Page last updated: 2024-09-04

fidarestat and sorbinil

fidarestat has been researched along with sorbinil in 10 studies

Compound Research Comparison

Studies
(fidarestat)
Trials
(fidarestat)
Recent Studies (post-2010)
(fidarestat)
Studies
(sorbinil)
Trials
(sorbinil)
Recent Studies (post-2010) (sorbinil)
973335004443

Protein Interaction Comparison

ProteinTaxonomyfidarestat (IC50)sorbinil (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)5.05
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.8698
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.5
Aldo-keto reductase family 1 member A1Homo sapiens (human)5.1333
Aldo-keto reductase family 1 member B1Homo sapiens (human)1.3166
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.04
Aldo-keto reductase family 1 member B1Bos taurus (cattle)1.7292
Aldo-keto reductase family 1 member A1Sus scrofa (pig)2.95
Aldo-keto reductase family 1 member A1Rattus norvegicus (Norway rat)0.8845
Aldo-keto reductase family 1 member B1Sus scrofa (pig)1.1
Mu-type opioid receptorCavia porcellus (domestic guinea pig)1.1

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (90.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matsumoto, Y; Matsushima, M; Oka, M; Sugiyama, S; Tsuruta, N1
Demopoulos, VJ; Nicolaou, I1
Carbone, V; Chung, RP; Darmanin, C; El-Kabbani, O; Mitschler, A; Oka, M; Podjarny, A; Schulze-Briese, C1
Chung, R; Cousido-Siah, A; El-Kabbani, O; Hazemann, I; Joachimiak, A; Klebe, G; Mitschler, A; Oka, M; Petrova, T; Podjarny, A; Steuber, H1
Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M1
Dhagat, U; El-Kabbani, O; Endo, S; Hara, A1
Alaparthi, MD; Bandaru, S; Chittineni, PR; Gopinath, G; Krupadanam, GLD; Pasala, VK; Perugu, S; Sagurthi, SR; Sankeshi, V1
Kato, N; Oka, M1
Ighani-Hosseinabad, F; Ramana, KV; Srivastava, SK; van Kuijk, FJ; Yadav, UC1
Ling, B; Liu, C; Liu, Y; Suo, Y; Wang, Z; Yu, Z; Zhang, R1

Reviews

1 review(s) available for fidarestat and sorbinil

ArticleYear
Aldose reductase inhibitors.
    Journal of enzyme inhibition, 2001, Volume: 16, Issue:6

    Topics: Aldehyde Reductase; Binding Sites; Clinical Trials as Topic; Crystallography, X-Ray; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Naphthalenes; Quinazolines

2001

Other Studies

9 other study(ies) available for fidarestat and sorbinil

ArticleYear
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
    Journal of medicinal chemistry, 2000, Jun-15, Volume: 43, Issue:12

    Topics: Aldehyde Reductase; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Models, Molecular; Molecular Structure; Stereoisomerism

2000
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
    Journal of medicinal chemistry, 2003, Jan-30, Volume: 46, Issue:3

    Topics: Acetates; Aldehyde Reductase; Animals; Diabetes Mellitus; Enzyme Inhibitors; Female; Fructose; Male; Monosaccharides; Oxidation-Reduction; Proteins; Pyrroles; Rats; Rats, Inbred F344; Serum Albumin; Structure-Activity Relationship

2003
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
    Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17

    Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Binding Sites; Crystallography, X-Ray; Holoenzymes; Imidazolidines; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Stereoisomerism; Structure-Activity Relationship; Swine

2005
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.
    Journal of medicinal chemistry, 2005, Sep-08, Volume: 48, Issue:18

    Topics: Aldehyde Reductase; Binding Sites; Calorimetry; Crystallization; Holoenzymes; Humans; Imidazolidines; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Thermodynamics

2005
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics

2007
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.
    Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldehyde Reductase; Animals; Binding Sites; Enzyme Inhibitors; Mice; Models, Molecular; Protein Binding; Substrate Specificity

2008
Design and synthesis of chiral 2H-chromene-N-imidazolo-amino acid conjugates as aldose reductase inhibitors.
    European journal of medicinal chemistry, 2016, Nov-29, Volume: 124

    Topics: Aldehyde Reductase; Amino Acids; Animals; Benzopyrans; Blood Glucose; Catalytic Domain; Cataract; Diabetes Complications; Disease Models, Animal; Drug Design; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Inhibitory Concentration 50; Molecular Docking Simulation; Rats; Stereoisomerism; Structure-Activity Relationship

2016
Prevention of posterior capsular opacification through aldose reductase inhibition.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:2

    Topics: Actins; Aldehyde Reductase; Animals; beta-Crystallins; Blotting, Western; Capsulorhexis; Cataract; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Epithelial Cells; Fibroblast Growth Factor 2; Imidazolidines; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Lens Capsule, Crystalline; Microscopy, Fluorescence; NF-kappa B; Organ Culture Techniques; Proliferating Cell Nuclear Antigen; Signal Transduction; Swine

2009
Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase.
    Journal of molecular graphics & modelling, 2009, Volume: 28, Issue:2

    Topics: Aldehyde Reductase; Enzyme Inhibitors; Hydrogen Bonding; Imidazolidines; Molecular Dynamics Simulation; Naphthalenes; Protein Structure, Secondary; Rhodanine; Thiazolidines

2009