fidarestat has been researched along with sorbinil in 10 studies
| Studies (fidarestat) | Trials (fidarestat) | Recent Studies (post-2010) (fidarestat) | Studies (sorbinil) | Trials (sorbinil) | Recent Studies (post-2010) (sorbinil) |
|---|---|---|---|---|---|
| 97 | 3 | 33 | 500 | 44 | 43 |
| Protein | Taxonomy | fidarestat (IC50) | sorbinil (IC50) |
|---|---|---|---|
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | 5.05 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.8698 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.5 | |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | 5.1333 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 1.3166 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 3.04 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 1.7292 | |
| Aldo-keto reductase family 1 member A1 | Sus scrofa (pig) | 2.95 | |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | 0.8845 | |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | 1.1 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (90.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, Y; Matsushima, M; Oka, M; Sugiyama, S; Tsuruta, N | 1 |
| Demopoulos, VJ; Nicolaou, I | 1 |
| Carbone, V; Chung, RP; Darmanin, C; El-Kabbani, O; Mitschler, A; Oka, M; Podjarny, A; Schulze-Briese, C | 1 |
| Chung, R; Cousido-Siah, A; El-Kabbani, O; Hazemann, I; Joachimiak, A; Klebe, G; Mitschler, A; Oka, M; Petrova, T; Podjarny, A; Steuber, H | 1 |
| Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M | 1 |
| Dhagat, U; El-Kabbani, O; Endo, S; Hara, A | 1 |
| Alaparthi, MD; Bandaru, S; Chittineni, PR; Gopinath, G; Krupadanam, GLD; Pasala, VK; Perugu, S; Sagurthi, SR; Sankeshi, V | 1 |
| Kato, N; Oka, M | 1 |
| Ighani-Hosseinabad, F; Ramana, KV; Srivastava, SK; van Kuijk, FJ; Yadav, UC | 1 |
| Ling, B; Liu, C; Liu, Y; Suo, Y; Wang, Z; Yu, Z; Zhang, R | 1 |
1 review(s) available for fidarestat and sorbinil
| Article | Year |
|---|---|
Aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Clinical Trials as Topic; Crystallography, X-Ray; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Naphthalenes; Quinazolines | 2001 |
9 other study(ies) available for fidarestat and sorbinil
| Article | Year |
|---|---|
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
Topics: Aldehyde Reductase; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Models, Molecular; Molecular Structure; Stereoisomerism | 2000 |
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Topics: Acetates; Aldehyde Reductase; Animals; Diabetes Mellitus; Enzyme Inhibitors; Female; Fructose; Male; Monosaccharides; Oxidation-Reduction; Proteins; Pyrroles; Rats; Rats, Inbred F344; Serum Albumin; Structure-Activity Relationship | 2003 |
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Binding Sites; Crystallography, X-Ray; Holoenzymes; Imidazolidines; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Stereoisomerism; Structure-Activity Relationship; Swine | 2005 |
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.
Topics: Aldehyde Reductase; Binding Sites; Calorimetry; Crystallization; Holoenzymes; Humans; Imidazolidines; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Thermodynamics | 2005 |
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics | 2007 |
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldehyde Reductase; Animals; Binding Sites; Enzyme Inhibitors; Mice; Models, Molecular; Protein Binding; Substrate Specificity | 2008 |
Design and synthesis of chiral 2H-chromene-N-imidazolo-amino acid conjugates as aldose reductase inhibitors.
Topics: Aldehyde Reductase; Amino Acids; Animals; Benzopyrans; Blood Glucose; Catalytic Domain; Cataract; Diabetes Complications; Disease Models, Animal; Drug Design; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Inhibitory Concentration 50; Molecular Docking Simulation; Rats; Stereoisomerism; Structure-Activity Relationship | 2016 |
Prevention of posterior capsular opacification through aldose reductase inhibition.
Topics: Actins; Aldehyde Reductase; Animals; beta-Crystallins; Blotting, Western; Capsulorhexis; Cataract; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Epithelial Cells; Fibroblast Growth Factor 2; Imidazolidines; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Lens Capsule, Crystalline; Microscopy, Fluorescence; NF-kappa B; Organ Culture Techniques; Proliferating Cell Nuclear Antigen; Signal Transduction; Swine | 2009 |
Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase.
Topics: Aldehyde Reductase; Enzyme Inhibitors; Hydrogen Bonding; Imidazolidines; Molecular Dynamics Simulation; Naphthalenes; Protein Structure, Secondary; Rhodanine; Thiazolidines | 2009 |