fingolimod hydrochloride has been researched along with sphingosine 1-phosphate in 267 studies
| Studies (fingolimod hydrochloride) | Trials (fingolimod hydrochloride) | Recent Studies (post-2010) (fingolimod hydrochloride) | Studies (sphingosine 1-phosphate) | Trials (sphingosine 1-phosphate) | Recent Studies (post-2010) (sphingosine 1-phosphate) |
|---|---|---|---|---|---|
| 2,771 | 157 | 2,062 | 3,796 | 23 | 2,148 |
| Protein | Taxonomy | fingolimod hydrochloride (IC50) | sphingosine 1-phosphate (IC50) |
|---|---|---|---|
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | 0.0019 | |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | 0.0522 | |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | 0.0008 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.023 | |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | 0.0004 | |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | 0.002 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 77 (28.84) | 29.6817 |
| 2010's | 160 (59.93) | 24.3611 |
| 2020's | 30 (11.24) | 2.80 |
| Authors | Studies |
|---|---|
| Bergstrom, J; Card, D; Hajdu, R; Hale, J; Keohane, C; Lynch, CL; Mandala, S; Milligan, J; Parsons, W; Quackenbush, E; Rosen, H; Rosenbach, M; Rupprecht, K; Shei, GJ; Thornton, R; Xie, J | 1 |
| Bromberg, JS; Fu, S; Gunn, MD; Honig, SM; Mao, X; Randolph, GJ; Yopp, A | 1 |
| Liao, J; Rosen, H | 1 |
| Goetzl, EJ; Gräler, MH | 1 |
| Allende, ML; Brinkmann, V; Cinamon, G; Cyster, JG; Lesneski, MJ; Lo, CG; Matloubian, M; Proia, RL; Xu, Y | 1 |
| Bergstrom, J; Card, D; Doherty, G; Forrest, M; Hajdu, R; Hale, J; Keohane, C; Mandala, S; Meyers, C; Milligan, J; Mills, S; Nomura, N; Proia, RL; Rosen, H; Rosenbach, M; Shei, GJ; Singer, II; Sun, SY; Tian, M; West, S; White, V; Xie, J | 1 |
| Burne, MJ; Garcia, JG; Hassoun, PM; McVerry, BJ; Pearse, D; Peng, X; Rabb, H; Sammani, S; Tuder, RM | 1 |
| Argraves, KM; Obeid, LM; Taha, TA | 1 |
| Butler, J; LaMontagne, K; Lana, D; Round, O | 1 |
| Brinkmann, V; Cyster, JG; Hla, T | 1 |
| Takeya, H | 1 |
| Barbour, SE; Milstien, S; Payne, SG; Spiegel, S | 1 |
| Allende, ML; Hajdu, R; Kawai, H; Keohane, CA; Mandala, S; Mi, Y; Olivera, A; Proia, RL; Rosenbach, M; Sasaki, T; Spiegel, S; van Echten-Deckert, G | 1 |
| Elices, MJ | 1 |
| Clemens, JJ; Davis, MD; Lynch, KR; Macdonald, TL | 2 |
| Cyster, JG | 1 |
| Bonasio, R; Gauguet, JM; Halin, C; Mandala, S; Mempel, TR; Proia, RL; Quackenbush, E; Scimone, ML; von Andrian, UH | 1 |
| Burcin, TL; Engelhard, VH; Kharel, Y; Lee, S; Ley, K; Lynch, KR; Macdonald, TL; Morris, MA; Pearson-White, S; Setiady, Y; Sheasley-O'neill, SL; Snyder, AH; Tung, KS; Zhu, R; Zigler, MA | 1 |
| Bromberg, JS; Ding, Y; Ledgerwood, L; Mao, M; Ochando, JC; Yopp, AC | 1 |
| Bernhardt, G; Czeloth, N; Förster, R; Genth, H; Hofmann, F | 1 |
| Bandhuvula, P; Oskouian, B; Saba, JD; Tam, YY | 1 |
| DA, WM; Huang, WR; Wang, LS | 1 |
| Hla, T | 1 |
| Baumruker, T; Brinkmann, V | 1 |
| Massberg, S; von Andrian, UH | 1 |
| Kihara, A | 1 |
| Hammad, H; Hijdra, D; Hoogsteden, HC; Idzko, M; Kool, M; Lambrecht, BN; Müller, T; Soullié, T; van Nimwegen, M; Willart, MA | 1 |
| Heusch, G; Keul, P; Levkau, B; Lucke, S; Schuchardt, M; Tölle, M; van der Giet, M; von Wnuck Lipinski, K | 1 |
| Aicher, A; Brinkmann, V; Chun, J; Dimmeler, S; Haendeler, J; Keul, P; Levkau, B; Reinhold, J; Rochwalsky, U; Seeger, F; Spyridopoulos, I; Urbich, C; Walter, DH; Zeiher, AM | 1 |
| Huwiler, A; Pfeilschifter, J | 2 |
| Gonzalez-Cabrera, PJ; Hla, T; Rosen, H | 1 |
| Gohda, M; Higuchi, M; Ishikawa, I; Kiyono, H; Kunisawa, J; Kurashima, Y; Miura, F; Ogahara, I | 1 |
| Assmann, G; Biessen, EA; Bot, M; Brinkmann, V; Brodde, M; Nofer, JR; Salm, P; Taylor, PJ; van Berkel, T | 1 |
| Cahalan, SM; Gonzalez-Cabrera, PJ; Rosen, H; Sanna, MG | 1 |
| Baumruker, T; Billich, A; Brinkmann, V | 1 |
| Chiba, K; Kataoka, H; Maeda, Y; Matsuyuki, H; Shimano, K; Sugahara, K | 1 |
| Chun, J | 1 |
| Goetzl, EJ; Huang, MC; Liao, JJ | 1 |
| Berg, KM; Bittman, R; Kapitonov, D; Milstien, S; Miner, AS; Payne, SG; Ratz, PH; Spiegel, S; Watterson, KR | 1 |
| Anada, Y; Igarashi, Y; Kihara, A | 1 |
| Gohda, M; Higuchi, M; Ishikawa, I; Kiyono, H; Kunisawa, J; Kurashima, Y; Shimizu, M; Takayama, N | 1 |
| Byrd, JC; Chen, CS; Dalton, JT; Frissora, F; Jarjoura, D; Lehman, A; Liu, Q; Ma, Y; Muthusamy, N; Perrotti, D; Santhanam, R; Zhao, X | 1 |
| Bea, F; Blessing, E; Dengler, TJ; Grone, HJ; Hansson, GK; Katus, HA; Klingenberg, R; Nofer, JR; Preusch, M; Rudling, M | 1 |
| Gohda, M; Higuchi, M; Ishikawa, I; Kim, N; Kiyono, H; Kunisawa, J; Kurashima, Y; Ogahara, I; Shimizu, M | 1 |
| Antel, JP; Jung, CG; Kennedy, TE; Kim, HJ; Miron, VE; Soliven, B | 1 |
| Bernhardt, G; Czeloth, N; Förster, R; Küster, B; Müller, W; Schippers, A; Wagner, N | 1 |
| Brinkmann, V; Chun, J; Ip, PC; Potts, EM; Salomone, S; Tyndall, S; Waeber, C | 1 |
| Allende, ML; Bromberg, JS; Ding, Y; Esses, SJ; Garin, A; Ginhoux, F; He, X; Lal, G; Ledgerwood, LG; Lira, SA; Merad, M; Ochando, JC; Peche, H; Schuchman, EH; Yang, Y; Zhang, N | 1 |
| Herzinger, T; Kleuser, B; Korting, HC; Schäfer-Korting, M | 1 |
| Da, WM; Zhu, HY | 1 |
| Brunati, AM; Carraro, A; Cillo, U; D'Amico, F; Gringeri, E; Massimino, ML; Nalesso, G; Pagano, MA; Tibaldi, E; Toninello, A | 1 |
| Kleuser, B; Kleuser, U; Kürschner, U; Schäfer-Korting, M; Schüppel, M | 1 |
| Cui, NQ; Li, DH; Liu, HB; Wang, Q; Xue, XP | 1 |
| Gohda, M; Higuchi, M; Ishikawa, I; Kagiyama, Y; Kiyono, H; Kunisawa, J; Kurashima, Y; Miura, F; Ogahara, I | 1 |
| Chwalla, I; Krump-Konvalinkova, V; Siess, W | 1 |
| Igarashi, Y; Kohno, T | 1 |
| Milstien, S; Paugh, SW; Spiegel, S; Takabe, K | 1 |
| Igarashi, Y; Kihara, A | 1 |
| Lynch, KR; Macdonald, TL | 1 |
| Awad, AS; Bajwa, A; Jo, SK; Kharel, Y; Lynch, KR; Okusa, MD; Vergis, AL; Ye, H | 1 |
| Berdyshev, EV; Bittman, R; Dudek, SM; Garcia, JG; Gorshkova, I; Lu, X; Mirzapoiazova, T; Natarajan, V; Skobeleva, A | 1 |
| Bäumer, W; Kietzmann, M; Kleuser, B; Lüth, A; Mischke, R; Reines, I; Tschernig, T | 1 |
| Aoki, J; Arima, N; Kano, K; Kitamura, H; Makide, K | 1 |
| Egen, JG; Germain, RN; Ishii, M; Klauschen, F; Meier-Schellersheim, M; Proia, RL; Saeki, Y; Vacher, J | 1 |
| Schluesener, HJ; Zhang, Z; Zhang, ZY | 1 |
| Bueno, V; Lopes, CT; Oshima, CT; Palma, PV; Salinas, NR | 1 |
| Bonz, A; Burkard, N; Ertl, G; Frantz, S; Hofmann, U; Ritter, O; Thoma, A; Vogt, C | 1 |
| Peyruchaud, O | 1 |
| Cumberbatch, M; Dearman, RJ; Kimber, I | 1 |
| Gidday, JM; Park, TS; Wacker, BK | 1 |
| Goda, N; Kataoka, N; Makino, H; Nishishita, S; Omori, K; Sarai, K; Sasaki, M; Shikata, K; Shikata, Y; Wada, J; Watanabe, N | 1 |
| Yamamura, T | 1 |
| Czech, B; Huwiler, A; Kahles, T; Mazaheri-Omrani, N; Neumann-Haefelin, T; Pfeilschifter, J; Pfeilschifter, W; Rami, A; Strobel, MA | 1 |
| Banerjee, A; Bankovich, AJ; Beilke, JN; Chun, J; Cyster, JG; Enders, A; Goodnow, CC; Jenne, CN; Lanier, LL; Miller, SA; Pereira, JP; Reiner, SL; Rivera, R; Roots, CM; Watson, SR; Weinmann, AS; Xu, Y | 1 |
| Brinkmann, V | 1 |
| Knudsen, E; Maghazachi, AA; Rolin, J; Sand, KL | 1 |
| Adamowicz, JJ; Berdyshev, EV; Diab, KJ; Garrison, J; Gu, Y; Hubbard, WC; Kamocki, K; Petrache, I; Rajashekhar, G; Rush, NI; Schweitzer, KS; Skobeleva, A | 1 |
| Brooks, SF; Chun, J; Fontaine, BA; Luster, AD; Shea, BS; Tager, AM | 1 |
| Hasegawa, T; Hayashi, K; Koide, Y; Konno, T; Mochizuki, N; Mori, K; Murakami, A; Ohnuma, S; Sakurai, A; Sasamori, J; Sato, Y; Takahashi, A; Takakura, N; Takasugi, H; Takeda, S; Watanabe, Y | 1 |
| Cyster, JG; Pereira, JP; Xu, Y | 1 |
| Martin, R | 1 |
| Chiba, K; Maeda, Y; Sato, N; Seki, N; Sugahara, K | 1 |
| Gräler, MH | 1 |
| Frey, O; Kamradt, T | 1 |
| Blaho, VA; Guo, C; Hla, T; Im, DS; Khanna, KM; Lefrancois, L; Oo, ML; Thangada, S | 1 |
| Ley, K; McDuffie, M; Morris, MA; Nadler, JL | 1 |
| Cho, WY; Jo, SK; Kim, HK; Kim, MG; Ko, YS; Lee, HY; Lee, SY | 1 |
| Berdyshev, EV; Bittman, R; Byun, HS; Gorshkova, I; Goya, J; Natarajan, V; Prestwich, GD | 1 |
| Antel, JP; Bar-Or, A; Blain, M; Durafourt, BA; Johnson, TA; Lambert, C | 1 |
| Edwards, J; Fujiwara, Y; Long, JS; Pyne, NJ; Pyne, S; Tannahill, CL; Tigyi, G | 1 |
| Di, W; Qi, Y; Wadham, C; Wang, L; Warren, A; Xia, P; Zhang, N | 1 |
| Chun, J; Noguchi, K | 1 |
| Choi, JW; Chun, J; Lee, CW | 1 |
| Ratner, M | 1 |
| Chiang, ET; Dudek, SM; Garcia, JG; Simmons, JT; Wang, L | 1 |
| Hisano, Y; Kawahara, A; Kobayashi, N; Nishi, T; Yamaguchi, A | 1 |
| Lai, WQ; Leung, BP; Wong, WS | 1 |
| Bieberich, E | 1 |
| Jeffery, DR; Markowitz, CE; Reder, AT; Tobias, K; Weinstock-Guttman, B | 1 |
| Claas, RF; Ferreirós, N; Hegen, B; Huwiler, A; Labocha, S; Meyer Zu Heringdorf, D; Pfeilschifter, J; Ter Braak, M; van Echten-Deckert, G | 1 |
| Bolli, MH; Lescop, C; Nayler, O | 1 |
| Brinkmann, V; Merkler, D; Pinschewer, DD | 1 |
| Antel, J; Bar-Or, A; Johnson, TA; Kappos, L; Mehling, M | 1 |
| Brinkmann, V; Hla, T | 1 |
| Chun, J; Miron, V; Soliven, B | 1 |
| Antel, J; Hohlfeld, R | 1 |
| Bittman, R; Li, Z; Lim, KG; Lu, X; Pyne, NJ; Pyne, S; Tonelli, F | 1 |
| Li, N; Li, PL; Wang, Z; Xia, M; Zhu, Q | 1 |
| Chun, J; Cohen, JA | 1 |
| Blaho, V; Chang, SH; Han, DK; Hla, T; Hwang, SI; Oo, ML; Rezaul, K; Thangada, S; Wu, MT | 1 |
| Cserti-Gazdewich, C; Dhabangi, A; Finney, CA; Hawkes, CA; Kain, DC; Kain, KC; Liles, WC; Musoke, C; Oravecz, T | 1 |
| Heytens, E; Oktay, K; Soleimani, R | 1 |
| Bittman, R; Lim, KG; Pyne, NJ; Pyne, S; Sun, C | 1 |
| Cartwright, EJ; Chacko, S; Chirico, D; Egom, EE; Fath-Ordoubadi, F; Ke, Y; Lei, M; Liu, W; Mamas, MA; Mohamed, TM; Shaheen, M; Shi, Y; Solaro, RJ; Stringer, SE; Wang, T; Wang, X | 1 |
| Milstien, S; Nagahashi, M; Spiegel, S; Stevenson, CE; Takabe, K | 1 |
| Hla, T; Obinata, H | 1 |
| Bittman, R; Pyne, NJ; Pyne, S | 1 |
| Graham, SL; Gupta, VK; Klistorner, A; You, Y | 1 |
| Bissel, P; Kharel, Y; Knott, K; Lynch, KR; Raje, MR; Santos, WL | 1 |
| Cyster, JG; Schwab, SR | 1 |
| Campbell, C; Cryan, J; Deeks, N; Demont, E; Dowell, S; Garden, H; Gaskin, P; Gray, JR; Haynes, A; Leavens, K; Morse, M; Patel, A; Taylor, S; Willis, R; Witherington, J | 1 |
| Hassan, M; Karmouty-Quintana, H; Marti-Solano, M; Martin, JG; Risse, PA; Siddiqui, S; Tsuchiya, K; Xicota-Vila, L | 1 |
| Amor, S; Kipp, M | 1 |
| Hogan, EL; Krotkiewski, H; Podbielska, M | 1 |
| Jin, J; Tian, YL; Wang, XJ | 1 |
| Nakamura, S; Okada, T | 1 |
| Fozard, JR; Trifilieff, A | 1 |
| Iwasaki, T; Kitano, S; Sano, H; Sato, C; Tsunemi, S | 1 |
| Danilycheva, IV; Kryzhanovskiĭ, SM; Shmyrev, VI | 1 |
| García-Merino, JA; Sánchez, AJ | 1 |
| Chiba, K; Yoshii, N | 1 |
| Lopez, AF; Pitman, MR; Pitson, SM; Woodcock, JM | 1 |
| Beppu, M; Kato, T; Masuko, K; Murata, M; Nakamura, H; Yudoh, K | 1 |
| Campos, CR; Cannon, RE; Hawkins, BT; Miller, DS; Peart, JC | 1 |
| Battaglia, G; Bruno, V; Caraci, F; Copani, A; Di Menna, L; Di Nuzzo, L; Molinaro, G; Nicoletti, F; Pozzilli, C; Riozzi, B; Turrini, R; Zappulla, C | 1 |
| Tar, L; Vécsei, L | 1 |
| Campos, CR; Cannon, RE; Cartwright, TA; Miller, DS | 1 |
| Hoogsteden, HC; Kleinjan, A; Lambrecht, BN; Leman, K; van Nimwegen, M | 1 |
| Allegood, JC; Avni, D; Hait, NC; Harikumar, KB; Huang, WC; Kim, EY; Kordula, T; Liang, J; Milstien, S; Nagahashi, M; Price, MM; Spiegel, S; Takabe, K; Yamada, A | 1 |
| Akhade, AS; Qadri, A; Sharma, N | 1 |
| Abassi, T; Berdyshev, E; Bittman, R; Dudek, SM; Garcia, JG; Huang, LS; Jacobson, JR; Mathew, B; Moreno-Vinasco, L; Natarajan, V; Wang, L; Weichselbaum, R; Zhao, Y | 1 |
| Honbo, N; Imhof, I; Karliner, JS; Li, L; Vessey, DA | 1 |
| Cha, SS; Chen, CS; Choi, CK; Galie, PA; Nguyen, DH; Stapleton, SC; Yang, MT | 1 |
| Ihlefeld, K; Pfeilschifter, J; Zu Heringdorf, DM | 1 |
| Bäumer, W; Dickhaut, J; Japtok, L; Kietzmann, M; Kleuser, B; Mischke, R; Schaper, K | 1 |
| Axelberg, H; Grände, PO; Lundblad, C | 1 |
| Cohen, JA; Willis, MA | 1 |
| Huwiler, A; Pfeilschifter, J; Schwalm, S | 1 |
| Dunk, CE; Lye, SJ; Zhang, J | 1 |
| Botchwey, EA; Bowers, DT; Das, A; Hughley, BB; Segar, CE | 1 |
| Bassilana, F; Bigaud, M; Billich, A; Brinkmann, V; Guerini, D | 1 |
| Chiba, K; Fukunari, A; Maeda, Y; Masuko, T; Sugahara, K; Takemoto, K; Utsumi, H; Yagi, H | 1 |
| Fujii, K; Hirafuji, M; Iizuka, K; Machida, T | 1 |
| Bittman, R; Ohotski, J; Pyne, NJ; Pyne, S; Rosen, H | 1 |
| Murayama, T; Nakamura, H | 1 |
| Calabresi, PA; Gocke, AR; Grishkan, IV; Hall, O; Klein, SL; Ntranos, A; Robinson, DP; Schott, JT; Tosi, DM | 1 |
| Botto, G; Pentimalli, F; Vanoli, E | 1 |
| Dev, KK; Sheridan, GK | 1 |
| Allegood, JC; Avni, D; Hait, NC; Knapp, PE; Lichtman, AH; Lu, J; Luo, C; Miles, MF; Milstien, S; O'Brien, M; Reeves, TM; Spiegel, S; Wise, LE | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Danhof, M; Luttringer, O; Ploeger, BA; Snelder, N; Stanski, DR | 1 |
| Faßbender, K; Halmer, R; Walter, S | 1 |
| Crespo, MI; García, IA; Gorlino, CV; Harman, MF; Maletto, BA; Morón, G; Pistoresi-Palencia, MC; Ranocchia, RP | 1 |
| Alessandri, G; Bornati, A; Campanella, R; de Rezende, G; Di Vito, C; Giussani, P; Hadi, LA; Marfia, G; Navone, SE; Parati, E; Rampini, P; Riboni, L; Riccitelli, E; Tringali, C; Viani, P | 1 |
| Banno, Y; Fujine, E; Ishitsuka, A; Kanoh, H; Mizutani, Y; Seishima, M; Tawada, C | 1 |
| Awojoodu, AO; Botchwey, EA; Chiappa, NF; Lynch, K; Ogle, ME; Peirce-Cottler, S; Sefcik, LS | 1 |
| Abraham, SN; Ang, WXG; Chan, EW; Gunn, MD; Huang, MN; Kunder, CA; St John, AL | 1 |
| Gutkind, S; Hla, T; Hwa, J; Obinata, H; Okuno, T; Stitham, J; Yokomizo, T | 1 |
| Hu, S; Jin, Y; Ni, H; Xu, H; Zhang, Q | 1 |
| Ding, LH; Liu, BC; Liu, D; Liu, H; Lv, LL; Ma, KL; Tang, RN; Wen, Y; Wu, M; Xu, M | 1 |
| Angioni, C; Arlt, O; Huwiler, A; Pfeilschifter, JM; Radeke, HH; Schmidt, H; Schröder, M; Schwiebs, A | 1 |
| Hla, T; Proia, RL | 1 |
| Ahmadiani, A; Asle-Rousta, M; Dargahi, L; Kolahdooz, Z; Nasoohi, S | 1 |
| Bittman, R; Dudek, SM; Garcia, JG; Wang, L | 1 |
| Egom, EE; Kruzliak, P; Lei, M; Rotrekl, V | 1 |
| Guerrero, M; Kays, J; Li, C; Li, JN; Nicol, GD | 1 |
| Charles, EJ; Huerter, ME; Johnston, WF; Kron, IL; Laubach, VE; Lynch, KR; Sharma, AK; Stone, ML; Zhao, Y | 1 |
| Prager, B; Ransohoff, RM; Spampinato, SF | 1 |
| Cai, Y; Heng, BC; Hong, L; Liu, H; Lu, P; Ouyang, H; Ren, H; Wang, J; Wang, Y; Zhou, J | 1 |
| Blaho, VA; Engelbrecht, E; Galvani, S; Han, MH; Hla, T; Kono, M; Liu, C; Proia, RL; Steinman, L; Swendeman, SL | 1 |
| Cotleur, A; Kanda, T; Love, A; Obermeier, B; Ransohoff, RM; Sano, Y; Spampinato, SF; Takeshita, Y | 1 |
| Bittman, R; Camp, SM; Chiang, ET; Dudek, SM; Garcia, JG; Natarajan, V; Sun, C; Usatyuk, PV | 1 |
| Dev, KK; O'Sullivan, C | 1 |
| Faber, H; Hofereiter, J; Hoffmann, FS; Hohlfeld, R; Krumbholz, M; Loleit, V; Meinl, E; Melms, J; Pütz, B; Rübsamen, H; Schwarz, S; Weber, F; Weber, P | 1 |
| Bendix, I; Felderhoff-Müser, U; Hadamitzky, M; Hansen, W; Herrmann, R; Herz, J; Heumann, R; Hou, X; Kempe, K; Lumpe, K; Reinboth, BS; Serdar, M; Sifringer, M; Sizonenko, SV; van de Looij, Y | 1 |
| Choi, JW; Chun, J; Han, JE; Jeon, S; Moon, E; Ryu, JH | 1 |
| Rana, A; Sharma, S | 1 |
| Gao, E; He, Y; Lee, Y; Tao, L; Wang, W; Xia, Y; Xin, C; Yan, W; Zhang, F; Zhang, H; Zhang, L; Zhao, S; Zhou, F; Zhu, D | 1 |
| Delgado, A; Martínez-Cartro, M | 1 |
| Grüner, S; Mayer, CA; Ottenlinger, F; Pfarr, K; Pfeilschifter, JM; Radeke, HH; Schwiebs, A; Wagner, A | 1 |
| Barnawi, J; Davies, LT; Haberberger, R; Hamon, R; Hodge, G; Hodge, S; Pitson, SM; Reynolds, PN; Roscioli, E; Tran, HB; Ween, M | 1 |
| Bock, S; Pfalzgraff, A; Weindl, G | 1 |
| Chae, MK; Kim, SE; Lee, EJ; Lee, JH; Yoon, JS | 1 |
| Asghar, MY; Kalhori, V; Magnusson, M; Pulli, I; Törnquist, K | 1 |
| Guerrero, M; Roberts, E; Urbano, M | 1 |
| Herr, DR; Ibrahim, MH; Johnson, SP; Lai, SL; Lopes, V; Murray, PG; Narayanaswamy, P; Panja Bernam, S; Paterson, IC; Patmanathan, SN; Torta, F; Wei, W; Wenk, MR; Yap, LF | 1 |
| Adams, BJ; Allegood, JC; Aoyagi, T; Huang, WC; Milstien, S; Miyazaki, H; Nagahashi, M; Rashid, OM; Spiegel, S; Takabe, K; Terracina, KP; Tsuchida, J; Wakai, T; Yamada, A | 1 |
| Beretta, M; Berno, V; Campanella, R; Fassina, L; Geginat, J; Gualtierotti, R; Hadi, LA; Ingegnoli, F; Levi, V; Marfia, G; Miozzo, M; Navone, SE; Paroni, M; Rampini, P; Riboni, L; Tremolada, C | 1 |
| Bauer, M; Benetti, E; Coldewey, SM; Collino, M; Huwiler, A; Pfeilschifter, J; Sponholz, C; Thiemermann, C | 1 |
| Han, MH; Tsai, HC | 1 |
| East, JE; Subrahmanyam, PB; Tiper, IV; Webb, TJ | 1 |
| Ader, I; Cuvillier, O; Gstalder, C | 1 |
| Sadik, CD; Thieme, M; Zillikens, D | 1 |
| Bidadkosh, A; Buikema, H; Deelman, LE; Hamidi Shishavan, M; Henning, RH; Lambooy, S; van den Born, J; Yazdani, S | 1 |
| Angerer, IC; Fitzner, B; Flechtner, K; Friess, J; Hecker, M; Koczan, D; Meister, S; Roch, L; Schröder, I; Thiesen, HJ; Winkelmann, A; Zettl, UK | 1 |
| Chew, WS; Herr, DR; Wang, W | 1 |
| Gräler, MH; Hemdan, NY; Reimann, CM; Weigel, C | 1 |
| Huo, Z; Li, C; Wang, R; Wang, Z; Zhao, Z | 1 |
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| Brait, VH; Gavaldà, A; Godessart, N; Planas, AM; Tarrasón, G | 1 |
| Jiménez-Altayó, F; Jurado, A; Meissner, A; Miro, F; Planas, AM; Vila, E | 1 |
| Allegood, J; Chalfant, CE; Karamichos, D; Mandal, NA; Nicholas, SE; Priyadarsini, S; Qi, H; Sarker-Nag, A | 1 |
| Chen, C; Han, Q; Liang, W; Luo, Z; Lv, X; Su, K; Wang, Y; Yan, M; Zeng, P | 1 |
| Dyckman, AJ | 1 |
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| Adams, DH; Frampton, J; Haldar, D; Henderson, NC; Houlihan, DD; Kalia, N; Kavanagh, D; King, A; Luu, N; Newsome, PN; Owen, A; Penny, J; Ramachandran, P; Reynolds, G; Sumption, H; Suresh, S; Than, NN | 1 |
| Huang, Z; Kumar T, P; Ma, S; Santhosh, D | 1 |
| Bertlich, M; Canis, M; Freytag, S; Ihler, F; Jakob, M; Pellkofer, H; Strupp, M; Weiss, BG | 1 |
| Danese, S; Furfaro, F; Vetrano, S | 1 |
| Hait, NC; Katsuta, E; Lyon, DE; Nagahashi, M; Rashid, OM; Raza, A; Sturgill, JL; Takabe, K; Yan, L | 1 |
| Chen, X; Germain, RN; Huang, Y; Kawabe, T; Li, W; Mao, K; Paul, WE; Sun, MA; Urban, JF; Usher, N; Zhu, J | 1 |
| Abe, M; Allegood, JC; Aoyagi, T; Hait, NC; Huang, WC; Katsuta, E; Milstien, S; Nagahashi, M; Nakajima, M; Sakimura, K; Spiegel, S; Takabe, K; Terracina, KP; Tsuchida, J; Wakai, T; Yamada, A; Yuza, K | 1 |
| Fu, J; Gao, F; Gao, Y; Li, Y; Meng, F; Yang, C | 1 |
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| Han, Y; Kuai, F; Su, J; Wang, L; Wang, Y; Zhou, S | 1 |
| Cuda, CM; Der, E; Gadhvi, GT; Gulinello, M; Makinde, HM; Mike, EV; Putterman, C; Stock, A; Winter, DR | 1 |
| Bieberich, E; Dinkins, MB; Elsherbini, A; Jiang, X; Kong, JN; Leanhart, S; Qin, H; Wang, G; Wang, R; Zhao, Y; Zhong, L; Zhu, Z | 1 |
| Boraldi, F; Fernandez, O; Garcia-Fernandez, M; Hurtado-Guerrero, I; Lara, E; Martín-Montañez, E; Oliver, B; Pavia, J; Valverde, N | 1 |
| Asgharpour, A; Bedossa, P; Cowart, LA; Maczis, MA; Montefusco, D; Rohrbach, TD; Sanyal, AJ; Spiegel, S | 1 |
| Brait, VH; Chamorro, A; Gallizioli, M; Justicia, C; Meissner, A; Miró-Mur, F; Planas, AM; Salas-Perdomo, A; Urra, X | 1 |
| Huang, JJ; Ji, J; Sun, XL; Wang, J; Wang, XP; Xue, TF; Yang, J | 1 |
| Cooper, BE; Ezzyat, Y; Fielding, RA; McDonald, DJ; Rice, NP; Rivas, DA | 1 |
| Akgün, K; Bucki, R; Proschmann, U; Sehr, T; Zendzian-Piotrowska, M; Ziemssen, T | 1 |
| Maeda, S; Matsuki, N; Nakagawa, T; Nakazawa, M; Ohno, K; Yokoyama, N; Yonezawa, T | 1 |
| Blanchard, F; Bougault, C; Briolay, A; Brizuela, L; El Jamal, A; Le Goff, B; Magne, D; Mebarek, S | 1 |
| Singh, SK; Spiegel, S | 1 |
| Brettle, M; Couttas, TA; Don, AS; Fath, T; Guillemin, GJ; Heng, B; Humphrey, SJ; Qi, Y; Stefen, H; Teo, JD; Tran, C | 1 |
| Chen, H; Han, M; Sun, T; Wang, D | 1 |
| Aoki, M; Honda, A; Kondo, A; Matsunaga, N; Ogawa, R; Okubo, Y; Takabe, K | 1 |
| Abdelshafy, AAA; Chu, X; Elsaid, KMK; Elshawwaf, M; Ghobrial, RM; Kloc, M; Uosef, A; Vaughn, N | 1 |
| Abouhany, R; Caroli, A; Grasso, G; Lanzillotta, M; Li, Q; Pan, G; Rurack, K; Sellergren, B; Shinde, S; Wan, W | 1 |
| Bosque, A; Bukrinsky, M; Chomont, N; Dubrovsky, L; Fromentin, R; Newman, D; Resop, RS; Rigsby, H | 1 |
| Breier, A; Francis, MM; Hummer, TA; Kovacs, RJ; Liffick, E; Mehdiyoun, NF; Visco, AC; Vohs, JL; Yang, Z; Zhang, Y | 1 |
| Engelhardt, B; Enzmann, G; Homann, T; Huwiler, A; Kleuser, B; Stark, H; Stepanovska, B; Tietz, S; Zivkovic, A | 1 |
| Choi, JW; Gaire, BP | 1 |
| Chen, CP; Chew, WS; Chua, XY; Herr, DR; Ho, LTY; Lai, MKP; Lam, BWS; Ong, WY; Xiang, P | 1 |
| Amargant, F; Duncan, FE; Johnson, BW; Larmore, MJ; Lawson, M; Manuel, SL; Pritchard, MT; Zelinski, MB | 1 |
| Filippi, M; Gelibter, S; Moiola, L; Nozzolillo, A; Orrico, M; Preziosa, P; Sangalli, F | 1 |
| Bayat, M; Haghani, M; Naseh, M; Rafati, A; Vatanparast, J | 1 |
| Homann, T; Huwiler, A; Imeri, F; Kleuser, B; Stark, H; Stepanovska Tanturovska, B; Zivkovic, A | 1 |
| Ali, S; Aziz, A; Egom, EE; Elfaki, MY; Memon, D; Shiwani, HA | 1 |
| Abe, S; Hait, NC; Ichikawa, H; Ikarashi, M; Koyama, Y; Ling, Y; Moro, K; Nagahashi, M; Okuda, S; Sakata, J; Sato, N; Shimada, Y; Takabe, K; Takeuchi, S; Toshikawa, C; Tsuchida, J; Wakai, T | 1 |
| Choi, JW; Kim, B; Kim, HJ; Kim, J; Kim, R; Kim, S; Kim, Y; Lee, EH; Park, JH; Park, KD; Park, SJ | 1 |
| Bravo, GÁ; Casadevall, MP; Cedeño, RR; Ramió-Torrentà, L | 1 |
| Hazarosova, R; Krastev, N; Krastev, P; Momchilova, A; Nikolova, B; Pankov, R; Pankov, S; Pinkas, A; Robev, B; Staneva, G; Vassileva, E | 1 |
| Aoki, H; Aoki, M; Hylemon, P; Sarkar, J; Takabe, K; Wu, R; Zhou, H | 1 |
| Carreras, I; Dedeoglu, A; Jung, Y; Lopez-Benitez, J; Tognoni, CM | 1 |
| Ansarin, K; Ardalan, M; Hejazian, SM; Hejazian, SS; Pourbayram Kaleybar, S; Teymouri, S; Zununi Vahed, S | 1 |
| Liu, L; Ma, M; Wu, H; Zhang, Y | 1 |
| van Echten-Deckert, G | 1 |
| Baweja, S; Bihari, C; Kumar, G; Kumar, J; Kumari, A; Maiwall, R; Mourya, AK; Negi, P; Rastogi, A; Reddy, GS; Sarin, SK; Sarohi, V; Sood, AK; Subudhi, PD; Thangariyal, S; Tomar, A; Tripathi, DM; Vashistha, C | 1 |
| Fernandes, V; Khatri, DK; Preeti, K; Singh, SB; Sood, A | 1 |
| Bellen, HJ; Chung, HL; Kanca, O; Lee, HK; Lu, S; Mok, JW; Park, YJ; Perrimon, N; Tattikota, SG; Ye, Q; Zuo, Z | 1 |
| Blecharz-Klin, K; Mirowska-Guzel, D; Piechal, A; Pyrzanowska, J; Strosznajder, RP; Wencel, PL | 1 |
| Olivero, G; Pittaluga, A; Roggeri, A; Usai, C; Vanmierlo, T | 1 |
67 review(s) available for fingolimod hydrochloride and sphingosine 1-phosphate
| Article | Year |
|---|---|
Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm.
Topics: Animals; Binding, Competitive; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Ligands; Lymphocytes; Lysophospholipids; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingolipids; Sphingosine | 2003 |
Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy.
Topics: Animals; Cell Movement; Fingolimod Hydrochloride; GTP-Binding Proteins; Immunosuppressive Agents; Lysophospholipids; Mice; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine | 2004 |
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
Topics: Animals; Cell Proliferation; Clinical Trials as Topic; Endothelium, Vascular; Fingolimod Hydrochloride; Heart Rate; Humans; Immunosuppressive Agents; Inflammation; Lymphocytes; Lysophospholipids; Models, Biological; Models, Chemical; Phosphorylation; Propylene Glycols; Protein Binding; Rats; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine; Thymus Gland | 2004 |
Modulation of adaptive immune responses by sphingosine-1-phosphate.
Topics: Animals; Cytokines; Fingolimod Hydrochloride; Humans; Immune System; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2004 |
Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century.
Topics: Animals; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Propylene Glycols; Sphingosine | 2004 |
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
Topics: Adaptation, Physiological; Animals; Antigen-Presenting Cells; Cell Movement; Chemokines; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lymphocytes; Lymphoid Tissue; Lysophospholipids; Models, Immunological; Plasma Cells; Propylene Glycols; Receptors, Chemokine; Sphingosine | 2005 |
Pulmonary and vascular pharmacology of sphingosine 1-phosphate.
Topics: Animals; Asthma; Capillary Permeability; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Lung; Lysophospholipids; Mast Cells; Muscle, Smooth, Vascular; Propylene Glycols; Receptors, Lysosphingolipid; Respiratory Mucosa; Signal Transduction; Sphingosine; T-Lymphocytes; Vasoconstriction | 2006 |
[Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics].
Topics: Animals; Biological Transport; Cell Membrane; Drug Design; Fingolimod Hydrochloride; Humans; Immune System; Immunosuppressive Agents; Lysophospholipids; Membrane Proteins; Neovascularization, Physiologic; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Saccharomyces cerevisiae Proteins; Signal Transduction; Sphingosine | 2006 |
Tipping the gatekeeper: S1P regulation of endothelial barrier function.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Movement; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Lectins, C-Type; Lymphocytes; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2007 |
FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.
Topics: Animals; Central Nervous System; Clinical Trials as Topic; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Lymphatic; Fingolimod Hydrochloride; Humans; Immunologic Factors; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine | 2007 |
Sphingosine-1-phosphate signaling and the skin.
Topics: Acne Vulgaris; Animals; Cell Transformation, Neoplastic; Connective Tissue; Epidermis; Fingolimod Hydrochloride; Humans; Immunity; Immunosuppressive Agents; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Skin; Sphingosine; T-Lymphocytes | 2007 |
[Regulation of immunity by sphingosine 1-phosphate and its G protein-coupled receptors--review].
Topics: Fingolimod Hydrochloride; Humans; Immunomodulation; Lysophospholipids; Propylene Glycols; Receptors, G-Protein-Coupled; Sphingosine | 2007 |
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Topics: Animals; Fingolimod Hydrochloride; Humans; Lysophospholipids; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Sphingosine; Sulfhydryl Compounds; Thiazolidines; Thiophenes | 2008 |
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Enzyme Activation; Fingolimod Hydrochloride; Humans; Hypersensitivity; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sulfhydryl Compounds | 2008 |
Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.
Topics: Animals; Biological Transport; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Phosphorylation; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2008 |
Sphingosine 1-phosphate chemical biology.
Topics: Animals; Biochemical Phenomena; Biochemistry; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2008 |
[Lysophospholipid mediators].
Topics: Animals; Cell Physiological Phenomena; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Insulin; Insulin Secretion; Lysophospholipids; Neurotransmitter Agents; Propylene Glycols; Receptors, G-Protein-Coupled; Sphingosine | 2009 |
Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Topics: Fingolimod Hydrochloride; Humans; Lysophospholipids; Neoplasms; Propylene Glycols; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sphingosine | 2009 |
[Molecular target drug development for curing multiple sclerosis].
Topics: Abatacept; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Autoimmunity; Clinical Trials as Topic; Daclizumab; Drug Discovery; Fingolimod Hydrochloride; Humans; Immunoconjugates; Immunoglobulin G; Integrin alpha4beta1; JC Virus; Leukoencephalopathy, Progressive Multifocal; Ligands; Lysophospholipids; Multiple Sclerosis; Natalizumab; Opportunistic Infections; Propylene Glycols; Receptors, Antigen, T-Cell; Sphingosine; Ustekinumab | 2009 |
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.
Topics: Animals; Astrocytes; Brain; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Gap Junctions; Humans; Immune System; Inflammation; Lymph Nodes; Lysophospholipids; Multiple Sclerosis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes | 2009 |
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Topics: Autoimmune Diseases; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2010 |
Roles for lysophospholipid S1P receptors in multiple sclerosis.
Topics: Animals; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Inflammation; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Phosphorylation; Propylene Glycols; Receptors, Lysophospholipid; Signal Transduction; Sphingosine | 2011 |
Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis.
Topics: Animals; Drugs, Investigational; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis, Relapsing-Remitting; Neuroglia; Phosphorylation; Prodrugs; Propylene Glycols; Protein Isoforms; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2010 |
Sphingosine kinase and sphingosine 1-phosphate in asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Humans; Inflammation; Lung; Lysophospholipids; Mast Cells; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine | 2011 |
Fingolimod for the treatment of relapsing multiple sclerosis.
Topics: Administration, Oral; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Interferon beta-1a; Interferon-beta; Lymphocytes; Lysophospholipids; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2011 |
Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls.
Topics: Animals; Fingolimod Hydrochloride; Humans; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship | 2011 |
Impact of sphingosine 1-phosphate modulation on immune outcomes.
Topics: Animals; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Immune System; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Virus Diseases | 2011 |
Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis.
Topics: Fingolimod Hydrochloride; Humans; Immune System; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2011 |
Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.
Topics: Animals; Autoimmune Diseases; Cardiovascular System; Central Nervous System; Fingolimod Hydrochloride; Humans; Immune System; Immunosuppressive Agents; Lymph Nodes; Lysophospholipids; Models, Biological; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2011 |
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.
Topics: Animals; Central Nervous System; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Disease Models, Animal; Fingolimod Hydrochloride; Heart Diseases; Humans; Immunosuppressive Agents; Infections; Liver Diseases; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Respiration Disorders; Sphingosine | 2011 |
Targeting sphingosine-1-phosphate in hematologic malignancies.
Topics: Animals; Fingolimod Hydrochloride; Hematologic Neoplasms; Humans; Immunosuppressive Agents; Lysophospholipids; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2011 |
Sphingosine 1-phosphate in coagulation and inflammation.
Topics: Animals; Atherosclerosis; Blood Coagulation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Lymph Nodes; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha | 2012 |
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.
Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mice; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Sphingosine; Vinyl Compounds | 2011 |
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.
Topics: Animals; Bone Marrow; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymph Nodes; Lymphocytes; Lymphoid Tissue; Lysophospholipids; Models, Biological; Propylene Glycols; Sphingosine; Thymus Gland | 2012 |
FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination.
Topics: Animals; Astrocytes; Axons; Central Nervous System; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mice; Microglia; Multiple Sclerosis; Myelin Sheath; Neurons; Oligodendroglia; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine | 2012 |
Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.
Topics: Apoptosis; Ceramides; Fatty Acids, Monounsaturated; Fingolimod Hydrochloride; Humans; Lysophospholipids; Metabolic Networks and Pathways; Multiple Sclerosis; Myelin Sheath; Propylene Glycols; Receptors, G-Protein-Coupled; Serine C-Palmitoyltransferase; Signal Transduction; Sphingolipids; Sphingosine | 2012 |
[Research progress of the selective sphingosine-1-phosphate receptor 1 agonists].
Topics: Animals; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship | 2012 |
[Role of S1P acting both inside and outside the cells].
Topics: Adaptive Immunity; Animals; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunity, Innate; Immunosuppressive Agents; Lysophospholipids; Membrane Microdomains; Nervous System Physiological Phenomena; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Second Messenger Systems; Sphingolipids; Sphingosine | 2012 |
[Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature].
Topics: Animals; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Immune System; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2012 |
[Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis].
Topics: Administration, Oral; Animals; Clinical Trials, Phase I as Topic; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Receptors, Lysosphingolipid; Secondary Prevention; Sphingosine; Th17 Cells | 2012 |
Molecular targets of FTY720 (fingolimod).
Topics: Antineoplastic Agents; Apoptosis; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphopenia; Lysophospholipids; Multiple Sclerosis; Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2012 |
[Fingolimod therapy in multiple sclerosis--the issue of the pathomechanism].
Topics: Administration, Oral; Animals; Blood-Brain Barrier; Cardiovascular System; Central Nervous System; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocyte Count; Lysophospholipids; Multiple Sclerosis; Organophosphates; Propylene Glycols; Sphingosine; Th17 Cells; Treatment Outcome | 2012 |
Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Biomarkers; Capillary Permeability; Fingolimod Hydrochloride; Humans; Lung; Lysophospholipids; Membrane Proteins; Nerve Tissue Proteins; Phosphotransferases (Alcohol Group Acceptor); Pneumonia; Propylene Glycols; Receptors, Lysosphingolipid; Sepsis; Sphingosine; Transferases (Other Substituted Phosphate Groups); Translational Research, Biomedical | 2013 |
Pharmacology of the sphingosine-1-phosphate signalling system.
Topics: Aldehyde-Lyases; Animals; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2013 |
Fingolimod therapy for multiple sclerosis.
Topics: Central Nervous System; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Sphingosine; Treatment Outcome | 2013 |
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Fibrosis; Fingolimod Hydrochloride; Glomerulonephritis; Humans; Inflammation; Kidney Failure, Chronic; Lysophospholipids; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2014 |
Second generation S1P pathway modulators: research strategies and clinical developments.
Topics: Biomedical Research; Clinical Medicine; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Research Design; Signal Transduction; Sphingosine | 2014 |
Role of sphingolipids in arachidonic acid metabolism.
Topics: Active Transport, Cell Nucleus; Animals; Arachidonic Acid; Cells, Cultured; Ceramides; Cyclooxygenase 2; Fingolimod Hydrochloride; Golgi Apparatus; Group IV Phospholipases A2; Humans; Inflammation; Lactosylceramides; Lysophospholipids; Propylene Glycols; Sphingolipids; Sphingomyelins; Sphingosine | 2014 |
Vagomimetic effects of fingolimod: physiology and clinical implications.
Topics: Animals; Atrioventricular Block; Bradycardia; Electrocardiography; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2014 |
Sphingolipids: important players in multiple sclerosis.
Topics: Ceramides; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Sphingolipids; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine | 2014 |
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.
Topics: Acute Lung Injury; Anemia, Sickle Cell; Animals; Autoimmune Diseases; Cardiovascular Diseases; Cell Physiological Phenomena; Disease Models, Animal; Fingolimod Hydrochloride; Hematopoietic Stem Cell Mobilization; Humans; Influenza, Human; Lysophospholipids; Membrane Lipids; Mice; Multiple Sclerosis; Neoplasms; Neovascularization, Physiologic; Neurogenesis; Propylene Glycols; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine | 2015 |
Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015).
Topics: Animals; Autoimmune Diseases; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Lysophospholipids; Multiple Sclerosis, Relapsing-Remitting; Patents as Topic; Receptors, Lysosphingolipid; Sphingosine | 2016 |
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation.
Topics: Animals; Autoimmune Diseases; Fingolimod Hydrochloride; Humans; Inflammation; Lymphocytes; Lysophospholipids; Molecular Targeted Therapy; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2016 |
Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.
Topics: Animals; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Hematologic Neoplasms; Host-Pathogen Interactions; Humans; Immune System; Immunosuppressive Agents; Infections; Inflammation; Lymphocytes; Lysophospholipids; Signal Transduction; Sphingosine; Transcription Factors | 2016 |
Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation.
Topics: Animals; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Receptors, Lymphocyte Homing; Receptors, Lysophospholipid; Skin Diseases; Sphingosine; Thiazoles | 2017 |
To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling.
Topics: Animals; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Signal Transduction; Sphingosine | 2016 |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment.
Topics: Animals; Epilepsy; Fingolimod Hydrochloride; Humans; Immunologic Factors; Lysophospholipids; Signal Transduction; Sphingosine | 2017 |
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P
Topics: Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Humans; Ligands; Lysophospholipids; Molecular Structure; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship | 2017 |
Past, Present and Future of Therapeutic Interventions Targeting Leukocyte Trafficking in Inflammatory Bowel Disease.
Topics: Animals; Antibodies, Monoclonal, Humanized; Cell Adhesion Molecules; Cell Communication; Chemotaxis, Leukocyte; Endothelial Cells; Fingolimod Hydrochloride; Gastrointestinal Agents; Gastrointestinal Tract; Humans; Immunoglobulins; Immunosuppressive Agents; Indans; Inflammatory Bowel Diseases; Integrins; Intercellular Adhesion Molecule-1; Leukocytes; Lysophospholipids; Mucoproteins; Natalizumab; Oxadiazoles; Phosphorothioate Oligonucleotides; Receptors, Lysosphingolipid; Sphingosine | 2018 |
Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain.
Topics: Bortezomib; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Neuralgia; Signal Transduction; Sphingosine; Triple Negative Breast Neoplasms | 2020 |
Potential sphingosine-1-phosphate-related therapeutic targets in the treatment of cerebral ischemia reperfusion injury.
Topics: Animals; Brain; Fingolimod Hydrochloride; Humans; Lysophospholipids; Reperfusion Injury; Sphingosine; Sphingosine-1-Phosphate Receptors | 2020 |
Sphingosine 1-Phosphate Receptors in Cerebral Ischemia.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Neovascularization, Physiologic; Nerve Tissue Proteins; Neuroprotective Agents; Phosphotransferases (Alcohol Group Acceptor); Rats; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors | 2021 |
Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment.
Topics: Aldehyde-Lyases; Alzheimer Disease; Animals; Cerebrovascular Disorders; Clinical Trials as Topic; Dementia, Vascular; Drug Delivery Systems; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Humans; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Lysophospholipids; Mice; Mice, Knockout; Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors | 2021 |
The emerging role of FTY720 as a sphingosine 1-phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms.
Topics: Animals; Brain Ischemia; Endothelial Cells; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Ischemic Stroke; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Stroke | 2021 |
Updates on sphingolipids: Spotlight on retinopathy.
Topics: Animals; Ceramides; Fingolimod Hydrochloride; Humans; Lysophospholipids; Molecular Targeted Therapy; Photoreceptor Cells, Vertebrate; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Pigment Epithelium; Signal Transduction; Sphingolipids; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors | 2021 |
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives.
Topics: Autoimmune Diseases; Fingolimod Hydrochloride; Humans; Lysophospholipids; Multiple Sclerosis; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2022 |
The role of sphingosine 1-phosphate metabolism in brain health and disease.
Topics: Animals; Brain; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mammals; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine | 2023 |
2 trial(s) available for fingolimod hydrochloride and sphingosine 1-phosphate
| Article | Year |
|---|---|
Effects of fingolimod, a sphingosine-1-phosphate (S1P) receptor agonist, on white matter microstructure, cognition and symptoms in schizophrenia.
Topics: Anisotropy; Brain; Cognition; Diffusion Tensor Imaging; Fingolimod Hydrochloride; Humans; Lysophospholipids; Magnetic Resonance Imaging; Pilot Projects; Schizophrenia; Sphingosine; White Matter | 2021 |
The effect of Fingolimod on patients with moderate to severe COVID-19.
Topics: COVID-19; Fingolimod Hydrochloride; Humans; SARS-CoV-2; Sphingosine | 2023 |
198 other study(ies) available for fingolimod hydrochloride and sphingosine 1-phosphate
| Article | Year |
|---|---|
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Topics: Animals; B-Lymphocytes; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Cyclic AMP; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Ligands; Lymph Nodes; Lymphocyte Count; Lymphopenia; Lysophospholipids; Mice; Organophosphates; Organophosphonates; Phosphorylation; Propylene Glycols; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Spleen; Stereoisomerism; T-Lymphocytes | 2002 |
FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.
Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chemokine CCL19; Chemokines, CC; Chemotaxis, Leukocyte; Cysteine; Fingolimod Hydrochloride; Immunosuppressive Agents; Leukotrienes; Lymph Nodes; Lysophospholipids; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Phosphorylation; Propylene Glycols; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; T-Lymphocytes | 2003 |
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors.
Topics: Animals; Chemotaxis; Dose-Response Relationship, Drug; Down-Regulation; Drug Design; Endocytosis; Fingolimod Hydrochloride; Gene Targeting; Humans; Immunosuppressive Agents; Jurkat Cells; Lymphocyte Subsets; Lymphopenia; Lysophospholipids; Mice; Propylene Glycols; Protein Isoforms; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Recombinant Fusion Proteins; Signal Transduction; Sphingosine; Transduction, Genetic; Transfection | 2004 |
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
Topics: Adoptive Transfer; Animals; Cell Movement; Chemotaxis; Chimera; Down-Regulation; Fingolimod Hydrochloride; Gene Deletion; Lymphocyte Activation; Lymphocytes; Lymphoid Tissue; Lysophospholipids; Mice; Mice, Knockout; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Thymus Gland | 2004 |
Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
Topics: Anesthesia; Animals; CHO Cells; Cricetinae; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Mice; Myocardium; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine | 2004 |
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; Endothelial Cells; Endotoxins; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney; Kidney Diseases; Lipopolysaccharides; Lung; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Neutrophils; Organ Size; Perfusion; Peroxidase; Pneumonia; Propylene Glycols; Respiratory Distress Syndrome; Sphingosine; Time Factors | 2004 |
Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells.
Topics: Calcium Signaling; Cells, Cultured; Endothelium, Vascular; Fingolimod Hydrochloride; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Immunosuppressive Agents; Isomerism; Lysophospholipids; Mitogen-Activated Protein Kinases; Molecular Structure; Organogenesis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship; Umbilical Veins | 2004 |
['Vegetable wasps and plant worms' and G-protein-coupled receptors].
Topics: Cordyceps; Depression, Chemical; Fatty Acids, Monounsaturated; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation Mediators; Ligands; Lymphocyte Count; Lymphocytes; Lysophospholipids; Phosphorylation; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine | 2004 |
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
Topics: Animals; Base Sequence; DNA; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocytes; Lymphopenia; Lysophospholipids; Mice; Mice, Knockout; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2004 |
Sphingosine 1-phosphate analogs as receptor antagonists.
Topics: Calcium; Cell Line; Cell Membrane; Cell Movement; Dose-Response Relationship, Drug; Drug Design; Fingolimod Hydrochloride; Guanosine Triphosphate; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Lipids; Lymphocytes; Lysophospholipids; Models, Chemical; Phosphoserine; Propylene Glycols; Protein Binding; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Structure-Activity Relationship; Transfection | 2005 |
The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.
Topics: Adoptive Transfer; Animals; Chemotaxis, Leukocyte; Fingolimod Hydrochloride; Immunosuppressive Agents; Integrins; Lymph Nodes; Lymphatic Vessels; Lymphocyte Count; Lymphocytes; Lysophospholipids; Mice; Mice, Knockout; Microscopy, Video; Peyer's Patches; Propylene Glycols; Sphingosine; T-Lymphocytes | 2005 |
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.
Topics: Animals; Benzimidazoles; Binding Sites; Bradycardia; CHO Cells; Cricetinae; Fingolimod Hydrochloride; Immunosuppressive Agents; Lethal Dose 50; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Structure-Activity Relationship | 2005 |
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
Topics: Animals; Fingolimod Hydrochloride; Flow Cytometry; Homozygote; Immunosuppressive Agents; Lymphocytes; Lymphopenia; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine | 2005 |
Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.
Topics: Animals; Cell Communication; Cell Movement; Chemokine CCL19; Chemokine CXCL12; Chemokines; Chemokines, CC; Chemokines, CXC; Endothelial Cells; Fingolimod Hydrochloride; Lymph Nodes; Lysophospholipids; Mice; Mice, Inbred C57BL; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Spleen; T-Lymphocytes | 2005 |
Sphingosine-1-phosphate mediates migration of mature dendritic cells.
Topics: Animals; Cell Differentiation; Cell Movement; Dendritic Cells; Fingolimod Hydrochloride; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2005 |
The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.
Topics: Aldehyde-Lyases; Animals; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Mice; Propylene Glycols; Sphingosine; Tissue Distribution | 2005 |
[Effects of sphingosine 1-phosphate on functions of T cell - review].
Topics: Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; T-Lymphocytes | 2005 |
Immunology. Dietary factors and immunological consequences.
Topics: Aldehyde-Lyases; Animals; Cell Movement; Chemotaxis, Leukocyte; Diet; Enzyme Inhibitors; Fingolimod Hydrochloride; Food Coloring Agents; Imidazoles; Immunosuppressive Agents; Lymphoid Tissue; Lysophospholipids; Mice; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes | 2005 |
Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration.
Topics: Animals; Autoantigens; Cell Movement; Central Nervous System; Down-Regulation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymph Nodes; Lysophospholipids; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Sphingosine; T-Lymphocytes | 2006 |
Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Cell Differentiation; Cell Movement; Cell Polarity; Dendritic Cells; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression Regulation; Heart; Lymph Nodes; Lymphocytes; Lysophospholipids; Mice; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2006 |
The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Movement; Cells, Cultured; Cholesterol, Dietary; Cytokines; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression Regulation; Immunohistochemistry; Lysophospholipids; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Probability; Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Statistics, Nonparametric | 2007 |
Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.
Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Lysophospholipids; Mice; Mice, Transgenic; Propylene Glycols; Receptors, CXCR4; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; src-Family Kinases; Stem Cells | 2007 |
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Ceramidases; Ceramides; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Lipid Metabolism; Lysophospholipids; Neoplasms; Neovascularization, Pathologic; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2006 |
Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
Topics: Cells, Cultured; Chloroquine; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Lysophospholipids; Oxadiazoles; Propylene Glycols; Protein Transport; Proteomics; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Ubiquitin | 2007 |
Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
Topics: Animals; Antibodies, Antiphospholipid; Antibodies, Bacterial; B-Lymphocytes; Bacterial Vaccines; Cell Movement; Female; Fingolimod Hydrochloride; Immunoglobulin A; Immunoglobulin J-Chains; Immunosuppressive Agents; Intestine, Small; Lymphoid Tissue; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, SCID; Peritoneal Cavity; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Streptococcus pneumoniae; Vaccination | 2007 |
FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.
Topics: Animals; Atherosclerosis; Cell Division; Cholesterol, HDL; Cytokines; Disease Models, Animal; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Count; Lymphocytes; Lysophospholipids; Macrophages; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Propylene Glycols; Receptors, LDL; Signal Transduction; Sphingosine; Triglycerides | 2007 |
Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Dendritic Cells; Dose-Response Relationship, Drug; Down-Regulation; Endocytosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Knockout; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiophenes | 2007 |
Immunology. The sources of a lipid conundrum.
Topics: Animals; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Mice; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2007 |
Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.
Topics: Animals; CD4 Antigens; Cells, Cultured; Cytokines; Fingolimod Hydrochloride; Immunosuppressive Agents; Interleukin-23; Lymphocyte Activation; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Spleen; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer | 2007 |
Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Female; Fingolimod Hydrochloride; Immunoblotting; Immunosuppressive Agents; Lysophospholipids; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Propylene Glycols; Rabbits; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Type C Phospholipases | 2007 |
The immunomodulator FTY720 is phosphorylated and released from platelets.
Topics: Animals; Blood Platelets; Cell Line; Erythrocytes; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Male; Phosphorylation; Plasma; Prodrugs; Propylene Glycols; Rats; Rats, Wistar; Sphingosine | 2007 |
Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Migration Inhibition; Cells, Cultured; Chemotaxis, Leukocyte; Diarrhea; Epitopes, T-Lymphocyte; Female; Fingolimod Hydrochloride; Food Hypersensitivity; Immunosuppressive Agents; Intestine, Large; Lysophospholipids; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Propylene Glycols; Sphingosine; Spleen; Th2 Cells | 2007 |
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.
Topics: Animals; Apoptosis; B-Lymphocytes; Caspases; Cell Line; Cysteine Endopeptidases; Down-Regulation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Lysophospholipids; Mice; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Propylene Glycols; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingosine; Xenograft Model Antitumor Assays | 2008 |
Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Fingolimod Hydrochloride; Hypercholesterolemia; Immunosuppressive Agents; Lipid Metabolism; Lymphocyte Subsets; Lymphocytes; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Knockout; Propylene Glycols; Sphingosine; Spleen | 2007 |
Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium.
Topics: Animals; CD4 Antigens; CD8 Antigens; Cell Adhesion Molecules; Cell Differentiation; Cell Movement; Epithelium; Female; Fingolimod Hydrochloride; Intestines; Lymphocyte Activation; Lymphocytes; Lysophospholipids; Mice; Mice, Inbred BALB C; Propylene Glycols; Sensitivity and Specificity; Sphingosine; Thymus Gland | 2007 |
FTY720 modulates human oligodendrocyte progenitor process extension and survival.
Topics: Cell Differentiation; Cell Line; Cell Movement; Cell Surface Extensions; Cell Survival; Cytoskeleton; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Oligodendroglia; Propylene Glycols; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Sphingosine; Stem Cells; Suramin | 2008 |
Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
Topics: Animals; Cell Line; Dendritic Cells; Fingolimod Hydrochloride; Integrins; Ligands; Lysophospholipids; Mice; Mice, Inbred C57BL; Propylene Glycols; Receptors, CCR7; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Spleen | 2007 |
Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
Topics: Animals; Cerebral Arteries; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; In Vitro Techniques; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Propylene Glycols; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Vasoconstriction | 2008 |
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
Topics: Animals; Cell Movement; Endothelium, Lymphatic; Fingolimod Hydrochloride; Homeostasis; Inflammation; Integrin alpha4beta1; Intercellular Adhesion Molecule-1; Lymph Nodes; Lymphatic Vessels; Lymphocyte Function-Associated Antigen-1; Lysophospholipids; Mice; Mice, Inbred C57BL; Models, Immunological; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; T-Lymphocytes; Vascular Cell Adhesion Molecule-1 | 2008 |
Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures.
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Fingolimod Hydrochloride; Immunologic Factors; Liver; Liver Cirrhosis; Lysophospholipids; Male; Platelet-Derived Growth Factor; Propylene Glycols; Protein Transport; Rats; Rats, Wistar; Receptor Cross-Talk; Signal Transduction; Sphingosine | 2008 |
Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype.
Topics: Cell Proliferation; Cells, Cultured; Fingolimod Hydrochloride; Humans; Insulin; Insulin-Like Growth Factor I; Keratinocytes; Lysophospholipids; Phosphorylation; Propylene Glycols; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2008 |
Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis.
Topics: Amylases; Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cytokines; Fingolimod Hydrochloride; Lipase; Lung; Lung Injury; Lysophospholipids; Macrophages, Alveolar; Male; NF-kappa B; Pancreatitis, Acute Necrotizing; Peroxidase; Propylene Glycols; Pulmonary Edema; Rats; Rats, Wistar; Sphingosine | 2008 |
Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
Topics: Animals; B-Lymphocytes; Female; Fingolimod Hydrochloride; Immunoglobulin A; Immunosuppressive Agents; Intestinal Mucosa; Intestines; Lysophospholipids; Mice; Mice, Inbred BALB C; Ovalbumin; Peyer's Patches; Plasma Cells; Propylene Glycols; Sphingosine | 2008 |
FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression.
Topics: Actins; Cell Adhesion Molecules; Cell Membrane; Cell Movement; Cells, Cultured; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Neovascularization, Physiologic; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Wound Healing | 2008 |
Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P.
Topics: Amino Acid Sequence; Animals; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Humans; Ligands; Lysophospholipids; Mice; Molecular Sequence Data; NIH 3T3 Cells; Phosphorylation; Propylene Glycols; Receptors, Lysosphingolipid; RGS Proteins; Sphingosine | 2008 |
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Topics: Animals; Fingolimod Hydrochloride; Gene Expression Regulation, Enzymologic; Kidney; Kidney Diseases; Lysophospholipids; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reperfusion Injury; RNA, Messenger; Sphingosine | 2009 |
FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
Topics: Cells, Cultured; Ceramides; Chromatography, Liquid; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lung; Lysophospholipids; Oxidoreductases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pulmonary Artery; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Serine C-Palmitoyltransferase; Sphingosine; Tandem Mass Spectrometry; Up-Regulation | 2009 |
Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.
Topics: Administration, Topical; Animals; Cell Movement; Dendritic Cells; Dermatitis, Allergic Contact; Female; Fingolimod Hydrochloride; Histocompatibility Antigens Class II; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred BALB C; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Skin; Sphingosine; Thiophenes; Toluene 2,4-Diisocyanate | 2009 |
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.
Topics: Animals; Bone and Bones; Bone Density; Bone Resorption; Cell Line; Cell Lineage; Chemotaxis; Female; Fingolimod Hydrochloride; Homeostasis; Lysophospholipids; Mice; Mice, Inbred C57BL; Monocytes; Osteoclasts; Osteoporosis; Ovariectomy; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2009 |
FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis.
Topics: Animals; Chemotaxis, Leukocyte; Fingolimod Hydrochloride; Flow Cytometry; Immunohistochemistry; Immunosuppressive Agents; Interleukin-17; Lymph Nodes; Lysophospholipids; Male; Neuritis, Autoimmune, Experimental; Propylene Glycols; Rats; Rats, Inbred Lew; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Sciatic Nerve; Signal Transduction; Sphingosine; T-Lymphocyte Subsets; T-Lymphocytes | 2009 |
Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720.
Topics: Adenoma; Animals; Apoptosis; Caspase 3; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Lung; Lung Neoplasms; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Proliferating Cell Nuclear Antigen; Propylene Glycols; Sphingosine; Urethane | 2009 |
Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Death; Cells, Cultured; ErbB Receptors; Fingolimod Hydrochloride; Humans; Lysophospholipids; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxadiazoles; Perfusion; Propylene Glycols; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; Recovery of Function; Signal Transduction; Sphingosine; Thiophenes; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2009 |
Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
Topics: Animals; Cell Movement; Dermatitis, Allergic Contact; Fingolimod Hydrochloride; Humans; Langerhans Cells; Lysophospholipids; Propylene Glycols; Sphingosine | 2009 |
Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2.
Topics: Animals; Arterioles; Brain Edema; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Fingolimod Hydrochloride; Hypoxia-Ischemia, Brain; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Lysophospholipids; Male; Mice; Microcirculation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reperfusion Injury; RNA, Messenger; Sphingosine | 2009 |
Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.
Topics: Actins; Adherens Junctions; Cadherins; Cell Adhesion Molecules; Cells, Cultured; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Fingolimod Hydrochloride; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hyperglycemia; Immunosuppressive Agents; Lysophospholipids; Microvessels; Monomeric GTP-Binding Proteins; Phosphorylation; Propylene Glycols; rac GTP-Binding Proteins; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; Sphingosine | 2009 |
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blood-Brain Barrier; Brain; Brain Ischemia; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Neutrophils; Propylene Glycols; Sphingosine | 2009 |
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
Topics: Animals; Bone Marrow Cells; Cell Count; Cell Movement; Ethylnitrosourea; Fingolimod Hydrochloride; Killer Cells, Natural; Lymph Nodes; Lymphocyte Activation; Lysophospholipids; Mice; Mice, Mutant Strains; Mutation; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Box Domain Proteins | 2009 |
FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.
Topics: Chemokines; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunoblotting; Immunosuppressive Agents; K562 Cells; Killer Cells, Natural; Lysophospholipids; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Up-Regulation | 2010 |
Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Ceramides; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Indoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Propylene Glycols; Pulmonary Alveoli; Pulmonary Emphysema; Pyrroles; Receptors, Lysosphingolipid; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sphingosine | 2010 |
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
Topics: Animals; beta-Alanine; Bleomycin; Blood Coagulation; Endothelial Cells; Fibrosis; Fingolimod Hydrochloride; Humans; Lung Injury; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Pneumonia; Propylene Glycols; Pulmonary Alveoli; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Survival Analysis; Thiophenes; Vascular Diseases | 2010 |
Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist.
Topics: Animals; Calcium; Cerebral Arteries; CHO Cells; Coronary Circulation; Cricetinae; Cricetulus; Dogs; Extracellular Signal-Regulated MAP Kinases; Fingolimod Hydrochloride; Heart Rate; Hydrazones; Lysophospholipids; Male; Phosphorylation; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; rho-Associated Kinases; Sphingosine; Vasoconstriction | 2010 |
A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow.
Topics: Animals; B-Lymphocytes; Bone Marrow; Bromodeoxyuridine; Cell Movement; Chemotaxis, Leukocyte; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Transgenic; Precursor Cells, B-Lymphoid; Propylene Glycols; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine | 2010 |
Multiple sclerosis: closing in on an oral treatment.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Clinical Trials, Phase III as Topic; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mitoxantrone; Multiple Sclerosis; Natalizumab; Propylene Glycols; Randomized Controlled Trials as Topic; Sphingosine | 2010 |
Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.
Topics: Adoptive Transfer; Animals; Bone Marrow; Cell Count; Cell Movement; Fingolimod Hydrochloride; Hypersensitivity, Delayed; Immunization; Lymphoid Tissue; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ovalbumin; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Thiophenes | 2010 |
Arthritis: where are the T cells?
Topics: Animals; Antigens; Arthritis; Arthritis, Experimental; Disease Models, Animal; Fingolimod Hydrochloride; Humans; Joints; Lysophospholipids; Mice; Propylene Glycols; Sphingosine; T-Lymphocytes, Helper-Inducer | 2010 |
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics.
Topics: Amino Acid Substitution; Animals; Base Sequence; Cell Membrane; Chemotaxis, Leukocyte; Endocytosis; Fingolimod Hydrochloride; Kinetics; Lymphopenia; Lysophospholipids; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutant Proteins; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes | 2010 |
Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells.
Topics: Adoptive Transfer; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Fingolimod Hydrochloride; Immunomodulation; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Propylene Glycols; Sphingosine; T-Lymphocytes | 2011 |
CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; CD4-Positive T-Lymphocytes; Dendritic Cells; Fingolimod Hydrochloride; Flow Cytometry; Forkhead Transcription Factors; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Kidney; Lymphocyte Culture Test, Mixed; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Spleen; T-Lymphocytes, Regulatory | 2011 |
Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal.
Topics: Aldehyde-Lyases; Aldehydes; Animals; Chromatography, High Pressure Liquid; Fingolimod Hydrochloride; Hydrogenation; Kinetics; Lysophospholipids; Mice; Microsomes, Liver; Propylene Glycols; Rats; Semicarbazones; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Stereoisomerism; Tandem Mass Spectrometry | 2011 |
Differential responses of human microglia and blood-derived myeloid cells to FTY720.
Topics: Blotting, Western; Cytokines; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Gene Expression; Humans; Immunosuppressive Agents; Lysophospholipids; Macrophages; Microglia; Myeloid Cells; Propylene Glycols; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine | 2011 |
Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Female; Fingolimod Hydrochloride; HEK293 Cells; Humans; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Propylene Glycols; Pyrazoles; Pyridines; Receptor, ErbB-2; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sphingosine | 2010 |
FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.
Topics: Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Cisplatin; Cytoprotection; Drug Screening Assays, Antitumor; Female; Fingolimod Hydrochloride; Humans; Inhibitory Concentration 50; Lysophospholipids; Necrosis; Ovarian Neoplasms; Propylene Glycols; Signal Transduction; Sphingosine | 2010 |
Novartis eyes oral MS drug as potential blockbuster.
Topics: Administration, Oral; Animals; Clinical Trials as Topic; Drug Approval; Drug Industry; Fingolimod Hydrochloride; Humans; Lymphocytes; Lysophospholipids; Multiple Sclerosis; Propylene Glycols; Sphingosine | 2010 |
FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl.
Topics: Adherens Junctions; Cells, Cultured; Endothelial Cells; Fingolimod Hydrochloride; Gene Expression Regulation; Humans; Inflammation; Lung; Lysophospholipids; Permeability; Phosphorylation; Propylene Glycols; Proto-Oncogene Proteins c-abl; Pulmonary Artery; RNA, Small Interfering; Signal Transduction; Sphingosine; Subcellular Fractions; Tight Junctions | 2011 |
The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.
Topics: Animals; Biological Transport; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Membrane Proteins; Mice; Phosphorylation; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2011 |
There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells.
Topics: Animals; Cell Differentiation; Cell Lineage; Cells, Cultured; Ceramides; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Mice; Molecular Structure; Oligodendroglia; Propylene Glycols; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine; Stem Cells | 2011 |
Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator.
Topics: Calcium; Fingolimod Hydrochloride; HEK293 Cells; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Stereoisomerism | 2011 |
The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.
Topics: Animals; Blood-Brain Barrier; Central Nervous System; Fingolimod Hydrochloride; Humans; Immunologic Factors; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Neurobiology; Neuroglia; Neurons; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2011 |
Modulation of sphingosine 1-phosphate signaling in neurologic disease.
Topics: Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Nervous System Diseases; Propylene Glycols; Signal Transduction; Sphingosine | 2011 |
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
Topics: Actins; Allosteric Regulation; Breast Neoplasms; Catalytic Domain; Cell Line, Tumor; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Models, Chemical; Neoplasm Proteins; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine | 2011 |
A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate.
Topics: Animals; Enzyme Inhibitors; Fingolimod Hydrochloride; Immunohistochemistry; Kidney Cortex; Kidney Medulla; Lipids; Lysophospholipids; Male; Natriuretic Agents; NG-Nitroarginine Methyl Ester; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Renal Circulation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Sphingosine | 2011 |
Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.
Topics: Animals; Capillary Leak Syndrome; Dose-Response Relationship, Drug; Endocytosis; Fingolimod Hydrochloride; Gene Knock-In Techniques; Lymphopenia; Lysophospholipids; Mice; Organophosphates; Peptide Hydrolases; Phosphorylation; Propylene Glycols; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pulmonary Edema; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Recombinant Fusion Proteins; Sphingosine; Sphingosine-1-Phosphate Receptors; Ubiquitin-Protein Ligases; Ubiquitination | 2011 |
S1P is associated with protection in human and experimental cerebral malaria.
Topics: Aldehyde-Lyases; Animals; Antimalarials; Artemisinins; Artesunate; Brain; Cell Adhesion Molecules; Child; Child, Preschool; Female; Fingolimod Hydrochloride; Humans; Imidazoles; Immunosuppressive Agents; Infant; Interferon-gamma; Lysophospholipids; Malaria, Cerebral; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Oximes; Plasmodium berghei; Propylene Glycols; Sphingosine; Survival Analysis; T-Lymphocytes; Treatment Outcome | 2011 |
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
Topics: Animals; Apoptosis; Cryopreservation; Female; Fingolimod Hydrochloride; Graft Survival; Humans; Immunohistochemistry; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, SCID; Neovascularization, Physiologic; Ovarian Follicle; Ovary; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Transplantation, Heterologous | 2011 |
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Topics: Actins; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Membrane; Enzyme Assays; Female; Fingolimod Hydrochloride; HEK293 Cells; Humans; Lysophospholipids; Microscopy, Fluorescence; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pseudopodia; Sphingosine | 2011 |
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Animals; Arrhythmias, Cardiac; Biotransformation; Blotting, Western; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Coronary Occlusion; Female; Fingolimod Hydrochloride; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Lysophospholipids; Male; Middle Aged; Myocardial Ischemia; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; p21-Activated Kinases; Pertussis Toxin; Propylene Glycols; Rats; Sphingolipids; Sphingosine | 2011 |
Focus on molecules: Sphingosine 1 Phosphate (S1P).
Topics: Animals; Calcium Channels; Cell Proliferation; Cell Survival; Eye Diseases; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Intermediate Filament Proteins; Lysophospholipids; Membrane Glycoproteins; Nerve Tissue Proteins; Opsins; Peripherins; Propylene Glycols; Receptors, Lysosphingolipid; Retinal Photoreceptor Cell Outer Segment; Rhodopsin; Sphingosine | 2012 |
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Enzyme Activation; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Kinetics; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine; Structure-Activity Relationship | 2012 |
The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists.
Topics: Animals; Arrestin; Fingolimod Hydrochloride; GTP-Binding Proteins; Lymphocytes; Lysophospholipids; Male; Multiple Sclerosis, Relapsing-Remitting; Propylene Glycols; Rats; Rats, Inbred Strains; Signal Transduction; Sphingosine | 2012 |
Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.
Topics: Airway Remodeling; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; CD3 Complex; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Male; Muscle, Smooth; Propylene Glycols; Rats; Severity of Illness Index; Sphingosine; Treatment Outcome | 2012 |
Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.
Topics: Albuterol; Animals; Asthma; beta-Alanine; Bronchial Hyperreactivity; Bronchoconstriction; Fingolimod Hydrochloride; Lung; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Rats; Rats, Inbred BN; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Tachyphylaxis; Thiophenes; Trachea | 2012 |
Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.
Topics: Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Line; Core Binding Factor Alpha 1 Subunit; Fingolimod Hydrochloride; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; Mice; Osteoblasts; Osteocalcin; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Smad Proteins; Sphingosine | 2012 |
[Basic mechanisms of action of fingolimod in relation to multiple sclerosis].
Topics: Animals; Atrophy; B-Lymphocytes; Brain; Cell Movement; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; L-Selectin; Lysophospholipids; Mice; Molecular Structure; Multiple Sclerosis; Neuroglia; Propylene Glycols; Rats; Receptors, CCR7; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocyte Subsets; Th17 Cells | 2012 |
Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.
Topics: Aged; Cartilage, Articular; Cells, Cultured; Chondrocytes; Drug Interactions; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Flavonoids; Gene Expression; Humans; Imidazoles; Immunosuppressive Agents; Lysophospholipids; Male; Mitogen-Activated Protein Kinases; Osteoarthritis; Pertussis Toxin; Propylene Glycols; Pyridines; RNA, Messenger; Sphingosine; Vascular Endothelial Growth Factor A | 2012 |
Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Calcium Channel Blockers; Capillaries; Drug Delivery Systems; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Nerve Tissue Proteins; Organophosphates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine; Tight Junctions; Tumor Necrosis Factor-alpha; Verapamil | 2012 |
Fingolimod protects cultured cortical neurons against excitotoxic death.
Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Neurons; Neuroprotective Agents; Organophosphates; Propylene Glycols; Rats; Sphingosine | 2013 |
Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Capillaries; Endothelial Cells; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nerve Tissue Proteins; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptors; Spinal Cord; Tumor Necrosis Factor-alpha | 2013 |
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model.
Topics: Administration, Topical; Animals; Apoptosis; Disease Models, Animal; Drug Delivery Systems; Eosinophils; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mast Cells; Mice; Mice, Inbred Strains; Ovalbumin; Propylene Glycols; Random Allocation; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Sphingosine; Th2 Cells | 2013 |
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Topics: Animals; Cell Transformation, Neoplastic; Colitis; Colon; Fingolimod Hydrochloride; Gene Deletion; Gene Expression Regulation, Neoplastic; Interleukin-6; Lysophospholipids; Mice; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Sphingosine; STAT3 Transcription Factor; Tumor Microenvironment | 2013 |
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells.
Topics: Calcium; Fingolimod Hydrochloride; Flagellin; Gene Expression Regulation; Humans; Interleukin-2; Interleukin-8; Jurkat Cells; Lipopeptides; Lymphocyte Activation; Lysophospholipids; Molecular Mimicry; Oxadiazoles; Propylene Glycols; Receptors, Antigen, T-Cell; Serum; Signal Transduction; Sphingosine; T-Lymphocytes; Thiophenes; Toll-Like Receptors; U937 Cells | 2013 |
FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.
Topics: Adenosine; Algorithms; Animals; Fingolimod Hydrochloride; Immunosuppressive Agents; In Vitro Techniques; Ischemic Postconditioning; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Perfusion; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Reperfusion Injury; Sphingosine | 2013 |
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro.
Topics: Biomimetics; Cell Polarity; Dimethylpolysiloxanes; Fingolimod Hydrochloride; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Lysophospholipids; Microfluidics; Models, Biological; Morphogenesis; Neovascularization, Physiologic; Propylene Glycols; Pseudopodia; Pyrroles; Sphingosine; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Cell Differentiation; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Keratinocytes; Local Lymph Node Assay; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, SCID; Propylene Glycols; Psoriasis; Receptors, Lysosphingolipid; Skin; Skin Transplantation; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors | 2013 |
Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat.
Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Cecum; Disease Models, Animal; Diuresis; Drug Evaluation, Preclinical; Edema; Endothelium, Vascular; Fingolimod Hydrochloride; Hematocrit; Hemodynamics; Hemoglobins; Intestinal Perforation; Lysophospholipids; Male; Plasma Volume; Propylene Glycols; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Sphingosine | 2013 |
Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration.
Topics: Cell Movement; Cells, Cultured; Decidua; Down-Regulation; Female; Fingolimod Hydrochloride; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Interleukin-8; Killer Cells, Natural; Lysophospholipids; Neovascularization, Physiologic; Propylene Glycols; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Trophoblasts; Vascular Endothelial Growth Factor A | 2013 |
The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages.
Topics: Animals; Fingolimod Hydrochloride; Lysophospholipids; Macrophages; Male; Mandible; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nanofibers; Polyesters; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; Wound Healing | 2013 |
S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1.
Topics: Aldehyde-Lyases; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Blood Vessels; Blotting, Western; Cell Movement; Extracellular Space; Female; Fingolimod Hydrochloride; Imidazoles; Immunohistochemistry; L-Selectin; Lectins, C-Type; Lysophospholipids; Male; Mice, Inbred C57BL; Microscopy, Confocal; Platelet Endothelial Cell Adhesion Molecule-1; Propylene Glycols; Rats, Inbred F344; Receptors, Lysosphingolipid; Sphingosine; Thymocytes; Thymus Gland; Time Factors; Up-Regulation | 2014 |
Sphingosine 1-phosphate increases an intracellular Ca(2+) concentration via S1P3 receptor in cultured vascular smooth muscle cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cells, Cultured; Fingolimod Hydrochloride; Lysophospholipids; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine | 2014 |
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; CSK Tyrosine-Protein Kinase; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Estrogen; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Thiazoles; Tyrosine | 2014 |
FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway.
Topics: Animals; CD8-Positive T-Lymphocytes; Chemotaxis, Leukocyte; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Flow Cytometry; Granzymes; Immunosuppressive Agents; Influenza A Virus, H1N1 Subtype; Interferon-gamma; Lysophospholipids; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Propylene Glycols; Signal Transduction; Sphingosine | 2014 |
Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred C57BL; Motor Activity; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Vocalization, Animal | 2014 |
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.
Topics: Animals; Blotting, Western; Brain; Exploratory Behavior; Extinction, Psychological; Fear; Fingolimod Hydrochloride; Gene Expression; Hippocampus; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Immunosuppressive Agents; Isoenzymes; Learning Disabilities; Lysophospholipids; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, SCID; Models, Molecular; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Spectrometry, Mass, Electrospray Ionization; Sphingosine | 2014 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation.
Topics: Administration, Intravenous; Administration, Oral; Animals; Blood Platelets; Double-Blind Method; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Randomized Controlled Trials as Topic; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sphingosine | 2014 |
Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes.
Topics: Adoptive Transfer; Animals; Antigen-Antibody Complex; Cell Movement; Female; Fingolimod Hydrochloride; Immune System Diseases; Immunosuppressive Agents; Inflammation; L-Selectin; Leukocyte Disorders; Lymph Nodes; Lymphatic Vessels; Lymphocyte Function-Associated Antigen-1; Lysophospholipids; Macrophage-1 Antigen; Mice; Mice, Inbred BALB C; Neutrophils; P-Selectin; Propylene Glycols; Receptors, CXCR4; Receptors, Lysosphingolipid; Sphingosine | 2014 |
Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells.
Topics: Animals; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Ceramides; Epidermal Growth Factor; Extracellular Fluid; Fibroblast Growth Factor 2; Fingolimod Hydrochloride; Glioblastoma; Humans; Immunosuppressive Agents; Ki-67 Antigen; Lysophospholipids; Mice; Mice, SCID; Middle Aged; Neoplastic Stem Cells; Propylene Glycols; Sphingolipids; Sphingosine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Fingolimod Hydrochloride; Humans; Inhibitory Concentration 50; Lysophospholipids; Melanoma; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Signal Transduction; Sphingosine | 2014 |
Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning.
Topics: Animals; Fingolimod Hydrochloride; Inflammation; Kinetics; Lactic Acid; Ligands; Lymphocytes; Lysophospholipids; Male; Mice, Inbred C57BL; Microvessels; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Propylene Glycols; Prostheses and Implants; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine; Tissue Engineering; Vascular Remodeling | 2014 |
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
Topics: Animals; CD11 Antigens; CD11b Antigen; Cell Movement; Chemokine CCL21; Dendritic Cells; Female; Fingolimod Hydrochloride; Integrin alpha Chains; Lymph Nodes; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Oxadiazoles; Phagocytes; Plague; Propylene Glycols; Receptors, CCR2; Receptors, CCR7; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Yersinia pestis | 2014 |
Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.
Topics: Aged; Animals; Case-Control Studies; Cell Line; Cells, Cultured; Coronary Artery Disease; Cricetulus; Drug Resistance; Endocytosis; Female; Fingolimod Hydrochloride; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Lysophospholipids; Male; Middle Aged; Mutant Proteins; Polymorphism, Single Nucleotide; Propylene Glycols; Receptors, Lysosphingolipid; Recombinant Fusion Proteins; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors | 2014 |
Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats.
Topics: Ammonia; Animals; Blood Glucose; Capillaries; Cell Adhesion Molecules; Collagen; Coronary Circulation; Coronary Disease; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Gene Expression Regulation; Interleukin-6; Lysophospholipids; Male; Microcirculation; Myocardium; Nitrogen Radioisotopes; Positron-Emission Tomography; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Transforming Growth Factor beta | 2014 |
FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway.
Topics: Acetylglucosaminidase; Albuminuria; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Down-Regulation; Fingolimod Hydrochloride; Immunosuppressive Agents; Inflammation Mediators; Kidney Tubules; Lymphocytes; Lysophospholipids; Macrophages; Male; Nephritis, Interstitial; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats, Wistar; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors | 2014 |
Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application.
Topics: Animals; Cells, Cultured; Female; Fingolimod Hydrochloride; Lysophospholipids; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Organophosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Spleen; Tandem Mass Spectrometry | 2015 |
Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Maze Learning; Memory Disorders; Oxadiazoles; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha | 2015 |
Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate.
Topics: Acute Lung Injury; Antigens, CD; Antigens, Nuclear; Cadherins; Endothelial Cells; Fingolimod Hydrochloride; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Immunosuppressive Agents; Lung; Lysophospholipids; Microscopy, Fluorescence; Nerve Tissue Proteins; Organophosphonates; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Receptors, Lysosphingolipid; RNA, Small Interfering; Sphingosine; Transcription Factors; Zonula Occludens-1 Protein | 2015 |
The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue.
Topics: Animals; Atrioventricular Node; Dissection; Fingolimod Hydrochloride; Gene Expression Regulation; Lysophospholipids; Rats; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Sphingosine | 2015 |
Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
Topics: Action Potentials; Anilides; Animals; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Fingolimod Hydrochloride; Ganglia, Spinal; Gene Expression Regulation; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred C57BL; Organophosphonates; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; RNA, Small Interfering; Sensory Receptor Cells; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazolidines | 2015 |
Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cyclopentanes; Cytokines; Fingolimod Hydrochloride; Flow Cytometry; Immunoenzyme Techniques; Immunosuppressive Agents; Lung Injury; Lysophospholipids; Mice; Mice, Inbred C57BL; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; Sphingosine; Sphingosine-1-Phosphate Receptors | 2015 |
Sphingosine 1-phosphate signaling at the blood-brain barrier.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Capillary Permeability; Endothelial Cells; Fingolimod Hydrochloride; Humans; Immunologic Factors; Lysophospholipids; Multiple Sclerosis; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2015 |
Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis.
Topics: Administration, Topical; Animals; Delayed-Action Preparations; Fingolimod Hydrochloride; Gliosis; Immunosuppressive Agents; Lysophospholipids; Male; Membranes, Artificial; Polyesters; Rats; Rats, Sprague-Dawley; Recovery of Function; Sphingosine; Spinal Cord Injuries; Treatment Outcome | 2015 |
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
Topics: Animals; Apolipoproteins; Apolipoproteins M; Blood-Brain Barrier; Cell Movement; Cell Proliferation; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Hematopoietic Stem Cells; Inflammation; Lipoproteins, HDL; Lymphocytes; Lymphoid Progenitor Cells; Lymphopoiesis; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Protein Binding; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2015 |
Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
Topics: Adult; Astrocytes; Blood-Brain Barrier; Cell Movement; Cell Survival; Cytokines; Endothelial Cells; Fingolimod Hydrochloride; Granulocyte-Macrophage Colony-Stimulating Factor; Healthy Volunteers; Humans; Inflammation; Leukocytes; Lysophospholipids; Microcirculation; Middle Aged; Multiple Sclerosis; Receptors, Lysosphingolipid; Signal Transduction; Sphingolipids; Sphingosine; Stress, Mechanical; Young Adult | 2015 |
Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720.
Topics: Calcium; Cell Line; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Fingolimod Hydrochloride; Fluorides; Glucuronides; Humans; Lysophospholipids; Microscopy, Fluorescence; Permeability; Phosphorylation; Pulmonary Artery; Signal Transduction; Sphingosine | 2015 |
Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling.
Topics: Animals; Apoptosis; Astrocytes; Demyelinating Diseases; Fingolimod Hydrochloride; Humans; Leukodystrophy, Globoid Cell; Lipopolysaccharides; Lysophospholipids; Mice; Microscopy, Fluorescence; Psychosine; Rats; Signal Transduction; Sphingosine | 2015 |
Fingolimod induces neuroprotective factors in human astrocytes.
Topics: Astrocytes; Chemokine CXCL10; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fetus; Fingolimod Hydrochloride; Heparin-binding EGF-like Growth Factor; Humans; Interleukin-11; Lysophospholipids; Microarray Analysis; Neural Stem Cells; Neuroprotective Agents; NF-kappa B; RNA, Messenger; RNA, Small Interfering; Sphingosine; Time Factors | 2015 |
Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia.
Topics: Animals; Animals, Newborn; Brain; Cognition Disorders; Diffusion Magnetic Resonance Imaging; Female; Fingolimod Hydrochloride; Hyperoxia; Lysophospholipids; Male; Microglia; Nerve Fibers, Myelinated; Oligodendroglia; Oxygen; Pregnancy; Random Allocation; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; White Matter | 2016 |
Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Fingolimod Hydrochloride; Lysophospholipids; Male; Mice; Mice, Inbred ICR; Microinjections; Neuroglia; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Stroke; Tumor Necrosis Factor-alpha | 2015 |
Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore.
Topics: Animals; Blood Glucose; Cardiotonic Agents; Creatine Kinase, MB Form; Diabetes Mellitus, Experimental; Diet, High-Fat; Fingolimod Hydrochloride; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Ischemic Preconditioning; Lipids; Lysophospholipids; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Sphingosine | 2016 |
Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction.
Topics: Animals; Animals, Newborn; Cytokines; Fingolimod Hydrochloride; Heart Diseases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocarditis; Myocytes, Cardiac; Phosphotransferases (Alcohol Group Acceptor); Rats, Sprague-Dawley; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Transfection; Ultrasonography | 2016 |
Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors.
Topics: Fingolimod Hydrochloride; Humans; Immune System; Immunosuppressive Agents; Lysophospholipids; Multiple Sclerosis; Nervous System; Receptors, Lysosphingolipid; Sphingolipids; Sphingosine | 2016 |
Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes.
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; DNA-Binding Proteins; Female; Fingolimod Hydrochloride; Histone Chaperones; Interferon-gamma; Interleukin-2; Interleukin-33; Lysophospholipids; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Oncogene Proteins; Organophosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Phosphatase 2; Sphingosine; Spleen | 2016 |
Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720.
Topics: Bronchi; Cells, Cultured; Epithelial Cells; Fingolimod Hydrochloride; Gene Expression Regulation, Enzymologic; Humans; Immunosuppressive Agents; Lysophospholipids; Macrophages, Alveolar; Phagocytosis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pulmonary Disease, Chronic Obstructive; Signal Transduction; Smoking; Sphingosine | 2016 |
Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Movement; Cytokines; Endocytosis; Fingolimod Hydrochloride; Humans; Langerhans Cells; Lysophospholipids; Phenotype; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2016 |
The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy.
Topics: Adipogenesis; Adult; Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cells, Cultured; Female; Fibroblasts; Fingolimod Hydrochloride; Graves Ophthalmopathy; Humans; Immunosuppressive Agents; Lysophospholipids; Male; Middle Aged; Orbit; PPAR gamma; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Lysosphingolipid; RNA, Messenger; Sphingosine | 2016 |
FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Movement; Chick Embryo; Chorioallantoic Membrane; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Sphingosine; Thyroid Neoplasms | 2016 |
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.
Topics: Aldehyde-Lyases; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Cisplatin; Drug Synergism; Female; Fingolimod Hydrochloride; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunosuppressive Agents; Kaplan-Meier Estimate; Lysophospholipids; Male; Middle Aged; Mouth Neoplasms; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors | 2016 |
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.
Topics: Activation, Metabolic; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Extracellular Fluid; Female; Fingolimod Hydrochloride; Humans; Isoenzymes; Lysophospholipids; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice, Inbred BALB C; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Random Allocation; Sphingosine; Tumor Microenvironment | 2016 |
The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.
Topics: Adipose Tissue; Adult; Cell Proliferation; Cell Separation; Chemotaxis; Culture Media, Conditioned; Cytokines; Down-Regulation; Female; Fingolimod Hydrochloride; Humans; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Mesenchymal Stem Cells; Microglia; Middle Aged; Phenotype; Proteome; Signal Transduction; Sphingosine | 2016 |
Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Fingolimod Hydrochloride; Heart; Humans; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardium; Peptidoglycan; Phosphatidylinositol 3-Kinases; Phosphorylation; Pilot Projects; Receptors, Lysosphingolipid; Sepsis; Sphingosine | 2016 |
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Fingolimod Hydrochloride; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lysophospholipids; Mice; Neovascularization, Pathologic; Oxygen Consumption; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A; Vascular Remodeling; Xenograft Model Antitumor Assays | 2016 |
Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries.
Topics: Animals; Body Weight; Endothelial Cells; Fingolimod Hydrochloride; Gene Expression Regulation; Hemodynamics; Humans; Lysophospholipids; Male; Mesenteric Arteries; Muscle Development; Myocytes, Smooth Muscle; Pressure; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Time Factors; Vasoconstriction | 2016 |
High-Resolution Expression Profiling of Peripheral Blood CD8
Topics: Adult; CD8-Positive T-Lymphocytes; Cytokines; Cytotoxicity, Immunologic; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Middle Aged; Multiple Sclerosis; Phenotype; Sphingosine | 2017 |
Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis.
Topics: Animals; Capillary Permeability; Cells, Cultured; Cytokines; Fingolimod Hydrochloride; Immunomodulation; Lysophospholipids; Membrane Proteins; Mice; Mice, Inbred C57BL; Phosphoric Monoester Hydrolases; Pyridoxine; Receptors, Lysosphingolipid; Sepsis; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A | 2016 |
Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720.
Topics: Adenosine Diphosphate; Animals; Anticoagulants; Arteriovenous Shunt, Surgical; Biomimetic Materials; Blood Platelets; Carotid Artery, Common; Chlorides; Disease Models, Animal; Ferric Compounds; Fibrinolytic Agents; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Platelet Aggregation; Platelet Function Tests; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thrombosis; Vena Cava, Inferior | 2017 |
Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice.
Topics: Animals; Cerebral Infarction; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Receptors, Lysosphingolipid; Reperfusion Injury; Sphingosine | 2016 |
Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension.
Topics: Adoptive Transfer; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Bone Marrow Transplantation; Cell Movement; Disease Models, Animal; Fingolimod Hydrochloride; Genetic Predisposition to Disease; Hypertension; Inflammation Mediators; Lymph Nodes; Lysophospholipids; Mesenteric Arteries; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; T-Lymphocytes; Time Factors; Vascular Remodeling | 2017 |
Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients.
Topics: Cell Line; Ceramides; Cornea; Fibroblasts; Fingolimod Hydrochloride; Humans; Keratoconus; Lysophospholipids; RNA, Messenger; Signal Transduction; Sphingolipids; Sphingosine; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3 | 2017 |
FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines.
Topics: Adult; Angiotensin II; Animals; Cell Adhesion; Enzyme-Linked Immunosorbent Assay; Female; Fingolimod Hydrochloride; Humans; Immunohistochemistry; Interleukin-6; Lysophospholipids; Male; Middle Aged; Podocytes; Radioimmunoassay; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Renal Insufficiency, Chronic; Sphingosine; Tumor Necrosis Factor-alpha; Wound Healing; Young Adult | 2017 |
Evaluation and Optimization of
Topics: Algorithms; Animals; Crystallography, X-Ray; Drug Design; Fingolimod Hydrochloride; Humans; Immunologic Factors; Lysophospholipids; Molecular Structure; Multiple Sclerosis; Protein Structure, Secondary; Receptors, Lysosphingolipid; Sphingosine | 2017 |
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
Topics: Actins; Aldehyde-Lyases; Animals; Cell Line; Cell Movement; Chemical and Drug Induced Liver Injury, Chronic; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Fingolimod Hydrochloride; Gene Expression; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Immunosuppressive Agents; Liver; Liver Cirrhosis; Lymph; Lysophospholipids; Macrophages; Male; Membrane Proteins; Mice; Monocytes; Neutrophils; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Sphingosine | 2017 |
A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
Topics: Brain; Embryo, Mammalian; Enzyme Activation; Fingolimod Hydrochloride; Guanine Nucleotide Exchange Factors; Hemorrhage; Humans; Integrin beta Chains; Lysophospholipids; Mutation; Neostriatum; Neovascularization, Physiologic; Neural Pathways; Neural Stem Cells; Organ Specificity; p38 Mitogen-Activated Protein Kinases; Phenotype; Receptors, Lysosphingolipid; Reward; Signal Transduction; Sphingosine; Transforming Growth Factor beta | 2017 |
Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow.
Topics: Animals; Blood Flow Velocity; Cochlea; Cytokines; Fingolimod Hydrochloride; Guinea Pigs; Immunosuppressive Agents; Lysophospholipids; Microcirculation; Microscopy, Fluorescence; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha | 2017 |
Targeting S1P in Inflammatory Bowel Disease: New Avenues for Modulating Intestinal Leukocyte Migration.
Topics: Animals; Camphanes; Cell Movement; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Inflammatory Bowel Diseases; Leukocytes; Lysophospholipids; Molecular Targeted Therapy; Oxadiazoles; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sulfhydryl Compounds; Sulfonamides | 2018 |
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Mammary Neoplasms, Experimental; Mice; Obesity; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Retrospective Studies; Sphingosine; STAT3 Transcription Factor | 2017 |
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense.
Topics: Adaptive Immunity; Animals; Cell Proliferation; Chemotaxis; Female; Fingolimod Hydrochloride; Homeodomain Proteins; Homeostasis; Immunity, Innate; Immunosuppressive Agents; Interleukin-17; Intestines; Lung; Lymphocytes; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mucous Membrane; Nippostrongylus; Sphingosine; Strongylida Infections; T-Lymphocytes | 2018 |
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Breast Neoplasms; Cell Line, Tumor; Culture Media, Conditioned; Cytokines; Diet, High-Fat; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Interleukin-6; Lung; Lysophospholipids; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Obesity; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors | 2018 |
The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus.
Topics: Anilides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclooxygenase 2; Disease Models, Animal; Drug Resistant Epilepsy; Fingolimod Hydrochloride; Hippocampus; Humans; Immunosuppressive Agents; Injections, Intraperitoneal; Lysophospholipids; Male; Organophosphonates; Phenytoin; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Up-Regulation | 2018 |
Exploring the Protective Role and the Mechanism of Sphingosine 1 Phosphate in Endotoxic Cardiomyocytes.
Topics: Animals; Apoptosis; Cell Line; Cytokines; Endotoxins; Fingolimod Hydrochloride; Lysophospholipids; MAP Kinase Signaling System; Myocytes, Cardiac; NF-kappa B; Rats; Sepsis; Sphingosine | 2019 |
Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling.
Topics: Animals; Astrocytes; Autoantibodies; Behavior Observation Techniques; Behavior, Animal; Brain; Cognition; Cytokines; Depression; Disease Models, Animal; Endothelial Cells; Female; Fingolimod Hydrochloride; Humans; Lupus Vasculitis, Central Nervous System; Lysophospholipids; Mice; Mice, Inbred MRL lpr; Microglia; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Treatment Outcome | 2018 |
Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide.
Topics: Amyloid beta-Peptides; Animals; Anion Transport Proteins; Cytokines; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Lysophospholipids; Maze Learning; Memory, Short-Term; Mice; Mice, Knockout; Microglia; NF-kappa B; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2019 |
The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells.
Topics: Animals; Antioxidants; Cell Death; Cell Line; Dopaminergic Neurons; Fingolimod Hydrochloride; Humans; Lysophospholipids; Membrane Potential, Mitochondrial; Mice; Mitochondria; Molecular Mimicry; Multiple Sclerosis; Neuroprotection; Oxidative Stress; Oxygen Consumption; Phosphates; Reactive Oxygen Species; Sphingosine; Sphingosine-1-Phosphate Receptors; Vitamin K 3 | 2019 |
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Topics: Acetylation; Animals; Diet, High-Fat; Fatty Acid Synthases; Female; Fingolimod Hydrochloride; Immunoblotting; Insulin Resistance; Liver; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organophosphates; Sphingolipids; Sphingosine; Triglycerides | 2019 |
Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke.
Topics: Animals; Brain; Brain Ischemia; Fingolimod Hydrochloride; Hemoglobins; Hemorrhage; Lymphocytes; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells; Reperfusion Injury; RNA, Messenger; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Stroke; T-Lymphocytes; Thrombocytopenia; Up-Regulation | 2019 |
The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation.
Topics: Acetylation; Animals; Brain Injuries; Cell Plasticity; Cells, Cultured; Fingolimod Hydrochloride; Glucose; Histone Deacetylase 1; Inflammation Mediators; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lysophospholipids; Microglia; Oxidation-Reduction; Oxygen; Phagocytosis; Phenotype; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Promoter Regions, Genetic; Rats; RNA, Small Interfering; Signal Transduction; Sphingosine | 2019 |
Sphingosine-1-phosphate analog FTY720 reverses obesity but not age-induced anabolic resistance to muscle contraction.
Topics: Aging; Animals; Cells, Cultured; Diet, High-Fat; Fingolimod Hydrochloride; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Skeletal; Obesity; Random Allocation; Sarcopenia; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators | 2019 |
Early central vs. peripheral immunological and neurobiological effects of fingolimod-a longitudinal study.
Topics: Adult; Biomarkers; Central Nervous System; Cerebrospinal Fluid; Female; Fingolimod Hydrochloride; Humans; Longitudinal Studies; Lysophospholipids; Male; Middle Aged; Multiple Sclerosis; Peripheral Nervous System; Sphingosine | 2019 |
Sphingosine-1-phosphate (S1P) signaling regulates the production of intestinal IgA and its potential role in the pathogenesis of canine inflammatory bowel disease.
Topics: Animals; Dog Diseases; Dogs; Feces; Fingolimod Hydrochloride; Gene Expression; Immunoglobulin A; Inflammatory Bowel Diseases; Intestines; Lysophospholipids; Male; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors | 2019 |
Cytokine-Induced and Stretch-Induced Sphingosine 1-Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis.
Topics: Adolescent; Adult; Aged; Animals; Calcification, Physiologic; Cells, Cultured; Chondrocytes; Cytokines; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Male; Metabolic Networks and Pathways; Mice; Middle Aged; Osteoblasts; Osteogenesis; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Spondylarthritis; Stress, Mechanical; Synovial Fluid; Tenocytes; Up-Regulation; Young Adult | 2019 |
Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.
Topics: Animals; Astrocytes; Cell Death; Fingolimod Hydrochloride; Gene Expression Regulation; Hippocampus; Humans; Lysophospholipids; Mice; Nerve Growth Factors; Neurons; Neuroprotective Agents; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators | 2020 |
The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars.
Topics: Animals; Cell Differentiation; Cicatrix, Hypertrophic; Cytokines; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Macrophages; Mechanical Phenomena; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; RAW 264.7 Cells; Sphingosine; Th1-Th2 Balance; Th2 Cells | 2020 |
Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages.
Topics: Actin Cytoskeleton; Animals; Azetidines; Benzyl Compounds; Cell Membrane; Chemokine CCL2; Down-Regulation; Fingolimod Hydrochloride; Graft Rejection; Humans; Lysophospholipids; Macrophages; Membrane Proteins; Mice; Multiple Sclerosis; Organ Transplantation; Phosphoric Monoester Hydrolases; RAW 264.7 Cells; Receptors, Interleukin-8A; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; United States; United States Food and Drug Administration | 2020 |
Selective detection of phospholipids using molecularly imprinted fluorescent sensory core-shell particles.
Topics: Fingolimod Hydrochloride; Fluorescence; Humans; Lysophospholipids; Molecular Imprinting; Nanoparticles; Polymers; Silicon Dioxide; Sphingosine | 2020 |
Fingolimod inhibits multiple stages of the HIV-1 life cycle.
Topics: Fingolimod Hydrochloride; HIV Infections; HIV-1; Humans; Lysophospholipids; Phosphorylation; SAM Domain and HD Domain-Containing Protein 1; Signal Transduction; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators; T-Lymphocytes; Virus Latency; Virus Replication | 2020 |
Morpholino Analogues of Fingolimod as Novel and Selective S1P
Topics: Animals; Central Nervous System; CHO Cells; Cricetulus; Disease Models, Animal; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Immunosuppressive Agents; Ligands; Lymphopenia; Lysophospholipids; Mice; Morpholinos; Multiple Sclerosis; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Spinal Cord; T-Lymphocytes | 2020 |
Sphingosine-1-phosphate and its mimetic FTY720 do not protect against radiation-induced ovarian fibrosis in the nonhuman primate†.
Topics: Animals; Female; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Macaca mulatta; Ovarian Diseases; Sphingosine; Sphingosine 1 Phosphate Receptor Modulators | 2021 |
Atrioventricular block after fingolimod resumption: a consequence of sphingosine-1-phosphate axis alteration due to COVID-19?
Topics: Atrioventricular Block; COVID-19; Fingolimod Hydrochloride; Humans; Lysophospholipids; Pandemics; SARS-CoV-2; Sphingosine | 2021 |
ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P
Topics: Animals; CHO Cells; Cricetulus; Fingolimod Hydrochloride; Humans; Lymphocyte Count; Lysophospholipids; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; T-Lymphocytes | 2021 |
Plasma Sphingosine-1-Phosphate Levels Are Associated with Progression of Estrogen Receptor-Positive Breast Cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Fingolimod Hydrochloride; Gene Expression; Humans; Lymphatic Metastasis; Lysophospholipids; MCF-7 Cells; Middle Aged; Plasma; Receptors, Estrogen; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors | 2021 |
Synthesis and Evaluation of Serinolamide Derivatives as Sphingosine-1-Phosphate-1 (S1P
Topics: Fingolimod Hydrochloride; Lymphocytes; Lysophospholipids; Receptors, Lysosphingolipid; Sphingosine | 2022 |
Resveratrol Affects Sphingolipid Metabolism in A549 Lung Adenocarcinoma Cells.
Topics: A549 Cells; Adenocarcinoma of Lung; Alkaline Ceramidase; Antioxidants; Biochemical Phenomena; Ceramides; Fingolimod Hydrochloride; Humans; Lysophospholipids; Neuroprotective Agents; Polyphenols; Resveratrol; Sphingolipids; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine | 2022 |
Conjugated Bile Acids Accelerate Progression of Pancreatic Cancer Metastasis via S1PR2 Signaling in Cholestasis.
Topics: Animals; Bile Acids and Salts; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholestasis; Fingolimod Hydrochloride; Humans; Liver Neoplasms; Mice; Pancreatic Neoplasms; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Steroids | 2023 |
Dysregulation of sphingosine-1-phosphate (S1P) and S1P receptor 1 signaling in the 5xFAD mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Fingolimod Hydrochloride; Lysophospholipids; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-akt; Sphingosine; Sphingosine-1-Phosphate Receptors; TOR Serine-Threonine Kinases | 2023 |
Modulation of blood-brain tumor barrier for delivery of magnetic hyperthermia to brain cancer.
Topics: Blood-Brain Barrier; Brain Neoplasms; Endothelial Cells; Fingolimod Hydrochloride; Glioblastoma; Humans; Hyperthermia, Induced; Magnetic Phenomena | 2023 |
Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod.
Topics: Animals; Fingolimod Hydrochloride; Hepatopulmonary Syndrome; Inflammation; Liver Cirrhosis; Mice; Niacinamide; Rats; Rats, Sprague-Dawley | 2023 |
Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia.
Topics: Animals; Apoptosis Regulatory Proteins; Cognition; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fingolimod Hydrochloride; Mice; Microglia; Neuroinflammatory Diseases; Phosphates; Phosphoric Monoester Hydrolases; Sphingosine; Tumor Suppressor Protein p53 | 2023 |
Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation.
Topics: Animals; Bezafibrate; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Multiple Sclerosis; Neuroglia; Neuroinflammatory Diseases; Propylene Glycols | 2023 |
Fingolimod Modulates the Gene Expression of Proteins Engaged in Inflammation and Amyloid-Beta Metabolism and Improves Exploratory and Anxiety-Like Behavior in Obese Mice.
Topics: Amyloid Precursor Protein Secretases; Animals; Anxiety; Aspartic Acid Endopeptidases; bcl-2-Associated X Protein; Cytokines; Diabetes Mellitus, Type 2; Fingolimod Hydrochloride; Gene Expression; Inflammation; Mice; Mice, Obese; Obesity; Receptors, Lysosphingolipid; RNA, Messenger | 2023 |
Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Glutamic Acid; Mice; Sphingosine-1-Phosphate Receptors | 2023 |