fidarestat has been researched along with epalrestat in 7 studies
| Studies (fidarestat) | Trials (fidarestat) | Recent Studies (post-2010) (fidarestat) | Studies (epalrestat) | Trials (epalrestat) | Recent Studies (post-2010) (epalrestat) |
|---|---|---|---|---|---|
| 97 | 3 | 33 | 243 | 22 | 100 |
| Protein | Taxonomy | fidarestat (IC50) | epalrestat (IC50) |
|---|---|---|---|
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | 7.9635 | |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | 6.5 | |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | 0.1836 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.5596 | |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | 2.6 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 0.1335 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 0.17 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.085 | |
| Aldo-keto reductase family 1 member A1 | Sus scrofa (pig) | 1.5 | |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | 1.5 | |
| Aldo-keto reductase family 1 member B7 | Rattus norvegicus (Norway rat) | 1.198 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Demopoulos, VJ; Nicolaou, I | 1 |
| Hotta, N; Kawamura, T; Sakakibara, F; Sakamoto, N; Sano, T; Sasaki, H; Suzuki, K | 1 |
| Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K | 1 |
| Hotta, N | 1 |
| Yasuda, H | 1 |
| Ling, B; Liu, C; Liu, Y; Suo, Y; Wang, Z; Yu, Z; Zhang, R | 1 |
| Chen, S; Chen, Y; Hu, X; Li, Q; Li, Z; Wang, Z; Xie, W; Zhai, J; Zhang, H; Zhang, L; Zhao, Y; Zheng, X | 1 |
2 review(s) available for fidarestat and epalrestat
| Article | Year |
|---|---|
[Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor].
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetic Angiopathies; Drug Design; Humans; Imidazolidines; Polymers; Polymorphism, Genetic; Pyrazines; Rhodanine; Spiro Compounds; Thiazolidines | 2005 |
[Pathophysiology and treatment for diabetic neuropathy].
Topics: Aldehyde Reductase; Diabetic Nephropathies; Enzyme Inhibitors; Genetic Therapy; Humans; Hypoglycemic Agents; Imidazolidines; Neuralgia; Neurologic Examination; Regenerative Medicine; Rhodanine; Thiazolidines | 2009 |
1 trial(s) available for fidarestat and epalrestat
| Article | Year |
|---|---|
Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils.
Topics: Adult; Aldehyde Reductase; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inositol; Linear Models; Male; Neutrophils; Reference Values; Rhodanine; Sorbitol; Thiazolidines | 1999 |
4 other study(ies) available for fidarestat and epalrestat
| Article | Year |
|---|---|
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Topics: Acetates; Aldehyde Reductase; Animals; Diabetes Mellitus; Enzyme Inhibitors; Female; Fructose; Male; Monosaccharides; Oxidation-Reduction; Proteins; Pyrroles; Rats; Rats, Inbred F344; Serum Albumin; Structure-Activity Relationship | 2003 |
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Fasting; Female; Glycated Hemoglobin; Humans; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Rhodanine; Sciatic Nerve; Sex Factors; Sorbitol; Thiazolidines | 2001 |
Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase.
Topics: Aldehyde Reductase; Enzyme Inhibitors; Hydrogen Bonding; Imidazolidines; Molecular Dynamics Simulation; Naphthalenes; Protein Structure, Secondary; Rhodanine; Thiazolidines | 2009 |
Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111).
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Benzothiazoles; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Flufenamic Acid; Hydrogen Bonding; Imidazolidines; Models, Molecular; Naphthalenes; Oleanolic Acid; Phthalazines; Protein Binding; Protein Structure, Secondary; Rhodanine; Structural Homology, Protein; Thiazolidines; Tryptophan | 2013 |