ferric-ammonium-citrate and erastin

Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective against AKI because of its antiapoptotic and anti-inflammatory properties. However, the role of HO-1 in regulating ferroptosis is unclear. The purpose of this study was to elucidate the role of HO-1 in regulating ferroptotic cell death in renal proximal tubule cells (PTCs). Immortalized PTCs obtained from HO-1

Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Carbolines; Cell Death; Cell Line; Cyclohexylamines; Deferoxamine; Dose-Response Relationship, Drug; Ferric Compounds; Glutathione; Heme Oxygenase-1; Iron Chelating Agents; Kidney Tubules, Proximal; Membrane Proteins; Mice, Knockout; Phenylenediamines; Piperazines; Quaternary Ammonium Compounds; Signal Transduction; Time Factors