fibrinopeptide-a and defibrotide

fibrinopeptide-a has been researched along with defibrotide* in 1 studies

Other Studies

1 other study(ies) available for fibrinopeptide-a and defibrotide

ArticleYear
Hemodialysis with defibrotide: effects on coagulation parameters.
    The International journal of artificial organs, 1992, Volume: 15, Issue:10

    In a crossover study conducted with eight uremic patients maintained on hemodialysis, the Authors compared the effects of heparin (100 IU/kg at the start of dialysis) and defibrotide (400 mg at the start, repeated at 2 hours of ongoing dialysis) on the parameters of blood coagulation (VIII:C, AT III, TAT, PC antigen and activity, PS, and FPA), each being assessed before dialysis and at 2, 3 and 4 hours of the ongoing procedure. Heparin-assisted dialysis resulted in a significant rise of VIII:C and AT III; with defibrotide, instead, there was evidence of thrombin activation (increased FPA and TAT). PC levels were raised with both dialysis modalities; however, PC activity and PS levels were increased only in defibrotide-assisted dialysis. There were no adverse reactions or evidence of fibrin formation. These results confirm the antithrombotic activity of defibrotide in the course of dialysis and indicate that this action is independent of thrombin neutralization.

    Topics: Antithrombin III; Blood Coagulation; Factor VIII; Fibrinolytic Agents; Fibrinopeptide A; Heparin; Humans; Peptide Hydrolases; Polydeoxyribonucleotides; Protein C; Protein S; Renal Dialysis

1992