fingolimod hydrochloride has been researched along with n,n-dimethylsphingenine in 9 studies
| Studies (fingolimod hydrochloride) | Trials (fingolimod hydrochloride) | Recent Studies (post-2010) (fingolimod hydrochloride) | Studies (n,n-dimethylsphingenine) | Trials (n,n-dimethylsphingenine) | Recent Studies (post-2010) (n,n-dimethylsphingenine) |
|---|---|---|---|---|---|
| 2,771 | 157 | 2,062 | 165 | 0 | 38 |
| Protein | Taxonomy | fingolimod hydrochloride (IC50) | n,n-dimethylsphingenine (IC50) |
|---|---|---|---|
| Lethal factor | Bacillus anthracis | 2.3 | |
| Sphingosine kinase 1 | Homo sapiens (human) | 4.5233 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goetschy, JF; Movva, NR; Roth, LW; Welsch, CA | 1 |
| Djanani, AM; Feistritzer, C; Kaneider, NC; Lindner, J; Mosheimer, BA; Sturn, DH; Wiedermann, CJ | 1 |
| Karliner, JS; Kelley, M; Li, L; Tao, R; Vessey, DA; Zhang, J | 1 |
| Fujita, T; Nagaoka, Y; Otsuki, K; Uesato, S | 1 |
| Coolen, C; Jones, C; Lopez, AF; Ma, Y; Pham, D; Pitson, SM; Woodcock, JM | 1 |
| Feng, Y; Mahmood, R; Ni, E; Qin, X; Sun, B; Xie, J; Yang, W; Yue, L; Yue, Z; Zhang, Y | 1 |
| Kim, BJ; Kim, WK; Nam, JH | 1 |
| Ahmadiani, A; Asle-Rousta, M; Dargahi, L; Kolahdooz, Z; Nasoohi, S | 1 |
| Hu, JP; Li, Y; Yang, S | 1 |
9 other study(ies) available for fingolimod hydrochloride and n,n-dimethylsphingenine
| Article | Year |
|---|---|
Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
Topics: Amino Acids; Biological Transport; Cell Division; Cell Membrane; Cytoskeleton; DNA, Complementary; Down-Regulation; Escherichia coli; Fingolimod Hydrochloride; Genotype; Immunoblotting; Immunosuppressive Agents; Mutation; Oligonucleotide Array Sequence Analysis; Phosphotransferases (Alcohol Group Acceptor); Plasmids; Polymerase Chain Reaction; Propylene Glycols; Reverse Transcriptase Polymerase Chain Reaction; RNA; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Sphingosine; Transcription, Genetic; Up-Regulation | 2004 |
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Topics: 1-Methyl-3-isobutylxanthine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Androstadienes; Bombesin; Calcitonin Gene-Related Peptide; Cell Movement; Chemotaxis, Leukocyte; Cholera Toxin; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation; Heterotrimeric GTP-Binding Proteins; Humans; Immunologic Factors; Indoles; Leukocytes, Mononuclear; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neuropeptides; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Lysosphingolipid; RNA, Messenger; Secretogranin II; Sphingosine; Staurosporine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.
Topics: Animals; Antibodies; Blotting, Western; Chromatography, Gel; Enzyme Activation; Fingolimod Hydrochloride; Isoenzymes; Mice; Myocardium; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Sphingosine | 2007 |
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indicators and Reagents; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Spectrophotometry, Infrared; Sphingosine | 2008 |
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Topics: 14-3-3 Proteins; Animals; Apoptosis; Caspases; Cell Survival; Chlorocebus aethiops; COS Cells; Fingolimod Hydrochloride; Humans; Jurkat Cells; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Isoforms; Protein Kinase C-delta; Sphingosine | 2010 |
Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.
Topics: Animals; Cells, Cultured; Fingolimod Hydrochloride; HEK293 Cells; Humans; Immunosuppressive Agents; Membrane Potentials; Membrane Transport Modulators; Mice; Myocytes, Cardiac; Organophosphates; Phosphorylation; Propylene Glycols; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Recombinant Proteins; Sphingosine; TRPM Cation Channels | 2013 |
Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine.
Topics: Animals; Biological Clocks; Chloride Channels; Female; Fingolimod Hydrochloride; Gastrointestinal Motility; HEK293 Cells; Humans; Interstitial Cells of Cajal; Intestine, Small; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Organophosphates; Patch-Clamp Techniques; Propylene Glycols; Sphingosine; TRPM Cation Channels | 2013 |
Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod.
Topics: Alzheimer Disease; Animals; Cyclooxygenase 2; Enzyme Inhibitors; Fingolimod Hydrochloride; Male; Maze Learning; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Tumor Necrosis Factor-alpha | 2014 |
The involvement of blood cells in the phosphorylation of the selective sphingosine-1-phosphate receptor 1 agonist SYL-927.
Topics: Administration, Oral; Animals; Blood Platelets; Erythrocytes; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptors, Lysosphingolipid; Sphingosine | 2019 |