fibrinopeptide-b has been researched along with acid-citrate-dextrose* in 1 studies
1 other study(ies) available for fibrinopeptide-b and acid-citrate-dextrose
Article | Year |
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A simple plasma anticoagulant-exchange method to increase the recovery of factor VIII in therapeutic concentrates.
Donor blood, primarily anticoagulated by acid citrate dextrose formula A (ACD-A), was separated by means of the HemaScience Autopheresis C plasmapheresis device. The citrated plasma was collected directly into a solution of heparin and calcium chloride to achieve a final plasma-ionised calcium concentration of approximately 2 mM, and a heparin concentration of 1.0 IU/ml. Heparin at this concentration provided adequate anticoagulation, and did not result in insoluble cryoprecipitates. Three pairs of donor-matched 4-kg plasma pools (anticoagulant-exchanged variant and ACD-A-anticoagulated control) were constructed and subsequently fractionated to an intermediate stage. The mean recovery of factor VIII from 3 anticoagulant-exchanged pools (394 IU/kg) was 23% greater than the mean recovery from the matched control pools (319 IU/kg). This increased recovery was not achieved at the expense of specific activity. Topics: Anticoagulants; Calcium; Citric Acid; Factor VIII; Fibrin Fibrinogen Degradation Products; Fibrinopeptide A; Fibrinopeptide B; Glucose; Heparin; Humans; Peptide Fragments; Plasmapheresis | 1990 |