fingolimod hydrochloride has been researched along with cyclosporine in 79 studies
| Studies (fingolimod hydrochloride) | Trials (fingolimod hydrochloride) | Recent Studies (post-2010) (fingolimod hydrochloride) | Studies (cyclosporine) | Trials (cyclosporine) | Recent Studies (post-2010) (cyclosporine) |
|---|---|---|---|---|---|
| 2,771 | 157 | 2,062 | 377 | 2 | 170 |
| 2,771 | 157 | 2,062 | 30,547 | 3,802 | 6,558 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (21.52) | 18.2507 |
| 2000's | 49 (62.03) | 29.6817 |
| 2010's | 12 (15.19) | 24.3611 |
| 2020's | 1 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, K; Fujita, T; Kiuchi, M; Kohara, T; Masubuchi, Y; Mishina, T; Teshima, K | 1 |
| Adachi, K; Aoki, Y; Arita, M; Chiba, K; Fujita, T; Hanano, T; Hoshino, Y; Kiuchi, M; Kohara, T; Minoguchi, M; Mishina, T; Nakao, N; Ohtsuki, M; Sasaki, S; Teshima, K | 1 |
| Chiba, K; Fujita, T; Hoshino, Y; Masubuchi, Y; Ohtsuki, M; Sasaki, S; Suzuki, C; Yanagawa, Y | 1 |
| Amano, Y; Chiba, K; Hoshino, Y; Masubuchi, Y; Ohtsuki, M; Suzuki, C | 1 |
| Amano, Y; Chiba, K; Higashi, H; Hoshino, Y; Kakefuda, T; Kataoka, H; Kawaguchi, T; Ohtsuki, M; Rahman, F; Suzuki, S; Teshima, K | 1 |
| Amemiya, H; Chiba, K; Enosawa, S; Hoshino, Y; Kakefuda, T; Suzuki, S | 1 |
| Amari, M; Amemiya, H; Chiba, K; Enosawa, S; Hoshino, Y; Kakefuda, T; Li, XK; Mitsusada, M; Naoe, S; Shinomiya, T; Suzuki, S; Takahara, S | 1 |
| Enosawa, S; Kakefuda, T; Kobayashi, E; Mitsusada, M; Miyata, M; Suzuki, S | 1 |
| Amemiya, H; Chiba, K; Hoshino, Y; Kakefuda, T; Kataoka, H; Kawaguchi, T; Rahman, F; Suzuki, S | 1 |
| Kahan, BD; Okamoto, M; Qu, X; Stepkowski, SM; Tejpal, N; Wang, ME; Yu, J | 1 |
| Chiba, K; Hoshino, Y; Kataoka, H; Kawaguchi, T; Masubuchi, Y; Ohtsuki, M; Yanagawa, Y | 1 |
| Chiba, K; Kataoka, H; Kawaguchi, T; Masubuchi, Y; Sugahara, K; Yanagawa, Y | 1 |
| Fukao, K; Jinzenji, Y; Otsuka, M; Sakurayama, N; Suzuki, S; Takada, Y; Taniguchi, H; Yuzawa, K | 1 |
| Kahan, BD; Okamoto, M; Qu, X; Stepkowski, SM; Tejpal, N; Wang, M; Yu, J | 1 |
| Chueh, SC; Clark, J; Kahan, BD; Qu, X; Stepkowski, SM; Troncoso, P; Wang, ME | 1 |
| Kahan, BD | 1 |
| Furukawa, Y; Hara, M; Hwang, MW; Iwasaki, A; Matsumori, A; Okada, M; Ono, K; Sasayama, S | 1 |
| Fujita, M; Fukai, M; Furukawa, H; Hayashi, T; Ishikawa, H; Jin, MB; Kishida, A; Magata, S; Masuko, H; Nagashima, K; Ogata, K; Omura, T; Shimamura, T; Suzuki, T; Taniguchi, M; Todo, S; Yamashita, K | 1 |
| Fujimura, A; Hashizume, K; Kanno, T; Kitoh, Y; Kobayashi, E; Miyashita, F; Mizuta, K; Mori, M; Ohmori, M | 1 |
| Chiba, K; Kobayakawa, T | 1 |
| Baumlin, Y; Hof, A; Hof, RP; Kraus, G; Nikolova, Z; Rudin, M | 1 |
| Bari, S; Groth, CG; Korsgren, O; Nava, S; Song, Z; Sundberg, B; Wennberg, L; Wijkström, M; Zhang, J | 1 |
| Chiba, K; Imayoshi, T; Matsuura, M; Okumoto, T | 1 |
| Bernhard, M; Hedinger, R; Kraus, G; Kunkler, A; Menninger, K; Quesniaux, VF; Schuurman, HJ; Vedrine, C | 1 |
| Kelly, DA; van Mourik, ID | 1 |
| Baumlin, Y; Hof, A; Hof, RP; Nikolova, Z | 2 |
| Hammond-McKibben, D; Hugo, R; Lake, P; Tart-Risher, N; Weetall, M; Zhang, J | 1 |
| Hof, RP; Nikolova, Z | 1 |
| Audet, M; Gaschen, L; Menninger, K; Quesniaux, V; Schuurman, HJ | 1 |
| Diaz-Romero, J; Vogt, G; Weckbecker, G | 1 |
| Morley, SJ; Pain, VM | 1 |
| Brinkmann, V; Chen, S; Feng, L; Pinschewer, DD | 1 |
| Dumont, FJ | 1 |
| Morel, D | 1 |
| Koshiba, T; Lu, Y; Mathieu, C; Overbergh, L; Pirenne, J; Rutgeerts, O; Tanaka, K; Van Damme, B; Waer, M; Yan, Y | 1 |
| Hatori, M; Ichimaru, N; Morozumi, K; Okuyama, A; Suzuki, K; Suzuki, S; Takahara, S; Tanaka, T; Wang, J; Yamanaka, H | 1 |
| Audet, M; Bernhard, M; Brinkmann, V; Gaschen, L; Kunkler, A; Maurer, C; Menninger, K; Quesniaux, V; Schuurman, HJ; Vedrine, C | 1 |
| Koshiba, T; Pirenne, J; Rutgeerts, O; Van Damme, B; Waer, M | 1 |
| Bennet, W; Goto, M; Groth, CG; Korsgren, O; Maeda, A; Wennberg, L; Zhang, J | 1 |
| Chodoff, L; Ferguson, RM; Gonwa, TA; Kahan, BD; Karlix, JL; Leichtman, AB; Mulgaonkar, S; Schmouder, RL; Skerjanec, A | 1 |
| Braun, WE | 1 |
| McDonald, RA; Nemeth, TL; Smith, JM | 1 |
| Barshes, NR; Goodpastor, SE; Goss, JA | 1 |
| Boira, JG; Charpentier, B; Kahan, BD; Madsen, S; Mourad, G; Mulgaonkar, S; Nashan, B; Pellet, P; Tedesco-Silva, H; Vanrenterghem, Y; Weimar, W | 1 |
| Honda, K; Kiyochi, H; Kobayashi, N; Sakagawa, T | 1 |
| Fujita, M; Fukai, M; Furukawa, H; Horiuchi, H; Jin, MB; Magata, S; Nagashima, K; Nomura, M; Shimamura, T; Suzuki, T; Taniguchi, M; Todo, S; Yamashita, K; Yokota, R | 1 |
| Enosawa, S; Fukuchi, K; Hakamata, Y; Iwanami, S; Kaneko, T; Kishi, T; Kobayashi, E; Kudou, S; Kuriyama, K; Matsumoto, K; Morishita, Y; Murakami, T; Shimizu, H; Takahashi, M; Takeyoshi, I; Yasue, T | 1 |
| Baczkowska, T; Durlik, M | 1 |
| Felipe, CR; Garcia, R; Machado, PG; Medina-Pestana, JO; Park, SI; Schmouder, R; Skerjanec, A; Tedesco-Silva, H | 1 |
| Cozzi, E; Schuurman, HJ; Smith, HT | 1 |
| Budde, K; Cole, E; Hsu, CH; Neumayer, HH; Schmouder, R; Skerjanec, A; Tedesco, H | 1 |
| Ahn, KO; Bang, BK; Choi, BS; Kim, J; Kim, JS; Kim, JY; Kim, YS; Li, C; Lim, SW; Yang, CW; Yang, HJ | 1 |
| Harada, T; Kanekake, H; Nishikido, M | 1 |
| Ferguson, R; Knoflach, A; Kunzendorf, U; Mulgaonkar, S; Oppenheimer, F; Patel, Y; Russ, G; Tedesco, H; Walker, R | 1 |
| Aradhye, S; Budde, K; Charpentier, B; Eisenberger, U; Eris, J; Hmissi, A; Klempnauer, J; Nashan, B; Pallardo, LM; Rostaing, L; Salvadori, M; Schena, FP | 1 |
| Bueno, V; Burdmann, EA; Cury, PM; Silva, FR; Silva, LB | 1 |
| Cibrik, D; Esmeraldo, Rde M; Gugliuzza, KK; Kahan, BD; Lord, H; Mulgaonkar, S; Pescovitz, MD; Rajagopalan, PR; Rees, MA; Salvadori, M; Slade, JM; Tedesco-Silva, H | 1 |
| Budde, K; Glander, P; Liefeld, L; Martini, S; Neumayer, HH; Offermann, G; Schmidt, S; van der Giet, M; Westhoff, TH; Zidek, W | 1 |
| Cremer, M; Hmissi, A; Lang, P; Mayer, H; Schena, FP; Shoker, A; Sommerer, C; Szakaly, P; Tedesco-Silva, H; Yoshimura, N | 1 |
| Delbridge, MS; El Nahas, AM; Haylor, J; Raftery, AT; Shrestha, BM | 1 |
| Illana Esteban, C | 1 |
| Almony, A; Blinder, KJ; Brennan, DC; Saab, G; Schuessler, R | 1 |
| Cho, JY | 1 |
| Giese, T; Meuer, S; Morath, C; Sommerer, C; Zeier, M | 1 |
| Baumann, M; Heemann, U; Liu, S; Lutz, J; Roos, M; Schmaderer, C; Strobl, M | 1 |
| Beerli, C; Bruns, C; Burkhart, C; Metzler, B; Morris, RE; Pally, C; Wagner, J; Weckbecker, G; Wieczorek, G | 1 |
| Lock, JF; Malinowski, M; Martus, P; Neuhaus, P; Stockmann, M | 1 |
| Nishi, S | 1 |
| Fujita, T; Kohno, T; Tsuji, T; Yoshida, Y | 1 |
| Abramowicz, D; Hoitsma, AJ; Proot, P; Vanrenterghem, Y; Woodle, ES | 1 |
| Gong, Y; Huang, Y; Jiang, J; Li, Y; Liu, Y; Wang, D; Wang, X; Xiao, H | 1 |
| Lei, T; Liu, G; Peng, J; Sun, C; Wang, R; Wu, T; Xu, K; Zhang, L; Zhao, Y | 1 |
| Graves, D; Vernino, S | 1 |
| Chen, Y; Huang, H; Jiang, J; Ouyang, Y; Wang, L; Xu, J; Ying, Y | 1 |
| Huang, Y; Jia, L; Liu, Y; Wang, L; Zhu, J | 1 |
| Xiao, W; Xu, GT; Ye, W; Zhang, J; Zhang, Y | 1 |
| Gao, M; Liu, D; Qu, S; Song, K; Yan, L | 1 |
| Altincatal, A; Berdofe, A; Centonze, D; de Moor, C; Jung, E; Kim, M; Nagpal, A; Naylor, ML; Popescu, C; Radhakrishnan, M; Rajbhandari, R; Reder, AT; Sandrock, AW; Smirnakis, K | 1 |
13 review(s) available for fingolimod hydrochloride and cyclosporine
| Article | Year |
|---|---|
The potential role of rapamycin in pediatric transplantation as observed from adult studies.
Topics: Acute Disease; Adult; Age Factors; Antibodies, Monoclonal; Basiliximab; Child; Cohort Studies; Cyclosporine; Drug Monitoring; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sirolimus; Sphingosine; Time Factors; Tyrphostins | 1999 |
[Immunosuppressive agent FTY720].
Topics: Acute Disease; Animals; Autoimmune Diseases; Cyclosporine; Drug Design; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Propylene Glycols; Sphingosine; Transplantation, Homologous | 2000 |
Immunosuppressive drugs in paediatric liver transplantation.
Topics: Animals; Child; Child, Preschool; Cyclosporine; Drug Interactions; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Liver Transplantation; Mycophenolic Acid; Propylene Glycols; Sirolimus; Sphingosine; Tacrolimus | 2001 |
FTY720: altered lymphocyte traffic results in allograft protection.
Topics: Animals; Autoimmune Diseases; Cell Movement; Chemokines; Clinical Trials as Topic; Cyclosporine; Diabetes Mellitus, Type 1; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Humans; Immunologic Memory; Immunosuppressive Agents; Inflammation; Islets of Langerhans Transplantation; Lymphocyte Activation; Lymphocytes; Models, Animal; Propylene Glycols; Safety; Sphingosine; Transplantation, Homologous | 2001 |
Treatment of transplant rejection: are the traditional immunosuppressants good enough?
Topics: Antibodies, Monoclonal; Antimetabolites; Calcineurin Inhibitors; Cyclosporine; Cytokines; Drug Design; Fingolimod Hydrochloride; Graft Rejection; Guanidines; Humans; Immunosuppressive Agents; Lymphocyte Activation; Molecular Structure; Organ Transplantation; Propylene Glycols; Signal Transduction; Sirolimus; Sphingosine; T-Lymphocytes; Tacrolimus; Triterpenes | 2001 |
Renal transplantation: basic concepts and evolution of therapy.
Topics: Antibodies, Monoclonal; Azathioprine; Calcineurin Inhibitors; Cyclosporine; Fingolimod Hydrochloride; Glucocorticoids; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Propylene Glycols; Receptors, Interleukin-2; Sirolimus; Sphingosine; Tacrolimus | 2003 |
Current immunosuppressive agents: efficacy, side effects, and utilization.
Topics: Abatacept; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antilymphocyte Serum; Area Under Curve; Basiliximab; Cyclosporine; Daclizumab; Drug Therapy, Combination; Drug Utilization; Everolimus; Fingolimod Hydrochloride; Graft Survival; Humans; Immunoconjugates; Immunoglobulin G; Immunosuppressive Agents; Muromonab-CD3; Mycophenolic Acid; Propylene Glycols; Recombinant Fusion Proteins; Sirolimus; Sphingosine; Tacrolimus | 2003 |
Pharmacologic immunosuppression.
Topics: Adrenal Cortex Hormones; Animals; Antimetabolites; Calcineurin Inhibitors; Cyclosporine; Fingolimod Hydrochloride; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Immunotherapy; Muromonab-CD3; Propylene Glycols; Sphingosine | 2004 |
[Immunossupresive drugs in renal transplantation].
Topics: Adrenal Cortex Hormones; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Azathioprine; Cyclosporine; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Propylene Glycols; Risk Factors; Rituximab; Sirolimus; Sphingosine; Tacrolimus | 2004 |
[Molecular action mechanisms of the therapeutic agents for kidney diseases: Immunosuppressants].
Topics: Antibodies, Monoclonal; Azathioprine; Basiliximab; Cyclophosphamide; Cyclosporine; Fatty Acids, Monounsaturated; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Diseases; Kidney Transplantation; Mycophenolic Acid; Propylene Glycols; Recombinant Fusion Proteins; Ribonucleosides; Sphingosine | 2006 |
[Cordyceps sinensis, a fungi used in the Chinese traditional medicine].
Topics: Animals; Cordyceps; Cyclosporine; Didanosine; Drug Costs; Drugs, Chinese Herbal; Fingolimod Hydrochloride; History, 19th Century; History, 20th Century; History, Ancient; Humans; Kidney Diseases; Larva; Medicine, Chinese Traditional; Moths; Mycology; Oxygen Consumption; Propylene Glycols; Sphingosine | 2007 |
[Immunosuppressive agents in kidney transplantation].
Topics: Antibodies; Antibodies, Monoclonal, Murine-Derived; Boronic Acids; Bortezomib; Cyclosporine; Everolimus; Fingolimod Hydrochloride; Graft Rejection; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Pyrazines; Rituximab; Sirolimus; Sphingosine; T-Lymphocytes; Tacrolimus; TOR Serine-Threonine Kinases | 2011 |
Immunotherapies in neurologic disorders.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Cyclophosphamide; Cyclosporine; Fingolimod Hydrochloride; Glatiramer Acetate; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosuppressive Agents; Interferon beta-1a; Interferon beta-1b; Interferon-beta; Mitoxantrone; Mycophenolic Acid; Natalizumab; Nervous System Diseases; Peptides; Plasma Exchange; Propylene Glycols; Rituximab; Sphingosine; Tacrolimus | 2012 |
12 trial(s) available for fingolimod hydrochloride and cyclosporine
| Article | Year |
|---|---|
The potential role of rapamycin in pediatric transplantation as observed from adult studies.
Topics: Acute Disease; Adult; Age Factors; Antibodies, Monoclonal; Basiliximab; Child; Cohort Studies; Cyclosporine; Drug Monitoring; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sirolimus; Sphingosine; Time Factors; Tyrphostins | 1999 |
Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study.
Topics: Adult; Cyclosporine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Count; Middle Aged; Placebos; Prednisone; Propylene Glycols; Sphingosine | 2003 |
FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation.
Topics: Adolescent; Adult; Aged; Cadaver; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Propylene Glycols; Safety; Sphingosine; Tissue Donors; Treatment Outcome | 2004 |
Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients.
Topics: Adolescent; Adult; Aged; Cyclosporine; Dose-Response Relationship, Drug; Female; Fingolimod Hydrochloride; Follow-Up Studies; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Count; Lymphocytes; Lymphopenia; Male; Middle Aged; Mycophenolic Acid; Propylene Glycols; Sphingosine; Time Factors | 2005 |
FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship.
Topics: Adult; Aged; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Models, Biological; Propylene Glycols; Sphingosine | 2005 |
FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study.
Topics: Adult; Biopsy; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Lung; Male; Middle Aged; Propylene Glycols; Sphingosine; Time Factors | 2006 |
FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia.
Topics: Adult; Australasia; Creatinine; Cyclosporine; Drug Therapy, Combination; Europe; Fingolimod Hydrochloride; Graft Survival; Histocompatibility Testing; Humans; Kidney Transplantation; Liver Function Tests; Mycophenolic Acid; Propylene Glycols; Safety; Sphingosine | 2006 |
Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation.
Topics: Adult; Creatinine; Cyclosporine; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Propylene Glycols; Sphingosine | 2006 |
The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients.
Topics: Adult; Animals; Arteries; Cyclosporine; Elasticity; Endothelium, Vascular; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mice; Middle Aged; Propylene Glycols; Sphingosine; Vasodilation | 2007 |
FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study.
Topics: Adult; Biopsy; Bradycardia; Cohort Studies; Cyclosporine; Double-Blind Method; Female; Fingolimod Hydrochloride; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mycophenolic Acid; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine | 2007 |
Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient.
Topics: Cyclosporine; Drug Therapy, Combination; Fingolimod Hydrochloride; Fluorescein Angiography; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Macular Edema; Prednisone; Propylene Glycols; Sphingosine; Tomography, Optical Coherence; Transplantation, Homologous | 2008 |
FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study.
Topics: Adolescent; Adult; Aged; Cyclosporine; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Follow-Up Studies; Glomerular Filtration Rate; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Function Tests; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Prognosis; Propylene Glycols; Sphingosine; Survival Rate; Tacrolimus; Young Adult | 2011 |
55 other study(ies) available for fingolimod hydrochloride and cyclosporine
| Article | Year |
|---|---|
Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720.
Topics: Animals; Ethanolamines; Fingolimod Hydrochloride; Host vs Graft Reaction; Immunosuppressive Agents; Propylene Glycols; Rats; Sphingosine; Structure-Activity Relationship; T-Lymphocytes | 1998 |
Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols.
Topics: Animals; Drug Evaluation, Preclinical; Fingolimod Hydrochloride; Graft Rejection; Immunosuppressive Agents; Inhibitory Concentration 50; Lymph Nodes; Organ Size; Propylene Glycols; Rats; Rats, Inbred F344; Rats, Inbred Lew; Skin Transplantation; Sphingosine; Stereoisomerism; Structure-Activity Relationship; T-Lymphocytes | 2000 |
FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats.
Topics: Animals; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Survival; Immunosuppressive Agents; Interleukin-2; Major Histocompatibility Complex; Male; Propylene Glycols; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Sphingosine; Spleen; T-Lymphocytes; Transplantation, Homologous | 1996 |
FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A.
Topics: Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fingolimod Hydrochloride; Flow Cytometry; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Lymphocytes; Male; Propylene Glycols; Rats; Rats, Inbred ACI; Rats, Inbred Strains; Sphingosine; Time Factors; Transplantation, Heterotopic; Transplantation, Homologous | 1996 |
FTY720, a novel immunosuppressant possessing unique mechanisms. III. Synergistic prolongation of canine renal allograft survival in combination with cyclosporine A.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Cyclosporine; Dogs; Drug Synergism; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Sphingosine; Time Factors; Transplantation, Homologous | 1996 |
Long-term graft acceptance in allografted rats and dogs by treatment with a novel immunosuppressant, FTY720.
Topics: Animals; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Liver Transplantation; Propylene Glycols; Rats; Rats, Inbred ACI; Rats, Inbred Strains; Sphingosine; Transplantation, Homologous | 1996 |
Induction of lymphocyte apoptosis and prolongation of allograft survival by FTY720.
Topics: Animals; Apoptosis; Cell Line; Creatinine; Cyclosporine; Dogs; Fingolimod Hydrochloride; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocytes; Lymphoma; Male; Mice; Mice, Mutant Strains; Neoplasm Transplantation; Propylene Glycols; Sphingosine; Time Factors; Transplantation, Homologous; Tumor Cells, Cultured | 1996 |
Prevention of graft rejection and graft-versus-host reaction by a novel immunosuppressant, FTY720, in rat small bowel transplantation.
Topics: Animals; Cyclosporine; Fingolimod Hydrochloride; Graft Rejection; Graft vs Host Reaction; Immunosuppressive Agents; Intestine, Small; Lymphocyte Count; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine | 1997 |
An immunosuppressive regimen using FTY720 combined with cyclosporin in canine kidney transplantation.
Topics: Animals; Cyclosporine; Dogs; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Survival; Graft vs Host Disease; Immunosuppressive Agents; Kidney Transplantation; Leukocyte Count; Propylene Glycols; Sphingosine | 1998 |
Immunosuppressive effects of FTY720 alone or in combination with cyclosporine and/or sirolimus.
Topics: Animals; Antibodies, Monoclonal; Cyclosporine; Drug Synergism; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lymphocytes; Male; Phytohemagglutinins; Polyenes; Propylene Glycols; Rats; Rats, Inbred BN; Rats, Inbred BUF; Rats, Inbred WF; Sirolimus; Sphingosine; Stimulation, Chemical | 1998 |
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing.
Topics: Animals; CD11 Antigens; Cell Line; Cell Movement; Cyclosporine; Fingolimod Hydrochloride; Graft Survival; Immunosuppressive Agents; Interleukin-2; Lymphocyte Count; Lymphocytes; Male; Propylene Glycols; Rats; Rats, Inbred F344; Skin Transplantation; Sphingosine; Tacrolimus | 1998 |
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production
Topics: Animals; CD3 Complex; Cell Movement; Cyclosporine; Cytokines; Fingolimod Hydrochloride; Graft Survival; Histocompatibility; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Culture Test, Mixed; Major Histocompatibility Complex; Male; Polymerase Chain Reaction; Propylene Glycols; Rats; Rats, Inbred F344; Rats, Inbred Strains; RNA, Messenger; Skin Transplantation; Sphingosine; T-Lymphocytes; Time Factors; Transplantation, Homologous | 1998 |
An effect of FTY720 on acute rejection in canine renal transplantation.
Topics: Acute Disease; Animals; Blood Cell Count; Cyclosporine; Dogs; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Count; Propylene Glycols; Sphingosine; Transplantation, Homologous | 1998 |
Synergistic interaction of FTY720 with cyclosporine or sirolimus to prolong heart allograft survival.
Topics: Animals; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Polyenes; Propylene Glycols; Rats; Rats, Inbred BUF; Rats, Inbred WF; Sirolimus; Sphingosine; Transplantation, Homologous | 1998 |
Prophylaxis of acute renal allograft rejection using FTY720 in combination with subtherapeutic doses of cyclosporine.
Topics: Acute Disease; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Graft Rejection; Immunosuppressive Agents; Kidney Transplantation; Macaca fascicularis; Propylene Glycols; Sphingosine; Transplantation, Homologous | 1999 |
FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation.
Topics: Animals; Coronary Artery Disease; Cyclosporine; Disease Progression; Fingolimod Hydrochloride; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Postoperative Complications; Propylene Glycols; Sphingosine; T-Lymphocytes, Cytotoxic | 1999 |
Prolongation of canine liver allograft survival by a novel immunosuppressant, FTY720: effect of monotherapy and combined treatment with conventional drugs.
Topics: Animals; Bilirubin; Cyclosporine; Dogs; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Liver Transplantation; Propylene Glycols; Sphingosine; Survival Rate; Tacrolimus; Time Factors | 2000 |
Effect of pretreatment with FTY720 and cyclosporin on ischaemia-reperfusion injury of the liver in rats.
Topics: Animals; Cyclosporine; Fingolimod Hydrochloride; Immunosuppressive Agents; Leukocyte Count; Leukocytes, Mononuclear; Liver; Male; Neutrophil Activation; Peroxidase; Propylene Glycols; Rats; Rats, Wistar; Reperfusion Injury; Sphingosine; Transaminases; Tumor Necrosis Factor-alpha | 1999 |
Prevention of graft vessel disease by combined FTY720/cyclosporine. A treatment in a rat carotid artery transplantation model.
Topics: Animals; Carotid Arteries; Carotid Artery Diseases; Cyclosporine; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Count; Magnetic Resonance Imaging; Male; Muscle, Smooth, Vascular; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine | 2000 |
FTY720 in combination with CsA inhibits islet xenograft rejection: a study in the pig-to-rat model.
Topics: Animals; Cyclosporine; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine; Swine; Transplantation, Heterologous | 2000 |
Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats.
Topics: Animals; Arthritis, Experimental; Cyclosporine; Edema; Fingolimod Hydrochloride; Immunosuppressive Agents; Leukocyte Count; Lymphocytes; Male; Monocytes; Mycobacterium tuberculosis; Neutrophils; Osteolysis; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine; Tacrolimus | 2000 |
The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD.
Topics: Administration, Oral; Animals; B-Lymphocytes; Cyclosporine; Dose-Response Relationship, Drug; Drug Tolerance; Everolimus; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Count; Lymphocyte Depletion; Macaca fascicularis; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Transplantation Immunology | 2000 |
Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to lewis heart and skin transplantation models.
Topics: Adjuvants, Immunologic; Animals; Body Weight; Cyclosporine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Heart Transplantation; Histocompatibility Antigens; Immunosuppressive Agents; Lymphocyte Count; Male; Models, Animal; Propylene Glycols; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Skin Transplantation; Sphingosine | 2001 |
A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor.
Topics: Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Everolimus; Fibrosarcoma; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Histocompatibility; Immunity, Cellular; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Mice, Nude; Models, Immunological; Neoplasm Transplantation; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Transplantation, Homologous; Tumor Cells, Cultured | 2001 |
Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count.
Topics: Animals; Carotid Arteries; Cyclosporine; Drug Therapy, Combination; Fingolimod Hydrochloride; Immunosuppressive Agents; Leukocyte Count; Lymphocyte Count; Propylene Glycols; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Sphingosine; Time Factors; Transplantation, Homologous; Tunica Intima | 2001 |
FTY-720 is efficacious in monkey kidney transplantation.
Topics: ABO Blood-Group System; Animals; B-Lymphocytes; Cyclosporine; Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Graft Survival; Histocompatibility Testing; Immunophenotyping; Immunosuppressive Agents; Kidney Transplantation; Macaca fascicularis; Major Histocompatibility Complex; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Time Factors | 2001 |
Coexpression of CD4 and CD8alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs.
Topics: Animals; Biomarkers; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8 Antigens; Concanavalin A; Cyclosporine; Everolimus; Fingolimod Hydrochloride; Flow Cytometry; Guanidines; Immunosuppressive Agents; Mitogens; Propylene Glycols; Rats; Rats, Inbred Lew; Sirolimus; Sphingosine; Tacrolimus | 2001 |
Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model.
Topics: Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Combinations; Female; Fingolimod Hydrochloride; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Lymphocyte Count; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Propylene Glycols; Sphingosine; Transplantation, Heterotopic; Transplantation, Homologous | 2001 |
Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.
Topics: Acetylcysteine; Apoptosis; Calpain; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Eukaryotic Initiation Factor-4G; fas Receptor; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Jurkat Cells; Leupeptins; Multienzyme Complexes; Peptide Fragments; Peptide Initiation Factors; Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine; T-Lymphocytes | 2001 |
[mTOR and FTY 720 inhibitors].
Topics: Cyclosporine; Drug Interactions; Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Hyperlipidemias; Immunosuppressive Agents; Kidney; Neoplasms; Propylene Glycols; Sirolimus; Sphingosine | 2001 |
Combined use of FTY720 and cyclosporine A prevents chronic allograft vasculopathy.
Topics: Animals; Blood Transfusion; Cyclosporine; Fingolimod Hydrochloride; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Male; Propylene Glycols; Rats; Rats, Inbred Strains; Sphingosine; Transplantation, Homologous | 2002 |
A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine.
Topics: Apoptosis; Cell Movement; Cyclosporine; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Propylene Glycols; Sphingosine; Transforming Growth Factor beta; Tumor Cells, Cultured | 2002 |
Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD.
Topics: Administration, Oral; Animals; B-Lymphocytes; Cyclosporine; Drug Combinations; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Count; Macaca fascicularis; Male; Phenotype; Propylene Glycols; Sirolimus; Sphingosine; T-Lymphocytes; Transplantation, Homologous | 2002 |
FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A.
Topics: Animals; Chronic Disease; Complement C3; Coronary Vessels; Cyclosporine; Drug Therapy, Combination; Endothelium, Vascular; Fingolimod Hydrochloride; Graft Rejection; Heart Transplantation; Immunoglobulin G; Immunohistochemistry; Immunosuppressive Agents; Lymphocyte Subsets; Lymphocytes; Male; Monocytes; Myocardium; Propylene Glycols; Rats; Sphingosine | 2003 |
Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats.
Topics: Animals; Blood Cell Count; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoantibodies; Mice; Mice, Nude; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine; Swine; Transplantation, Heterologous | 2003 |
Rejection following donor or recipient preoperative treatment with FTY720 in rat small bowel transplantation.
Topics: Adjuvants, Immunologic; Animals; Cell Movement; Cyclosporine; Drug Synergism; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Intestine, Small; Lymph Nodes; Lymphocyte Count; Lymphocytes; Male; Premedication; Preoperative Care; Propylene Glycols; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sphingosine; Tissue Donors | 2004 |
A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments.
Topics: Animals; Blood Cell Count; Coronary Vessels; Cyclosporine; Dogs; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Intestines; Kidney; Liver Transplantation; Lung; Propylene Glycols; Sphingosine; Survival Analysis; Tacrolimus | 2004 |
KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.
Topics: Animals; Bradycardia; Chemotaxis, Leukocyte; Chronic Disease; Cyclosporine; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Guinea Pigs; Heart Rate; Heart Transplantation; Immunosuppressive Agents; Male; Molecular Structure; Propylene Glycols; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Rats, Wistar; Skin Transplantation; Sphingosine; Sulfhydryl Compounds; Transplantation, Heterotopic; Transplantation, Homologous | 2005 |
Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates.
Topics: Animals; Cyclophosphamide; Cyclosporine; Drug Synergism; Everolimus; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Leukocyte Count; Macaca fascicularis; Male; Methotrexate; Mycophenolic Acid; Organ Transplantation; Papio; Propylene Glycols; Sirolimus; Sphingosine | 2005 |
Effect of FTY720 on chronic cyclosporine nephropathy in rats.
Topics: Angiotensin II; Animals; Chronic Disease; Cyclosporine; Extracellular Matrix Proteins; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney; Kidney Diseases; Lymphocytes; Macrophages; Male; Osteopontin; Propylene Glycols; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Sphingosine; T-Lymphocytes; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
FTY720 in combination with cyclosporine--an analysis of skin allograft survival and renal function.
Topics: Animals; Body Weight; Cell Count; Creatinine; Cyclosporine; Drug Therapy, Combination; Fingolimod Hydrochloride; Graft Survival; Histocompatibility Antigens Class II; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Kidney; Lymph Nodes; Lymphocyte Count; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Potassium; Propylene Glycols; Skin Transplantation; Sodium; Sphingosine; Spleen; Transplantation, Homologous | 2006 |
FTY720 reduces extracellular matrix expansion associated with ischemia-reperfusion induced injury.
Topics: Animals; Creatinine; Cyclosporine; Disease Models, Animal; Extracellular Matrix; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney Transplantation; Male; Propylene Glycols; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sphingosine; Transplantation, Homologous | 2007 |
Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii.
Topics: Aniline Compounds; Animals; Antibiotics, Antineoplastic; Cell Proliferation; Crotonates; Cyclosporine; Fingolimod Hydrochloride; Fungi; Hydroxybutyrates; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide; Nitriles; Propylene Glycols; Sphingosine; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Toluidines; Tumor Necrosis Factor-alpha | 2008 |
Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients.
Topics: Cyclosporine; Fingolimod Hydrochloride; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Kidney Transplantation; Lymphocyte Activation; Lymphopenia; Methylprednisolone; NFATC Transcription Factors; Propylene Glycols; RNA, Messenger; Sphingosine; T-Lymphocytes | 2008 |
Treatment of chronic allograft nephropathy at late stages using everolimus or FTY720 in combination with cyclosporine.
Topics: Animals; Chronic Disease; Cyclosporine; Drug Therapy, Combination; Everolimus; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Propylene Glycols; Rats; Rats, Inbred F344; Rats, Inbred Lew; Sirolimus; Sphingosine; Transplantation, Homologous | 2008 |
Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
Topics: Animals; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Everolimus; Fingolimod Hydrochloride; Heart Transplantation; Immunosuppressive Agents; Male; Propylene Glycols; Protein Kinase C; Pyrroles; Quinazolines; Rats; Rats, Inbred Lew; Rats, Wistar; Sirolimus; Sphingosine | 2010 |
Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function.
Topics: Animals; Biological Transport; Cyclosporine; Diarrhea; Everolimus; Fingolimod Hydrochloride; Glucose; Immunosuppressive Agents; Intestinal Absorption; Intestine, Large; Intestine, Small; Male; Mycophenolic Acid; Propylene Glycols; Rats; Rats, Wistar; Sirolimus; Sphingosine; Tacrolimus | 2011 |
Relapse of experimental autoimmune encephalomyelitis after discontinuation of FTY720 (Fingolimod) treatment, but not after combination of FTY720 and pathogenic autoantigen.
Topics: Animals; Autoantigens; Cyclosporine; Demyelinating Diseases; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Fingolimod Hydrochloride; Glycoproteins; Immunosuppression Therapy; Immunosuppressive Agents; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Nerve Tissue Proteins; Peptide Fragments; Propylene Glycols; Remission Induction; Secondary Prevention; Specific Pathogen-Free Organisms; Sphingosine; Spinal Cord | 2011 |
Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice.
Topics: Administration, Ophthalmic; Animals; Cell Proliferation; Cornea; Corneal Transplantation; Cyclosporine; Cytokines; Fingolimod Hydrochloride; Forkhead Transcription Factors; Gels; Graft Survival; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ophthalmic Solutions; Propylene Glycols; Sphingosine; T-Lymphocytes, Regulatory; Transplantation, Homologous | 2012 |
Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cell Count; Cyclophosphamide; Cyclosporine; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immune Tolerance; Immunity; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Mycophenolic Acid; Ovalbumin; Propylene Glycols; Sirolimus; Sphingosine; Spleen; T-Lymphocytes, Regulatory | 2012 |
FTY720 and cyclosporin protect ovarian tissue grafted into rabbits.
Topics: Adolescent; Adult; Animals; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Cyclosporine; Female; Fingolimod Hydrochloride; Graft Survival; Humans; Interferon-gamma; Interleukin-4; Ki-67 Antigen; Ovary; Propylene Glycols; Rabbits; Sphingosine; Transplantation, Heterologous | 2013 |
Effects of topical sphingosine-1-phosphate 1 receptor agonist on corneal allograft in mice.
Topics: Administration, Topical; Allografts; Animals; B7-2 Antigen; Cornea; Corneal Transplantation; CTLA-4 Antigen; Cyclosporine; Dendritic Cells; Fingolimod Hydrochloride; Graft Rejection; Graft Survival; Histocompatibility Antigens Class II; Immune Tolerance; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Animal; Ophthalmic Solutions; Propylene Glycols; Real-Time Polymerase Chain Reaction; Receptors, Lysosphingolipid; RNA, Messenger; Sphingosine | 2014 |
FTY720 ameliorates Dry Eye Disease in NOD mice: Involvement of leukocytes inhibition and goblet cells regeneration in ocular surface tissue.
Topics: Animals; Cell Count; Conjunctiva; Cyclosporine; Disease Models, Animal; Dry Eye Syndromes; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Goblet Cells; Immunohistochemistry; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lacrimal Apparatus; Leukocytes; Male; Mice; Mice, Inbred NOD; Real-Time Polymerase Chain Reaction; Regeneration; RNA, Messenger; Tears; Tumor Necrosis Factor-alpha | 2015 |
Modulation of Cell-Mediated Immunity to Suppress High Fat Diet-Induced Obesity and Insulin Resistance.
Topics: Animals; Cyclosporine; Diet, High-Fat; Fingolimod Hydrochloride; Gene Expression Regulation; Immunity, Cellular; Immunosuppressive Agents; Insulin Resistance; Mice, Inbred C57BL; Obesity; Weight Gain | 2016 |
COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alemtuzumab; Azathioprine; Black or African American; Cladribine; Comorbidity; COVID-19; Crotonates; Cyclophosphamide; Cyclosporine; Databases, Factual; Dimethyl Fumarate; Female; Fingolimod Hydrochloride; Hospitalization; Humans; Hydroxybutyrates; Immunologic Factors; Immunosuppressive Agents; Incidence; Interferon-beta; Logistic Models; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Mitoxantrone; Multiple Sclerosis; Mycophenolic Acid; Natalizumab; Nitriles; Obesity; Risk Factors; Rituximab; SARS-CoV-2; Toluidines; United States; White People; Young Adult | 2021 |