fibrin and titanium-dioxide

Polymer-free drug-eluting stents (DES) may overcome the shortcomings of polymer-based DES. The aim of this study was to examine the effect of the polymer-free TiO2 film-coated stent with abciximab or alpha lipoic acid in a porcine coronary overstretch restenosis model.. Pigs were randomized into four groups in which the coronary arteries (24 pigs, 48 coronaries in each group) had TiO2 film-coated stent with abciximab (TCA, n = 12), TiO2 film-coated stent with alpha lipoic acid (TCALA, n = 12), biolimus A9-eluting stents with biodegradable polymer (BES, n = 12), and TiO2 film-coated stent (TCstent, n = 12). Histopathologic analysis was performed at 28 days after stenting.. There was no significant difference in the injury score and internal elastic lamina (IEL) among the four groups. There were significant differences in the lumen area, neointima area, percent area stenosis, fibrin score, and inflammation score among the four groups [2.7 ± 1.0mm(2), 2.6 ± 0.94 mm(2), 48.9 ± 16.25%, 1.0 (range 0.0-3.0), 1.0 (range 0.0-2.0) in TCA stent group vs. 2.7 ± 1.24 mm(2), 2.9 ± 0.83 mm(2), 53.5 ± 17.19%, 1.0 (range 0.0-2.0), 1.0 (range 0.0-2.0) in TCALA stent group vs. 2.7 ± 1.30 mm(2), 2.6 ± 1.06 mm(2), 50.1 ± 23.20%, 2.0 (range 1.0-3.0), 2.0 (range 1.0-3.0) in BES group vs. 1.7 ± 0.63 mm(2), 3.3 ± 0.58 mm(2), 60.2 ± 10.12%, 0.5 (range 0.0-2.0), 1.0 (range 0.0-2.0) in TC stent group, respectively].. TCA and TCALA are more effective to reduce neointimal hyperplasia compared to TC. Moreover, fibrin and inflammation scores are significantly lower in TCA and TCALA than BES in porcine coronary restenosis model.

Topics: Abciximab; Animals; Antibodies, Monoclonal; Coronary Restenosis; Disease Models, Animal; Drug-Eluting Stents; Fibrin; Hyperplasia; Immunoglobulin Fab Fragments; Inflammation; Male; Neointima; Percutaneous Coronary Intervention; Polymers; Swine; Thioctic Acid; Time Factors; Titanium; Treatment Outcome

The aim of this in vitro study was to evaluate the influence of 3 different implant surface treatments on the extension of human blood clot formation. For this purpose, the 3 types of surfaces (as-machined; test group 1, titanium discs blasted with aluminum oxide particles and washed with nitric acid; test group 2, titanium discs blasted with titanium oxide particles and washed with maleic acid) obtained were evaluated regarding topography and blood clot extension formation. Data suggest that different treatments applied on implant surfaces confer different mechanical and chemical properties, and that titanium discs blasted with aluminum oxide particles and washed with nitric acid exhibited the widest blood clot extension (P < .001).

Topics: Acid Etching, Dental; Aluminum Oxide; Blood Coagulation; Coated Materials, Biocompatible; Fibrin; Humans; Nitric Acid; Statistics, Nonparametric; Surface Properties; Titanium