fingolimod hydrochloride has been researched along with sew2871 in 30 studies
| Studies (fingolimod hydrochloride) | Trials (fingolimod hydrochloride) | Recent Studies (post-2010) (fingolimod hydrochloride) | Studies (sew2871) | Trials (sew2871) | Recent Studies (post-2010) (sew2871) |
|---|---|---|---|---|---|
| 2,771 | 157 | 2,062 | 95 | 0 | 57 |
| Protein | Taxonomy | fingolimod hydrochloride (IC50) | sew2871 (IC50) |
|---|---|---|---|
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | 0.037 | |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | 4.6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 17 (56.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Abe, M; Brinkmann, V; Coates, PT; Colvin, BL; De Creus, A; Lan, YY; Thomson, AW | 1 |
| Awad, AS; Foss, FW; Huang, L; Li, L; Lynch, KR; Macdonald, TL; Okusa, MD; Ye, H | 1 |
| Bruns, CJ; Graeb, C; Guba, M; Heeschen, C; Ischenko, I; Jauch, KW; Joka, M; Papyan, A; Schmid, G; Schrepfer, S | 1 |
| Gonzalez-Cabrera, PJ; Hla, T; Rosen, H | 1 |
| Chiba, K; Kataoka, H; Maeda, Y; Matsuyuki, H; Shimano, K; Sugahara, K | 1 |
| Bassilana, F; Cortes-Cros, M; Craveiro, LM; Dev, KK; Guerini, D; Mullershausen, F; Osinde, M; Schwab, ME; Seuwen, K; Shin, Y; Sivasankaran, R; Thallmair, M; Wishart, WL | 1 |
| Brinkmann, V; Chun, J; Ip, PC; Potts, EM; Salomone, S; Tyndall, S; Waeber, C | 1 |
| Huwiler, A; Pfeilschifter, J | 1 |
| Chwalla, I; Krump-Konvalinkova, V; Siess, W | 1 |
| Bäumer, W; Kietzmann, M; Kleuser, B; Lüth, A; Mischke, R; Reines, I; Tschernig, T | 1 |
| Bonz, A; Burkard, N; Ertl, G; Frantz, S; Hofmann, U; Ritter, O; Thoma, A; Vogt, C | 1 |
| Bae, H; Dukala, D; Jung, CG; Kakazu, R; Kim, HJ; Soliven, B; Wollmann, R | 1 |
| Knudsen, E; Maghazachi, AA; Rolin, J; Sand, KL | 1 |
| Hasegawa, Y; Rolland, W; Sozen, T; Suzuki, H; Zhang, JH | 1 |
| Brooks, SF; Chun, J; Fontaine, BA; Luster, AD; Shea, BS; Tager, AM | 1 |
| Bajwa, A; Dondeti, KR; Haase, VH; Huang, L; Jo, SK; Lynch, KR; Macdonald, TL; Okusa, MD; Rosin, DL; Ye, H | 1 |
| Chiba, K; Maeda, Y; Sato, N; Seki, N; Sugahara, K | 1 |
| Awad, AS; Bolton, WK; Huang, L; Khutsishvili, K; Lynch, KR; Okusa, MD; Rouse, MD | 1 |
| Heytens, E; Oktay, K; Soleimani, R | 1 |
| Dev, KK; Sheridan, GK | 1 |
| Akhade, AS; Qadri, A; Sharma, N | 1 |
| Absalom, AR; Bouma, HR; Buikema, H; Epema, AH; Henning, RH; Houwertjes, MC; Mungroop, HE; Samarska, IV | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Al-Jarallah, A; Chen, X; González, L; Trigatti, BL | 1 |
| Abraham, SN; Ang, WXG; Chan, EW; Gunn, MD; Huang, MN; Kunder, CA; St John, AL | 1 |
| Ahmadiani, A; Dargahi, L; Khallaghi, B; Safarian, F | 1 |
| Ahmadiani, A; Asle-Rousta, M; Dargahi, L; Kolahdooz, Z; Nasoohi, S | 1 |
| Klebe, D; Krafft, PR; LeGrand, J; Lekic, T; Rolland, WB; Weldon, AJ; Xu, L; Zhang, JH | 1 |
| Donahue, RR; Doolen, S; Grachen, CM; Iannitti, T; Shaw, BC; Taylor, BK | 1 |
| Busra Azizoglu, Z; Canatan, H; Eken, A; Zehra Okus, F | 1 |
1 review(s) available for fingolimod hydrochloride and sew2871
| Article | Year |
|---|---|
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Topics: Animals; Fingolimod Hydrochloride; Humans; Lysophospholipids; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Sphingosine; Sulfhydryl Compounds; Thiazolidines; Thiophenes | 2008 |
29 other study(ies) available for fingolimod hydrochloride and sew2871
| Article | Year |
|---|---|
The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Adhesion Molecules; Cell Differentiation; Dendritic Cells; DNA Primers; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Depletion; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Oxadiazoles; Polymerase Chain Reaction; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Thiophenes | 2005 |
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.
Topics: Animals; Capillary Permeability; Creatinine; Fingolimod Hydrochloride; Kidney; Leukocytes; Lymphocyte Count; Mice; Mice, Inbred C57BL; Oxadiazoles; Peroxidase; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; T-Lymphocytes; Thiophenes | 2006 |
The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Cell Division; Cells, Cultured; Coculture Techniques; Collagen; Drug Combinations; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Laminin; Mice; Mice, Inbred C57BL; Muscle, Smooth; Neoplasm Transplantation; Neovascularization, Pathologic; Neutralization Tests; Oxadiazoles; Propylene Glycols; Proteoglycans; Receptors, CXCR4; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Transcriptional Activation; Transplantation, Isogeneic; Umbilical Veins; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2007 |
Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
Topics: Cells, Cultured; Chloroquine; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Lysophospholipids; Oxadiazoles; Propylene Glycols; Protein Transport; Proteomics; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Ubiquitin | 2007 |
Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Dendritic Cells; Dose-Response Relationship, Drug; Down-Regulation; Endocytosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Knockout; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiophenes | 2007 |
Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Astrocytes; beta-Alanine; Calcium Signaling; Cell Movement; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Embryo, Mammalian; Fingolimod Hydrochloride; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Immunosuppressive Agents; Inositol Phosphates; Organ Culture Techniques; Oxadiazoles; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; Thiophenes | 2007 |
Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
Topics: Animals; Cerebral Arteries; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; In Vitro Techniques; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Propylene Glycols; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Vasoconstriction | 2008 |
FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression.
Topics: Actins; Cell Adhesion Molecules; Cell Membrane; Cell Movement; Cells, Cultured; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Neovascularization, Physiologic; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Wound Healing | 2008 |
Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.
Topics: Administration, Topical; Animals; Cell Movement; Dendritic Cells; Dermatitis, Allergic Contact; Female; Fingolimod Hydrochloride; Histocompatibility Antigens Class II; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred BALB C; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Skin; Sphingosine; Thiophenes; Toluene 2,4-Diisocyanate | 2009 |
Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Death; Cells, Cultured; ErbB Receptors; Fingolimod Hydrochloride; Humans; Lysophospholipids; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxadiazoles; Perfusion; Propylene Glycols; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; Recovery of Function; Signal Transduction; Sphingosine; Thiophenes; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2009 |
Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy.
Topics: Animals; Autoimmunity; Blood-Nerve Barrier; Blotting, Western; Cell Culture Techniques; Cell Proliferation; Cell Survival; Cytokines; Electrophysiology; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred NOD; Mice, Transgenic; Oxadiazoles; Polymerase Chain Reaction; Polyneuropathies; Propylene Glycols; Schwann Cells; Severity of Illness Index; Sphingosine; Spleen; Thiophenes | 2009 |
FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.
Topics: Chemokines; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunoblotting; Immunosuppressive Agents; K562 Cells; Killer Cells, Natural; Lysophospholipids; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Up-Regulation | 2010 |
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Fingolimod Hydrochloride; Immunosuppressive Agents; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Nerve Degeneration; Neuroprotective Agents; Oxadiazoles; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Stroke; Thiophenes; Treatment Outcome | 2010 |
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
Topics: Animals; beta-Alanine; Bleomycin; Blood Coagulation; Endothelial Cells; Fibrosis; Fingolimod Hydrochloride; Humans; Lung Injury; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Pneumonia; Propylene Glycols; Pulmonary Alveoli; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Survival Analysis; Thiophenes; Vascular Diseases | 2010 |
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Movement; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Homeodomain Proteins; Kidney Tubules, Proximal; Leukocytes; Lipopolysaccharides; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Signal Transduction; Sphingosine; Thiophenes | 2010 |
Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.
Topics: Adoptive Transfer; Animals; Bone Marrow; Cell Count; Cell Movement; Fingolimod Hydrochloride; Hypersensitivity, Delayed; Immunization; Lymphoid Tissue; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ovalbumin; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Thiophenes | 2010 |
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fingolimod Hydrochloride; Kidney; Lymphocytes; Mice; Mice, Inbred C57BL; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Podocytes; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha | 2011 |
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
Topics: Animals; Apoptosis; Cryopreservation; Female; Fingolimod Hydrochloride; Graft Survival; Humans; Immunohistochemistry; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, SCID; Neovascularization, Physiologic; Ovarian Follicle; Ovary; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Transplantation, Heterologous | 2011 |
S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Movement; Cerebellum; Chemokine CCL20; Chemokine CCL3; Chemokines; Demyelinating Diseases; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Lysophosphatidylcholines; Myelin Basic Protein; Neurofilament Proteins; Organ Culture Techniques; Oxadiazoles; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes | 2012 |
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells.
Topics: Calcium; Fingolimod Hydrochloride; Flagellin; Gene Expression Regulation; Humans; Interleukin-2; Interleukin-8; Jurkat Cells; Lipopeptides; Lymphocyte Activation; Lysophospholipids; Molecular Mimicry; Oxadiazoles; Propylene Glycols; Receptors, Antigen, T-Cell; Serum; Signal Transduction; Sphingosine; T-Lymphocytes; Thiophenes; Toll-Like Receptors; U937 Cells | 2013 |
S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.
Topics: Animals; Blood Gas Analysis; Cardiopulmonary Bypass; Cell Count; Coronary Vessels; Fingolimod Hydrochloride; Follow-Up Studies; Interleukin-6; Lymphocytes; Male; Mesenteric Arteries; Oxadiazoles; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Vasoconstriction; Vasodilation | 2014 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists.
Topics: Animals; Cell Line; Cell Movement; Cells, Cultured; Fingolimod Hydrochloride; Intracellular Signaling Peptides and Proteins; Lipoproteins, HDL; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxadiazoles; Pertussis Toxin; Propylene Glycols; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; Scavenger Receptors, Class B; Sphingosine; Thiophenes | 2014 |
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
Topics: Animals; CD11 Antigens; CD11b Antigen; Cell Movement; Chemokine CCL21; Dendritic Cells; Female; Fingolimod Hydrochloride; Integrin alpha Chains; Lymph Nodes; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Oxadiazoles; Phagocytes; Plague; Propylene Glycols; Receptors, CCR2; Receptors, CCR7; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Yersinia pestis | 2014 |
Activation of S1P₁ receptor regulates PI3K/Akt/FoxO3a pathway in response to oxidative stress in PC12 cells.
Topics: Animals; Fingolimod Hydrochloride; Forkhead Box Protein O3; Forkhead Transcription Factors; Neurons; Neuroprotective Agents; Oxadiazoles; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; Thiophenes | 2015 |
Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Maze Learning; Memory Disorders; Oxadiazoles; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha | 2015 |
Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups.
Topics: Animals; Body Water; Brain; Brain Chemistry; Brain Edema; Cognition; Female; Fingolimod Hydrochloride; Intracranial Hemorrhages; Leukocyte Count; Male; Neuroprotective Agents; Oxadiazoles; Phosphoserine; Pregnancy; Pyrones; Quinolines; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Thiophenes; Tight Junction Proteins | 2017 |
Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn.
Topics: Anilides; Animals; Central Nervous System Sensitization; Disease Models, Animal; eIF-2 Kinase; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Organophosphonates; Oxadiazoles; Pain Threshold; Peptide Fragments; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Spinal Cord; Spinal Nerve Roots; Subcellular Fractions; Thiophenes | 2018 |
S1P analogues SEW2871, BAF312 and FTY720 affect human Th17 and Treg generation ex vivo.
Topics: Animals; Azetidines; Benzyl Compounds; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Interleukin-23; Lysophospholipids; Mice; Neurodegenerative Diseases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes, Regulatory; Th17 Cells; Thiophenes | 2022 |