fexofenadine and cyclosporine

fexofenadine has been researched along with cyclosporine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's10 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benet, LZ; Christians, U; Silverman, JA; Soldner, A; Susanto, M; Wacher, VJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Avdeef, A; Tam, KY1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dresser, GK; Kim, RB; Schwarz, UI; Wilkinson, GR1
Milne, RW; Ngo, SN; Turkanovic, J1
Fukuda, K; Horie, T; Shitara, Y; Suzuki, K1
Dahlgren, D; Lennernäs, H; Roos, C; Sjögren, E1

Reviews

2 review(s) available for fexofenadine and cyclosporine

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for fexofenadine and cyclosporine

ArticleYear
Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects.
    Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:1

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Drug Administration Schedule; Enzyme Induction; Female; Gene Expression Regulation; Genes, MDR; Humans; Hypericum; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Plant Preparations; Reference Values; Terfenadine

2003

Other Studies

11 other study(ies) available for fexofenadine and cyclosporine

ArticleYear
Grapefruit juice activates P-glycoprotein-mediated drug transport.
    Pharmaceutical research, 1999, Volume: 16, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Biological Availability; Biological Transport, Active; Caco-2 Cells; Cells, Cultured; Citrus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diuretics, Osmotic; Dogs; Humans; Kidney; Mannitol; Oxidoreductases, N-Demethylating; Pharmacokinetics; Vinblastine

1999
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Effect of St John's wort on the disposition of fexofenadine in the isolated perfused rat liver.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:8

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Cyclosporine; Drug Interactions; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Hypericum; Liver; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Terfenadine

2009
Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats.
    Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:7

    Topics: Administration, Oral; Animals; Anti-Allergic Agents; Antifungal Agents; Cyclosporine; Gene Expression Regulation; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestines; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; RNA, Messenger; Terfenadine

2012
Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data.
    Molecular pharmaceutics, 2015, Jun-01, Volume: 12, Issue:6

    Topics: Budesonide; Colon; Cyclosporine; Fenofibrate; Humans; Intestinal Absorption; Intestinal Mucosa; Lisdexamfetamine Dimesylate; Metoprolol; Nifedipine; Pyrimidines; Ranitidine; Rivastigmine; Sumatriptan; Terfenadine; Theophylline

2015