fidarestat has been researched along with sorbitol in 15 studies
| Studies (fidarestat) | Trials (fidarestat) | Recent Studies (post-2010) (fidarestat) | Studies (sorbitol) | Trials (sorbitol) | Recent Studies (post-2010) (sorbitol) |
|---|---|---|---|---|---|
| 97 | 3 | 33 | 6,530 | 359 | 946 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, N; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K | 1 |
| Hotta, N; Kawamura, T; Matsumae, H; Sakamoto, N; Sano, T; Suzuki, K | 1 |
| Hamada, Y; Hara, T; Hotta, N; Koh, N; Mori, K; Nakamura, J; Nakashima, E; Naruse, K; Sakakibara, F; Wakao, T | 1 |
| Hamada, Y; Hotta, N; Kakuta, H; Koh, N; Matsubara, A; Mizuno, K; Nakamura, J; Naruse, K; Sakakibara, F; Sasaki, H | 1 |
| Hotta, N; Kawamura, T; Sakakibara, F; Sakamoto, N; Sano, T; Sasaki, H; Suzuki, K | 1 |
| Kato, N; Makino, M; Mizuno, K; Suzuki, T; Yagihashi, S | 1 |
| Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K | 1 |
| Amano, S; Hirooka, H; Inagaki, Y; Jomori, T; Kato, N; Makino, M; Okamoto, T; Takeuchi, M; Taniko, K; Yamagishi, Si | 1 |
| Abatan, OI; Frank, RN; Kumagai, AK; Minchenko, AG; Obrosova, IG; Stevens, MJ; Vasupuram, R; White, L | 1 |
| Akiyama, N; Hamada, Y; Hirooka, H; Horiuchi, S; Hotta, N; Kamiya, H; Li, W; Nakamura, J; Nakashima, E; Naruse, K; Oiso, Y; Takahashi, N | 1 |
| Hirooka, H; Obrosova, IG; Pacher, P; Stevens, MJ; Szabó, C; Yorek, MA; Zsengeller, Z | 1 |
| Miyasita, Y; Oyama, T; Shirai, K; Watanabe, H | 1 |
| Hattori, T; Matsubara, A; Ogura, Y; Taniguchi, K | 1 |
| Agardh, CD; Agardh, E; El-Remessy, AB; Maksimchyk, Y; Obrosova, IG; Pacher, P; Smith, ML | 1 |
| Hirooka, H; Nadler, JL; Obrosova, IG; Shevalye, H; Stavniichuk, R | 1 |
1 trial(s) available for fidarestat and sorbitol
| Article | Year |
|---|---|
Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils.
Topics: Adult; Aldehyde Reductase; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inositol; Linear Models; Male; Neutrophils; Reference Values; Rhodanine; Sorbitol; Thiazolidines | 1999 |
14 other study(ies) available for fidarestat and sorbitol
| Article | Year |
|---|---|
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin | 1992 |
Effects of glucose and SNK-860, an aldose reductase inhibitor, on the polyol pathway and chemiluminescence response of human neutrophils in vitro.
Topics: Adult; Aldehyde Reductase; Blood Glucose; Case-Control Studies; Galactose; Glucose; Humans; Imidazoles; Imidazolidines; Luminescent Measurements; Mannitol; Neutrophils; Reference Values; Sorbitol; Tetradecanoylphorbol Acetate | 1995 |
Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats.
Topics: 2,3-Diphosphoglycerate; Aldehyde Reductase; Animals; Body Weight; Diabetic Neuropathies; Diphosphoglyceric Acids; Enzyme Inhibitors; Erythrocytes; Imidazoles; Imidazolidines; Male; Motor Neurons; Neural Conduction; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1995 |
Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats.
Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Electroretinography; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Sprague-Dawley; Retina; Sorbitol | 1995 |
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Fructose; Glycated Hemoglobin; Imidazoles; Imidazolidines; Inositol; Male; Myelin Sheath; Nerve Fibers; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Sural Nerve; Tibial Nerve; Time Factors | 2000 |
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Fasting; Female; Glycated Hemoglobin; Humans; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Rhodanine; Sciatic Nerve; Sex Factors; Sorbitol; Thiazolidines | 2001 |
Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes.
Topics: Aldehyde Reductase; Animals; Blood-Retinal Barrier; Capillary Permeability; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA; Endothelial Growth Factors; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; L-Iditol 2-Dehydrogenase; Lymphokines; Male; Pericytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; RNA, Messenger; Sorbitol; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Angiogenesis Inducing Agents; Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Fructose; Gene Expression; Glucose; Glutathione; Glutathione Peroxidase; Imidazoles; Imidazolidines; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Retina; Retinal Vessels; RNA, Messenger; Sorbitol; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2003 |
Suppression of 3-deoxyglucosone and heparin-binding epidermal growth factor-like growth factor mRNA expression by an aldose reductase inhibitor in rat vascular smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Blotting, Northern; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Epidermal Growth Factor; Glucose; Glycation End Products, Advanced; Heparin-binding EGF-like Growth Factor; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; Mitogens; Muscle, Smooth, Vascular; Oxidative Stress; Rats; RNA, Messenger; Sorbitol; Thiobarbituric Acid Reactive Substances; Thymidine | 2004 |
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.
Topics: Aldehyde Reductase; Animals; Aorta; Arterioles; Cattle; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fructose; Imidazolidines; Male; Motor Neurons; Neural Conduction; Neurons, Afferent; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Tyrosine | 2005 |
The role of polyol pathway in high glucose-induced endothelial cell damages.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehyde Reductase; Carbohydrate Metabolism; Caspase 3; Cells, Cultured; Culture Media; Deoxyguanosine; DNA Fragmentation; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Glucose; Humans; Imidazolidines; Polymers; Signal Transduction; Sorbitol | 2006 |
Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo.
Topics: Acridine Orange; Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Fluorophotometry; Fructose; Imidazolidines; Intercellular Adhesion Molecule-1; Leukocytes; Male; Microscopy, Fluorescence; Rats; Rats, Long-Evans; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sorbitol; Vascular Endothelial Growth Factor A | 2010 |
Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina.
Topics: Aldehyde Reductase; Animals; Apoptosis; Blotting, Western; Drug Evaluation, Preclinical; Female; Fructose; Glucose; Imidazolidines; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intravenous; L-Iditol 2-Dehydrogenase; Rats; Rats, Wistar; Reperfusion Injury; Retina; Sorbitol | 2010 |
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Glucose; Blotting, Western; Calcium; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme-Linked Immunosorbent Assay; Fructose; Ganglia, Spinal; Imidazolidines; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Sciatic Nerve; Sorbitol; Spinal Cord; Streptozocin | 2012 |