fentanyl has been researched along with naltrexone in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (12.12) | 18.7374 |
| 1990's | 50 (30.30) | 18.2507 |
| 2000's | 41 (24.85) | 29.6817 |
| 2010's | 36 (21.82) | 24.3611 |
| 2020's | 18 (10.91) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B | 1 |
| Burke, TF; Comer, SD; Lewis, JW; Woods, JH | 1 |
| Crisp, T; Perni, VC; Stafinsky, JL; Uram, M | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Malan, JH; Quandt, SK; Raath, JP | 1 |
| Holtzman, SG; Paronis, CA | 1 |
| France, CP; Medzihradsky, F; Rice, KC; Seggel, MR; Winger, G; Woods, JH | 1 |
| Mjanger, E; Yaksh, TL | 1 |
| Jang, Y; Yoburn, BC | 1 |
| Botschev, C; Müller, N | 1 |
| Sharpe, LG | 1 |
| Ableitner, A; Ayesta, FJ; Emmett-Oglesby, MW; Herz, A; Shippenberg, TS | 1 |
| Mueller, J; Quock, RM | 1 |
| Gaumann, DM; Tyce, GM; Yaksh, TL | 1 |
| Adams, JU; Holtzman, SG; Paronis, CA | 1 |
| Beilin, B; Gale, RP; Liebeskind, JC; Martin, FC; Shavit, Y | 1 |
| Blalock, JE; Carr, DJ; DeCosta, BR; Guarcello, V; Jacobson, AE; Kim, CH; Rice, KC | 1 |
| Carino, MA; Chinn, C; Horita, A | 1 |
| Abdelhamid, EM; Archer, S; Koolpe, GA; Michael, J; Michael, M; Nelson, WL; Simon, EJ | 1 |
| Croughan, J; Sanders, K | 1 |
| Bice, AN; Dannals, RF; Frost, JJ; Lee, MC; Tanada, S; Wagner, HN | 1 |
| Dykstra, LA; Negus, SS | 1 |
| Holtzman, SG | 3 |
| Martin, WR; Wettstein, JG | 1 |
| Harty, GJ; Onofrio, BM; Yaksh, TL | 1 |
| Arendt, RM; Schulz, R; Vollmar, AM | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| DiFazio, CA; Dixon, R; Gal, TJ | 1 |
| DiFazio, CA; Gal, TJ | 1 |
| Freye, E; Hartung, E; Kaliebe, S | 1 |
| Herz, A; Schulz, R; Wüster, M | 1 |
| Gioannini, T; Gorissen, H; Maryanoff, BE; Simon, EJ | 1 |
| Cools, AR; Megens, AA | 1 |
| Gates, CC; Haigh, JC | 1 |
| Fujinami, T; Nishimura, M; Saeki, T; Sato, N; Watanabe, Y | 1 |
| Bagley, JR; Brockunier, LL; Flynn, D; France, CP; Gerak, LR; Medzihradsky, F; Winger, GD; Woods, JH | 1 |
| Gupta, SK; Hwang, SS; Southam, MA | 1 |
| Carpenter, JW; Leith, DE; Shaw, ML | 1 |
| Bagley, JR; Baker, ML; Brockunier, LL; Carr, DJ; France, CP; Holmes, C | 1 |
| Bayer, BM; Flores, LR; Wahl, SM | 1 |
| House, JD; Makhay, MM; Walker, EA; Young, AM | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
| Osifchin, E; Veng-Pedersen, P; Waters, SJ; Wilhelm, JA; Zakszewski, TB | 2 |
| Clyde, VL; Ramsay, EC; Sleeman, JM | 1 |
| Lance, WR; Miller, MW; Wild, MA | 1 |
| Butour, JL; Meunier, JC; Moisand, C; Mollereau, C; Parmentier, M | 1 |
| Cook, CD; Morgan, D; Negus, SS; Picker, MJ | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Coulais, Y; Francés, B; Goeldner, M; Guiraud, R; Hirth, C; Méjean-Galzi, A; Tafani, JA; Zajac, JM | 1 |
| Rothe, KS; Stevens, CW | 1 |
| Carter, W; Ramsay, EC; Sleeman, JM; Tobin, T | 1 |
| Citino, SB; Heard, DJ; Schumacher, J; Young, L | 1 |
| Civelek, AC; Dannals, RF; Dixon, RB; Joh, T; Kao, PF; Kim, S; Ravert, HT; Villemagne, VL; Wagner, HN | 1 |
| Stevens, CW; Willenbring, S | 1 |
| Bagley, JR; Brockunier, LL; France, CP; Gauthier, CA; Gerak, LR | 1 |
| Brewer, C; Gastfriend, DR | 1 |
| Bagley, JR; Brandt, MR; Brockunier, LL; France, CP; Gerak, LR; Landers, LK; Lelas, S | 1 |
| Braselton, WE; Cook, RA; Dierenfeld, ES; House, C; Karesh, WB; Puche, H; Torres, A; Uhart, MM | 1 |
| Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB | 1 |
| Morgan, D; Picker, MJ | 1 |
| Bartok, RE; Craft, RM; Heideman, LM | 1 |
| Cheng, CH; Naylor, RJ; Ngan, MP; Rudd, JA; Wai, MK | 1 |
| Grech, DM; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Bagley, JR; Brockunier, LL; France, CP; Gerak, LR; Moerschbaecher, JM | 1 |
| Sutherland, J; Walker, EA; Young, AM; Zhang, L | 1 |
| Dougherty, TB; Porche, VH; Thall, PF | 1 |
| Bagley, JR; Brockunier, LL; France, CP; Gauthier, CA | 1 |
| Mama, KR; Steffey, EP; Withrow, SJ | 1 |
| Akil, H; Bonner, G; Meng, F | 1 |
| Kearns, KS; Ramsay, EC; Swenson, B | 1 |
| Cebra, CK; Larsen, RS; Wild, MA | 1 |
| Hales, TG; Law, PY; Piros, ET; Prather, PL; Song, L | 1 |
| Breiter, H; D'Ambra, MN; Elman, I; Gastfriend, DR; Kane, M; Krause, S; Morris, R; Tuffy, L | 1 |
| Holtzman, SG; White, DA | 1 |
| Burns, MM; Chumpa, A; Kaplan, RL; Shannon, MW | 1 |
| Bush, M; Citino, SB; Grobler, D; Lance, W | 1 |
| Bu, H; Chen, YL; Halls, TD; Jiang, X; Naidong, W; Shou, WZ | 1 |
| Imai, S; Itou, Y; Narita, M; Suzuki, T; Yajima, Y | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Barrett, AC; Picker, MJ; Smith, ES | 1 |
| Ballachey, BE; McCormick, C; Monson, DH | 1 |
| Hunter, RP; Isaza, R; Koch, DE; Mutlow, A | 1 |
| Adams, KA; Miller, BF; Miller, KV; Muller, LI; Osborn, DA; Ramsay, EC; Storms, TN; Warren, RJ | 1 |
| Lance, WR; Miller, MW; Wolfe, LL | 1 |
| Bares, R; Braus, DF; Braus, DH; Croissant, B; Dohmen, BM; Heinz, A; Hermann, D; Machulla, HJ; Mann, K; Mundle, G; Reimold, M; Schumann, G; Wrase, J | 1 |
| Carpenter, JW; Hunter, RP; Isaza, R; Koch, DE; Mutlow, A | 1 |
| Aalto, S; Hagelberg, N; Hietala, J; Ingman, K; Juhakoski, A; Kallio, A; Karhuvaara, S; Någren, K; Oikonen, V; Scheinin, H | 1 |
| Riters, LV; Schroeder, MB | 1 |
| Darwish, M; Hellriegel, E; Jiang, JG; Kirby, M; Robertson, P | 1 |
| Carpenter, JW; Cole, A; Dresser, BL; Hunter, RP; Isaza, R; Koch, DE; Mutlow, A | 1 |
| Buck, DJ; Davis, RL; Saffarian, N; Stevens, CW | 1 |
| Dannals, RF; Frost, JJ; Kim, YK; Lee, JS; McCaul, ME; Wand, GS; Weerts, EM | 1 |
| Greenwald, MK | 1 |
| Butelman, ER; Chait, BT; Kreek, MJ; Mandau, M; Reed, B; Yuferov, V | 1 |
| Virk, MS; Williams, JT | 1 |
| Arastu, MF; Dean, RL; Deaver, DR; Dong, N; Gastfriend, DR; Kriksciukaite, K; O'Driscoll, K; Reitano, K; Todtenkopf, MS | 1 |
| Martin, KK; Stahlheber, BW; Stevens, CW | 1 |
| Bear, AE; Folk, JE; Negus, SS; Rice, KC | 1 |
| Alonso, A; Darstein, C; Molenberghs, G; Renard, D | 1 |
| Arout, C; Caldwell, M; Dahan, A; Kest, B; Waxman, AR | 1 |
| Baud, FJ; Chevillard, L; Mégarbane, B; Risède, P | 1 |
| Darwish, M; Kirby, M; Robertson, P; Tracewell, W; Xie, F | 1 |
| Erickson, TB; George, AV; Lu, JJ; Metz, J; Pisano, MV | 1 |
| Caulkett, NA; Shury, TK; Woodbury, MR | 1 |
| Boyce, M; Eriksson, C; Kilborn, J; Lister, N; Tamaoka, M; Warrington, S | 1 |
| Bührer, C; Degenhardt, P; Garten, L | 1 |
| Beaver, J; Bullmore, ET; Bush, MA; Gunn, RN; Hill, S; Howard, J; Long, C; Makwana, A; Matthews, PM; Miller, SR; Nathan, PJ; Newbould, RD; Passchier, J; Rabiner, EA; Reiley, R; Searle, G | 1 |
| Bihel, F; Bockel, F; Bourguignon, JJ; Elhabazi, K; Maldonado, R; Meziane, H; Mollereau, C; Moulédous, L; Petit-demoulière, B; Schmitt, M; Simonin, F; Trigo, JM; Zajac, JM | 1 |
| Chateauraynaud, J; Gavello-Baudy, S; Laboureyras, E; Laulin, JP; Le Roy, C; Simonnet, G | 1 |
| Moore, KT; Natarajan, J; Richarz, U; Sathyan, G; Vandenbossche, J | 1 |
| Bobeck, EN; Haseman, RA; Hong, D; Ingram, SL; Morgan, MM | 1 |
| Banks, ML; Lunzer, MM; Negus, SS; Portoghese, PS; Rice, KC; Yekkirala, AS | 1 |
| Kellie, KA; Kreeger, TJ | 1 |
| Chavan, A; Dillaha, L; Goskonda, V; Parikh, N | 1 |
| Kalk, P; Moore, RP; Rainwater, KL; Sykes, JM; Valitutto, MT | 1 |
| Bilsky, EJ; Cain, JP; Hruby, VJ; Hu, J; Kumirov, VK; Lee, YS; Podolsky, AT; Sandweiss, A; Vanderah, TW; Vardanyan, RS | 1 |
| Dong, H; Gao, X; Gong, Z; Ma, W; Su, R; Yong, Z | 1 |
| Herrero, JF; Herrero-Zorita, C; Ramos-Zepeda, GA | 1 |
| Bell, RL; Gonzales, CR; Hart, JC; Lowe, SL; McKinzie, DL; McKinzie, JH; Mitch, CH; Need, AB; Rorick-Kehn, LM; Statnick, MA; Stoltz, RR; Suico, JG; Tauscher-Wisniewski, S; Weller, MA; Witcher, JW; Wong, CJ | 1 |
| Cui, XL; Li, RP; Liao, X; Liu, GP; Sun, C; Wang, SY; Xu, YC; Xue, FS; Yang, GZ | 1 |
| Lindsey, AM; Prinssen, EP; Rice, KC; Saccone, PA; Sulima, A; Wichmann, J; Woods, JH; Zelenock, KA | 1 |
| Buck, RK; Fosgate, GT; Gerlach, C; Kästner, SBR; Kummrow, M; Meyer, LRC; Stegmann, GF; Zeiler, GE | 1 |
| Batra, A; Hansson, AC; Hermann, D; Hirth, N; Hoffmann, S; Kiefer, F; la Fougère, C; Mann, K; Noori, HR; Reimold, M; Reischl, G; Smolka, MN; Sommer, WH; Spanagel, R | 1 |
| Altshuler, D; Merchan, C; Papadopoulos, J | 1 |
| Alexander-Scott, N; Boss, R; Brinkley-Rubinstein, L; Clarke, J; Green, TC; Marshall, BDL; Rich, JD | 1 |
| Banks, ML; Negus, SS; Schwienteck, KL | 1 |
| Abad-Santos, F; Alday, E; Belmonte, C; Hernández-Martínez, M; Herrador, C; Koller, D; Mejía, G; Ochoa, D; Román, M; Saiz-Rodríguez, M; Zubiaur, P | 1 |
| Banks, ML; Blough, BE; Faunce, KE; Grim, TW; Negus, SS; Obeng, S; Rice, KC; Schwienteck, KL; Zhang, Y | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Beeker, A; Berkhof, J; Neefjes, ECW; Rhodius, CA; Ten Oever, D; van den Berg, HP; van der Vliet, HJ; van der Vorst, MJDL; van der Wijngaart, H; Verheul, HMW | 1 |
| Banks, ML; Blake, S; Bremer, PT; Faunce, KE; Hwang, CS; Janda, KD; Natori, Y; Townsend, EA; Zhou, B | 1 |
| Banks, ML; Blake, S; Bremer, PT; Hwang, CS; Janda, KD; Poklis, JL; Tenney, RD; Zhou, B | 1 |
| Banks, ML; Blake, S; Bremer, PT; Negus, SS; Poklis, JL; Schwienteck, KL; Townsend, EA | 1 |
| McCranor, BJ; Pierce, SA; Racine, MC; Sciuto, AM; Tressler, J; Tuet, WY; Wong, B | 1 |
| Bardo, MT; Beckmann, JS; Hammerslag, LR; Hofford, RS; Kang, Q; Kryscio, RJ | 1 |
| Chen, Y; Fu, C; Hu, R; Huang, C; Jiang, H; Li, C; Sun, Y; Tang, D; Wang, H; Yan, J; Zhu, J | 1 |
| Banks, ML; Bremer, PT; Faunce, KE; Janda, KD; Jaster, AM; Negus, SS; Robinson, HL; Townsend, EA | 1 |
| Disney, A; France, CP; Gerak, LR; Husbands, SM; Javors, MA; Maguire, DR; Sanchez, JJ | 1 |
| Freier, A; Lorch, U; Pierscionek, T; Spencer, CS; Täubel, J | 1 |
| Baamonde, A; González-Rodríguez, S; Lastra, A; Machelska, H; Menéndez, L; Seitz, V; Stein, C | 1 |
| Townsend, EA | 1 |
| Gault, A; Wahl, G | 1 |
| Flynn, SM; France, CP | 1 |
| Baynard, C; Butelman, ER; Hedrick, SL; Horn, J; Jackson, K; Kaska, S; Kreek, MJ; Leggas, M; Luo, D; Niloy, KK; Prisinzano, TE; Sarma, R | 1 |
| Cook, RR; Fanucchi, L; Foot, C; King, C; Korthuis, PT; Lucas, GM; Lum, PJ; Rodriguez, A; Tookes, H; Torralva, R; Vergara-Rodriguez, P; Waddell, EN | 1 |
| Laks, J; Peterkin, A; Weinstein, ZM | 1 |
| Schmitz, ZP; Soghoian, SE; Warstadt, NM | 1 |
| Banks, ML; Negus, SS; Santos, EJ | 1 |
| Marcus, MM; St Onge, CM; Taylor, KM; Townsend, EA | 1 |
| Inomata, A; Makino, K; Moriyasu, T; Nakagawa, Y; Nakajima, J; Ono, Y; Sakamoto, M; Suzuki, J; Suzuki, T; Tada, Y; Takahashi, H; Tayama, K | 1 |
| Bassman, JR; Beardsley, PM; Hassanien, SH; Holt, MC; Iula, DM; Layle, NK; Stevens, DL; Varshneya, NB | 1 |
| Benner, JD; Cohen, SM; Fishman, M; Hollenbaugh, JA | 1 |
2 review(s) available for fentanyl and naltrexone
| Article | Year |
|---|---|
Drug discrimination studies.
Topics: Analgesics, Opioid; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Fentanyl; Generalization, Stimulus; Macaca mulatta; Morphine; Nalorphine; Naloxone; Naltrexone; Pentazocine; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Current Best Practices for Acute and Chronic Management of Patients with Opioid Use Disorder.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Comorbidity; Disease Management; Drug Overdose; Female; Fentanyl; Harm Reduction; Humans; Male; Mental Disorders; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Practice Guidelines as Topic; Prevalence | 2022 |
18 trial(s) available for fentanyl and naltrexone
| Article | Year |
|---|---|
Prolonged blockade of opioid effect with oral nalmefene.
Topics: Administration, Oral; Adult; Analgesia; Clinical Trials as Topic; Double-Blind Method; Fentanyl; Humans; Male; Naltrexone; Narcotic Antagonists; Respiration; Time Factors | 1986 |
Prolonged antagonism of opioid action with intravenous nalmefene in man.
Topics: Adult; Drug Interactions; Fentanyl; Humans; Male; Muscle Rigidity; Naltrexone; Pain; Respiration; Tidal Volume; Time Factors | 1986 |
Efficacy and safety of naltrexone hydrochloride for antagonizing carfentanil citrate immobilization in captive Rocky Mountain elk (Cervus elaphus nelsoni).
Topics: Analgesics, Opioid; Animals; Deer; Female; Fentanyl; Immobilization; Male; Naltrexone; Narcotic Antagonists | 1996 |
Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system.
Topics: Adult; Analgesics, Opioid; Brain; Carbon Radioisotopes; Cross-Over Studies; Female; Fentanyl; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Time Factors; Tomography, Emission-Computed | 1997 |
Maximum tolerated dose of nalmefene in patients receiving epidural fentanyl and dilute bupivacaine for postoperative analgesia.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Fentanyl; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain, Postoperative | 2000 |
Nalmefene for elective reversal of procedural sedation in children.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Antidotes; Child; Child, Preschool; Emergency Medical Services; Female; Fentanyl; Humans; Infant; Male; Midazolam; Naltrexone; Narcotic Antagonists | 2001 |
Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing.
Topics: Adolescent; Adult; Analgesics, Opioid; Area Under Curve; Caudate Nucleus; Electrocardiography; Fentanyl; Glucuronides; Humans; Male; Naltrexone; Narcotic Antagonists; Positron-Emission Tomography; Prefrontal Cortex; Receptors, Opioid, mu; Thalamus | 2005 |
Single-dose and steady-state pharmacokinetics of fentanyl buccal tablet in healthy volunteers.
Topics: Administration, Buccal; Adolescent; Adult; Chromatography, High Pressure Liquid; Drug Tolerance; Female; Fentanyl; Half-Life; Humans; Male; Middle Aged; Naltrexone; Tablets; Tandem Mass Spectrometry; Time Factors | 2007 |
Dose proportionality of fentanyl buccal tablet in doses ranging from 600 to 1300 microg in healthy adult subjects: a randomized, open-label, four-period, crossover, single-centre study.
Topics: Administration, Buccal; Adolescent; Adult; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Time Factors; Young Adult | 2010 |
Pharmacokinetics, safety, and tolerability of ascending doses of sublingual fentanyl, with and without naltrexone, in Japanese subjects.
Topics: Absorption; Administration, Sublingual; Adult; Analgesics, Opioid; Asian People; Blood Gas Monitoring, Transcutaneous; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Female; Fentanyl; Half-Life; Humans; Japan; Male; Mouth Mucosa; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Respiratory Insufficiency; Tablets; Young Adult | 2011 |
Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans.
Topics: Adult; Amygdala; Brain; Brain Mapping; Corpus Striatum; Dose-Response Relationship, Drug; Fentanyl; Food; Humans; Indans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Radioligand Assay; Radionuclide Imaging; Reward; Triazoles | 2011 |
Randomized 5-treatment crossover study to assess the effects of external heat on serum fentanyl concentrations during treatment with transdermal fentanyl systems.
Topics: Administration, Cutaneous; Adolescent; Adult; Analgesics, Opioid; Area Under Curve; Combined Modality Therapy; Cross-Over Studies; Female; Fentanyl; Humans; Hyperthermia, Induced; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Young Adult | 2012 |
Pharmacokinetics and dose proportionality of fentanyl sublingual spray: a single-dose 5-way crossover study.
Topics: Administration, Sublingual; Adolescent; Adult; Analgesics, Opioid; Analysis of Variance; Area Under Curve; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Hydrogen-Ion Concentration; Linear Models; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Single-Blind Method; Temperature; Young Adult | 2013 |
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Topics: Adolescent; Adult; Animals; Benzamides; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fentanyl; Humans; Male; Middle Aged; Miosis; Morphine; Mydriasis; Naltrexone; Narcotic Antagonists; Narcotics; Pupil; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Young Adult | 2014 |
Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis.
Topics: Adult; Aged; Alcoholism; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Positron-Emission Tomography; Receptors, Opioid, mu; Tissue Banks; Ventral Striatum | 2017 |
Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects.
Topics: Adolescent; Adult; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Catechol O-Methyltransferase; Cross-Over Studies; Cytochrome P-450 Enzyme System; Female; Fentanyl; Gene Frequency; Genotype; Humans; Male; Middle Aged; Naltrexone; Pharmacogenetics; Polymorphism, Genetic; Receptors, Adrenergic, beta-1; Receptors, Opioid, mu; Young Adult | 2019 |
Safety, Tolerability, and Dose Proportionality of a Novel Transdermal Fentanyl Matrix Patch and Bioequivalence With a Matrix Fentanyl Patch: Two Phase 1 Single-Center Open-Label, Randomized Crossover Studies in Healthy Japanese Volunteers.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Compounding; Drug Delivery Systems; Drug Tolerance; Fentanyl; Healthy Volunteers; Humans; Japan; Naltrexone; Narcotic Antagonists; Reproducibility of Results; Safety; Therapeutic Equivalency; Transdermal Patch | 2021 |
Associations between fentanyl use and initiation, persistence, and retention on medications for opioid use disorder among people living with uncontrolled HIV disease.
Topics: Buprenorphine; Delayed-Action Preparations; Fentanyl; HIV Infections; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders | 2021 |
145 other study(ies) available for fentanyl and naltrexone
| Article | Year |
|---|---|
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation | 2019 |
Clocinnamox: a novel, systemically-active, irreversible opioid antagonist.
Topics: Analgesia; Animals; Cinnamates; Dose-Response Relationship, Drug; Fentanyl; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1992 |
The noradrenergic component contributing to spinal fentanyl-induced antinociception is supraspinally mediated.
Topics: Adrenergic Antagonists; Analgesics; Animals; Fentanyl; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Naltrexone; Norepinephrine; Pain Measurement; Phentolamine; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin Antagonists; Spinal Cord | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Ostrich (Struthio camelus) immobilisation using carfentanil and xylazine and reversal with yohimbine and naltrexone.
Topics: Animals; Birds; Fentanyl; Immobilization; Naltrexone; Xylazine; Yohimbine | 1992 |
Apparent pA2 value of naltrexone is not changed in rats following continuous exposure to morphine or naloxone.
Topics: Analysis of Variance; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pain Measurement; Rats; Rats, Inbred Strains | 1992 |
Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects.
Topics: Alfentanil; Analgesics; Animals; Columbidae; Discrimination Learning; Female; Fentanyl; In Vitro Techniques; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Self Administration; Structure-Activity Relationship | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
Evaluation of receptor mechanism mediating fentanyl analgesia and toxicity.
Topics: Analgesics; Animals; Brain; Drug Tolerance; Fentanyl; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1991 |
Opiate receptor antagonists for delusions of parasitosis.
Topics: Delusions; Female; Fentanyl; Fluspirilene; Humans; Middle Aged; Myiasis; Naloxone; Naltrexone; Narcotic Antagonists | 1991 |
Separate neural mechanisms mediate sufentanil-induced pupillary responses in the cat.
Topics: Analgesics, Opioid; Animals; Cats; Clonidine; Drug Interactions; Fentanyl; Male; Morphine; Mydriasis; Naltrexone; Pupil; Receptors, Opioid; Receptors, Opioid, mu; Sufentanil | 1991 |
Paradoxical effect of chronic fentanyl treatment on naltrexone-induced supersensitivity and upregulation.
Topics: Analgesia; Animals; Autoradiography; Behavior, Animal; Discrimination Learning; Dose-Response Relationship, Drug; Drug Hypersensitivity; Drug Interactions; Fentanyl; Male; Naltrexone; Narcotics; Nociceptors; Rats; Rats, Inbred Strains; Time Factors; Up-Regulation | 1992 |
Protection by U-50,488H against beta-chlornaltrexamine antagonism of nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Fentanyl; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Pyrrolidines; Sufentanil | 1991 |
Effects of sufentanil and naltrexone on adrenal vein catecholamines and neuropeptides during splanchnic nerve stimulation in cats.
Topics: Adrenal Glands; Analgesics; Animals; Blood Pressure; Catecholamines; Cats; Electric Stimulation; Fentanyl; Heart Rate; Naltrexone; Neuropeptides; Splanchnic Nerves; Sufentanil; Veins | 1990 |
Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fentanyl; Levorphanol; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors | 1990 |
Suppression of natural killer cell activity by high-dose narcotic anesthesia in rats.
Topics: Anesthesia; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Drug; Fentanyl; Interferons; Killer Cells, Natural; Morphine; Naltrexone; Sufentanil; Time Factors | 1989 |
Opioid receptors on cells of the immune system: evidence for delta- and kappa-classes.
Topics: Animals; Benzeneacetamides; Cell Line; Fentanyl; Indicators and Reagents; Macrophages; Mice; Mice, Inbred C57BL; Naltrexone; Pyrrolidines; Receptors, Opioid | 1989 |
Fentanyl produces cholinergically-mediated analeptic and EEG arousal effects in rats.
Topics: Anesthesia; Animals; Atropine; Brain; Central Nervous System Stimulants; Choline; Electroencephalography; Fentanyl; Hippocampus; Injections; Male; Naltrexone; Parasympathetic Nervous System; Pentobarbital; Rats; Rats, Inbred Strains; Sleep; Stimulation, Chemical | 1989 |
Chloroacryloyl amides and alpha-methylenelactones from naltrexone, oxymorphone and fentanyl.
Topics: Acrylates; Animals; Binding Sites; Brain; Chemical Phenomena; Chemistry; Fentanyl; Hydromorphone; In Vitro Techniques; Membranes; Naloxone; Naltrexone; Oxymorphone; Rats; Stereoisomerism | 1985 |
Urine testing in impaired physicians.
Topics: Fentanyl; Humans; Naltrexone; Opioid-Related Disorders; Patient Compliance; Physician Impairment | 1989 |
Duration of occupancy of opiate receptors by naltrexone.
Topics: Administration, Oral; Adult; Brain; Carbon Radioisotopes; Female; Fentanyl; Humans; Male; Naltrexone; Radionuclide Imaging; Receptors, Opioid; Receptors, Opioid, mu; Time Factors | 1988 |
Kappa antagonist properties of buprenorphine in the shock titration procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Buprenorphine; Electroshock; Fentanyl; Male; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1988 |
An analysis of naltrexone and naloxone's possible agonistic actions in the dog.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Dogs; Drug Synergism; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Reaction Time; Reflex; Reflex, Pupillary | 1985 |
High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications.
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Cats; Drug Tolerance; Fentanyl; Hyperesthesia; Methadone; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Drug; Stimulation, Chemical; Strychnine; Sufentanil; Sulfates; Touch | 1986 |
The effect of opioids on rat plasma atrial natriuretic peptide.
Topics: Amino Acids; Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Male; Naltrexone; Narcotics; Radioimmunoassay; Rats; Rats, Inbred Strains | 1987 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Fentanyl; Male; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Prevention of late fentanyl-induced respiratory depression after the injection of opiate antagonists naltrexone and S-20682: comparison with naloxone.
Topics: Animals; Carbon Dioxide; Depression, Chemical; Dogs; Electroencephalography; Fentanyl; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oxygen; Partial Pressure; Respiration; Time Factors | 1983 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Potential affinity labels for the opiate receptor based on fentanyl and related compounds.
Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Fentanyl; In Vitro Techniques; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Intraseptally injected opiate agents: effects on morphine-induced behaviour of cats.
Topics: Animals; Behavior, Animal; beta-Endorphin; Cats; Endorphins; Enkephalin, Methionine; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Septal Nuclei; Septum Pellucidum | 1982 |
Capture of wood bison (Bison bison athabascae) using carfentanil-based mixtures.
Topics: Analgesics, Opioid; Animals; Bison; Diprenorphine; Drug Combinations; Female; Fentanyl; Hypnotics and Sedatives; Immobilization; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Northwest Territories; Piperidines; Tranquilizing Agents; Xylazine | 1995 |
Electrophysiological demonstration and activation of mu-opioid receptors in the rabbit sinoatrial node.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Fentanyl; Microelectrodes; Naltrexone; Narcotic Antagonists; Narcotics; Patch-Clamp Techniques; Rabbits; Receptors, Opioid, mu; Sinoatrial Node | 1995 |
Behavioral effects and receptor binding affinities of fentanyl derivatives in rhesus monkeys.
Topics: Animals; Behavior, Animal; Fentanyl; Heart Rate; Macaca mulatta; Nalbuphine; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Self Administration | 1995 |
Evaluation of diurnal variation in fentanyl clearance.
Topics: Circadian Rhythm; Drug Administration Schedule; Fentanyl; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Naltrexone | 1995 |
Complications with the use of carfentanil citrate and xylazine hydrochloride to immobilize domestic horses.
Topics: Analgesics, Opioid; Animals; Animals, Domestic; Fentanyl; Horse Diseases; Horses; Hypertension; Immobilization; Naloxone; Naltrexone; Pulmonary Edema; Tachycardia; Xylazine | 1995 |
OHM3295: a fentanyl-related 4-heteroanilido piperidine with analgesic effects but not suppressive effects on splenic NK activity in mice.
Topics: Analgesics; Animals; Fentanyl; Immunosuppressive Agents; Killer Cells, Natural; Male; Mice; Naltrexone; Spleen | 1994 |
Mechanisms of morphine-induced immunosuppression: effect of acute morphine administration on lymphocyte trafficking.
Topics: Adrenalectomy; Animals; Cell Movement; Fentanyl; Immunosuppression Therapy; Leukocyte Count; Lymphocyte Activation; Lymphocyte Count; Lymphocytes; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; T-Lymphocyte Subsets | 1995 |
In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.
Topics: Analgesia; Animals; Benzomorphans; Buprenorphine; Discrimination, Psychological; Etorphine; Fentanyl; Male; Morphine; Nalbuphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
Duration of opioid antagonism by nalmefene and naloxone in the dog: an integrated pharmacokinetic/pharmacodynamic comparison.
Topics: Animals; Blood Gas Monitoring, Transcutaneous; Dogs; Female; Fentanyl; Infusions, Intravenous; Models, Biological; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Respiration | 1995 |
Duration of opioid antagonism by nalmefene and naloxone in the dog. A nonparametric pharmacodynamic comparison based on generalized cross-validated spline estimation.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Computer Simulation; Cross-Over Studies; Dogs; Drug Tolerance; Fentanyl; Injections, Intravenous; Male; Models, Statistical; Naloxone; Naltrexone; Narcotic Antagonists; Respiratory Insufficiency; Time Factors | 1995 |
Immobilization of black bears (Ursus americanus) with orally administered carfentanil citrate.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Diazepam; Female; Fentanyl; Immobilization; Male; Muscle Relaxants, Central; Muscle, Skeletal; Naltrexone; Narcotic Antagonists; Oxygen; Respiration; Ursidae | 1995 |
Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Diprenorphine; Dynorphins; Etorphine; Fentanyl; Glutamine; Histamine; Humans; Kinetics; Ligands; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid | 1996 |
Effects of the delta opioid against BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure.
Topics: Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination, Psychological; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Receptors, Opioid, delta | 1996 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
In vivo binding of [125I]NH2-carfentanil to mu opioid receptors in mouse brain.
Topics: Animals; Autoradiography; Brain; Fentanyl; Injections, Intraperitoneal; Iodine Radioisotopes; Logistic Models; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Radioligand Assay; Receptors, Opioid, mu | 1994 |
Antagonism of morphine-like discriminative effects by beta-funaltrexamine.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cisterna Magna; Discrimination Learning; Fentanyl; Injections; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Immobilization of domestic goats (Capra hircus) using orally administered carfentanil citrate and detomidine hydrochloride.
Topics: Absorption; Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Blood Pressure; Body Temperature; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Fentanyl; Goats; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Naltrexone; Narcotic Antagonists; Respiration; Saponins; Yohimbine | 1997 |
Cardiopulmonary effects of carfentanil in dama gazelles (Gazella dama).
Topics: Analgesics, Opioid; Animals; Animals, Zoo; Antelopes; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Female; Fentanyl; Heart Rate; Immobilization; Male; Naltrexone; Narcotic Antagonists; Oximetry; Oxygen; Pregnancy; Reproducibility of Results; Respiration | 1997 |
Spinal mu, delta and kappa opioids alter chemical, mechanical and thermal sensitivities in amphibians.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Enkephalin, Leucine-2-Alanine; Fentanyl; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Spinal Cord | 1997 |
The rate-decreasing effects of fentanyl derivatives in pigeons before, during and after chronic morphine treatment.
Topics: Analgesics; Animals; Columbidae; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Morphine; Naltrexone | 1998 |
Rapid opioid detoxification.
Topics: Adult; Drug Implants; Fentanyl; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders | 1998 |
Pharmacological profile of a deuterium-substituted mirfentanil derivative, OHM10579, in rhesus monkeys.
Topics: Analgesics; Animals; Behavior, Animal; Deuterium; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Fentanyl; Macaca mulatta; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Respiratory Mechanics | 1998 |
Health evaluation of free-ranging guanaco (Lama guanicoe).
Topics: Analgesics, Opioid; Anesthetics; Animals; Animals, Domestic; Animals, Wild; Antibodies; Antidotes; Blood Chemical Analysis; Camelids, New World; Communicable Diseases; Drug Combinations; Enzymes; Female; Fentanyl; Flumazenil; Health Status; Immobilization; Male; Minerals; Naltrexone; Narcotic Antagonists; Physical Examination; Reference Values; Sheep; Tiletamine; Vitamins; Zolazepam | 1998 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor.
Topics: Animals; Buprenorphine; Butorphanol; Columbidae; Discrimination Learning; Female; Fentanyl; Levallorphan; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1998 |
Effect of gonadectomy on discriminative stimulus effects of morphine in female versus male rats.
Topics: Animals; Buprenorphine; Castration; Discrimination Learning; Female; Fentanyl; Gonadal Steroid Hormones; Injections; Male; Morphine; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1999 |
Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Female; Fentanyl; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Receptors, Opioid; Shrews; Vomiting | 1999 |
Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations.
Topics: Amphetamine; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Anxiety Agents; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid; Saimiri; Selective Serotonin Reuptake Inhibitors | 1999 |
Effects of a novel fentanyl derivative on drug discrimination and learning in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Fentanyl; Macaca mulatta; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 1999 |
Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Fentanyl; Male; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil.
Topics: Analgesics; Animals; Arousal; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Fentanyl; Ketamine; Morphine; Naltrexone | 1999 |
Use of orally administered carfentanil prior to isoflurane-induced anesthesia in a Kodiak brown bear.
Topics: Acid-Base Equilibrium; Administration, Oral; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Pressure; Fentanyl; Fibrosarcoma; Forelimb; Heart Rate; Isoflurane; Male; Naltrexone; Narcotic Antagonists; Preanesthetic Medication; Respiration; Soft Tissue Neoplasms; Ursidae | 2000 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Oral induction of anesthesia with droperidol and transmucosal carfentanil citrate in chimpanzees (Pan troglodytes).
Topics: Administration, Oral; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Blood Gas Analysis; Body Temperature; Droperidol; Female; Fentanyl; Heart Rate; Least-Squares Analysis; Male; Mouth Mucosa; Naltrexone; Oximetry; Pan troglodytes; Tiletamine; Zolazepam | 2000 |
Diagnosis and treatment of obstructive urolithiasis in a captive Rocky Mountain wapiti (Cervus elaphus nelsoni).
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Deer; Fentanyl; Hematuria; Hydrogen-Ion Concentration; Male; Naltrexone; Penis; Phenylbutazone; Specific Gravity; Urethra; Urethral Obstruction; Urinary Bladder; Urinary Calculi | 2000 |
delta-Opioid receptors are more efficiently coupled to adenylyl cyclase than to L-type Ca(2+) channels in transfected rat pituitary cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkylating Agents; Analgesics, Opioid; Animals; Barium; Calcium Channels, L-Type; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Heterotrimeric GTP-Binding Proteins; Ion Channels; Naltrexone; Pituitary Gland; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella | 2000 |
Ultrarapid opioid detoxification: effects on cardiopulmonary physiology, stress hormones and clinical outcomes.
Topics: Adrenocorticotropic Hormone; Adult; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; Blood Pressure; Female; Fentanyl; Follow-Up Studies; Heart Rate; Humans; Hydrocortisone; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Respiration; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2001 |
Acute opioid pretreatment potentiates naltrexone-induced drinking suppression in water-deprived rats.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Fentanyl; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Water Deprivation | 2001 |
Anesthesia of boma-captured Lichtenstein's hartebeest (Sigmoceros lichtensteinii) with a combination of thiafentanil, medetomidine, and ketamine.
Topics: Adrenergic alpha-Agonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Antelopes; Drug Synergism; Female; Fentanyl; Ketamine; Male; Medetomidine; Naltrexone; Narcotic Antagonists | 2002 |
Simultaneous development of six LC-MS-MS methods for the determination of multiple analytes in human plasma.
Topics: Albuterol; Chromatography, Liquid; Clonidine; Fentanyl; Humans; Loratadine; Mass Spectrometry; Naltrexone; Pharmaceutical Preparations; Ritonavir; Technology, Pharmaceutical | 2002 |
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 2002 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 2003 |
Use of irreversible antagonists to determine the relative efficacy of mu-opioids in a pigeon drug discrimination procedure: comparison of beta-funaltrexamine and clocinnamox.
Topics: Animals; Cinnamates; Columbidae; Female; Fentanyl; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Reaction Time; Receptors, Opioid, mu; Sufentanil | 2003 |
Chemical anesthesia of northern sea otters (Enhydra lutris): results of past field studies.
Topics: Anesthesia; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Azaperone; Body Temperature; Diazepam; Female; Fentanyl; Heart Rate; Hypnotics and Sedatives; Immobilization; Logistic Models; Male; Naloxone; Naltrexone; Narcotic Antagonists; Otters; Respiration; Seizures; Time Factors; Tremor | 2001 |
Extraction and quantitation of carfentanil and naltrexone in goat plasma with liquid chromatography-mass spectrometry.
Topics: Analgesics, Opioid; Animals; Chromatography, Liquid; Fentanyl; Goats; Naltrexone; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2003 |
A comparison of carfentanil/xylazine and Telazol/xylazine for immobilization of white-tailed deer.
Topics: Adrenergic alpha-Agonists; Anesthetics; Animals; Deer; Dose-Response Relationship, Drug; Drug Combinations; Female; Fentanyl; Heart Rate; Immobilization; Injections, Intramuscular; Male; Naltrexone; Random Allocation; Respiration; Safety; Tiletamine; Time Factors; Xylazine; Yohimbine; Zolazepam | 2003 |
Immobilization of mule deer with thiafentanil (A-3080) or thiafentanil plus xylazine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Combined; Animals; Cross-Over Studies; Deer; Dose-Response Relationship, Drug; Female; Fentanyl; Immobilization; Male; Naltrexone; Narcotic Antagonists; Random Allocation; Respiration; Time Factors; Xylazine; Yohimbine | 2004 |
Correlation of stable elevations in striatal mu-opioid receptor availability in detoxified alcoholic patients with alcohol craving: a positron emission tomography study using carbon 11-labeled carfentanil.
Topics: Adult; Alcohol Drinking; Alcoholism; Basal Ganglia; Behavior, Addictive; Carbon Radioisotopes; Fentanyl; Hospitalization; Humans; Male; Naltrexone; Narcotic Antagonists; Positron-Emission Tomography; Psychiatric Status Rating Scales; Receptors, Opioid, mu; Severity of Illness Index; Temperance | 2005 |
Pharmacokinetics of carfentanil and naltrexone in domestic goats (Capra hircus).
Topics: Absorption; Analgesics, Opioid; Animals; Cross-Over Studies; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Goats; Half-Life; Immobilization; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Male; Metabolic Clearance Rate; Naltrexone; Narcotic Antagonists; Random Allocation | 2004 |
Pharmacological manipulations of dopamine and opioids have differential effects on sexually motivated song in male European starlings.
Topics: Analgesics, Opioid; Animals; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Implants; Female; Fentanyl; Male; Motivation; Naltrexone; Narcotic Antagonists; Orchiectomy; Piperazines; Receptors, Dopamine D1; Receptors, Opioid; Reward; Sexual Behavior, Animal; Starlings; Testosterone; Vocalization, Animal | 2006 |
Pharmacokinetics and pharmacodynamics of carfentanil and naltrexone in female common eland (Taurotragus oryx).
Topics: Analgesics, Opioid; Animals; Antelopes; Area Under Curve; Body Temperature; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Half-Life; Heart Rate; Immobilization; Injections, Intramuscular; Metabolic Clearance Rate; Naltrexone; Narcotic Antagonists; Random Allocation; Respiration | 2006 |
The opioid antagonist, beta-funaltrexamine, inhibits chemokine expression in human astroglial cells.
Topics: Analysis of Variance; Astrocytes; Astrocytoma; Cell Line, Tumor; Cell Survival; Chemokine CXCL10; Chemokines; Chemokines, CXC; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fentanyl; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 2007 |
Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects.
Topics: Adult; Alcoholism; Analgesics, Opioid; Data Interpretation, Statistical; Female; Fentanyl; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Temperance | 2008 |
Behavioral economic analysis of drug preference using multiple choice procedure data.
Topics: Choice Behavior; Economics; Fentanyl; Fluoxetine; Hallucinogens; Humans; Hydromorphone; Injections, Intramuscular; Methadone; Models, Psychological; Motivation; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Narcotics; Psychotropic Drugs; Recreation; Selective Serotonin Reuptake Inhibitors; Substance Abuse, Intravenous; Substance-Related Disorders | 2008 |
Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; beta-Endorphin; Biomarkers; Biotransformation; Dose-Response Relationship, Drug; Fentanyl; Injections, Intravenous; Loperamide; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Neurosecretory Systems; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2008 |
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.
Topics: Analgesics, Opioid; Animals; Down-Regulation; Electrophysiology; Enkephalins; Etorphine; Fentanyl; In Vitro Techniques; Male; Naltrexone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2008 |
Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone.
Topics: Alcoholism; Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Interactions; Fentanyl; Humans; Hydrocodone; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Respiration | 2008 |
Nociceptin produces antinociception after spinal administration in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Spinal; Naltrexone; Nociceptin; Opioid Peptides; Pain Threshold; Peptide Fragments; Rana pipiens | 2009 |
Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Hot Temperature; Ligands; Macaca mulatta; Naltrexone; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2009 |
Evaluation of biomarkers for pharmacological activity.
Topics: Adult; Algorithms; Analgesics, Opioid; Biomarkers; Computer Simulation; Cross-Over Studies; Fentanyl; Hormones; Humans; Longitudinal Studies; Male; Multivariate Analysis; Naltrexone; Narcotic Antagonists; Pharmacology, Clinical; Research Design | 2009 |
Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2009 |
Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats.
Topics: Animals; Blood Gas Analysis; Buprenorphine; Catheterization; Fentanyl; Lactic Acid; Male; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory Insufficiency; Respiratory Mechanics | 2009 |
Carfentanil--an ultra potent opioid.
Topics: Accidents, Occupational; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Veterinarians | 2010 |
Intranasal naltrexone and atipamezole for reversal of white-tailed deer immobilized with carfentanil and medetomidine.
Topics: Administration, Intranasal; Adrenergic alpha-Antagonists; Animals; Cross-Over Studies; Deer; Dose-Response Relationship, Drug; Drug Combinations; Female; Fentanyl; Imidazoles; Immobilization; Injections, Intramuscular; Medetomidine; Naltrexone; Narcotic Antagonists; Random Allocation | 2010 |
Resolution of opioid-induced postoperative ileus in a newborn infant after methylnaltrexone.
Topics: Aortic Arch Syndromes; Coronary Disease; Extracorporeal Membrane Oxygenation; Fatal Outcome; Female; Fentanyl; Humans; Infant, Newborn; Intestinal Pseudo-Obstruction; Naltrexone; Narcotic Antagonists; Narcotics; Pain, Postoperative; Postoperative Complications; Quaternary Ammonium Compounds; Remission Induction | 2011 |
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug Tolerance; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Neuropeptide; Substance Withdrawal Syndrome | 2012 |
Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Carrageenan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fentanyl; Hyperalgesia; Inflammation; Ketamine; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Swimming; Time Factors | 2011 |
Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Fentanyl; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time | 2012 |
Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Calcium Signaling; Data Interpretation, Statistical; Female; Fentanyl; HEK293 Cells; Humans; Injections, Spinal; Macaca mulatta; Male; Methadone; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2012 |
Sufentanil citrate immobilization of Alaskan moose calves.
Topics: Alaska; Anesthesia Recovery Period; Animals; Animals, Newborn; Animals, Wild; Deer; Dose-Response Relationship, Drug; Female; Fentanyl; Immobilization; Male; Naltrexone; Narcotics; Oxygen; Respiration; Sufentanil; Time Factors; Tolazoline; Xylazine | 2012 |
Comparison of two injectable immobilization combinations in Himalayan tahr (Hemitragus jemlahicus): medetomidine, ketamine, and atipamezole versus carfentanil, xylazine, naltrexone, and atipamezole.
Topics: Animals; Fentanyl; Hypnotics and Sedatives; Imidazoles; Ketamine; Medetomidine; Naltrexone; Ruminants; Xylazine | 2013 |
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Nalmefene reverses carfentanil-induced loss of righting reflex and respiratory depression in rats.
Topics: Analgesics, Opioid; Animals; Blood Gas Analysis; Dose-Response Relationship, Drug; Fentanyl; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Reflex, Righting; Respiratory Insufficiency; Time Factors | 2014 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fentanyl; Inflammation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord | 2014 |
κ-Opioid receptors are involved in enhanced cardioprotection by combined fentanyl and limb remote ischemic postconditioning.
Topics: Animals; Extremities; Fentanyl; Ischemic Postconditioning; Male; Myocardial Reperfusion Injury; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2015 |
Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys.
Topics: Analgesics, Opioid; Animals; Benzimidazoles; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Fentanyl; GABA Modulators; Imidazoles; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Pain Measurement; Piperidines; Receptors, Opioid; Spiro Compounds | 2016 |
Propofol-medetomidine-ketamine total intravenous anaesthesia in thiafentanil-medetomidine-immobilized impala (Aepyceros melampus).
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia, Intravenous; Anesthetics, Combined; Animals; Antelopes; Female; Fentanyl; Heart Rate; Hypnotics and Sedatives; Imidazoles; Ketamine; Medetomidine; Naltrexone; Narcotic Antagonists; Propofol; Prospective Studies; Respiratory Rate | 2017 |
Methylnaltrexone Versus Naloxone for Opioid-Induced Constipation in the Medical Intensive Care Unit.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Electronic Health Records; Female; Fentanyl; Heart Rate; Humans; Intensive Care Units; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies | 2017 |
Postincarceration Fatal Overdoses After Implementing Medications for Addiction Treatment in a Statewide Correctional System.
Topics: Adolescent; Adult; Buprenorphine; Cause of Death; Drug Overdose; Female; Fentanyl; Health Plan Implementation; Humans; Male; Methadone; Middle Aged; Naltrexone; Odds Ratio; Opioid-Related Disorders; Patient Discharge; Prisoners; Prisons; Retrospective Studies; Rhode Island; Transitional Care; Young Adult | 2018 |
Sex differences in the effectiveness of buprenorphine to decrease rates of responding in rhesus monkeys.
Topics: Analgesics; Animals; Behavior, Animal; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Macaca mulatta; Male; Naltrexone; Receptors, Opioid, mu; Sex Factors | 2019 |
Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Female; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds; Thiophenes | 2019 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
Optimal treatment of opioid induced constipation in daily clinical practice - an observational study.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Fentanyl; Humans; Laxatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Oxycodone; Pain Management; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies; Surveys and Questionnaires | 2019 |
Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Behavior, Animal; Choice Behavior; Clonidine; Drug-Seeking Behavior; Feeding Behavior; Female; Fentanyl; Food; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Tetanus Toxoid; Vaccines, Conjugate | 2019 |
Vaccine blunts fentanyl potency in male rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Fentanyl; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Nociception; Oxycodone; Receptors, Opioid, mu; Tetanus Toxoid; Vaccines; Vaccines, Conjugate | 2019 |
Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Fentanyl; Heroin; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Rats; Tetanus Toxoid; Vaccination | 2019 |
Changes in murine respiratory dynamics induced by aerosolized carfentanil inhalation: Efficacy of naloxone and naltrexone.
Topics: Administration, Inhalation; Aerosols; Analgesics, Opioid; Animals; Computer Simulation; Dose-Response Relationship, Drug; Fentanyl; Humans; Lung; Male; Mice; Models, Biological; Naloxone; Naltrexone; Narcotic Antagonists; Plethysmography, Whole Body; Respiration; Respiratory Insufficiency; Risk Assessment | 2019 |
Changes in fentanyl demand following naltrexone, morphine, and buprenorphine in male rats.
Topics: Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement Schedule; Self Administration | 2020 |
GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats.
Topics: Adjuvants, Anesthesia; Allosteric Regulation; Analgesia; Anesthesia; Animals; Delayed Emergence from Anesthesia; Dexmedetomidine; Drug Combinations; Drug Evaluation, Preclinical; Female; Fentanyl; Flumazenil; GABA-A Receptor Antagonists; Ketamine; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Nociception; Pain Measurement; Rats; Receptors, N-Methyl-D-Aspartate; Reflex, Righting; Rotarod Performance Test | 2020 |
Evaluation of a Dual Fentanyl/Heroin Vaccine on the Antinociceptive and Reinforcing Effects of a Fentanyl/Heroin Mixture in Male and Female Rats.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Fentanyl; Heroin; Male; Naltrexone; Rats; Vaccines | 2020 |
Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Fentanyl; Macaca mulatta; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Self Administration | 2020 |
A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Fentanyl; Hydrogen-Ion Concentration; Hyperalgesia; Ligands; Male; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, mu | 2020 |
Effects of kappa opioid receptor agonists on fentanyl vs. food choice in male and female rats: contingent vs. non-contingent administration.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Fentanyl; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Spiro Compounds | 2021 |
Reversal of ingested fentanyl patch toxicity with oral naltrexone in remote Australia: case report.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Australia; Fentanyl; Humans; Male; Naltrexone; Opioid-Related Disorders; Out-of-Hospital Cardiac Arrest; Rural Population; Transdermal Patch; Treatment Outcome | 2021 |
Discriminative stimulus effects of carfentanil in rats discriminating fentanyl: Differential antagonism by naltrexone.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Fentanyl; Heroin; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2021 |
Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent.
Topics: Analgesics, Opioid; Animals; Drug Design; Fentanyl; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists | 2021 |
Olanzapine/samidorphan precipitated opioid withdrawal in a patient taking transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Naltrexone; Olanzapine; Substance Withdrawal Syndrome | 2022 |
Role of Efficacy as a Determinant of Locomotor Activation by Mu Opioid Receptor Ligands in Female and Male Mice.
Topics: Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; Fentanyl; Ligands; Male; Mice; Naltrexone; Rats; Receptors, Opioid, mu | 2022 |
Sensitivity of a fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Male; Naltrexone; Opioid-Related Disorders; Rats; Self Administration; Social Interaction | 2022 |
Hepatic and renal toxicities and metabolism of fentanyl analogues in rats.
Topics: Analgesics, Opioid; Animals; Fentanyl; Liver; Naltrexone; Narcotic Antagonists; Rats | 2023 |
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.
Topics: Analgesics, Opioid; Animals; Fentanyl; Hypoventilation; Male; Mice; Morphine; Naltrexone; Receptors, Opioid, mu | 2023 |
Fentanyl-induced respiratory depression in rodents is inhibited by bioabsorbable, subcutaneous naltrexone implants at 3.5 months.
Topics: Absorbable Implants; Animals; Fentanyl; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency; Rodentia | 2023 |