ferrostatin-1 has been researched along with ferric-chloride* in 1 studies
1 other study(ies) available for ferrostatin-1 and ferric-chloride
| Article | Year |
|---|---|
Ferrostatin-1 obviates seizures and associated cognitive deficits in ferric chloride-induced posttraumatic epilepsy via suppressing ferroptosis.
Posttraumatic epilepsy (PTE) is a prevalent complication of brain trauma. Current anti-epileptic drugs available do not have satisfactory response to PTE. It is of desperate need to explore novel therapeutic approaches for curing PTE. Our prior work revealed that ferroptosis, a recently discovered mode of cell death, occurs in rodent model of PTE. In the present study, we aimed to further investigate the effect of ferrostatin-1 (Fer-1), a specific ferroptosis inhibitor, on seizure behavior and cognitive deficit in a mouse model of PTE. The preparation of PTE was performed by stereotaxical injection in the somatosensory cortex region of 50 mM FeCl Topics: Animals; Chlorides; Cognition; Cognitive Dysfunction; Cyclohexylamines; Ferric Compounds; Ferroptosis; Humans; Mice; Phenylenediamines; Seizures | 2022 |