fidarestat has been researched along with minalrestat in 4 studies
| Studies (fidarestat) | Trials (fidarestat) | Recent Studies (post-2010) (fidarestat) | Studies (minalrestat) | Trials (minalrestat) | Recent Studies (post-2010) (minalrestat) |
|---|---|---|---|---|---|
| 97 | 3 | 33 | 9 | 0 | 1 |
| Protein | Taxonomy | fidarestat (IC50) | minalrestat (IC50) |
|---|---|---|---|
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | 0.74 | |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | 0.0067 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 0.045 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 0.014 | |
| Aldo-keto reductase family 1 member A1 | Sus scrofa (pig) | 0.04 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M | 1 |
| Dhagat, U; El-Kabbani, O; Endo, S; Hara, A | 1 |
| Diederich, WE; Fridh, V; Heine, A; Klebe, G; Pol, E; Rechlin, C; Scheer, F; Terwesten, F; Toth, P; Wulsdorf, T | 1 |
| Darmanin, C; El-Kabbani, O; Hazemann, I; Joachimiak, A; Mitschler, A; Oka, M; Podjarny, A; Ruiz, F; Schneider, TR; Schulze-Briese, C; Tomizaki, T | 1 |
4 other study(ies) available for fidarestat and minalrestat
| Article | Year |
|---|---|
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics | 2007 |
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldehyde Reductase; Animals; Binding Sites; Enzyme Inhibitors; Mice; Models, Molecular; Protein Binding; Substrate Specificity | 2008 |
Price for Opening the Transient Specificity Pocket in Human Aldose Reductase upon Ligand Binding: Structural, Thermodynamic, Kinetic, and Computational Analysis.
Topics: Aldehyde Reductase; Binding Sites; Humans; Kinetics; Ligands; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Structure-Activity Relationship; Thermodynamics | 2017 |
Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Holoenzymes; Imidazoles; Imidazolidines; Imides; Macromolecular Substances; Models, Molecular; Molecular Structure; Quinolones | 2004 |