fg-9041 and cyclo(prolylglycyl)

Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have first demonstrated that DNQX, an inhibitor of AMPA receptors, and K252A, an ihibitor of Trk receptors, prevented the anxiolytic effect of CPG, which confirms the formulated hypothesis.

Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain-Derived Neurotrophic Factor; Carbazoles; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Peptides, Cyclic; Protein-Tyrosine Kinases; Quinoxalines; Receptors, AMPA