Page last updated: 2024-09-02

fingolimod hydrochloride and oxadiazoles

fingolimod hydrochloride has been researched along with oxadiazoles in 48 studies

Compound Research Comparison

Studies (fingolimod hydrochloride)	Trials (fingolimod hydrochloride)	Recent Studies (post-2010) (fingolimod hydrochloride)	Studies (oxadiazoles)	Trials (oxadiazoles)	Recent Studies (post-2010) (oxadiazoles)
2,771	157	2,062	6,057	257	2,359

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (27.08)	29.6817
2010's	29 (60.42)	24.3611
2020's	6 (12.50)	2.80

Authors

Authors	Studies
Abe, M; Brinkmann, V; Coates, PT; Colvin, BL; De Creus, A; Lan, YY; Thomson, AW	1
Baumruker, T; Billich, A; Ettmayer, P; Guerini, D; Mechtcheriakova, D; Nussbaumer, P; Streiff, MB	1
Awad, AS; Foss, FW; Huang, L; Li, L; Lynch, KR; Macdonald, TL; Okusa, MD; Ye, H	1
Bruns, CJ; Graeb, C; Guba, M; Heeschen, C; Ischenko, I; Jauch, KW; Joka, M; Papyan, A; Schmid, G; Schrepfer, S	1
Gonzalez-Cabrera, PJ; Hla, T; Rosen, H	1
Chiba, K; Kataoka, H; Maeda, Y; Matsuyuki, H; Shimano, K; Sugahara, K	1
Bassilana, F; Cortes-Cros, M; Craveiro, LM; Dev, KK; Guerini, D; Mullershausen, F; Osinde, M; Schwab, ME; Seuwen, K; Shin, Y; Sivasankaran, R; Thallmair, M; Wishart, WL	1
Brinkmann, V; Chun, J; Ip, PC; Potts, EM; Salomone, S; Tyndall, S; Waeber, C	1
Huwiler, A; Pfeilschifter, J	1
Chwalla, I; Krump-Konvalinkova, V; Siess, W	1
Bäumer, W; Kietzmann, M; Kleuser, B; Lüth, A; Mischke, R; Reines, I; Tschernig, T	1
Bonz, A; Burkard, N; Ertl, G; Frantz, S; Hofmann, U; Ritter, O; Thoma, A; Vogt, C	1
Bae, H; Dukala, D; Jung, CG; Kakazu, R; Kim, HJ; Soliven, B; Wollmann, R	1
Knudsen, E; Maghazachi, AA; Rolin, J; Sand, KL	1
Hasegawa, Y; Rolland, W; Sozen, T; Suzuki, H; Zhang, JH	1
Brooks, SF; Chun, J; Fontaine, BA; Luster, AD; Shea, BS; Tager, AM	1
Bajwa, A; Dondeti, KR; Haase, VH; Huang, L; Jo, SK; Lynch, KR; Macdonald, TL; Okusa, MD; Rosin, DL; Ye, H	1
Chiba, K; Maeda, Y; Sato, N; Seki, N; Sugahara, K	1
Awad, AS; Bolton, WK; Huang, L; Khutsishvili, K; Lynch, KR; Okusa, MD; Rouse, MD	1
Heytens, E; Oktay, K; Soleimani, R	1
Cahalan, SM; Cameron, MD; Gonzalez-Cabrera, PJ; Kago, T; Leaf, NB; Nguyen, N; Rosen, H; Sarkisyan, G	1
Dev, KK; Sheridan, GK	1
Bergonzini, V; Costa, S; Galletti, M; Nofer, JR; Pignatti, E; Poti, F; Simoni, M; Weber, C	1
Charlton, SJ; Dowling, MR; Riddy, DM; Stamp, C; Sykes, DA	1
Akhade, AS; Qadri, A; Sharma, N	1
Absalom, AR; Bouma, HR; Buikema, H; Epema, AH; Henning, RH; Houwertjes, MC; Mungroop, HE; Samarska, IV	1
Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A	1
Chen, Y; Cheng, Q; Gong, H; Hu, B; Lei, L; Lin, D; Liu, H; Ma, S; Mei, Y; Wu, Y; Yu, X; Zhao, L; Zhao, Y	1
Al-Jarallah, A; Chen, X; González, L; Trigatti, BL	1
Abraham, SN; Ang, WXG; Chan, EW; Gunn, MD; Huang, MN; Kunder, CA; St John, AL	1
Harada, H; Hattori, K; Hirose, J; Kawato, Y; Koshika, T; Maeda, M; Morokata, T; Nagasaka, Y; Okada, Y; Saito, R; Yamamoto, R	1
Ahmadiani, A; Dargahi, L; Khallaghi, B; Safarian, F	1
Ahmadiani, A; Asle-Rousta, M; Dargahi, L; Kolahdooz, Z; Nasoohi, S	1
Bamias, G; Behrens, EH; Boyer, JD; Clark, D; Gima, L; González-Cabrera, P; Jedlicka, P; Karuppuchamy, T; Peach, R; Rivera-Nieves, J; Rosen, H; Sarkisyan, G; Scott, F; Veny, M	1
Klebe, D; Krafft, PR; LeGrand, J; Lekic, T; Rolland, WB; Weldon, AJ; Xu, L; Zhang, JH	1
Chaudhry, BZ; Cohen, JA; Conway, DS	1
Danese, S; Furfaro, F; Vetrano, S	1
Donahue, RR; Doolen, S; Grachen, CM; Iannitti, T; Shaw, BC; Taylor, BK	1
Bielawski, J; Kim, S; Kong, Y; Li, J; Yang, H; Zhou, B	1
Buc, M	1
Panés, J; Salas, A	1
Camp, SM; Garcia, JGN; Marciniak, A; Polt, R	1
Kao, D; Mehta, R; Patterson-Lomba, O; Pelletier, C; Sheffield, JK; Signorovitch, J; Stonehouse, T; Swallow, E; Yin, L	1
Chun, J; Giovannoni, G; Hunter, SF	1
Callegari, I; Derfuss, T; Galli, E	1
Cohen, JA; McGinley, MP	1
Gu, ZC; Lv, Y; Ma, CL; Zhao, Z; Zhong, MK	1
Busra Azizoglu, Z; Canatan, H; Eken, A; Zehra Okus, F	1

Reviews

9 review(s) available for fingolimod hydrochloride and oxadiazoles

Article	Year
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochemical pharmacology, 2008, May-15, Volume: 75, Issue:10 Topics: Animals; Fingolimod Hydrochloride; Humans; Lysophospholipids; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Sphingosine; Sulfhydryl Compounds; Thiazolidines; Thiophenes	2008
Sphingosine 1-Phosphate Receptor Modulators for the Treatment of Multiple Sclerosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017, Volume: 14, Issue:4 Topics: Animals; Azetidines; Benzyl Compounds; Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immunologic Factors; Indans; Indoles; Multiple Sclerosis; Naphthalenes; Oxadiazoles; Propanolamines; Receptors, Lysosphingolipid; Thiazoles; Treatment Outcome	2017
New biological agents in the treatment of multiple sclerosis. Bratislavske lekarske listy, 2018, Volume: 119, Issue:4 Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Products; Cladribine; Daclizumab; Dimethyl Fumarate; Fingolimod Hydrochloride; Humans; Immunoglobulin G; Immunologic Factors; Immunosuppressive Agents; Indans; Multiple Sclerosis; Natalizumab; Neuromyelitis Optica; Oxadiazoles; Rituximab	2018
Past, Present and Future of Therapeutic Interventions Targeting Leukocyte Trafficking in Inflammatory Bowel Disease. Journal of Crohn's & colitis, 2018, Aug-22, Volume: 12, Issue:suppl_2 Topics: Animals; Antibodies, Monoclonal, Humanized; Cell Adhesion Molecules; Cell Communication; Chemotaxis, Leukocyte; Endothelial Cells; Fingolimod Hydrochloride; Gastrointestinal Agents; Gastrointestinal Tract; Humans; Immunoglobulins; Immunosuppressive Agents; Indans; Inflammatory Bowel Diseases; Integrins; Intercellular Adhesion Molecule-1; Leukocytes; Lysophospholipids; Mucoproteins; Natalizumab; Oxadiazoles; Phosphorothioate Oligonucleotides; Receptors, Lysosphingolipid; Sphingosine	2018
An update on sphingosine-1-phosphate receptor 1 modulators. Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24 Topics: Autoimmune Diseases; Biological Availability; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Multiple Sclerosis; Oxadiazoles; Receptors, Lysosphingolipid; Sphingolipids	2018
Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects. Drugs, 2021, Volume: 81, Issue:2 Topics: Animals; Azetidines; Benzyl Compounds; Fingolimod Hydrochloride; Humans; Indans; Multiple Sclerosis; Oxadiazoles; Prodrugs; Signal Transduction; Sphingosine-1-Phosphate Receptors	2021
Update on treatment in multiple sclerosis. Presse medicale (Paris, France : 1983), 2021, Volume: 50, Issue:2 Topics: Abnormalities, Drug-Induced; Algorithms; Antibodies, Monoclonal, Humanized; Cladribine; Crotonates; Dimethyl Fumarate; Female; Fingolimod Hydrochloride; Hematopoietic Stem Cell Transplantation; Humans; Hydroxybutyrates; Immunologic Factors; Immunosuppressive Agents; Indans; Interferon-beta; Male; Mitoxantrone; Multiple Sclerosis; Natalizumab; Nitriles; Oxadiazoles; Pregnancy; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Toluidines	2021
Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions. Lancet (London, England), 2021, 09-25, Volume: 398, Issue:10306 Topics: Animals; Azetidines; Benzyl Compounds; Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immune System Diseases; Indans; Multiple Sclerosis; Nervous System Diseases; Oxadiazoles; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Thiazoles	2021
Risk for Cardiovascular Adverse Events Associated With Sphingosine-1-Phosphate Receptor Modulators in Patients With Multiple Sclerosis: Insights From a Pooled Analysis of 15 Randomised Controlled Trials. Frontiers in immunology, 2021, Volume: 12 Topics: Azetidines; Benzyl Compounds; Bradycardia; Drug-Related Side Effects and Adverse Reactions; Fingolimod Hydrochloride; Humans; Hypertension; Indans; Multiple Sclerosis; Oxadiazoles; Randomized Controlled Trials as Topic; Risk; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors	2021

Trials

1 trial(s) available for fingolimod hydrochloride and oxadiazoles

Article	Year
Comparative safety and efficacy of ozanimod versus fingolimod for relapsing multiple sclerosis. Journal of comparative effectiveness research, 2020, Volume: 9, Issue:4 Topics: Adult; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Liver; Lymphocyte Count; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Oxadiazoles	2020

Other Studies

38 other study(ies) available for fingolimod hydrochloride and oxadiazoles

Article	Year
The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:11 Topics: Animals; Apoptosis; B-Lymphocytes; Cell Adhesion Molecules; Cell Differentiation; Dendritic Cells; DNA Primers; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Depletion; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Oxadiazoles; Polymerase Chain Reaction; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Thiophenes	2005
NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies. Bioorganic & medicinal chemistry letters, 2006, Jan-01, Volume: 16, Issue:1 Topics: Calcium; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunosuppressive Agents; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Chemical; Oxadiazoles; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Binding; Receptors, Lysosphingolipid; Recombinant Proteins; Sphingosine; Substrate Specificity; Time Factors	2006
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American journal of physiology. Renal physiology, 2006, Volume: 290, Issue:6 Topics: Animals; Capillary Permeability; Creatinine; Fingolimod Hydrochloride; Kidney; Leukocytes; Lymphocyte Count; Mice; Mice, Inbred C57BL; Oxadiazoles; Peroxidase; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; T-Lymphocytes; Thiophenes	2006
The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1. Journal of cellular biochemistry, 2007, May-01, Volume: 101, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Cell Division; Cells, Cultured; Coculture Techniques; Collagen; Drug Combinations; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Laminin; Mice; Mice, Inbred C57BL; Muscle, Smooth; Neoplasm Transplantation; Neovascularization, Pathologic; Neutralization Tests; Oxadiazoles; Propylene Glycols; Proteoglycans; Receptors, CXCR4; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Transcriptional Activation; Transplantation, Isogeneic; Umbilical Veins; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2007
Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. The Journal of biological chemistry, 2007, Mar-09, Volume: 282, Issue:10 Topics: Cells, Cultured; Chloroquine; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Lysophospholipids; Oxadiazoles; Propylene Glycols; Protein Transport; Proteomics; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Ubiquitin	2007
Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. Journal of immunology (Baltimore, Md. : 1950), 2007, Mar-15, Volume: 178, Issue:6 Topics: Animals; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Dendritic Cells; Dose-Response Relationship, Drug; Down-Regulation; Endocytosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Knockout; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiophenes	2007
Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors. Journal of neurochemistry, 2007, Volume: 102, Issue:4 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Astrocytes; beta-Alanine; Calcium Signaling; Cell Movement; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Embryo, Mammalian; Fingolimod Hydrochloride; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Immunosuppressive Agents; Inositol Phosphates; Organ Culture Techniques; Oxadiazoles; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; Thiophenes	2007
Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools. British journal of pharmacology, 2008, Volume: 153, Issue:1 Topics: Animals; Cerebral Arteries; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; In Vitro Techniques; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Propylene Glycols; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Vasoconstriction	2008
FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression. Biochemical and biophysical research communications, 2008, Jun-13, Volume: 370, Issue:4 Topics: Actins; Cell Adhesion Molecules; Cell Membrane; Cell Movement; Cells, Cultured; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Neovascularization, Physiologic; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Wound Healing	2008
Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration. The Journal of investigative dermatology, 2009, Volume: 129, Issue:8 Topics: Administration, Topical; Animals; Cell Movement; Dendritic Cells; Dermatitis, Allergic Contact; Female; Fingolimod Hydrochloride; Histocompatibility Antigens Class II; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred BALB C; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Skin; Sphingosine; Thiophenes; Toluene 2,4-Diisocyanate	2009
Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. Cardiovascular research, 2009, Jul-15, Volume: 83, Issue:2 Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Death; Cells, Cultured; ErbB Receptors; Fingolimod Hydrochloride; Humans; Lysophospholipids; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxadiazoles; Perfusion; Propylene Glycols; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; Recovery of Function; Signal Transduction; Sphingosine; Thiophenes; Time Factors; Ventricular Function, Left; Ventricular Pressure	2009
Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy. Journal of neuroimmunology, 2009, Sep-29, Volume: 214, Issue:1-2 Topics: Animals; Autoimmunity; Blood-Nerve Barrier; Blotting, Western; Cell Culture Techniques; Cell Proliferation; Cell Survival; Cytokines; Electrophysiology; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred NOD; Mice, Transgenic; Oxadiazoles; Polymerase Chain Reaction; Polyneuropathies; Propylene Glycols; Schwann Cells; Severity of Illness Index; Sphingosine; Spleen; Thiophenes	2009
FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer immunology, immunotherapy : CII, 2010, Volume: 59, Issue:4 Topics: Chemokines; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunoblotting; Immunosuppressive Agents; K562 Cells; Killer Cells, Natural; Lysophospholipids; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Up-Regulation	2010
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke, 2010, Volume: 41, Issue:2 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Fingolimod Hydrochloride; Immunosuppressive Agents; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Nerve Degeneration; Neuroprotective Agents; Oxadiazoles; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Stroke; Thiophenes; Treatment Outcome	2010
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. American journal of respiratory cell and molecular biology, 2010, Volume: 43, Issue:6 Topics: Animals; beta-Alanine; Bleomycin; Blood Coagulation; Endothelial Cells; Fibrosis; Fingolimod Hydrochloride; Humans; Lung Injury; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Pneumonia; Propylene Glycols; Pulmonary Alveoli; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Survival Analysis; Thiophenes; Vascular Diseases	2010
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:6 Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Movement; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Homeodomain Proteins; Kidney Tubules, Proximal; Leukocytes; Lipopolysaccharides; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Signal Transduction; Sphingosine; Thiophenes	2010
Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow. International immunology, 2010, Volume: 22, Issue:6 Topics: Adoptive Transfer; Animals; Bone Marrow; Cell Count; Cell Movement; Fingolimod Hydrochloride; Hypersensitivity, Delayed; Immunization; Lymphoid Tissue; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ovalbumin; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Thiophenes	2010
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney international, 2011, Volume: 79, Issue:10 Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fingolimod Hydrochloride; Kidney; Lymphocytes; Mice; Mice, Inbred C57BL; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Podocytes; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha	2011
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. PloS one, 2011, Apr-29, Volume: 6, Issue:4 Topics: Animals; Apoptosis; Cryopreservation; Female; Fingolimod Hydrochloride; Graft Survival; Humans; Immunohistochemistry; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, SCID; Neovascularization, Physiologic; Ovarian Follicle; Ovary; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Transplantation, Heterologous	2011
S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. Molecular pharmacology, 2012, Volume: 81, Issue:2 Topics: Animals; Central Nervous System; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fingolimod Hydrochloride; Immunosuppressive Agents; Indans; Lymphopenia; Mice; Multiple Sclerosis; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine	2012
S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia, 2012, Volume: 60, Issue:3 Topics: Animals; Animals, Newborn; Astrocytes; Cell Movement; Cerebellum; Chemokine CCL20; Chemokine CCL3; Chemokines; Demyelinating Diseases; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Lysophosphatidylcholines; Myelin Basic Protein; Neurofilament Proteins; Organ Culture Techniques; Oxadiazoles; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes	2012
Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice. Vascular pharmacology, 2012, Aug-19, Volume: 57, Issue:1 Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Atherosclerosis; Body Weight; CD11b Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Fingolimod Hydrochloride; Genes, MHC Class II; Indans; Interleukin-2; Interleukin-6; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Oxadiazoles; Proprotein Convertases; Propylene Glycols; Receptors, LDL; Receptors, Lysosphingolipid; Serine Endopeptidases; Sphingosine; Spleen	2012
Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3 receptor ligands using the DiscoveRx PathHunter™ and Ca2+ release functional assays. British journal of pharmacology, 2012, Volume: 167, Issue:4 Topics: Animals; Arrestins; beta-Arrestins; Binding, Competitive; Biological Assay; Calcium; CHO Cells; Cricetinae; Cricetulus; Fingolimod Hydrochloride; Humans; Indans; Ligands; Organophosphates; Oxadiazoles; Propylene Glycols; Radioligand Assay; Receptors, Lysosphingolipid; Sphingosine	2012
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. Journal of leukocyte biology, 2013, Volume: 93, Issue:4 Topics: Calcium; Fingolimod Hydrochloride; Flagellin; Gene Expression Regulation; Humans; Interleukin-2; Interleukin-8; Jurkat Cells; Lipopeptides; Lymphocyte Activation; Lysophospholipids; Molecular Mimicry; Oxadiazoles; Propylene Glycols; Receptors, Antigen, T-Cell; Serum; Signal Transduction; Sphingosine; T-Lymphocytes; Thiophenes; Toll-Like Receptors; U937 Cells	2013
S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes. PloS one, 2014, Volume: 9, Issue:5 Topics: Animals; Blood Gas Analysis; Cardiopulmonary Bypass; Cell Count; Coronary Vessels; Fingolimod Hydrochloride; Follow-Up Studies; Interleukin-6; Lymphocytes; Male; Mesenteric Arteries; Oxadiazoles; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Vasoconstriction; Vasodilation	2014
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. The Journal of biological chemistry, 2014, Jul-25, Volume: 289, Issue:30 Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes	2014
The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. Cellular & molecular immunology, 2015, Volume: 12, Issue:6 Topics: Animals; Bone Marrow Transplantation; Cell Movement; Chemokine CCL2; Chemokine CCL7; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression Regulation; Graft vs Host Disease; Human Umbilical Vein Endothelial Cells; Humans; Immunosuppressive Agents; Indans; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monocytes; Oxadiazoles; Receptors, Lysosphingolipid; Severity of Illness Index; Signal Transduction; T-Lymphocytes; Whole-Body Irradiation	2015
High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. PloS one, 2014, Volume: 9, Issue:9 Topics: Animals; Cell Line; Cell Movement; Cells, Cultured; Fingolimod Hydrochloride; Intracellular Signaling Peptides and Proteins; Lipoproteins, HDL; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxadiazoles; Pertussis Toxin; Propylene Glycols; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; Scavenger Receptors, Class B; Sphingosine; Thiophenes	2014
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. Immunity, 2014, Sep-18, Volume: 41, Issue:3 Topics: Animals; CD11 Antigens; CD11b Antigen; Cell Movement; Chemokine CCL21; Dendritic Cells; Female; Fingolimod Hydrochloride; Integrin alpha Chains; Lymph Nodes; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Oxadiazoles; Phagocytes; Plague; Propylene Glycols; Receptors, CCR2; Receptors, CCR7; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Yersinia pestis	2014
ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PloS one, 2014, Volume: 9, Issue:10 Topics: Animals; Benzimidazoles; Blood Pressure; Bronchoconstriction; Cell Line; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Heart Rate; Lymphocytes; Male; Mice; Oxadiazoles; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine	2014
Activation of S1P₁ receptor regulates PI3K/Akt/FoxO3a pathway in response to oxidative stress in PC12 cells. Journal of molecular neuroscience : MN, 2015, Volume: 56, Issue:1 Topics: Animals; Fingolimod Hydrochloride; Forkhead Box Protein O3; Forkhead Transcription Factors; Neurons; Neuroprotective Agents; Oxadiazoles; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; Thiophenes	2015
Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2015, Volume: 42, Issue:3 Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Maze Learning; Memory Disorders; Oxadiazoles; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha	2015
Sphingosine-1-phosphate receptor-1 (S1P Mucosal immunology, 2017, Volume: 10, Issue:1 Topics: Animals; Cell Movement; Cells, Cultured; Colitis; Dendritic Cells; Dextran Sulfate; Disease Models, Animal; Endothelium; Fingolimod Hydrochloride; Humans; Immunologic Factors; Immunologic Memory; Indans; Inflammatory Bowel Diseases; Intestines; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxadiazoles; Receptors, Lysosphingolipid	2017
Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups. Journal of neurochemistry, 2017, Volume: 140, Issue:5 Topics: Animals; Body Water; Brain; Brain Chemistry; Brain Edema; Cognition; Female; Fingolimod Hydrochloride; Intracranial Hemorrhages; Leukocyte Count; Male; Neuroprotective Agents; Oxadiazoles; Phosphoserine; Pregnancy; Pyrones; Quinolines; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Thiophenes; Tight Junction Proteins	2017
Targeting S1P in Inflammatory Bowel Disease: New Avenues for Modulating Intestinal Leukocyte Migration. Journal of Crohn's & colitis, 2018, Aug-22, Volume: 12, Issue:suppl_2 Topics: Animals; Camphanes; Cell Movement; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Inflammatory Bowel Diseases; Leukocytes; Lysophospholipids; Molecular Targeted Therapy; Oxadiazoles; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sulfhydryl Compounds; Sulfonamides	2018
Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. Pain, 2018, Volume: 159, Issue:2 Topics: Anilides; Animals; Central Nervous System Sensitization; Disease Models, Animal; eIF-2 Kinase; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Organophosphonates; Oxadiazoles; Pain Threshold; Peptide Fragments; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Spinal Cord; Spinal Nerve Roots; Subcellular Fractions; Thiophenes	2018
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination. Glia, 2018, Volume: 66, Issue:3 Topics: Animals; Apoptosis; Brain; Chimera; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Gene Expression; Gliosis; Indans; Inflammation; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Neuroprotective Agents; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; White Matter	2018
S1P analogues SEW2871, BAF312 and FTY720 affect human Th17 and Treg generation ex vivo. International immunopharmacology, 2022, Volume: 107 Topics: Animals; Azetidines; Benzyl Compounds; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Interleukin-23; Lysophospholipids; Mice; Neurodegenerative Diseases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes, Regulatory; Th17 Cells; Thiophenes	2022