fexinidazole has been researched along with nifurtimox in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fairlamb, AH; Oza, SL; Patterson, S; Read, KD; Sokolova, AY; Wyllie, S | 1 |
| Brun, R; Diederich, F; Giroud, M; Haap, W; Kaiser, M; Kuhn, B; Kuratli, C; Martin, RE; Saint-Auret, S; Schirmeister, T; Schuler, F | 1 |
| Azas, N; Boudot, C; Bourgeade-Delmas, S; Castera-Ducros, C; Cohen, A; Courtioux, B; Crozet, MD; Fairlamb, A; Fersing, C; Hutter, S; Moreau, A; Pedron, J; Pratviel, G; Primas, N; Rathelot, P; Sournia-Saquet, A; Stigliani, JL; Valentin, A; Vanelle, P; Verhaeghe, P; Wyllie, S | 1 |
| Azas, N; Basmaciyan, L; Belle Mbou, V; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, É; Casanova, M; Castera-Ducros, C; Cohen, A; Courtioux, B; Fairlamb, AH; Fersing, C; Hutter, S; Laget, M; Milne, R; Pedron, J; Piednoel, M; Primas, N; Rathelot, P; Since, M; Sournia-Saquet, A; Valentin, A; Vanelle, P; Verhaeghe, P; Wyllie, S | 1 |
| Azas, N; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, É; Brossas, JY; Castera-Ducros, C; Corvaisier, S; Courtioux, B; Destere, A; Fairlamb, AH; Fersing, C; Hutter, S; Malzert-Fréon, A; Mazier, D; Paoli-Lombardo, R; Paris, L; Pedron, J; Pinault, E; Primas, N; Rathelot, P; Seguy, L; Since, M; Sournia-Saquet, A; Stigliani, JL; Valentin, A; Vanelle, P; Verhaeghe, P; Wyllie, S | 1 |
| Avery, VM; Charman, SA; Chatelain, E; Cornwall, S; Denny, WA; Francisco, AF; Keenan, M; Kelly, JM; Marshall, AJ; O'Connor, PD; Perez, CJ; Read, KD; Riley, J; Sykes, ML; Thompson, AM; Thompson, RCA; White, KL; Zulfiqar, B | 1 |
| Jennings, FW | 1 |
| Moreno, SN; Yan, W | 1 |
| Barrett, MP | 1 |
| Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR | 1 |
| Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P | 1 |
| Berriman, M; Fairlamb, AH; Foth, BJ; Kelner, A; Sokolova, AY; Wyllie, S | 1 |
| Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL | 1 |
| Badibabi, LK; Bardonneau, C; Bernhard, S; Blesson, S; Bonama, AK; Dama, FR; Delhomme, S; Heradi, JA; Ilunga, M; Kalonji, WM; Kuziena, W; Lubaki, JF; Lukula, PK; Lumbala, C; Mandula, G; Mbembo, HM; Mesu, VKBK; Mordt, OV; Ngima, PN; Scherrer, B; Simon, F; Solomo, JLL; Strub-Wourgaft, N; Tarral, A; Tete, DN; Vuvu, SL | 1 |
| Akl, EA; Barrett, MP; Bergman, H; Chappuis, F; Erphas, O; Franco, JR; Kadima Ebeja, A; Kazumba, L; Lejon, V; Lindner, AK; Mwamba, E; Priotto, G; Seixas, J; Simarro, P; Villanueva, G | 1 |
| Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Mota, SLA; Pereira, DE | 1 |
2 review(s) available for fexinidazole and nifurtimox
| Article | Year |
|---|---|
Potential new drugs for human African trypanosomiasis: some progress at last.
Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2011 |
1 trial(s) available for fexinidazole and nifurtimox
| Article | Year |
|---|---|
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial.
Topics: Administration, Oral; Adult; Democratic Republic of the Congo; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2018 |
13 other study(ies) available for fexinidazole and nifurtimox
| Article | Year |
|---|---|
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Humans; Mice; Nifurtimox; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; Female; Humans; Leishmania donovani; Ligands; Mice; Microsomes, Liver; Molecular Structure; Nitriles; Plasmodium falciparum; Protozoan Proteins; Rats; Structure-Activity Relationship; Swine; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2018 |
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Leishmania donovani; Models, Molecular; Molecular Structure; Nitroreductases; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2018 |
Nongenotoxic 3-Nitroimidazo[1,2-
Topics: | 2019 |
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
Topics: Dose-Response Relationship, Drug; Molecular Structure; Nitroimidazoles; Parasitic Sensitivity Tests; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2020 |
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Topics: Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination; Female; Ketoconazole; Metronidazole; Mice; Nifurtimox; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.
Topics: Animals; Cells, Cultured; DNA Replication; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance; Gamma Rays; Muscle, Skeletal; Nifurtimox; Nitroimidazoles; Rats; Reproduction; Thiadiazoles; Trypanocidal Agents; Trypanosoma cruzi; Uracil | 1998 |
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi.
Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Parasitemia; Pentamidine; Rats; Rats, Wistar; Suramin; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis | 2013 |
Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.
Topics: Antiprotozoal Agents; Drug Resistance; Genome, Protozoan; Nifurtimox; Nitroimidazoles; Nitroreductases; Parasitic Sensitivity Tests; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Trypanosoma brucei brucei | 2016 |
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiprotozoal Agents; Child; Child, Preschool; Eflornithine; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Trypanosoma brucei gambiense; Trypanosomiasis, African; World Health Organization; Young Adult | 2020 |
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment.
Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Humans; Inhibitory Concentration 50; Mice; Neglected Diseases; Nifurtimox; Nitro Compounds; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Sulfones | 2021 |