Page last updated: 2024-09-04

fidarestat and imidazolidines

fidarestat has been researched along with imidazolidines in 78 studies

Compound Research Comparison

Studies (fidarestat)	Trials (fidarestat)	Recent Studies (post-2010) (fidarestat)	Studies (imidazolidines)	Trials (imidazolidines)	Recent Studies (post-2010) (imidazolidines)
97	3	33	1,666	186	358

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (12.82)	18.2507
2000's	37 (47.44)	29.6817
2010's	30 (38.46)	24.3611
2020's	1 (1.28)	2.80

Authors

Authors	Studies
Kato, N; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K	1
Hotta, N; Kawamura, T; Matsumae, H; Sakamoto, N; Sano, T; Suzuki, K	1
Baba, Y; Fukushima, M; Kondo, Y; Kurono, M; Matsumoto, Y; Miura, K; Mizuno, K; Unno, R; Usui, T; Yamaguchi, T	1
Akita, M; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K	1
Hamada, Y; Hara, T; Hotta, N; Koh, N; Mori, K; Nakamura, J; Nakashima, E; Naruse, K; Sakakibara, F; Wakao, T	1
Hamada, Y; Hotta, N; Kakuta, H; Koh, N; Matsubara, A; Mizuno, K; Nakamura, J; Naruse, K; Sakakibara, F; Sasaki, H	1
Hibi, C	2
Akagi, Y; Fukuda, M; Kubo, E; Miyoshi, N	1
Hotta, N; Kawamura, T; Sakakibara, F; Sakamoto, N; Sano, T; Sasaki, H; Suzuki, K	1
Akagi, Y; Kubo, E; Matsubara, A; Mizuno, K; Nakamura, S; Takahashi, Y; Tsuzuki, S	1
Mizuno, K; Suzuki, T; Tanaka, T; Taniko, K	1
Matsumoto, Y; Matsushima, M; Oka, M; Sugiyama, S; Tsuruta, N	1
Kato, N; Makino, M; Mizuno, K; Suzuki, T; Yagihashi, S	1
Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K	1
Hotta, N; Ishii, J; Kaneko, T; Kikkawa, R; Koike, Y; Matsuoka, K; Sakamoto, N; Shigeta, Y; Sugimura, K; Takahashi, A; Toyota, T	1
Kato, N; Oka, M	1
Amano, S; Hirooka, H; Inagaki, Y; Jomori, T; Kato, N; Makino, M; Okamoto, T; Takeuchi, M; Taniko, K; Yamagishi, Si	1
Abatan, OI; Frank, RN; Kumagai, AK; Minchenko, AG; Obrosova, IG; Stevens, MJ; Vasupuram, R; White, L	1
Akagi, Y; Kubo, E; Takamura, Y; Tsuzuki, S	1
Akagi, Y; Kubo, E; Morikubo, S; Takamura, Y; Tsuzuki, S	1
Giannoukakis, N	1
Akiyama, N; Hamada, Y; Hirooka, H; Horiuchi, S; Hotta, N; Kamiya, H; Li, W; Nakamura, J; Nakashima, E; Naruse, K; Oiso, Y; Takahashi, N	1
Darmanin, C; El-Kabbani, O; Hazemann, I; Joachimiak, A; Mitschler, A; Oka, M; Podjarny, A; Ruiz, F; Schneider, TR; Schulze-Briese, C; Tomizaki, T	1
Agthong, S; Middlemas, AB; Price, SA; Tomlinson, DR	1
Darmanin, C; El-Kabbani, O; Hazemann, I; Mitschler, A; Oka, M; Podjarny, A; Schulze-Briese, C; Tomizaki, T	1
Chin, S; Otsuki, S; Uehara, K; Yagihashi, S; Yamagishi, S	1
Hirooka, H; Obrosova, IG; Pacher, P; Stevens, MJ; Szabó, C; Yorek, MA; Zsengeller, Z	1
Hotta, N	1
Akagi, Y; Kubo, E	1
Carbone, V; Chung, RP; Darmanin, C; El-Kabbani, O; Mitschler, A; Oka, M; Podjarny, A; Schulze-Briese, C	1
Chung, R; Cousido-Siah, A; El-Kabbani, O; Hazemann, I; Joachimiak, A; Klebe, G; Mitschler, A; Oka, M; Petrova, T; Podjarny, A; Steuber, H	1
Miyasita, Y; Oyama, T; Shirai, K; Watanabe, H	1
Kato, N; Kihara, M; Kusunoki, S; Kuzumoto, Y; Low, PA	1
Cheung, AK; Chiu, JF; Chung, SK; Chung, SS; He, QY; Hung, VK; Lo, AC; Yeung, CM	1
El-Kabbani, O; Podjarny, A	1
Drel, VR; Ilnytska, O; Lyzogubov, VV; Mashtalir, N; Nadler, JL; Obrosova, IG; Pavlov, IA	1
Cheung, AK; Chung, SK; Chung, SS; Lo, AC; So, KF	1
Dong, F; Ren, J	1
Carbone, V; El-Kabbani, O; Ginell, S; Hazemann, I; Joachimiak, A; Mitschler, A; Podjarny, A; Zhao, HT	1
Ali, TK; Drel, VR; El-Remessy, AB; Julius, U; Obrosova, IG; Pacher, P; Shin, J	1
Ighani-Hosseinabad, F; Ramana, KV; Srivastava, SK; van Kuijk, FJ; Yadav, UC	1
Yasuda, H	1
Bendeif, el-E; Fournier, B; Guillot, B; Jelsch, C; Lecomte, C; Podjarny, A	1
Ling, B; Liu, C; Liu, Y; Suo, Y; Wang, Z; Yu, Z; Zhang, R	1
Agardh, CD; Agardh, E; Obrosova, IG; Smith, ML	1
Chung, S; Hibi, C; Kato, N; Mizukami, H; Nukada, H; Ogasawara, S; Yagihashi, S; Yamagishi, S	1
Hattori, T; Matsubara, A; Ogura, Y; Taniguchi, K	1
Choi, R; Chung, CH; Hong, SW; Kim, BH; Kim, JH; Kim, SH; Koh, JH; Lee, EY; Lee, MY; Nam, SM; Sung, JK; Yoo, JH	1
Agardh, CD; Agardh, E; El-Remessy, AB; Maksimchyk, Y; Obrosova, IG; Pacher, P; Smith, ML	1
Ramana, KV; Reddy, AB; Srivastava, SK; Tammali, R	1
Ramana, KV; Saxena, A; Srivastava, SK; Tammali, R	2
Awasthi, S; Evers, BM; Qiu, S; Ramana, KV; Reddy, AB; Rychahou, PG; Saxena, A; Srivastava, SK; Tammali, R	1
Ramana, KV; Shoeb, M; Srivastava, SK; Yadav, UC	2
Aguilera-Aguirre, L; Boldogh, I; Ramana, KV; Srivastava, SK; Yadav, UC	1
Hibi, C; Inaba, W; Kamata, K; Kato, N; Mizukami, H; Takahashi, K; Yagihashi, S	1
Hirooka, H; Nadler, JL; Obrosova, IG; Shevalye, H; Stavniichuk, R	1
Cousido-Siah, A; Farrés, J; Mitschler, A; Parés, X; Podjarny, A; Ruiz, FX	1
Aguilera-Aguirre, L; Bolodgh, I; Mishra, R; Ramana, KV; Srivatsava, SK; Sur, S; Yadav, UC	1
Aguilera-Aguirre, L; Boldogh, I; Boulares, HA; Calhoun, WJ; Naura, AS; Ramana, KV; Srivastava, SK; Yadav, UC	1
Ramana, KV; Srivastava, SK; Yadav, UCS	1
Ramana, KV; Saxena, A; Shoeb, M; Srivastava, SK	1
Chen, S; Chen, Y; Hu, X; Li, Q; Li, Z; Wang, Z; Xie, W; Zhai, J; Zhang, H; Zhang, L; Zhao, Y; Zheng, X	1
Ciddi, V; Dodda, D	1
Dominguez, JM; Grant, MB; Yorek, MA	1
Ramana, KV; Saxena, A; Shoeb, M; Srivastava, SK; Tammali, R	1
Banerjee, SK; Bhandi, MM; Borkar, RM; Dubey, AP; Nandekar, PP; Sangamwar, AT; Srinivas, R	1
Chavan, BB; Kalariya, PD; Khatoon, L; Ragampeta, S; Talluri, MV	1
Pandey, S	1
Awasthi, S; Pal, PB; Ramana, KV; Sonowal, H; Srivastava, SK; Wen, JJ	1
Pal, PB; Ramana, KV; Shukla, K; Sonowal, H; Srivastava, SK	2
Ramana, KV; Saxena, A; Shukla, K; Sonowal, H; Srivastava, SK	1
Pal, P; Ramana, KV; Saxena, A; Shukla, K; Sonowal, H; Srivastava, SK	1
Asthana, S; Banerjee, SK; Borkar, RM; Gajji, S; Jala, A; Kamal, A; Mohammed, SA; Ragampeta, S; Reddy, VG; Srivastava, M	1

Reviews

9 review(s) available for fidarestat and imidazolidines

Article	Year
[Aldose reductase inhibitor SNK-860]. Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl Topics: Aldehyde Reductase; Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diabetic Neuropathies; Enzyme Inhibitors; Erythrocyte Deformability; Humans; Imidazoles; Imidazolidines; Platelet Aggregation	1997
Aldose reductase inhibitors. Journal of enzyme inhibition, 2001, Volume: 16, Issue:6 Topics: Aldehyde Reductase; Binding Sites; Clinical Trials as Topic; Crystallography, X-Ray; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Naphthalenes; Quinazolines	2001
[Fidarestat (SNK-860)]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Aldehyde Reductase; Animals; Clinical Trials, Phase III as Topic; Diabetic Neuropathies; Diabetic Retinopathy; Endothelial Growth Factors; Humans; Hypoglycemic Agents; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; Lymphokines; Neural Conduction; Neurons, Afferent; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
Fidarestat. Aldos, SK 860, SNK 860. Drugs in R&D, 2002, Volume: 3, Issue:4 Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Humans; Imidazoles; Imidazolidines	2002
Fidarestat. Sanwa Kagaku/NC Curex/Sankyo. Current opinion in investigational drugs (London, England : 2000), 2003, Volume: 4, Issue:10 Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diabetic Neuropathies; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Structure-Activity Relationship	2003
[Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6 Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetic Angiopathies; Drug Design; Humans; Imidazolidines; Polymers; Polymorphism, Genetic; Pyrazines; Rhodanine; Spiro Compounds; Thiazolidines	2005
[Role of aldose reductase in the progression of diabetic retinopathies]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6 Topics: Aldehyde Reductase; Animals; Apoptosis; Clinical Trials as Topic; Diabetic Retinopathy; Humans; Imidazolidines; Macular Edema; Polymorphism, Genetic; Retina	2005
Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites. Cellular and molecular life sciences : CMLS, 2007, Volume: 64, Issue:15 Topics: Aldehyde Reductase; Amino Acid Substitution; Animals; Catalytic Domain; Diabetes Mellitus; Enzyme Inhibitors; Glucose; Humans; Imidazolidines; In Vitro Techniques; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins	2007
[Pathophysiology and treatment for diabetic neuropathy]. Rinsho shinkeigaku = Clinical neurology, 2009, Volume: 49, Issue:4 Topics: Aldehyde Reductase; Diabetic Nephropathies; Enzyme Inhibitors; Genetic Therapy; Humans; Hypoglycemic Agents; Imidazolidines; Neuralgia; Neurologic Examination; Regenerative Medicine; Rhodanine; Thiazolidines	2009

Trials

2 trial(s) available for fidarestat and imidazolidines

Article	Year
Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils. Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:1 Topics: Adult; Aldehyde Reductase; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inositol; Linear Models; Male; Neutrophils; Reference Values; Rhodanine; Sorbitol; Thiazolidines	1999
Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes care, 2001, Volume: 24, Issue:10 Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Electrophysiology; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Hypesthesia; Imidazoles; Imidazolidines; Male; Middle Aged; Pain; Paresthesia; Placebos	2001

Article

Year

Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils.

Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:1

Topics: Adult; Aldehyde Reductase; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inositol; Linear Models; Male; Neutrophils; Reference Values; Rhodanine; Sorbitol; Thiazolidines

1999

Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study.

Diabetes care, 2001, Volume: 24, Issue:10

Topics: Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Electrophysiology; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Hypesthesia; Imidazoles; Imidazolidines; Male; Middle Aged; Pain; Paresthesia; Placebos

2001

Other Studies

67 other study(ies) available for fidarestat and imidazolidines

Article	Year
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo Metabolism: clinical and experimental, 1992, Volume: 41, Issue:10 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin	1992
Effects of glucose and SNK-860, an aldose reductase inhibitor, on the polyol pathway and chemiluminescence response of human neutrophils in vitro. Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:5 Topics: Adult; Aldehyde Reductase; Blood Glucose; Case-Control Studies; Galactose; Glucose; Humans; Imidazoles; Imidazolidines; Luminescent Measurements; Mannitol; Neutrophils; Reference Values; Sorbitol; Tetradecanoylphorbol Acetate	1995
Synthesis and aldose reductase inhibitory activity of 2-substituted-6-fluoro-2,3-dihydrospiro [4H-1-benzopyran-4, 4'-imidazolidine]-2',5'-diones. Arzneimittel-Forschung, 1994, Volume: 44, Issue:3 Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry, Physical; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Lens, Crystalline; Male; Rats; Rats, Sprague-Dawley; Spiro Compounds; Stereoisomerism	1994
Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of retinal tissues in a streptozotocin-induced diabetic rat model. Acta medica Okayama, 1993, Volume: 47, Issue:5 Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels	1993
Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats. European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1 Topics: 2,3-Diphosphoglycerate; Aldehyde Reductase; Animals; Body Weight; Diabetic Neuropathies; Diphosphoglyceric Acids; Enzyme Inhibitors; Erythrocytes; Imidazoles; Imidazolidines; Male; Motor Neurons; Neural Conduction; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol	1995
Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Experimental physiology, 1995, Volume: 80, Issue:6 Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Electroretinography; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Sprague-Dawley; Retina; Sorbitol	1995
Cataract formation through the polyol pathway is associated with free radical production. Experimental eye research, 1999, Volume: 68, Issue:4 Topics: Aldehyde Reductase; Animals; Cataract; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Galactose; Hydroxyl Radical; Imidazoles; Imidazolidines; Male; Models, Biological; Polymers; Rats; Rats, Sprague-Dawley	1999
Inhibitory effect of orally administered aldose reductase inhibitor SNK-860 on corneal polyol accumulation in galactose-fed rats. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1999, Volume: 237, Issue:9 Topics: Administration, Oral; Aldehyde Reductase; Animals; Cornea; Corneal Stroma; Endothelium, Corneal; Enzyme Inhibitors; Epithelium; Galactose; Imidazoles; Imidazolidines; Male; Polymers; Rats; Rats, Sprague-Dawley	1999
Inhibitory effects of fidarestat on aldose reductase and aldehyde reductase activity evaluated by a new method using HPLC with post-column spectrophotometric detection. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:2 Topics: Aldehyde Reductase; Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Erythrocytes; Humans; Imidazoles; Imidazolidines; Kidney; Lens, Crystalline; Male; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spectrophotometry, Ultraviolet; Tissue Distribution	2000
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography. Journal of medicinal chemistry, 2000, Jun-15, Volume: 43, Issue:12 Topics: Aldehyde Reductase; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Models, Molecular; Molecular Structure; Stereoisomerism	2000
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats. Diabetes research and clinical practice, 2000, Volume: 50, Issue:2 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Fructose; Glycated Hemoglobin; Imidazoles; Imidazolidines; Inositol; Male; Myelin Sheath; Nerve Fibers; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Sural Nerve; Tibial Nerve; Time Factors	2000
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes. Pharmacology, 2001, Volume: 62, Issue:4 Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Fasting; Female; Glycated Hemoglobin; Humans; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Rhodanine; Sciatic Nerve; Sex Factors; Sorbitol; Thiazolidines	2001
Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes. Biochemical and biophysical research communications, 2002, Nov-29, Volume: 299, Issue:2 Topics: Aldehyde Reductase; Animals; Blood-Retinal Barrier; Capillary Permeability; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA; Endothelial Growth Factors; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; L-Iditol 2-Dehydrogenase; Lymphokines; Male; Pericytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; RNA, Messenger; Sorbitol; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes, 2003, Volume: 52, Issue:3 Topics: Aldehyde Reductase; Angiogenesis Inducing Agents; Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Fructose; Gene Expression; Glucose; Glutathione; Glutathione Peroxidase; Imidazoles; Imidazolidines; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Retina; Retinal Vessels; RNA, Messenger; Sorbitol; Superoxide Dismutase; Vascular Endothelial Growth Factor A	2003
Apoptotic cell death in the lens epithelium of rat sugar cataract. Experimental eye research, 2003, Volume: 77, Issue:1 Topics: Aldehyde Reductase; Animals; Apoptosis; Blotting, Western; Cataract; DNA Fragmentation; Epithelial Cells; Galactitol; Galactose; Genes, p53; Imidazoles; Imidazolidines; In Situ Nick-End Labeling; Lens, Crystalline; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53	2003
[The inhibitory effect of aldose reductase inhibitor for proliferation in the lens epithelial cells of rat sugar cataract]. Nippon Ganka Gakkai zasshi, 2003, Volume: 107, Issue:10 Topics: Aldehyde Reductase; Animals; Cataract; Cell Division; Epithelial Cells; Galactose; Imidazoles; Imidazolidines; Lens, Crystalline; Male; Rats; Rats, Sprague-Dawley; Sugar Alcohols	2003
Suppression of 3-deoxyglucosone and heparin-binding epidermal growth factor-like growth factor mRNA expression by an aldose reductase inhibitor in rat vascular smooth muscle cells. Biochemical and biophysical research communications, 2004, Feb-06, Volume: 314, Issue:2 Topics: Aldehyde Reductase; Animals; Blotting, Northern; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Epidermal Growth Factor; Glucose; Glycation End Products, Advanced; Heparin-binding EGF-like Growth Factor; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; Mitogens; Muscle, Smooth, Vascular; Oxidative Stress; Rats; RNA, Messenger; Sorbitol; Thiobarbituric Acid Reactive Substances; Thymidine	2004
Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors. Proteins, 2004, Jun-01, Volume: 55, Issue:4 Topics: Aldehyde Reductase; Binding Sites; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Holoenzymes; Imidazoles; Imidazolidines; Imides; Macromolecular Substances; Models, Molecular; Molecular Structure; Quinolones	2004
Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase. Diabetes, 2004, Volume: 53, Issue:7 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Imidazoles; Imidazolidines; Insulin; Male; Mitogen-Activated Protein Kinases; Motor Neurons; Neural Conduction; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Rats; Rats, Wistar; Spinal Cord; Time Factors; Tissue Distribution	2004
High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. Journal of medicinal chemistry, 2004, Aug-26, Volume: 47, Issue:18 Topics: Aldehyde Reductase; Binding Sites; Citrates; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Molecular Structure; Protein Binding; Stereoisomerism; Substrate Specificity	2004
Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice. Diabetes, 2004, Volume: 53, Issue:12 Topics: Actins; Aldehyde Reductase; Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Ganglia, Spinal; Humans; Imidazolidines; Isoenzymes; Mice; Mice, Transgenic; Neural Conduction; Neurons; Protein Kinase C; Reference Values; Substance P	2004
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. Diabetes, 2005, Volume: 54, Issue:1 Topics: Aldehyde Reductase; Animals; Aorta; Arterioles; Cattle; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fructose; Imidazolidines; Male; Motor Neurons; Neural Conduction; Neurons, Afferent; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Tyrosine	2005
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Binding Sites; Crystallography, X-Ray; Holoenzymes; Imidazolidines; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Stereoisomerism; Structure-Activity Relationship; Swine	2005
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex. Journal of medicinal chemistry, 2005, Sep-08, Volume: 48, Issue:18 Topics: Aldehyde Reductase; Binding Sites; Calorimetry; Crystallization; Holoenzymes; Humans; Imidazolidines; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Thermodynamics	2005
The role of polyol pathway in high glucose-induced endothelial cell damages. Diabetes research and clinical practice, 2006, Volume: 73, Issue:3 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehyde Reductase; Carbohydrate Metabolism; Caspase 3; Cells, Cultured; Culture Media; Deoxyguanosine; DNA Fragmentation; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Glucose; Humans; Imidazolidines; Polymers; Signal Transduction; Sorbitol	2006
Effect of the aldose reductase inhibitor fidarestat on experimental diabetic neuropathy in the rat. Diabetologia, 2006, Volume: 49, Issue:12 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehyde Reductase; Animals; Blood Flow Velocity; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Glutathione; Imidazolidines; Male; Mice; Neurons; Rats; Rats, Sprague-Dawley; Sciatic Nerve	2006
Deletion of aldose reductase leads to protection against cerebral ischemic injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:8 Topics: Aldehyde Reductase; Animals; Apoptosis; Behavior, Animal; Brain; Brain Injuries; Brain Ischemia; Caspase 3; Gene Deletion; Imidazolidines; Infarction, Middle Cerebral Artery; Iron; L-Iditol 2-Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Transgenic; Oxidative Stress; Receptors, Transferrin; Transferrin; Tyrosine	2007
High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition. Diabetes, 2007, Volume: 56, Issue:10 Topics: Aldehyde Reductase; Animals; Body Temperature Regulation; Diabetic Neuropathies; Dietary Fats; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Imidazolidines; Mice; Mice, Inbred C57BL; Neurons, Afferent; Obesity; Prediabetic State; Radioimmunoassay; Sensory Thresholds; Touch	2007
Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury. Experimental eye research, 2007, Volume: 85, Issue:5 Topics: Aldehyde Reductase; Animals; Apoptosis; Gene Deletion; Glutamic Acid; Imidazolidines; L-Iditol 2-Dehydrogenase; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neuroglia; Oxidative Stress; Papilledema; Pyrimidines; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells	2007
Fidarestat improves cardiomyocyte contractile function in db/db diabetic obese mice through a histone deacetylase Sir2-dependent mechanism. Journal of hypertension, 2007, Volume: 25, Issue:10 Topics: Aldehyde Reductase; Animals; Diabetes Complications; Enzyme Inhibitors; I-kappa B Proteins; Imidazolidines; In Vitro Techniques; Male; Mice; Mice, Obese; Myocardial Contraction; Myocytes, Cardiac; Naphthalenes; Obesity; Phosphorylation; Pyrones; Sirtuin 1; Sirtuins; Superoxides	2007
Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: implications for the inhibition mechanism. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Aldehyde Reductase; Crystallography, X-Ray; Humans; Imidazolidines; Models, Molecular; Molecular Structure; Protein Binding; Stereoisomerism	2008
Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. International journal of molecular medicine, 2008, Volume: 21, Issue:6 Topics: Aldehyde Reductase; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blood Glucose; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glial Fibrillary Acidic Protein; Imidazolidines; Immunohistochemistry; In Situ Nick-End Labeling; Neuroglia; Ophthalmoscopy; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Retina; Streptozocin; Tyrosine	2008
Prevention of posterior capsular opacification through aldose reductase inhibition. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:2 Topics: Actins; Aldehyde Reductase; Animals; beta-Crystallins; Blotting, Western; Capsulorhexis; Cataract; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Epithelial Cells; Fibroblast Growth Factor 2; Imidazolidines; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Lens Capsule, Crystalline; Microscopy, Fluorescence; NF-kappa B; Organ Culture Techniques; Proliferating Cell Nuclear Antigen; Signal Transduction; Swine	2009
Charge density and electrostatic interactions of fidarestat, an inhibitor of human aldose reductase. Journal of the American Chemical Society, 2009, Aug-12, Volume: 131, Issue:31 Topics: Aldehyde Reductase; Catalytic Domain; Enzyme Inhibitors; Humans; Hydrogen Bonding; Imidazolidines; Models, Molecular; Static Electricity; X-Ray Diffraction	2009
Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase. Journal of molecular graphics & modelling, 2009, Volume: 28, Issue:2 Topics: Aldehyde Reductase; Enzyme Inhibitors; Hydrogen Bonding; Imidazolidines; Molecular Dynamics Simulation; Naphthalenes; Protein Structure, Secondary; Rhodanine; Thiazolidines	2009
The aldose reductase inhibitor fidarestat suppresses ischemia-reperfusion-induced inflammatory response in rat retina. Pharmacology, 2009, Volume: 84, Issue:5 Topics: Aldehyde Reductase; Animals; Female; Gene Expression; Imidazolidines; Inflammation; Intercellular Adhesion Molecule-1; Rats; Rats, Wistar; Reperfusion Injury; Retina; Tumor Necrosis Factor-alpha	2009
The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice. The Journal of pathology, 2010, Volume: 220, Issue:5 Topics: Acute Kidney Injury; Aldehyde Reductase; Animals; Enzyme Inhibitors; Hindlimb; Imidazolidines; Ischemia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Necrosis; Polymers; Signal Transduction	2010
Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. Current eye research, 2010, Volume: 35, Issue:2 Topics: Acridine Orange; Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Fluorophotometry; Fructose; Imidazolidines; Intercellular Adhesion Molecule-1; Leukocytes; Male; Microscopy, Fluorescence; Rats; Rats, Long-Evans; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sorbitol; Vascular Endothelial Growth Factor A	2010
Aldose reductase inhibitor ameliorates renal vascular endothelial growth factor expression in streptozotocin-induced diabetic rats. Yonsei medical journal, 2010, Volume: 51, Issue:3 Topics: Aldehyde Reductase; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazolidines; Kidney; Losartan; Male; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A	2010
Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina. International journal of molecular medicine, 2010, Volume: 26, Issue:1 Topics: Aldehyde Reductase; Animals; Apoptosis; Blotting, Western; Drug Evaluation, Preclinical; Female; Fructose; Glucose; Imidazolidines; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intravenous; L-Iditol 2-Dehydrogenase; Rats; Rats, Wistar; Reperfusion Injury; Retina; Sorbitol	2010
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo. Angiogenesis, 2011, Volume: 14, Issue:2 Topics: Aldehyde Reductase; Angiogenesis Inducing Agents; Animals; Capillaries; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Collagen; Drug Combinations; Endothelial Cells; Humans; Imidazolidines; Interleukin-6; Laminin; Matrix Metalloproteinases; Mice; Neovascularization, Pathologic; Neovascularization, Physiologic; NF-kappa B; Phosphatidylinositol 3-Kinases; Proteoglycans; Proto-Oncogene Proteins c-akt; Rats; Spheroids, Cellular; Umbilical Veins	2011
Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells. The Journal of biological chemistry, 2011, Jul-08, Volume: 286, Issue:27 Topics: Aldehyde Reductase; Caco-2 Cells; Cell Hypoxia; Colonic Neoplasms; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Dinoprostone; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazolidines; Leupeptins; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein-Lysine 6-Oxidase; Proto-Oncogene Proteins c-akt; RNA, Messenger; RNA, Neoplasm; Vascular Endothelial Growth Factor A; Vimentin	2011
Inhibition of aldose reductase prevents colon cancer metastasis. Carcinogenesis, 2011, Volume: 32, Issue:8 Topics: Aldehyde Reductase; Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Colonic Neoplasms; Humans; Imidazolidines; Immunoenzyme Techniques; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering	2011
Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in Lewis rats. Investigative ophthalmology & visual science, 2011, Oct-11, Volume: 52, Issue:11 Topics: Aldehyde Reductase; Animals; Aqueous Humor; Autoimmune Diseases; Cyclooxygenase 2; Cytokines; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Eye Proteins; Fluorescent Antibody Technique, Indirect; Imidazolidines; Lymphocyte Activation; Male; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Retinitis; Retinol-Binding Proteins; T-Lymphocytes; Uveitis	2011
Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice. Investigative ophthalmology & visual science, 2011, Oct-17, Volume: 52, Issue:11 Topics: Adoptive Transfer; Aldehyde Reductase; Animals; Aqueous Humor; Autoimmune Diseases; Blotting, Western; Cells, Cultured; Chemokines; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Eye Proteins; Fluorescent Antibody Technique, Indirect; Imidazolidines; Leukocytes; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Retinol-Binding Proteins; T-Lymphocytes; Uveitis	2011
Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma. Respiratory research, 2011, Nov-03, Volume: 12 Topics: Aldehyde Reductase; Ambrosia; Animals; Asthma; Imidazolidines; Mice; Mice, Knockout; Plant Extracts; Pollen; Rhinitis, Allergic, Seasonal; Treatment Outcome	2011
Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat. PloS one, 2012, Volume: 7, Issue:1 Topics: Acute Kidney Injury; Aldehyde Reductase; Animals; Apoptosis; Blotting, Western; Cytokines; Gene Expression Regulation; Imidazolidines; Kidney; Kidney Tubules; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Neutrophils; Organ Specificity; Polymers; RNA, Messenger; Survival Analysis; Systemic Inflammatory Response Syndrome; Time Factors	2012
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. Biochemical pharmacology, 2012, Apr-01, Volume: 83, Issue:7 Topics: Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Glucose; Blotting, Western; Calcium; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme-Linked Immunosorbent Assay; Fructose; Ganglia, Spinal; Imidazolidines; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Sciatic Nerve; Sorbitol; Spinal Cord; Streptozocin	2012
X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chemico-biological interactions, 2013, Feb-25, Volume: 202, Issue:1-3 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Imidazolidines; Inhibitory Concentration 50; NADP; Naphthalenes	2013
Prevention of allergic rhinitis by aldose reductase inhibition in a murine model. Inflammation & allergy drug targets, 2013, Volume: 12, Issue:3 Topics: Aldehyde Reductase; Allergens; Ambrosia; Animals; Cell Degranulation; Cells, Cultured; Disease Models, Animal; Humans; Imidazolidines; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nasal Mucosa; Pollen; Rhinitis, Allergic, Seasonal; Tryptases	2013
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. PloS one, 2013, Volume: 8, Issue:2 Topics: Airway Remodeling; Aldehyde Reductase; Animals; Asthma; Biomarkers; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypersensitivity; Imidazolidines; Inflammation; Lung; Metaplasia; Mice; Mucus; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1	2013
Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells. Free radical biology & medicine, 2013, Volume: 65 Topics: Acrolein; Aldehyde Reductase; Apoptosis; Blotting, Western; Bronchi; Cells, Cultured; Comet Assay; DNA Damage; Enzyme Inhibitors; Humans; Imidazolidines; Reactive Oxygen Species; Respiratory Mucosa; RNA, Small Interfering; Transfection	2013
Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:15 Topics: Aldehyde Reductase; Animals; Apoptosis Regulatory Proteins; Caco-2 Cells; Cell Death; Cell Survival; Colonic Neoplasms; HT29 Cells; Humans; Imidazolidines; Immunohistochemistry; Mice; Mice, Nude; MicroRNAs; Phosphorylation; RNA-Binding Proteins; Signal Transduction; Transfection; Xenograft Model Antitumor Assays	2013
Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111). FEBS letters, 2013, Nov-15, Volume: 587, Issue:22 Topics: Aldehyde Reductase; Aldo-Keto Reductases; Benzothiazoles; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Flufenamic Acid; Hydrogen Bonding; Imidazolidines; Models, Molecular; Naphthalenes; Oleanolic Acid; Phthalazines; Protein Binding; Protein Structure, Secondary; Rhodanine; Structural Homology, Protein; Thiazolidines; Tryptophan	2013
Therapeutic potential of resveratrol in diabetic complications: In vitro and in vivo studies. Pharmacological reports : PR, 2014, Volume: 66, Issue:5 Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Imidazolidines; Inhibitory Concentration 50; Kidney Function Tests; Lens, Crystalline; Male; Rats; Rats, Wistar; Resveratrol; Stilbenes; Streptozocin	2014
Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats. Diabetes, 2015, Volume: 64, Issue:2 Topics: Adipose Tissue; Animals; Bone Marrow; Cytokines; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fish Oils; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Hypoglycemic Agents; Imidazolidines; Inflammation; Insulin; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neuropeptide Y; Nitric Oxide Synthase Type II; Pain Measurement; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin; Stem Cells; Streptozocin; Thioctic Acid; Tyrosine 3-Monooxygenase	2015
Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice. Cancer letters, 2014, Dec-01, Volume: 355, Issue:1 Topics: Aldehyde Reductase; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; HT29 Cells; Humans; Imidazolidines; Inflammation Mediators; Intestinal Mucosa; Male; Mice, Inbred C57BL; Obesity; Oxidative Stress; Precancerous Conditions; Signal Transduction	2014
Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography-high resolution mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2015, Volume: 102 Topics: Animals; Biotransformation; Blood Proteins; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Female; Imidazolidines; Protein Binding; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution	2015
LC-MS-MS Characterization of Forced Degradation Products of Fidarestat, a Novel Aldose Reductase Inhibitor: Development and Validation of a Stability-Indicating RP-HPLC Method. Journal of chromatographic science, 2015, Volume: 53, Issue:9 Topics: Aldehyde Reductase; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Stability; Hydrolysis; Imidazolidines; Linear Models; Oxidation-Reduction; Photolysis; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2015
Aldose Reductase Inhibitor Fidarestat as a Promising Drug Targeting Autophagy in Colorectal Carcinoma: a Pilot Study. Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:12 Topics: Aldehyde Reductase; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomarkers, Tumor; Cell Line, Tumor; Colorectal Neoplasms; Drug Delivery Systems; Enzyme Inhibitors; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; HT29 Cells; Humans; Imidazolidines; Membrane Proteins; Microtubule-Associated Proteins; Pilot Projects	2015
Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity. Scientific reports, 2017, 06-09, Volume: 7, Issue:1 Topics: Aldehyde Reductase; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cardiotoxicity; Cell Proliferation; Colonic Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Imidazolidines; Mice; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Xenograft Model Antitumor Assays	2017
Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins. Journal of diabetes research, 2017, Volume: 2017 Topics: Aldehyde Reductase; Animals; Catalase; Cell Survival; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Heart; Heme Oxygenase-1; Hyperglycemia; Imidazolidines; Kidney; Membrane Proteins; Mice; Monocytes; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Superoxide Dismutase	2017
Aldose Reductase Inhibitor, Fidarestat Prevents High-fat Diet-induced Intestinal Polyps in Apc Current cancer drug targets, 2018, Volume: 18, Issue:9 Topics: Adenomatous Polyposis Coli Protein; Aldehyde Reductase; Animals; Colonic Neoplasms; Diet, High-Fat; Enzyme Inhibitors; Female; Imidazolidines; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL	2018
Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells. Cancer letters, 2017, 12-28, Volume: 411 Topics: Aldehyde Reductase; AMP-Activated Protein Kinase Kinases; Animals; Cell Line, Tumor; Colonic Neoplasms; HCT116 Cells; Heme Oxygenase-1; HT29 Cells; Humans; Imidazolidines; Mice; Mice, Nude; Mitochondria; NF-E2-Related Factor 2; Organelle Biogenesis; Oxidative Stress; Protein Kinases; Signal Transduction; Xenograft Model Antitumor Assays	2017
Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction. Biochemical pharmacology, 2018, Volume: 150 Topics: Aldehyde Reductase; Animals; Antibiotics, Antineoplastic; Cell Death; Dose-Response Relationship, Drug; Doxorubicin; Female; Human Umbilical Vein Endothelial Cells; Humans; Imidazolidines; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Oxidative Stress	2018
Aldose reductase regulates hyperglycemia-induced HUVEC death via SIRT1/AMPK-α1/mTOR pathway. Journal of molecular endocrinology, 2019, 07-01, Volume: 63, Issue:1 Topics: Aldehyde Reductase; AMP-Activated Protein Kinases; Animals; bcl-2-Associated X Protein; Caspase 3; Cell Death; Cell Survival; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Imidazolidines; Intercellular Adhesion Molecule-1; Male; Mice; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sirtuin 1; THP-1 Cells; TOR Serine-Threonine Kinases; Vascular Cell Adhesion Molecule-1	2019
Identification and characterization of in vitro and in vivo fidarestat metabolites: Toxicity and efficacy evaluation of metabolites. Journal of mass spectrometry : JMS, 2021, Volume: 56, Issue:2 Topics: Aldehyde Reductase; Animals; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Female; Humans; Imidazolidines; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2021