fentanyl and norfentanyl

fentanyl has been researched along with norfentanyl in 66 studies

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (9.09)18.2507
2000's14 (21.21)29.6817
2010's32 (48.48)24.3611
2020's14 (21.21)2.80

Authors

AuthorsStudies
Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B1
McMullin, M; Rieders, MF; Schulman, S; Silverstein, JH; Zahl, K1
Feierman, DE2
Guengerich, FP; Tateishi, T; Wood, AJ; Wood, M1
Guengerich, FP; Krivoruk, Y; Tateishi, T; Ueng, YF; Wood, AJ; Wood, M1
Feierman, DE; Lasker, JM1
Andurkar, SV; Clark, CR; DeRuiter, J; Huber, T; Valaer, AK1
Day, J; Lugo, RA; Slawson, M; Wilkins, D1
Altuntas, TG; Hoffer, C; Kharasch, ED; Whittington, D1
Carpenter, JW; Hunter, RP; Isaza, R; Koch, DE1
Hoffer, C; Kharasch, ED; Whittington, D2
Backer, R; Poklis, A1
Ekman, L; Huynh, NH; Johansson, M; Tyrefors, N1
Gock, SB; Jannetto, PJ; Jentzen, JM; Jin, M; Wong, SH1
Kuepper, U; Madea, B; Musshoff, F; Trafkowski, J1
Coopman, V; Cordonnier, J; Pien, K; Van Varenbergh, D1
Behonick, GS; Flomenbaum, MA; Hull, MJ; Juhascik, M; Mazur, F1
Laine, K; Neuvonen, M; Neuvonen, PJ; Olkkola, KT; Saari, TI1
Callery, PS; Kraner, JC; Peer, CJ; Shakleya, DM; Younis, IR1
Godderis, L; Menten, JJ; Poels, KL; Van Nimmen, NF; Veulemans, HA1
Carson, HJ; Dudley, MH; Garg, U; Knight, LD1
Tytgat, J; Verplaetse, R2
Alvarez, I; Bermejo, AM; Cabarcos, P; Fernández, P; Strano-Rossi, S; Tabernero, MJ1
Christians, U; Clavijo, CF; Cromie, M; Galinkin, JL; Hoffman, KL; Schniedewind, B; Thomas, JJ1
Haefeli, WE; Jantos, R; König, SK; Mahlke, N; Mikus, G; Skopp, G; Weiss, J; Ziesenitz, VC1
Endres, GW; Fantegrossi, WE; James, LP; Kennedy, PD; Knight, LD; Marraffa, JM; Moran, CL; Moran, JH; Patton, AL; Pulla, S; Rusch, NJ; Seely, KA1
Doi, M; Kawakami, J; Naito, T; Sato, S; Tanaka, N; Yagi, T1
Bista, SR; Hardy, J; Haywood, A; Lobb, M; Norris, R; Tapuni, A2
Mahlke, NS; Mikus, G; Skopp, G; Ziesenitz, V1
Haefeli, WE; König, SK; Mahlke, NS; Mikus, G; Skopp, G; Ziesenitz, VC1
Bista, SR; Good, P; Hardy, J; Haywood, A; Lobb, M; Norris, R; Tapuni, A1
Arbefeville, E; Chrostowski, L; Devers, K; Hair, L; Mainland, M; Merves, M; Pearson, J; Poklis, A; Poklis, J; Wolf, C1
Chiravuri, S; Kaye, AD; Ruan, X3
Backer, R; Cummings, OT; Enders, JR; McIntire, GL; Poklis, A1
ElSohly, MA; Godfrey, M; Gul, SW; Gul, W; Stamper, B1
Cummings, OT; Enders, J; McIntire, GL1
Goggin, MM; Janis, GC; Nguyen, A1
Brooker, IT; Dolinak, D; Gilson, TP; Kaspar, CK; Lavins, ES; Mazzola, CD; Perch, S; Schueler, HE; Sofalvi, S1
Chatterton, CN; Scott-Ham, M1
Gill, CG; Hessels, AJ; Krogh, ET; Palaty, J; Vandergrift, GW1
Avedschmidt, S; Gupta, A; Isenschmid, D; Kesha, K; Moons, D; Schmidt, C1
Palmquist, KB; Swortwood, MJ2
Doberentz, E; Geile, J; Kraemer, M; Maas, A; Madea, B1
Anders, S; Andresen-Streichert, H; Falckenberg, M; Iwersen-Bergmann, S; Mueller, A; Otto, B; Reiter, A1
Apollonio, LG; Brooker, IT; Clyde, CL; Gilson, TP; Goggin, C; Kaspar, CK; Kucmanic, J; Lavins, ES; Marshall, B; Mazzola, CD; Mitchell-Mata, CL; Moore, D; Rico, RN; Sofalvi, S1
Bardenheuer, HJ; Burhenne, J; Geist, MJP; Mikus, G; Skopp, G; Ziesenitz, VC1
Amante, E; Bigiarini, R; Di Corcia, D; McKnight, C; Palamar, JJ; Salomone, A; Vincenti, M; Vinsick, L1
Gleba, J; Kim, J1
Arroyo-Mora, LE; Bailey, K; Cox, J; DelTondo, J; Field, A; Gebhardt, M; Kraner, J; Ott, C; Train, A1
Chen, H; Feng, S; Li, Z; Liu, K; Wang, P1
Hobelmann, JG; Huhn, AS; Oyler, GA; Strain, EC1
Bisch, M; Gambier, N; Gibaja, V; Javot, L; Jouzeau, JY; Jung, J; Kolodziej, A; Pape, E; Scala-Bertola, J1
Field, TA; Saia, K; Wanar, A1
Bian, J; Chen, Y; Duan, H; Li, L; Liu, L; Lyu, L; Xu, Z; Yu, X; Zhang, Y1
Carotti, A; Cirrincione, M; Mercolini, L; Protti, M; Sardella, R; Varfaj, I1
Al-Qurain, AA; Mackenzie, L; Roberts, MS; Wiese, MD; Williams, DB1
Basu, S; Bernstein, S; Flood, JG; Griggs, D; Khaliq, T; Leffert, L; Mahowald, G; Siegel, M; Uljon, S1
Brousa, E; Kevrekidis, DP; Mastrogianni, O; Orfanidis, A; Raikos, N; Zagelidou, H1
Clinton Frazee, C; Garg, U; Shell, S1

Trials

7 trial(s) available for fentanyl and norfentanyl

ArticleYear
Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:3

    Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Fentanyl; Humans; Injections, Intravenous; Intestinal Absorption; Male; Miosis; Quinidine; Time Factors

2004
Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.
    Anesthesiology, 2004, Volume: 101, Issue:3

    Topics: Adult; Analgesics, Opioid; Antibiotics, Antitubercular; Antiemetics; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Chromatography, High Pressure Liquid; Citrus; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Female; Fentanyl; Food-Drug Interactions; Half-Life; Humans; Intestines; Liver; Male; Oxidoreductases, N-Demethylating; Pupil; Rifampin; Spectrometry, Mass, Electrospray Ionization; Troleandomycin

2004
Urine concentrations of fentanyl and norfentanyl during application of Duragesic transdermal patches.
    Journal of analytical toxicology, 2004, Volume: 28, Issue:6

    Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; Fentanyl; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Immunoenzyme Techniques; Pain

2004
Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl.
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:1

    Topics: Administration, Oral; Analgesics, Opioid; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Inhibitors; Female; Fentanyl; Fluconazole; Humans; Injections, Intravenous; Male; Pyrimidines; Tissue Distribution; Triazoles; Voriconazole

2008
Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beings.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 113, Issue:1

    Topics: Adult; Analgesics, Opioid; Biological Transport; Cross-Over Studies; Female; Fentanyl; Genotype; HEK293 Cells; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Middle Aged; Organic Anion Transporters; Polymorphism, Single Nucleotide; Prospective Studies; Rifampin

2013
Pharmacokinetic interaction of intravenous fentanyl with ketoconazole.
    Journal of clinical pharmacology, 2015, Volume: 55, Issue:6

    Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Fentanyl; Healthy Volunteers; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Naloxone; Prospective Studies; Tandem Mass Spectrometry; Young Adult

2015
Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients.
    Scientific reports, 2019, 10-10, Volume: 9, Issue:1

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Cytochrome P-450 CYP3A; Female; Fentanyl; Humans; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Neoplasms; Palliative Care; Transdermal Patch

2019

Other Studies

59 other study(ies) available for fentanyl and norfentanyl

ArticleYear
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
    Journal of medicinal chemistry, 2019, 11-14, Volume: 62, Issue:21

    Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation

2019
An analysis of the duration of fentanyl and its metabolites in urine and saliva.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:3

    Topics: Adult; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Saliva; Substance Abuse Detection; Time Factors

1993
Identification of cytochrome P450 3A1/2 as the major P450 isoform responsible for the metabolism of fentanyl by rat liver microsomes.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:5

    Topics: Anesthetics, Intravenous; Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; GABA Modulators; Gas Chromatography-Mass Spectrometry; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Sodium Chloride

1996
Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol.
    Biochemical pharmacology, 1995, Nov-27, Volume: 50, Issue:11

    Topics: Analgesics, Opioid; Biotransformation; Dealkylation; Drug Monitoring; Fentanyl; Humans; In Vitro Techniques; Microsomes, Liver; Phenylacetates; Phenylethyl Alcohol; Tritium

1995
Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:1

    Topics: Analgesics, Opioid; Animals; Antibodies; Antibody Specificity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; Humans; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Norpregnenes; Rabbits; Sufentanil; Troleandomycin

1996
Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9

    Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Tolbutamide

1996
Development of a gas chromatographic-mass spectrometric drug screening method for the N-dealkylated metabolites of fentanyl, sufentanil, and alfentanil.
    Journal of chromatographic science, 1997, Volume: 35, Issue:10

    Topics: Alfentanil; Analgesics, Opioid; Drug Residues; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Sensitivity and Specificity; Sufentanil

1997
The effect of paracetamol (acetaminophen) on fentanyl metabolism in vitro.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Intravenous; Animals; Biotransformation; Fentanyl; Humans; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley

2000
Analysis of fentanyl and norfentanyl in human plasma by liquid chromatography-tandem mass spectrometry using electrospray ionization.
    Journal of analytical toxicology, 2003, Volume: 27, Issue:7

    Topics: Adolescent; Child; Child, Preschool; Chromatography, High Pressure Liquid; Fentanyl; Humans; Infant; Sensitivity and Specificity; Specimen Handling; Spectrometry, Mass, Electrospray Ionization

2003
Simultaneous extraction and quantitation of fentanyl and norfentanyl from primate plasma with LC/MS detection.
    Journal of pharmaceutical and biomedical analysis, 2004, Feb-18, Volume: 34, Issue:3

    Topics: Animals; Chromatography, Liquid; Fentanyl; Mass Spectrometry; Primates

2004
Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate.
    Anesthesiology, 2004, Volume: 101, Issue:3

    Topics: Administration, Oral; Aged; Aging; Analgesics, Opioid; Area Under Curve; Chromatography, High Pressure Liquid; Female; Fentanyl; Humans; Intestinal Absorption; Male; Middle Aged; Mucous Membrane; Pupil; Spectrometry, Mass, Electrospray Ionization

2004
Determination of fentanyl in human plasma and fentanyl and norfentanyl in human urine using LC-MS/MS.
    Journal of pharmaceutical and biomedical analysis, 2005, Apr-29, Volume: 37, Issue:5

    Topics: Chromatography, Liquid; Fentanyl; Humans; Mass Spectrometry

2005
Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases.
    Journal of analytical toxicology, 2005, Volume: 29, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Autopsy; Cause of Death; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA Fingerprinting; Female; Fentanyl; Homozygote; Humans; Male; Middle Aged; Opioid-Related Disorders; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Substance Abuse Detection

2005
An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites.
    Journal of mass spectrometry : JMS, 2006, Volume: 41, Issue:5

    Topics: Analgesics, Opioid; Chromatography, Liquid; Fentanyl; Humans; Morphine Derivatives; Palliative Care; Patient Compliance; Spectrometry, Mass, Electrospray Ionization; Tilidine

2006
LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic transdermal therapeutic systems.
    Forensic science international, 2007, Jul-04, Volume: 169, Issue:2-3

    Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Bile; Chromatography, Liquid; Female; Fentanyl; Forensic Toxicology; Gastrointestinal Contents; Humans; Kidney; Liver; Neoplasms; Pain; Spectrometry, Mass, Electrospray Ionization; Suicide; Vitreous Body

2007
Fatalities associated with fentanyl and co-administered cocaine or opiates.
    Journal of forensic sciences, 2007, Volume: 52, Issue:6

    Topics: Accidents; Adult; Aged; Aged, 80 and over; Cannabinoids; Cause of Death; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Drug Overdose; Ethanol; Female; Fentanyl; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Narcotics; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders

2007
Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases.
    Journal of analytical toxicology, 2007, Volume: 31, Issue:8

    Topics: Adult; Deuterium; Drug Overdose; Fatal Outcome; Female; Fentanyl; Forensic Medicine; Humans; Male; Middle Aged; Narcotics; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection

2007
Fentanyl transdermal absorption linked to pharmacokinetic characteristics in patients undergoing palliative care.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:6

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Carriers; Female; Fentanyl; Humans; Male; Middle Aged; Neoplasms; Pain; Palliative Care; Skin Absorption

2010
A fatality involving an unusual route of fentanyl delivery: Chewing and aspirating the transdermal patch.
    Legal medicine (Tokyo, Japan), 2010, Volume: 12, Issue:3

    Topics: Administration, Oral; Adult; Bronchi; Fentanyl; Forensic Pathology; Forensic Toxicology; Humans; Male; Mastication; Methamphetamine; Narcotics; Respiratory Aspiration; Substance-Related Disorders

2010
Development and validation of a sensitive ultra performance liquid chromatography tandem mass spectrometry method for the analysis of fentanyl and its major metabolite norfentanyl in urine and whole blood in forensic context.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Jul-15, Volume: 878, Issue:22

    Topics: Chromatography, High Pressure Liquid; Fentanyl; Forensic Sciences; Humans; Tandem Mass Spectrometry

2010
Determination of fentanyl, metabolite and analogs in urine by GC/MS.
    Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:7

    Topics: Alfentanil; Calibration; Fentanyl; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Linear Models; Liquid-Liquid Extraction; Reproducibility of Results; Sufentanil

2011
Development and validation of a sensitive UPLC-MS/MS method for the analysis of narcotic analgesics in urine and whole blood in forensic context.
    Forensic science international, 2012, Feb-10, Volume: 215, Issue:1-3

    Topics: Analgesics, Opioid; Analysis of Variance; Buprenorphine; Chromatography, Liquid; Fentanyl; Forensic Toxicology; Humans; Meperidine; Pirinitramide; Regression Analysis; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tilidine; Tramadol

2012
A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children.
    Journal of separation science, 2011, Volume: 34, Issue:24

    Topics: Blood Volume; Child; Chromatography, High Pressure Liquid; Fentanyl; Humans; Sensitivity and Specificity; Tandem Mass Spectrometry

2011
Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS.
    Analytical chemistry, 2014, Feb-04, Volume: 86, Issue:3

    Topics: Analgesics, Opioid; Animals; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Fentanyl; Humans; Male; Rats; Tandem Mass Spectrometry; Urinalysis

2014
Impact of CYP3A5*3 on plasma exposure and urinary excretion of fentanyl and norfentanyl in the early postsurgical period.
    Therapeutic drug monitoring, 2014, Volume: 36, Issue:3

    Topics: Aged; Analgesics, Opioid; Body Mass Index; Cytochrome P-450 CYP3A; Female; Fentanyl; Genotype; Humans; Infusions, Intravenous; Japan; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Genetic; Postoperative Period; Renal Elimination

2014
Development, validation and application of an HPLC-MS/MS method for the determination of fentanyl and nor-fentanyl in human plasma and saliva.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jun-01, Volume: 960

    Topics: Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fentanyl; Humans; Linear Models; Pain; Reproducibility of Results; Saliva; Sensitivity and Specificity; Tandem Mass Spectrometry

2014
Quantitative low-volume assay for simultaneous determination of fentanyl, norfentanyl, and minor metabolites in human plasma and urine by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
    International journal of legal medicine, 2014, Volume: 128, Issue:5

    Topics: Chromatography, Liquid; Fentanyl; Forensic Toxicology; Humans; Limit of Detection; Narcotics; Tandem Mass Spectrometry

2014
Protein binding of fentanyl and its metabolite nor-fentanyl in human plasma, albumin and α-1 acid glycoprotein.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:3

    Topics: Administration, Cutaneous; Adsorption; Adult; Aged; Aged, 80 and over; Albumins; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Male; Metabolome; Middle Aged; Orosomucoid; Protein Binding; Solutions; Ultrafiltration

2015
Saliva versus Plasma for Pharmacokinetic and Pharmacodynamic Studies of Fentanyl in Patients with Cancer.
    Clinical therapeutics, 2015, Nov-01, Volume: 37, Issue:11

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chromatography, High Pressure Liquid; Female; Fentanyl; Humans; Male; Middle Aged; Neoplasms; Pain; Pain Measurement; Saliva; Tandem Mass Spectrometry

2015
Postmortem tissue distribution of acetyl fentanyl, fentanyl and their respective nor-metabolites analyzed by ultrahigh performance liquid chromatography with tandem mass spectrometry.
    Forensic science international, 2015, Volume: 257

    Topics: Adult; Bile; Brain Chemistry; Chromatography, Liquid; Designer Drugs; Fentanyl; Forensic Toxicology; Humans; Liver; Middle Aged; Narcotics; Postmortem Changes; Tandem Mass Spectrometry; Tissue Distribution; Vitreous Body

2015
Using postmortem blood and urine norfentanyl/fentanyl ratios in the investigation of fentanyl-related deaths.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:9

    Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Forensic Toxicology; Humans

2016
Toxicological testing when evaluating fatal cases suspected of acute fentanyl toxicity.
    Forensic science, medicine, and pathology, 2016, Volume: 12, Issue:3

    Topics: Analgesics, Opioid; Cytochrome P-450 Enzyme System; Drug Tolerance; Fentanyl; Forensic Toxicology; Humans; Transdermal Patch

2016
Fentanyl-Norfentanyl Concentrations During Transdermal Patch Application: LC-MS-MS Urine Analysis.
    Journal of analytical toxicology, 2016, Volume: 40, Issue:8

    Topics: Administration, Cutaneous; Adult; Aged; Chromatography, Liquid; Female; Fentanyl; Humans; Male; Middle Aged; Models, Theoretical; Retrospective Studies; Substance Abuse Detection; Tandem Mass Spectrometry; Transdermal Patch

2016
LC-MS-MS Method for the Analysis of Miscellaneous Drugs in Wastewater During Football Games III.
    Journal of analytical toxicology, 2016, Volume: 40, Issue:8

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Residues; Fentanyl; Football; Humans; Illicit Drugs; Limit of Detection; Meperidine; Methadone; Mississippi; Phencyclidine; Pyrrolidines; Reproducibility of Results; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol; Wastewater

2016
Response to: Fentanyl-Norfentanyl Concentrations During Transdermal Patch Application: LC-MS-MS Urine Analysis.
    Journal of analytical toxicology, 2017, 03-01, Volume: 41, Issue:2

    Topics: Chromatography, Liquid; Fentanyl; Tandem Mass Spectrometry; Transdermal Patch

2017
Fentanyl-Norfentanyl Concentrations During Transdermal Patch Application: LC-MS-MS Urine Analysis.
    Journal of analytical toxicology, 2017, 03-01, Volume: 41, Issue:2

    Topics: Chromatography, Liquid; Fentanyl; Tandem Mass Spectrometry; Transdermal Patch

2017
Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl.
    Journal of analytical toxicology, 2017, Jun-01, Volume: 41, Issue:5

    Topics: Analgesics, Opioid; Fentanyl; Furans; Illicit Drugs; Mass Spectrometry; Substance Abuse Detection

2017
An LC-MS-MS Method for the Analysis of Carfentanil, 3-Methylfentanyl, 2-Furanyl Fentanyl, Acetyl Fentanyl, Fentanyl and Norfentanyl in Postmortem and Impaired-Driving Cases.
    Journal of analytical toxicology, 2017, Jul-01, Volume: 41, Issue:6

    Topics: Analgesics, Opioid; Autopsy; Chromatography, Liquid; Driving Under the Influence; Enzyme-Linked Immunosorbent Assay; Fentanyl; Furans; Gas Chromatography-Mass Spectrometry; Humans; Substance Abuse Detection; Tandem Mass Spectrometry

2017
The distribution and redistribution of fentanyl & norfentanyl in post mortem samples.
    Forensic science international, 2018, Volume: 284

    Topics: Accidents; Analgesics, Opioid; Chromatography, Liquid; Drug Overdose; Fentanyl; Forensic Toxicology; Humans; Liver; Opioid-Related Disorders; Postmortem Changes; Tandem Mass Spectrometry; Vitreous Body

2018
Paper spray mass spectrometry for the direct, semi-quantitative measurement of fentanyl and norfentanyl in complex matrices.
    Clinical biochemistry, 2018, Volume: 54

    Topics: Fentanyl; Mass Spectrometry

2018
Acetyl Fentanyl: Trends and Concentrations in Metro Detroit.
    Journal of forensic sciences, 2019, Volume: 64, Issue:1

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Central Nervous System Depressants; Chromatography, Liquid; Cocaine; Cohort Studies; Coroners and Medical Examiners; Drug Overdose; Ethanol; Female; Fentanyl; Heroin; Humans; Illicit Drugs; Male; Mass Spectrometry; Michigan; Opioid-Related Disorders; Racial Groups; Urban Population

2019
Data-independent screening method for 14 fentanyl analogs in whole blood and oral fluid using LC-QTOF-MS.
    Forensic science international, 2019, Volume: 297

    Topics: Alfentanil; Chromatography, Liquid; Fentanyl; Forensic Toxicology; Furans; Humans; Illicit Drugs; Limit of Detection; Mass Spectrometry; Remifentanil; Saliva; Solid Phase Extraction; Substance Abuse Detection; Substance-Related Disorders; Sufentanil

2019
Fatal misuse of transdermal fentanyl patches.
    Forensic science international, 2019, Volume: 302

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Chromatography, Liquid; Female; Fentanyl; Hair; Humans; Male; Mass Spectrometry; Opioid-Related Disorders; Prescription Drug Misuse; Pulmonary Edema; Retrospective Studies; Transdermal Patch; Urinary Retention

2019
Fast increase of postmortem fentanyl blood concentrations after transdermal application: A call to careful interpretation.
    Forensic science international, 2019, Volume: 302

    Topics: Aged; Analgesics, Opioid; Chromatography, Liquid; Edetic Acid; Female; Fentanyl; Forensic Toxicology; Humans; Male; Middle Aged; Postmortem Changes; Tandem Mass Spectrometry; Transdermal Patch

2019
Unique Structural/Stereo-Isomer and Isobar Analysis of Novel Fentanyl Analogues in Postmortem and DUID Whole Blood by UHPLC-MS-MS.
    Journal of analytical toxicology, 2019, Oct-17, Volume: 43, Issue:9

    Topics: Analgesics, Opioid; Autopsy; Chromatography, High Pressure Liquid; Fentanyl; Humans; Isomerism; Limit of Detection; Tandem Mass Spectrometry

2019
Toward the Interpretation of Positive Testing for Fentanyl and Its Analogs in Real Hair Samples: Preliminary Considerations.
    Journal of analytical toxicology, 2020, May-18, Volume: 44, Issue:4

    Topics: Analgesics, Opioid; Chromatography, Liquid; Fentanyl; Hair; Humans; Illicit Drugs; Limit of Detection; Substance Abuse Detection

2020
Determination of Morphine, Fentanyl and Their Metabolites in Small Sample Volumes Using Liquid Chromatography Tandem Mass Spectrometry.
    Journal of analytical toxicology, 2020, May-18, Volume: 44, Issue:4

    Topics: Animals; Chromatography, Liquid; Fentanyl; Heroin; Morphine; Morphine Derivatives; Rats; Reproducibility of Results; Substance Abuse Detection; Tandem Mass Spectrometry

2020
Quantitation of Fentanyl and Metabolites from Liver Tissue Using a Validated QuEChERS Extraction and LC-MS-MS Analysis.
    Journal of analytical toxicology, 2021, Jan-21, Volume: 44, Issue:9

    Topics: Analgesics, Opioid; Autopsy; Chromatography, Liquid; Drug Overdose; Fentanyl; Forensic Toxicology; Humans; Limit of Detection; Liver; Postmortem Changes; Substance Abuse Detection; Tandem Mass Spectrometry

2021
Development and Clinical Validation of a Sensitive Lateral Flow Assay for Rapid Urine Fentanyl Screening in the Emergency Department.
    Clinical chemistry, 2020, 02-01, Volume: 66, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Biological Assay; Chromatography, Liquid; Drug Overdose; Emergency Service, Hospital; Female; Fentanyl; Gold; Humans; Immunoassay; Male; Metal Nanoparticles; Middle Aged; Point-of-Care Testing; Sensitivity and Specificity; Substance Abuse Detection; Tandem Mass Spectrometry; Urinalysis

2020
Quantification of Furanylfentanyl and its Metabolites in Human and Rat Plasma Using LC-MS-MS.
    Journal of analytical toxicology, 2020, Jul-31, Volume: 44, Issue:6

    Topics: Analgesics, Opioid; Animals; Chromatography, Liquid; Fentanyl; Forensic Toxicology; Furans; Humans; Illicit Drugs; Limit of Detection; Plasma; Rats; Reproducibility of Results; Substance Abuse Detection; Tandem Mass Spectrometry

2020
Protracted renal clearance of fentanyl in persons with opioid use disorder.
    Drug and alcohol dependence, 2020, 09-01, Volume: 214

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Chromatography, Liquid; Drug Contamination; Female; Fentanyl; Humans; Male; Mass Spectrometry; Middle Aged; Narcotics; Opioid-Related Disorders

2020
Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.
    Forensic science international, 2020, Volume: 317

    Topics: Adolescent; Adult; Aged; Alfentanil; Analgesics, Opioid; Benzamides; Child; Child, Preschool; Chromatography, Liquid; Female; Fentanyl; France; Furans; Humans; Infant; Infant, Newborn; Limit of Detection; Male; Middle Aged; Neonatal Abstinence Syndrome; Piperidines; Remifentanil; Retrospective Studies; Substance Abuse Detection; Substance-Related Disorders; Sufentanil; Tandem Mass Spectrometry; Young Adult

2020
Delayed Norfentanyl Clearance During Pregnancy.
    Obstetrics and gynecology, 2020, Volume: 136, Issue:5

    Topics: Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Metabolic Clearance Rate; Opioid-Related Disorders; Pregnancy; Pregnancy Complications

2020
Determination of Fentanyl, Alpha-Methylfentanyl, Beta-Hydroxyfentanyl and the Metabolite Norfentanyl in Rat Urine by LC-MS-MS.
    Journal of analytical toxicology, 2022, Apr-21, Volume: 46, Issue:4

    Topics: Analgesics, Opioid; Animals; Chromatography, Liquid; Fentanyl; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2022
Original enantioseparation of illicit fentanyls with cellulose-based chiral stationary phases under polar-ionic conditions.
    Journal of chromatography. A, 2021, Apr-26, Volume: 1643

    Topics: Cellulose; Chromatography, High Pressure Liquid; Fentanyl; Mass Spectrometry; Stereoisomerism

2021
Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetr
    Journal of pharmaceutical and biomedical analysis, 2021, Sep-05, Volume: 203

    Topics: Aged; Chromatography, Liquid; Fentanyl; Humans; Morphinans; Oxycodone; Oxymorphone; Reproducibility of Results; Tandem Mass Spectrometry; Tramadol

2021
Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC-MS/MS.
    The journal of applied laboratory medicine, 2022, 06-30, Volume: 7, Issue:4

    Topics: Bupivacaine; Chromatography, Liquid; Female; Fentanyl; Humans; Tandem Mass Spectrometry

2022
Determination of fentanyl and norfentanyl in cerumen in the setting of postmortem investigation.
    Journal of forensic sciences, 2022, Volume: 67, Issue:5

    Topics: Analgesics, Opioid; Cerumen; Fentanyl; Forensic Toxicology; Tandem Mass Spectrometry

2022
Quantification of Fentanyl and Norfentanyl in Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry.
    Methods in molecular biology (Clifton, N.J.), 2024, Volume: 2737

    Topics: Analgesics, Opioid; Chromatography, Liquid; Fentanyl; Tandem Mass Spectrometry

2024