ferrous-citrate and tetraphenylphosphonium

ferrous-citrate has been researched along with tetraphenylphosphonium* in 1 studies

Other Studies

1 other study(ies) available for ferrous-citrate and tetraphenylphosphonium

ArticleYear
Oxidative damage of mitochondria induced by Fe(II)citrate is potentiated by Ca2+ and includes lipid peroxidation and alterations in membrane proteins.
    Archives of biochemistry and biophysics, 1994, Volume: 308, Issue:1

    Isolated rat liver mitochondria exposed to Fe(II)citrate undergo lipid peroxidation and alterations in membrane proteins. These processes were associated with irreversible decrease in membrane potential and mitochondrial swelling. Lipid peroxidation was evidenced by the production of thiobarbituric acid-reactive substances and also by the reaction of these products with membrane proteins, through the formation of Schiff bases. Alterations in membrane proteins were also characterized by the loss of specific proteins that could be recovered from the mitochondrial supernatant as shown by SDS-polyacrylamide gel electrophoresis. The degree of both lipid peroxidation and alterations in membrane proteins were diminished by EGTA, ruthenium red, or dibucaine. This strongly indicates that Ca2+ potentiates the oxidative damage of mitochondria exposed to Fe(II)citrate.

    Topics: Animals; Calcium; Citric Acid; Drug Synergism; Egtazic Acid; Ferrous Compounds; Intracellular Membranes; Iron; Kinetics; Lipid Peroxidation; Membrane Potentials; Membrane Proteins; Mitochondria, Liver; Mitochondrial Swelling; Onium Compounds; Organophosphorus Compounds; Oxygen Consumption; Rats; Rats, Wistar; Ruthenium Red; Time Factors

1994