume: 554, Issue:1-2 Topics: Animals; Biotransformation; Cell Line; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mice; Octoxynol; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine; Transfection	2003
Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. Prostaglandins & other lipid mediators, 2004, Volume: 73, Issue:1-2 Topics: Calcium Signaling; Cells, Cultured; Endothelium, Vascular; Fingolimod Hydrochloride; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Immunosuppressive Agents; Isomerism; Lysophospholipids; Mitogen-Activated Protein Kinases; Molecular Structure; Organogenesis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship; Umbilical Veins	2004
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Androstadienes; Bombesin; Calcitonin Gene-Related Peptide; Cell Movement; Chemotaxis, Leukocyte; Cholera Toxin; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation; Heterotrimeric GTP-Binding Proteins; Humans; Immunologic Factors; Indoles; Leukocytes, Mononuclear; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neuropeptides; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Lysosphingolipid; RNA, Messenger; Secretogranin II; Sphingosine; Staurosporine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin	2004
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. The Journal of biological chemistry, 2004, Dec-10, Volume: 279, Issue:50 Topics: Animals; Base Sequence; DNA; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocytes; Lymphopenia; Lysophospholipids; Mice; Mice, Knockout; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2004
Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells. Experimental & molecular medicine, 2004, Oct-31, Volume: 36, Issue:5 Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Line; DNA Fragmentation; Endothelial Cells; Enzyme Inhibitors; Fingolimod Hydrochloride; Kidney; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine; Swine; Up-Regulation	2004
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of biological chemistry, 2005, Nov-04, Volume: 280, Issue:44 Topics: Animals; Fingolimod Hydrochloride; Flow Cytometry; Homozygote; Immunosuppressive Agents; Lymphocytes; Lymphopenia; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine	2005
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood, 2006, Feb-15, Volume: 107, Issue:4 Topics: Animals; Cell Movement; Fingolimod Hydrochloride; Flow Cytometry; Immunosuppressive Agents; Kinetics; Lymphocytes; Mice; Mice, Knockout; Phosphates; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Propylene Glycols; RNA, Messenger; Sphingosine	2006
NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies. Bioorganic & medicinal chemistry letters, 2006, Jan-01, Volume: 16, Issue:1 Topics: Calcium; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunosuppressive Agents; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Chemical; Oxadiazoles; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Binding; Receptors, Lysosphingolipid; Recombinant Proteins; Sphingosine; Substrate Specificity; Time Factors	2006
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. Current pharmaceutical design, 2006, Volume: 12, Issue:35 Topics: Amidohydrolases; Animals; Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Ceramidases; Ceramides; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Lipid Metabolism; Lysophospholipids; Neoplasms; Neovascularization, Pathologic; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine	2006
Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. The Journal of biological chemistry, 2007, May-25, Volume: 282, Issue:21 Topics: Animals; Apoptosis; Autoimmune Diseases; bcl-2-Associated X Protein; Calcium Signaling; Caspases; Cell Membrane Permeability; Drug Resistance, Neoplasm; Endoplasmic Reticulum; Fingolimod Hydrochloride; HeLa Cells; Humans; Immunosuppressive Agents; Jurkat Cells; Lymphoproliferative Disorders; Mice; Mice, Knockout; Mitochondria; Mutagenesis; Organ Specificity; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Transport; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine; Spleen; Thymus Gland	2007
Immunology. The sources of a lipid conundrum. Science (New York, N.Y.), 2007, Apr-13, Volume: 316, Issue:5822 Topics: Animals; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2007
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2 Topics: Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Fingolimod Hydrochloride; Immunosuppressive Agents; Microglia; Neurotrophin 3; Oligodendroglia; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sphingosine; Stem Cells	2007
Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. Journal of biochemical and molecular toxicology, 2007, Volume: 21, Issue:5 Topics: Animals; Antibodies; Blotting, Western; Chromatography, Gel; Enzyme Activation; Fingolimod Hydrochloride; Isoenzymes; Mice; Myocardium; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Sphingosine	2007
Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25 Topics: Animals; Calcium; Cell Line; Cricetinae; Cricetulus; Fingolimod Hydrochloride; Humans; Immunologic Factors; Mice; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Propylene Glycols; Radioligand Assay; Receptors, Lysosphingolipid; Sphingosine; Stereoisomerism; Structure-Activity Relationship	2007
Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues. ChemMedChem, 2008, Volume: 3, Issue:7 Topics: Catalysis; Fingolimod Hydrochloride; Immunosuppressive Agents; Models, Chemical; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine	2008
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:6 Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indicators and Reagents; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Spectrophotometry, Infrared; Sphingosine	2008
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney international, 2009, Volume: 75, Issue:2 Topics: Animals; Fingolimod Hydrochloride; Gene Expression Regulation, Enzymologic; Kidney; Kidney Diseases; Lysophospholipids; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reperfusion Injury; RNA, Messenger; Sphingosine	2009
FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. The Journal of biological chemistry, 2009, Feb-27, Volume: 284, Issue:9 Topics: Cells, Cultured; Ceramides; Chromatography, Liquid; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lung; Lysophospholipids; Oxidoreductases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pulmonary Artery; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Serine C-Palmitoyltransferase; Sphingosine; Tandem Mass Spectrometry; Up-Regulation	2009
Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720. Pathology international, 2009, Volume: 59, Issue:6 Topics: Apoptosis; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Fibroblasts; Fingolimod Hydrochloride; Fluorescent Antibody Technique; Humans; Immunosuppressive Agents; In Situ Nick-End Labeling; Microscopy, Confocal; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Synovial Membrane	2009
Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. Stroke, 2009, Volume: 40, Issue:10 Topics: Animals; Arterioles; Brain Edema; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Fingolimod Hydrochloride; Hypoxia-Ischemia, Brain; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Lysophospholipids; Male; Mice; Microcirculation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reperfusion Injury; RNA, Messenger; Sphingosine	2009
Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. American journal of respiratory and critical care medicine, 2010, Feb-15, Volume: 181, Issue:4 Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Ceramides; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Indoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Propylene Glycols; Pulmonary Alveoli; Pulmonary Emphysema; Pyrroles; Receptors, Lysosphingolipid; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sphingosine	2010
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cellular signalling, 2010, Volume: 22, Issue:9 Topics: 14-3-3 Proteins; Animals; Apoptosis; Caspases; Cell Survival; Chlorocebus aethiops; COS Cells; Fingolimod Hydrochloride; Humans; Jurkat Cells; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Isoforms; Protein Kinase C-delta; Sphingosine	2010
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cellular signalling, 2010, Volume: 22, Issue:10 Topics: Androgens; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Humans; Male; Muscle, Smooth, Vascular; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pulmonary Artery; Sphingosine; Stereoisomerism; Vinyl Compounds	2010
FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1. Cancer research, 2010, Nov-01, Volume: 70, Issue:21 Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Fingolimod Hydrochloride; Flow Cytometry; Gamma Rays; Humans; Immunosuppressive Agents; Male; Mice; Mice, Nude; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostatic Neoplasms; Radiation Tolerance; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sphingosine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2010
Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. Biochemical pharmacology, 2011, Mar-01, Volume: 81, Issue:5 Topics: Calcium; Fingolimod Hydrochloride; HEK293 Cells; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Stereoisomerism	2011
Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis. Circulation research, 2011, Feb-04, Volume: 108, Issue:3 Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Movement; Cell Proliferation; Disease Models, Animal; Fingolimod Hydrochloride; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Peritonitis; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thioglycolates	2011
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney international, 2011, Volume: 79, Issue:10 Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fingolimod Hydrochloride; Kidney; Lymphocytes; Mice; Mice, Inbred C57BL; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Podocytes; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha	2011
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. The Journal of biological chemistry, 2011, May-27, Volume: 286, Issue:21 Topics: Actins; Allosteric Regulation; Breast Neoplasms; Catalytic Domain; Cell Line, Tumor; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Models, Chemical; Neoplasm Proteins; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine	2011
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cellular signalling, 2011, Volume: 23, Issue:10 Topics: Actins; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Membrane; Enzyme Assays; Female; Fingolimod Hydrochloride; HEK293 Cells; Humans; Lysophospholipids; Microscopy, Fluorescence; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pseudopodia; Sphingosine	2011
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochemical and biophysical research communications, 2011, Sep-23, Volume: 413, Issue:2 Topics: Animals; Brain Ischemia; Enzyme Activation; Fingolimod Hydrochloride; Gene Deletion; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine	2011
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorganic & medicinal chemistry, 2012, Jan-01, Volume: 20, Issue:1 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Enzyme Activation; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Kinetics; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine; Structure-Activity Relationship	2012
FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase. British journal of pharmacology, 2012, Volume: 166, Issue:4 Topics: Animals; Blood Pressure; Carotid Arteries; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Fingolimod Hydrochloride; Hypertension; Immunosuppressive Agents; Isoenzymes; Male; Muscle, Smooth, Vascular; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sphingosine; Thromboxane A2; Vascular Resistance; Vasoconstrictor Agents	2012
Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorganic & medicinal chemistry letters, 2012, Nov-15, Volume: 22, Issue:22 Topics: Cyclohexylamines; Enzyme Inhibitors; Fingolimod Hydrochloride; Isoenzymes; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Binding; Sphingosine; Structure-Activity Relationship	2012
Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. The American journal of pathology, 2012, Volume: 180, Issue:4 Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Fingolimod Hydrochloride; Hemodynamics; Histamine; Human Umbilical Vein Endothelial Cells; Humans; Immunosuppressive Agents; Leukocyte Count; Leukocyte Rolling; MAP Kinase Signaling System; Mice; Mice, Knockout; Neutrophil Infiltration; P-Selectin; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Up-Regulation	2012
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. British journal of pharmacology, 2013, Volume: 168, Issue:6 Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Fingolimod Hydrochloride; Free Radical Scavengers; Humans; Isoenzymes; Male; Neoplasm Proteins; Oxidative Stress; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Processing, Post-Translational; Protein Stability; Receptors, Androgen; RNA, Messenger; Sphingosine; Thiazoles	2013
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jan-01, Volume: 19, Issue:1 Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Line, Tumor; Cetuximab; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Fingolimod Hydrochloride; Gene Expression; Humans; Mice; Mice, Nude; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Treatment Outcome; Xenograft Model Antitumor Assays	2013
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer cell, 2013, Jan-14, Volume: 23, Issue:1 Topics: Animals; Cell Transformation, Neoplastic; Colitis; Colon; Fingolimod Hydrochloride; Gene Deletion; Gene Expression Regulation, Neoplastic; Interleukin-6; Lysophospholipids; Mice; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine; STAT3 Transcription Factor; Tumor Microenvironment	2013
Synthesis of selective inhibitors of sphingosine kinase 1. Chemical communications (Cambridge, England), 2013, Mar-14, Volume: 49, Issue:21 Topics: Cell Line; Enzyme Inhibitors; Fingolimod Hydrochloride; HEK293 Cells; Humans; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine	2013
FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning. Medical science monitor basic research, 2013, Apr-09, Volume: 19 Topics: Adenosine; Algorithms; Animals; Fingolimod Hydrochloride; Immunosuppressive Agents; In Vitro Techniques; Ischemic Postconditioning; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Perfusion; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reperfusion Injury; Sphingosine	2013
FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. PloS one, 2013, Volume: 8, Issue:5 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Mice; Mice, Inbred BALB C; Neurons; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Signal Transduction; Sphingosine; Sulfhydryl Compounds	2013
FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatric blood & cancer, 2013, Volume: 60, Issue:9 Topics: Animals; Cell Death; Child; Child, Preschool; Drug Synergism; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Infant; Male; Mice; Mice, Nude; Neuroblastoma; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Signal Transduction; Sphingolipids; Sphingosine; Topoisomerase I Inhibitors; Topotecan; Xenograft Model Antitumor Assays	2013
Role of the sphingosine metabolism pathway on neurons against experimental cerebral ischemia in rats. Translational stroke research, 2013, Volume: 4, Issue:5 Topics: Animals; Brain Ischemia; Disease Models, Animal; Fingolimod Hydrochloride; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Male; Neurons; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Sprague-Dawley; Sphingosine	2013
FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease. Human molecular genetics, 2014, May-01, Volume: 23, Issue:9 Topics: Animals; Brain; Cell Line; Disease Models, Animal; Fingolimod Hydrochloride; Huntington Disease; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Transgenic; Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Real-Time Polymerase Chain Reaction; Sphingosine	2014
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor Cellular signalling, 2014, Volume: 26, Issue:5 Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; CSK Tyrosine-Protein Kinase; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Estrogen; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Thiazoles; Tyrosine	2014
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. Nature neuroscience, 2014, Volume: 17, Issue:7 Topics: Animals; Blotting, Western; Brain; Exploratory Behavior; Extinction, Psychological; Fear; Fingolimod Hydrochloride; Gene Expression; Hippocampus; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Immunosuppressive Agents; Isoenzymes; Learning Disabilities; Lysophospholipids; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, SCID; Models, Molecular; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Spectrometry, Mass, Electrospray Ionization; Sphingosine	2014
Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9 Topics: Administration, Intravenous; Administration, Oral; Animals; Blood Platelets; Double-Blind Method; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Randomized Controlled Trials as Topic; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sphingosine	2014
FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression. International journal of molecular medicine, 2014, Volume: 34, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Fingolimod Hydrochloride; Humans; Inhibitory Concentration 50; Lysophospholipids; Melanoma; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Signal Transduction; Sphingosine	2014
The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination. British journal of pharmacology, 2015, Volume: 172, Issue:1 Topics: Amyloid beta-Protein Precursor; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Fingolimod Hydrochloride; Gene Expression Regulation; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Neuroprotective Agents; Phosphatidate Phosphatase; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2015
Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics. Oncotarget, 2014, Sep-15, Volume: 5, Issue:17 Topics: Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Cell Line, Tumor; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Microscopy, Electron, Transmission; Phosphotransferases (Alcohol Group Acceptor); Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Propylene Glycols; Sphingosine; Thiazoles; Unfolded Protein Response	2014
Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod. Journal of molecular neuroscience : MN, 2014, Volume: 54, Issue:4 Topics: Alzheimer Disease; Animals; Cyclooxygenase 2; Enzyme Inhibitors; Fingolimod Hydrochloride; Male; Maze Learning; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Tumor Necrosis Factor-alpha	2014
Involvement of vacuolar H(+)-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720. Pigment cell & melanoma research, 2015, Volume: 28, Issue:2 Topics: Adenosine Triphosphate; Autophagy; Cell Death; Cell Line, Tumor; Cell Membrane; Dimethyl Sulfoxide; Fingolimod Hydrochloride; Humans; Macrolides; Melanoma; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Phosphatase 2; Reactive Oxygen Species; Sphingosine; Vacuolar Proton-Translocating ATPases	2015
FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. Acta pharmacologica Sinica, 2014, Volume: 35, Issue:12 Topics: Acetylglucosaminidase; Albuminuria; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation Mediators; Kidney Tubules; Lymphocytes; Lysophospholipids; Macrophages; Male; Nephritis, Interstitial; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats, Wistar; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors	2014
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer. International journal of cancer, 2015, Jul-01, Volume: 137, Issue:1 Topics: Adenocarcinoma, Clear Cell; Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; RNA, Small Interfering; Sphingosine; Xenograft Model Antitumor Assays	2015
Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Biological chemistry, 2015, Volume: 396, Issue:6-7 Topics: Animals; Cells, Cultured; Female; Fingolimod Hydrochloride; Lysophospholipids; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Organophosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Spleen; Tandem Mass Spectrometry	2015
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer. Oncotarget, 2015, Sep-29, Volume: 6, Issue:29 Topics: Adult; Animals; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Disease Progression; Disease-Free Survival; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Fingolimod Hydrochloride; Formaldehyde; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Immunohistochemistry; Lymphatic Metastasis; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasm Transplantation; Paraffin Embedding; Phosphotransferases (Alcohol Group Acceptor); Prognosis; Thiazoles; Uterine Cervical Neoplasms	2015
Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling. Mediators of inflammation, 2015, Volume: 2015 Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Fingolimod Hydrochloride; Lysophospholipids; Male; Mice; Mice, Inbred ICR; Microinjections; Neuroglia; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Stroke; Tumor Necrosis Factor-alpha	2015
Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. American journal of physiology. Heart and circulatory physiology, 2016, Jan-15, Volume: 310, Issue:2 Topics: Animals; Animals, Newborn; Cytokines; Fingolimod Hydrochloride; Heart Diseases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocarditis; Myocytes, Cardiac; Phosphotransferases (Alcohol Group Acceptor); Rats, Sprague-Dawley; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Transfection; Ultrasonography	2016
Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. European journal of immunology, 2016, Volume: 46, Issue:4 Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; DNA-Binding Proteins; Female; Fingolimod Hydrochloride; Histone Chaperones; Interferon-gamma; Interleukin-2; Interleukin-33; Lysophospholipids; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oncogene Proteins; Organophosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Phosphatase 2; Sphingosine; Spleen	2016
Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720. Journal of leukocyte biology, 2016, Volume: 100, Issue:1 Topics: Bronchi; Cells, Cultured; Epithelial Cells; Fingolimod Hydrochloride; Gene Expression Regulation, Enzymologic; Humans; Immunosuppressive Agents; Lysophospholipids; Macrophages, Alveolar; Phagocytosis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pulmonary Disease, Chronic Obstructive; Signal Transduction; Smoking; Sphingosine	2016
Topical Application of Fingolimod Perturbs Cutaneous Inflammation. Journal of immunology (Baltimore, Md. : 1950), 2016, 05-01, Volume: 196, Issue:9 Topics: Administration, Topical; Animals; Capillary Permeability; Cell Movement; Cells, Cultured; Cytokines; Dermatitis; Disease Models, Animal; Fingolimod Hydrochloride; Histamine; Humans; Immunoglobulin E; Inflammation Mediators; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Neutrophils; Phosphotransferases (Alcohol Group Acceptor); Skin	2016
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Scientific reports, 2016, 05-10, Volume: 6 Topics: Aldehyde-Lyases; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Cisplatin; Drug Synergism; Female; Fingolimod Hydrochloride; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunosuppressive Agents; Kaplan-Meier Estimate; Lysophospholipids; Male; Middle Aged; Mouth Neoplasms; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors	2016
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. Journal of mammary gland biology and neoplasia, 2016, Volume: 21, Issue:1-2 Topics: Activation, Metabolic; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Extracellular Fluid; Female; Fingolimod Hydrochloride; Humans; Isoenzymes; Lysophospholipids; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice, Inbred BALB C; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Random Allocation; Sphingosine; Tumor Microenvironment	2016
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Molecular cancer therapeutics, 2016, Volume: 15, Issue:10 Topics: Animals; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Fingolimod Hydrochloride; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Mice; Neovascularization, Pathologic; Oxygen Consumption; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A; Vascular Remodeling; Xenograft Model Antitumor Assays	2016
Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma. Oncotarget, 2016, Dec-06, Volume: 7, Issue:49 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemoradiotherapy; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Fingolimod Hydrochloride; Humans; Ki-67 Antigen; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Time Factors; Transfection; Xenograft Model Antitumor Assays	2016
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. Gastroenterology, 2017, Volume: 153, Issue:1 Topics: Actins; Aldehyde-Lyases; Animals; Cell Line; Cell Movement; Chemical and Drug Induced Liver Injury, Chronic; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Fingolimod Hydrochloride; Gene Expression; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Immunosuppressive Agents; Liver; Liver Cirrhosis; Lymph; Lysophospholipids; Macrophages; Male; Membrane Proteins; Mice; Monocytes; Neutrophils; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Sphingosine	2017
Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade. Breast cancer research : BCR, 2017, Aug-04, Volume: 19, Issue:1 Topics: Animals; Caspase 3; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Fingolimod Hydrochloride; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Insulin-Like Growth Factor Binding Protein 3; Mice; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2017
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. The Journal of surgical research, 2017, Volume: 219 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Mammary Neoplasms, Experimental; Mice; Obesity; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Retrospective Studies; Sphingosine; STAT3 Transcription Factor	2017
Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats. Mediators of inflammation, 2017, Volume: 2017 Topics: Animals; Blood Gas Analysis; Fingolimod Hydrochloride; Hindlimb; Immunosuppressive Agents; Lung Injury; Male; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger	2017
Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase. Neuropharmacology, 2018, Volume: 135 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; bcl-Associated Death Protein; Brain; Fingolimod Hydrochloride; Male; Mice; MPTP Poisoning; Neuroprotection; Parkinson Disease; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pramipexole; Proto-Oncogene Proteins c-akt; Rotarod Performance Test; Tyrosine 3-Monooxygenase	2018
The involvement of blood cells in the phosphorylation of the selective sphingosine-1-phosphate receptor 1 agonist SYL-927. Die Pharmazie, 2019, 02-01, Volume: 74, Issue:2 Topics: Administration, Oral; Animals; Blood Platelets; Erythrocytes; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptors, Lysosphingolipid; Sphingosine	2019
Cytokine-Induced and Stretch-Induced Sphingosine 1-Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019, Volume: 34, Issue:12 Topics: Adolescent; Adult; Aged; Animals; Calcification, Physiologic; Cells, Cultured; Chondrocytes; Cytokines; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Metabolic Networks and Pathways; Mice; Middle Aged; Osteoblasts; Osteogenesis; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Spondylarthritis; Stress, Mechanical; Synovial Fluid; Tenocytes; Up-Regulation; Young Adult	2019
FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation. International journal of molecular sciences, 2021, Jul-06, Volume: 22, Issue:14 Topics: Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; MCF-7 Cells; Neoplastic Stem Cells; Phosphotransferases (Alcohol Group Acceptor); Protein Phosphatase 2; Up-Regulation	2021
Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice. European journal of pharmacology, 2022, Oct-15, Volume: 933 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Fingolimod Hydrochloride; Interferon-gamma; Iridoids; Lipopolysaccharides; Macrophages; Mice; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction	2022
FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages. International journal of molecular sciences, 2022, Nov-23, Volume: 23, Issue:23 Topics: Animals; Atherosclerosis; ATP Binding Cassette Transporter 1; Cholesterol; Fingolimod Hydrochloride; Foam Cells; Liver X Receptors; Mice; Phosphotransferases (Alcohol Group Acceptor)	2022