Page last updated: 2024-09-02

fingolimod hydrochloride and sirolimus

fingolimod hydrochloride has been researched along with sirolimus in 44 studies

Compound Research Comparison

Studies (fingolimod hydrochloride)	Trials (fingolimod hydrochloride)	Recent Studies (post-2010) (fingolimod hydrochloride)	Studies (sirolimus)	Trials (sirolimus)	Recent Studies (post-2010) (sirolimus)
2,771	157	2,062	20,711	2,368	11,516

Protein Interaction Comparison

Protein	Taxonomy	sirolimus (IC50)
Bile salt export pump	Homo sapiens (human)	10
ATP-dependent translocase ABCB1	Homo sapiens (human)	1.25
Cytochrome P450 3A4	Homo sapiens (human)	2
Cytochrome P450 2C9	Homo sapiens (human)	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	Mus musculus (house mouse)	0.001
Cytochrome P450 2C19	Homo sapiens (human)	4
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	0.0897
Peptidyl-prolyl cis-trans isomerase FKBP1A	Homo sapiens (human)	0.0042
Regulatory-associated protein of mTOR	Homo sapiens (human)	0.225
Target of rapamycin complex subunit LST8	Homo sapiens (human)	0.225
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	1.9
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	1.1

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (6.82)	18.2507
2000's	26 (59.09)	29.6817
2010's	14 (31.82)	24.3611
2020's	1 (2.27)	2.80

Authors

Authors	Studies
Kahan, BD; Okamoto, M; Qu, X; Stepkowski, SM; Tejpal, N; Wang, ME; Yu, J	1
Kahan, BD; Okamoto, M; Qu, X; Stepkowski, SM; Tejpal, N; Wang, M; Yu, J	1
Kahan, BD	3
Hong, JC; Kahan, BD; Katz, SM	1
Baumlin, Y; Hof, A; Hof, RP; Nikolova, Z	1
Bernhard, M; Hedinger, R; Kraus, G; Kunkler, A; Menninger, K; Quesniaux, VF; Schuurman, HJ; Vedrine, C	1
Kelly, DA; van Mourik, ID	1
Pohanka, E	1
Hammond-McKibben, D; Hugo, R; Lake, P; Tart-Risher, N; Weetall, M; Zhang, J	1
Audet, M; Gaschen, L; Menninger, K; Quesniaux, V; Schuurman, HJ	1
Diaz-Romero, J; Vogt, G; Weckbecker, G	1
Dumont, FJ	1
Morel, D	1
Audet, M; Bernhard, M; Brinkmann, V; Gaschen, L; Kunkler, A; Maurer, C; Menninger, K; Quesniaux, V; Schuurman, HJ; Vedrine, C	1
Cai, DH; Chen, H; Zhang, H; Zhao, DM	1
Braun, WE	1
McDonald, RA; Nemeth, TL; Smith, JM	1
Cottens, S; Hering, BJ; Kenyon, NM; Kenyon, NS; Kirchhof, N; Lake, P; Mullon, C; Ricordi, C; Wijkstrom, M	1
Cerio, J; Gabardi, S	1
Baczkowska, T; Durlik, M	1
Cai, JQ; Dong, WP; Tan, JM; Wang, JB; Wang, YF	1
Cozzi, E; Schuurman, HJ; Smith, HT	1
Foster, C; Kovarik, JM; Lorber, MI; Tedesco-Silva, H	1
Alperovich, G; Bolaños, N; Carrera, M; Cruzado, JM; Franquesa, M; Gomà, M; Grinyó, JM; Herrero-Fresneda, I; Lloberas, N; Poveda, R; Rama, I; Torras, J	1
Fischereder, M	1
Cai, M; Shen, Y; Wang, C; Wang, X; Xia, W; Xie, H; Zheng, S; Zhou, L	1
Baumann, M; Heemann, U; Liu, S; Lutz, J; Roos, M; Schmaderer, C; Strobl, M	1
Beerli, C; Bruns, C; Burkhart, C; Metzler, B; Morris, RE; Pally, C; Wagner, J; Weckbecker, G; Wieczorek, G	1
McFadden, G; Werden, SJ	1
Bueno, V; Cordeiro, JA; Lopes, CT; Rosin, FC	1
Bueno, V; Cordeiro, JA; de Franco, MF; Lopes, CT; Pletiskaitz, TM	1
Aronovich, A; Bachar-Lustig, E; Bitcover, R; Cohen, S; Eventov-Friedman, S; Feine, I; Katchman, H; Reisner, Y; Rosen, C; Shezen, E; Tal, O; Tchorsh-Yutsis, D; Zangi, L; Zlotnikov Klionsky, Y	1
Lock, JF; Malinowski, M; Martus, P; Neuhaus, P; Stockmann, M	1
Nishi, S	1
Domínguez, J; Giacaman, A; Lira, F; Mendez, G	1
Belyaev, O; Bergmann, U; Burr, W; McArthur, N; Müller, CA; Munding, J; Tannapfel, A; Uhl, W; Werner, J	1
Lei, T; Liu, G; Peng, J; Sun, C; Wang, R; Wu, T; Xu, K; Zhang, L; Zhao, Y	1
Dalrymple, NA; Gavrilovskaya, IN; Gorbunova, EE; Mackow, ER	1
Bi, Y; Chen, W; Chu, Y; Liu, G; Liu, H; Lu, Y; Wang, R; Wang, X; Yang, H; Yang, R; Zhang, Y; Zhang, Z	1
Cao, R; Guo, L; Hou, H; Li, B; Quan, M; Song, X; Sun, H; Sun, Y; Zhang, J	1
Fan, Y; Gong, TT; Lei, L; Liang, X; Liu, H; Shan, ZY; Sun, RZ; Wang, Q	1
Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M	1

Reviews

11 review(s) available for fingolimod hydrochloride and sirolimus

Article	Year
The potential role of rapamycin in pediatric transplantation as observed from adult studies. Pediatric transplantation, 1999, Volume: 3, Issue:3 Topics: Acute Disease; Adult; Age Factors; Antibodies, Monoclonal; Basiliximab; Child; Cohort Studies; Cyclosporine; Drug Monitoring; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sirolimus; Sphingosine; Time Factors; Tyrphostins	1999
Immunosuppressive drugs in paediatric liver transplantation. Paediatric drugs, 2001, Volume: 3, Issue:1 Topics: Animals; Child; Child, Preschool; Cyclosporine; Drug Interactions; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Liver Transplantation; Mycophenolic Acid; Propylene Glycols; Sirolimus; Sphingosine; Tacrolimus	2001
New immunosuppressive drugs: an update. Current opinion in urology, 2001, Volume: 11, Issue:2 Topics: Adrenal Cortex Hormones; Alkylating Agents; Calcineurin Inhibitors; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Purines; Pyrimidines; Sirolimus; Sphingosine; Vitamin D	2001
Treatment of transplant rejection: are the traditional immunosuppressants good enough? Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:3 Topics: Antibodies, Monoclonal; Antimetabolites; Calcineurin Inhibitors; Cyclosporine; Cytokines; Drug Design; Fingolimod Hydrochloride; Graft Rejection; Guanidines; Humans; Immunosuppressive Agents; Lymphocyte Activation; Molecular Structure; Organ Transplantation; Propylene Glycols; Signal Transduction; Sirolimus; Sphingosine; T-Lymphocytes; Tacrolimus; Triterpenes	2001
Renal transplantation: basic concepts and evolution of therapy. Journal of clinical apheresis, 2003, Volume: 18, Issue:3 Topics: Antibodies, Monoclonal; Azathioprine; Calcineurin Inhibitors; Cyclosporine; Fingolimod Hydrochloride; Glucocorticoids; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Propylene Glycols; Receptors, Interleukin-2; Sirolimus; Sphingosine; Tacrolimus	2003
Current immunosuppressive agents: efficacy, side effects, and utilization. Pediatric clinics of North America, 2003, Volume: 50, Issue:6 Topics: Abatacept; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antilymphocyte Serum; Area Under Curve; Basiliximab; Cyclosporine; Daclizumab; Drug Therapy, Combination; Drug Utilization; Everolimus; Fingolimod Hydrochloride; Graft Survival; Humans; Immunoconjugates; Immunoglobulin G; Immunosuppressive Agents; Muromonab-CD3; Mycophenolic Acid; Propylene Glycols; Recombinant Fusion Proteins; Sirolimus; Sphingosine; Tacrolimus	2003
Future immunosuppressive agents in solid-organ transplantation. Progress in transplantation (Aliso Viejo, Calif.), 2004, Volume: 14, Issue:2 Topics: Drug Approval; Drug Interactions; Drug Monitoring; Everolimus; Fingolimod Hydrochloride; Forecasting; Graft Survival; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Mycophenolic Acid; Organ Transplantation; Propylene Glycols; Safety; Sirolimus; Sphingosine; Transplantation Immunology; Treatment Outcome	2004
[Immunossupresive drugs in renal transplantation]. Polskie Archiwum Medycyny Wewnetrznej, 2004, Volume: 112 Spec No Topics: Adrenal Cortex Hormones; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Azathioprine; Cyclosporine; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Propylene Glycols; Risk Factors; Rituximab; Sirolimus; Sphingosine; Tacrolimus	2004
Chemokines and chemokine receptors in renal transplantation--from bench to bedside. Acta physiologica Hungarica, 2007, Volume: 94, Issue:1-2 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; CCR5 Receptor Antagonists; Chemokines; Chemotaxis; Clinical Trials as Topic; Duffy Blood-Group System; Fingolimod Hydrochloride; Graft Rejection; Humans; Kidney Transplantation; Models, Animal; Propylene Glycols; Receptors, CCR1; Receptors, Cell Surface; Receptors, Chemokine; Sirolimus; Sphingosine	2007
[Immunosuppressive agents in kidney transplantation]. Nihon Jinzo Gakkai shi, 2011, Volume: 53, Issue:1 Topics: Antibodies; Antibodies, Monoclonal, Murine-Derived; Boronic Acids; Bortezomib; Cyclosporine; Everolimus; Fingolimod Hydrochloride; Graft Rejection; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Pyrazines; Rituximab; Sirolimus; Sphingosine; T-Lymphocytes; Tacrolimus; TOR Serine-Threonine Kinases	2011
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? Epilepsia, 2020, Volume: 61, Issue:3 Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Ceftriaxone; Dibenzazepines; Drug Repositioning; Epilepsy; Epilepsy, Post-Traumatic; Erythropoietin; Fingolimod Hydrochloride; GABA Agents; Gabapentin; Humans; Immunologic Factors; Inflammation; Interleukin 1 Receptor Antagonist Protein; Isoflurane; Levetiracetam; Losartan; Neuroprotective Agents; Oxidative Stress; Pregabalin; Pyrrolidinones; Sirolimus; Stroke; Topiramate; Translational Research, Biomedical; Vigabatrin	2020

Trials

2 trial(s) available for fingolimod hydrochloride and sirolimus

Article

Year

The potential role of rapamycin in pediatric transplantation as observed from adult studies.

Pediatric transplantation, 1999, Volume: 3, Issue:3

Topics: Acute Disease; Adult; Age Factors; Antibodies, Monoclonal; Basiliximab; Child; Cohort Studies; Cyclosporine; Drug Monitoring; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sirolimus; Sphingosine; Time Factors; Tyrphostins

1999

Exposure-efficacy relationships of a fingolimod-everolimus regimen in kidney transplant patients at risk for delayed graft function.

Transplantation proceedings, 2006, Volume: 38, Issue:10

Topics: Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney Function Tests; Kidney Transplantation; Lymphocyte Count; Postoperative Complications; Propylene Glycols; Sirolimus; Sphingosine

2006

Other Studies

32 other study(ies) available for fingolimod hydrochloride and sirolimus

Article	Year
Immunosuppressive effects of FTY720 alone or in combination with cyclosporine and/or sirolimus. Transplantation, 1998, Apr-15, Volume: 65, Issue:7 Topics: Animals; Antibodies, Monoclonal; Cyclosporine; Drug Synergism; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lymphocytes; Male; Phytohemagglutinins; Polyenes; Propylene Glycols; Rats; Rats, Inbred BN; Rats, Inbred BUF; Rats, Inbred WF; Sirolimus; Sphingosine; Stimulation, Chemical	1998
Synergistic interaction of FTY720 with cyclosporine or sirolimus to prolong heart allograft survival. Transplantation proceedings, 1998, Volume: 30, Issue:5 Topics: Animals; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Polyenes; Propylene Glycols; Rats; Rats, Inbred BUF; Rats, Inbred WF; Sirolimus; Sphingosine; Transplantation, Homologous	1998
New immunosuppressive agents. Transplantation proceedings, 2000, Volume: 32, Issue:3 Topics: Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Propylene Glycols; Sirolimus; Sphingosine; Transplantation	2000
The peripheral lymphocyte count predicts graft survival in DA to Lewis heterotopic heart transplantation treated with FTY720 and SDZ RAD. Transplant immunology, 2000, Volume: 8, Issue:2 Topics: Animals; Body Weight; Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Lymphocyte Count; Male; Myocardium; Propylene Glycols; Rats; Rats, Inbred Lew; Sirolimus; Sphingosine; Transplantation, Heterotopic	2000
The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD. Transplant immunology, 2000, Volume: 8, Issue:3 Topics: Administration, Oral; Animals; B-Lymphocytes; Cyclosporine; Dose-Response Relationship, Drug; Drug Tolerance; Everolimus; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Count; Lymphocyte Depletion; Macaca fascicularis; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Transplantation Immunology	2000
A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3 Topics: Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Everolimus; Fibrosarcoma; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Histocompatibility; Immunity, Cellular; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Mice, Nude; Models, Immunological; Neoplasm Transplantation; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Transplantation, Homologous; Tumor Cells, Cultured	2001
FTY-720 is efficacious in monkey kidney transplantation. Transplantation proceedings, 2001, Volume: 33, Issue:3 Topics: ABO Blood-Group System; Animals; B-Lymphocytes; Cyclosporine; Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Graft Survival; Histocompatibility Testing; Immunophenotyping; Immunosuppressive Agents; Kidney Transplantation; Macaca fascicularis; Major Histocompatibility Complex; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Time Factors	2001
Coexpression of CD4 and CD8alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs. Journal of immunological methods, 2001, Aug-01, Volume: 254, Issue:1-2 Topics: Animals; Biomarkers; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8 Antigens; Concanavalin A; Cyclosporine; Everolimus; Fingolimod Hydrochloride; Flow Cytometry; Guanidines; Immunosuppressive Agents; Mitogens; Propylene Glycols; Rats; Rats, Inbred Lew; Sirolimus; Sphingosine; Tacrolimus	2001
[mTOR and FTY 720 inhibitors]. Presse medicale (Paris, France : 1983), 2001, Sep-01, Volume: 30, Issue:24 Pt 2 Topics: Cyclosporine; Drug Interactions; Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Hyperlipidemias; Immunosuppressive Agents; Kidney; Neoplasms; Propylene Glycols; Sirolimus; Sphingosine	2001
Update on pharmacokinetic/pharmacodynamic studies with FTY720 and sirolimus. Therapeutic drug monitoring, 2002, Volume: 24, Issue:1 Topics: Animals; Drug Interactions; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Organ Transplantation; Propylene Glycols; Rats; Sirolimus; Sphingosine	2002
Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD. Transplantation, 2002, Oct-15, Volume: 74, Issue:7 Topics: Administration, Oral; Animals; B-Lymphocytes; Cyclosporine; Drug Combinations; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Count; Macaca fascicularis; Male; Phenotype; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Transplantation, Homologous	2002
Sirolimus and FTY720: new approaches to transplant immunosuppression. Transplantation proceedings, 2002, Volume: 34, Issue:7 Topics: Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Multicenter Studies as Topic; Propylene Glycols; Sirolimus; Sphingosine; Transplantation Immunology	2002
[Effects of three different immunosuppressive drugs on SD rat islet cell viability]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2003, Volume: 23, Issue:2 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Survival; Cells, Cultured; Daclizumab; Fingolimod Hydrochloride; Immunoglobulin G; Immunosuppressive Agents; Islets of Langerhans; Propylene Glycols; Rats; Sirolimus; Sphingosine	2003
Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720. Transplantation, 2004, Mar-27, Volume: 77, Issue:6 Topics: Animals; Antibodies, Monoclonal; Basiliximab; Diabetes Mellitus, Experimental; Everolimus; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Macaca fascicularis; Propylene Glycols; Recombinant Fusion Proteins; Sirolimus; Sphingosine	2004
[Study of the effects of immunosuppressive agents on human islet cells in vitro]. Zhonghua yi xue za zhi, 2005, Mar-16, Volume: 85, Issue:10 Topics: Cell Separation; Cell Survival; Cells, Cultured; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Islets of Langerhans; Propylene Glycols; Sirolimus; Sphingosine; Tacrolimus	2005
Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates. Toxicology, 2005, Sep-15, Volume: 213, Issue:1-2 Topics: Animals; Cyclophosphamide; Cyclosporine; Drug Synergism; Everolimus; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Leukocyte Count; Macaca fascicularis; Male; Methotrexate; Mycophenolic Acid; Organ Transplantation; Papio; Propylene Glycols; Sirolimus; Sphingosine	2005
New immunosuppresor strategies in the treatment of murine lupus nephritis. Lupus, 2007, Volume: 16, Issue:1 Topics: Administration, Oral; Animals; Antibodies, Antinuclear; Apoptosis; Autoantigens; Cell Movement; Chromatin; Complement C3; Complement C3 Nephritic Factor; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Glomerular Mesangium; Immunoglobulin G; Immunosuppressive Agents; Injections, Intraperitoneal; Kidney Glomerulus; Lupus Nephritis; Lymphocytes; Mice; Mice, Inbred NZB; Nucleosomes; Propylene Glycols; Proteinuria; Receptors, Lysosphingolipid; Sirolimus; Sphingosine	2007
Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro. Transplantation proceedings, 2008, Volume: 40, Issue:5 Topics: Cell Division; Cell Line, Tumor; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Pancreatic Neoplasms; Propylene Glycols; Sirolimus; Sphingosine	2008
Treatment of chronic allograft nephropathy at late stages using everolimus or FTY720 in combination with cyclosporine. Transplantation proceedings, 2008, Volume: 40, Issue:10 Topics: Animals; Chronic Disease; Cyclosporine; Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Rats; Rats, Inbred F344; Rats, Inbred Lew; Sirolimus; Sphingosine; Transplantation, Homologous	2008
Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720. Transplant international : official journal of the European Society for Organ Transplantation, 2010, May-01, Volume: 23, Issue:5 Topics: Animals; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Everolimus; Fingolimod Hydrochloride; Heart Transplantation; Immunosuppressive Agents; Male; Propylene Glycols; Protein Kinase C; Pyrroles; Quinazolines; Rats; Rats, Inbred Lew; Rats, Wistar; Sirolimus; Sphingosine	2010
Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells. Journal of virology, 2010, Volume: 84, Issue:7 Topics: Cell Line, Tumor; Fingolimod Hydrochloride; Humans; Intracellular Signaling Peptides and Proteins; Myxoma virus; Neoplasms; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Propylene Glycols; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Sphingosine; TOR Serine-Threonine Kinases; Viral Proteins; Viral Tropism; Virus Replication	2010
Cell phenotype evaluation at various sites after skin transplantation and FTY720 plus sirolimus therapy. Transplantation proceedings, 2010, Volume: 42, Issue:2 Topics: Animals; Cell Count; Fingolimod Hydrochloride; Flow Cytometry; Graft Survival; Immunosuppressive Agents; Leukocyte Count; Leukocytes; Male; Mice; Mice, Inbred BALB C; Models, Animal; Phenotype; Propylene Glycols; Sirolimus; Skin; Skin Transplantation; Sphingosine; Transplantation, Homologous	2010
Sirolimus in combination with FTY720: analysis of urinary and serum parameters. Transplantation proceedings, 2010, Volume: 42, Issue:2 Topics: Animals; Creatinine; Diuresis; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Mice; Mice, Inbred C57BL; Propylene Glycols; Proteinuria; Sirolimus; Sphingosine	2010
Embryonic pig pancreatic tissue for the treatment of diabetes: potential role of immune suppression with "off-the-shelf" third-party regulatory T cells. Transplantation, 2011, Feb-27, Volume: 91, Issue:4 Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Diabetes Mellitus; Embryo, Mammalian; Fingolimod Hydrochloride; Graft Survival; Immunosuppressive Agents; Insulin; Mice; Mice, Inbred C57BL; Pancreas Transplantation; Propylene Glycols; Sirolimus; Sphingosine; Swine; T-Lymphocytes, Regulatory; Transplantation Tolerance; Transplantation, Heterologous	2011
Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function. Transplant international : official journal of the European Society for Organ Transplantation, 2011, Volume: 24, Issue:2 Topics: Animals; Biological Transport; Cyclosporine; Diarrhea; Everolimus; Fingolimod Hydrochloride; Glucose; Immunosuppressive Agents; Intestinal Absorption; Intestine, Large; Intestine, Small; Male; Mycophenolic Acid; Propylene Glycols; Rats; Rats, Wistar; Sirolimus; Sphingosine; Tacrolimus	2011
Short-term immunossupressive treatment of the donor does not prevent ischemia-reperfusion kidney damage in the rat. Transplantation proceedings, 2011, Volume: 43, Issue:9 Topics: Animals; Cadaver; Creatinine; Fingolimod Hydrochloride; Graft Survival; Hypertonic Solutions; Immunosuppressive Agents; Kidney Transplantation; Male; Propylene Glycols; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Sphingosine; Tissue Donors	2011
Effects of FTY720 and rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat. Pancreas, 2012, Volume: 41, Issue:7 Topics: Acute Disease; Amylases; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Fingolimod Hydrochloride; Hydrocortisone; Immunosuppressive Agents; Interleukin-10; Interleukin-6; Pancreas; Pancreatitis; Propylene Glycols; Rats; Rats, Wistar; Sirolimus; Sphingosine; T-Lymphocytes; Taurocholic Acid	2012
Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo. Transplant immunology, 2012, Volume: 27, Issue:1 Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cell Count; Cyclophosphamide; Cyclosporine; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immune Tolerance; Immunity; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Mycophenolic Acid; Ovalbumin; Propylene Glycols; Sirolimus; Sphingosine; Spleen; T-Lymphocytes, Regulatory	2012
Role of vascular and lymphatic endothelial cells in hantavirus pulmonary syndrome suggests targeted therapeutic approaches. Lymphatic research and biology, 2013, Volume: 11, Issue:3 Topics: Animals; Antibodies; Capillary Permeability; Cricetinae; Endothelial Cells; Fingolimod Hydrochloride; Hantavirus Pulmonary Syndrome; Host-Pathogen Interactions; Humans; Immunosuppressive Agents; Mesocricetus; Orthohantavirus; Propylene Glycols; Pulmonary Edema; Signal Transduction; Sirolimus; Sphingosine; Vascular Endothelial Growth Factor Receptor-2	2013
Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells. Journal of immunology (Baltimore, Md. : 1950), 2014, Apr-01, Volume: 192, Issue:7 Topics: Animals; CD11b Antigen; Cell Differentiation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Fingolimod Hydrochloride; Immunoblotting; Immunosuppressive Agents; Liver; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; Nitric Oxide; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Propylene Glycols; Receptors, Chemokine; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sirolimus; Sphingosine; T-Lymphocytes, Regulatory; Th1 Cells; TOR Serine-Threonine Kinases	2014
Rapamycin and fingolimod modulate Treg/Th17 cells in experimental autoimmune encephalomyelitis by regulating the Akt-mTOR and MAPK/ERK pathways. Journal of neuroimmunology, 2018, 11-15, Volume: 324 Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-akt; Sirolimus; T-Lymphocytes, Regulatory; Th17 Cells; TOR Serine-Threonine Kinases	2018
Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy. BioMed research international, 2018, Volume: 2018 Topics: Animals; Arginase; Atherosclerosis; Autophagy; Biomarkers; Cyclooxygenase 2; Fingolimod Hydrochloride; Foam Cells; Interleukin-6; Lipoproteins, LDL; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Microtubule-Associated Proteins; Nitric Oxide Synthase Type II; Receptors, Lysosphingolipid; Sirolimus; Transforming Growth Factor alpha	2018