ferrous-fumarate and monomethylarsonic-acid

To examine the role of iron and zinc in arsenic excretion and metabolism in children.. An analysis of urinary arsenic (UAs) concentrations from a double-blind randomized trial originally testing the efficacy of iron and zinc for lowering blood lead levels in children. A 2 × 2 factorial design was used, with children randomized individually, stratified by sex and classroom, to receive 30?mg ferrous fumarate (n?=?148), 30?mg zinc oxide (n?=?144), iron and zinc together (n?=?148), or placebo (n?=?151). Of the 602 children enrolled, 527 completed the 6-month treatment, and 485 had both baseline and final UAs values. The baseline total UAs concentration ranged from 3.2 to 215.9?µg/L.. At baseline, children in the highest tertile of serum ferritin concentration had higher excretion of dimethylarsinic acid (DMA; 1.93?±?0.86%; P?

Topics: Arsenic; Arsenicals; Cacodylic Acid; Child; Dietary Supplements; Double-Blind Method; Environmental Exposure; Female; Ferritins; Ferrous Compounds; Humans; Male; Mexico; Trace Elements; Water; Water Supply; Zinc Oxide