fexofenadine and itraconazole

fexofenadine has been researched along with itraconazole in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (54.55)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cha, IJ; Choi, YG; Hong, WS; Lee, SS; Nguyen, PM; Shin, JG; Shon, JH; Yoon, YR1
Shimizu, M; Sugawara, K; Tateishi, T; Uno, T3
Miura, M; Suzuki, T; Tateishi, T; Uno, T1
Miura, M; Uno, T1
Srinivas, NR1
Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N1

Reviews

2 review(s) available for fexofenadine and itraconazole

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Clinical pharmacokinetics of fexofenadine enantiomers.
    Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:1

    Topics: Antifungal Agents; Calcium Channel Blockers; Drug Interactions; Histamine H1 Antagonists; Humans; Itraconazole; Stereoisomerism; Terfenadine; Verapamil

2010

Trials

6 trial(s) available for fexofenadine and itraconazole

ArticleYear
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism.
    Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:2

    Topics: Adult; Antifungal Agents; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Interactions; Genes, MDR; Haplotypes; Histamine H1 Antagonists; Humans; Itraconazole; Male; Polymorphism, Genetic; Terfenadine

2005
Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.
    British journal of clinical pharmacology, 2006, Volume: 61, Issue:5

    Topics: Adult; Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Diltiazem; Drug Administration Schedule; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Itraconazole; Male; Terfenadine; Time Factors

2006
Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.
    British journal of clinical pharmacology, 2006, Volume: 62, Issue:3

    Topics: Adult; Antifungal Agents; Cross-Over Studies; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Itraconazole; Japan; Male; Terfenadine

2006
Lack of dose-dependent effects of itraconazole on the pharmacokinetic interaction with fexofenadine.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:11

    Topics: Administration, Oral; Adult; Aged; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Itraconazole; Male; Middle Aged; Terfenadine

2006
The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers.
    British journal of clinical pharmacology, 2008, Volume: 65, Issue:5

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Drug Combinations; Drug Interactions; Female; Humans; Itraconazole; Male; Terfenadine

2008
Prediction of area under the curve for a p-glycoprotein, a CYP3A4 and a CYP2C9 substrate using a single time point strategy: assessment using fexofenadine, itraconazole and losartan and metabolites.
    Drug development and industrial pharmacy, 2016, Volume: 42, Issue:6

    Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Itraconazole; Losartan; Polypharmacy; Terfenadine

2016

Other Studies

3 other study(ies) available for fexofenadine and itraconazole

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
    Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:4

    Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil

2020