fibrin and methacrylamide

Platelet-rich plasma (PRP) has attracted much attention for the treatment of articular cartilage defects or wounds due to its intrinsic content of growth factors relevant for tissue repair. However, the short residence time of PRP in vivo, due to the action of lytic enzymes, its weak mechanical properties and the consequent short-term release of bioactive factors has restricted its application and efficacy. The present work aimed at designing new formulation strategies for PRP, based on the use of platelet concentrate (PC)-loaded hydrogels or interpenetrating polymer networks, directed at improving mechanical stability and sustaining the release of bioactive growth factors over a prolonged time-span. The interpenetrating hydrogels comprised two polymer networks interlaced on a molecular scale: (

Topics: Acrylamides; Adhesiveness; Animals; Biocompatible Materials; Cartilage, Articular; Fibrin; Horses; Hyaluronic Acid; Hydrogels; Intercellular Signaling Peptides and Proteins; Platelet-Rich Plasma; Polyethylene Glycols; Polymers; Rheology; Sulfones; Temperature; Wound Healing