fentanyl has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (12.86) | 18.7374 |
| 1990's | 24 (34.29) | 18.2507 |
| 2000's | 15 (21.43) | 29.6817 |
| 2010's | 17 (24.29) | 24.3611 |
| 2020's | 5 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Dockendorff, C; Huang, XP; Rosas, R; Roth, BL | 1 |
| Avery, BA; Behnke, M; Chear, NJ; Hiranita, T; Kamble, SH; León, F; McCurdy, CR; McMahon, LR; Obeng, S; Patel, A; Ramanathan, S; Reeves, ME; Restrepo, LF; Sharma, A | 1 |
| Allaoa, A; Ansonoff, M; Devi, LA; Faouzi, A; Gomes, I; Gupta, A; Keresztes, AI; Le Rouzic, V; Majumdar, S; Massaly, N; Morón, JA; Pan, YX; Pintar, J; Streicher, JM; Uprety, R; Yoon, HJ; Zhang, T | 1 |
| Asher, WB; Bernhard, SM; Chakraborty, S; Che, T; Chintala, SM; DiBerto, JF; Eans, SO; Faouzi, A; Filizola, M; Gutridge, AM; Javitch, JA; Jilakara, R; Majumdar, S; Margolis, EB; McLaughlin, JP; Nelson, MNF; Nuthikattu, N; Provasi, D; Ramsey, S; Roth, BL; Sames, D; van Rijn, RM; Wilson, LL; Zhou, Y | 1 |
| Costa, EM; Hoffmann, BB; Loew, GH | 1 |
| Chi, ZQ; Masuo, Y; Pélaprat, D; Rostène, W; Wang, H | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Brine, GA; Carroll, FI; Jacobson, AE; Rice, KC; Rothman, RB; Seggel, M; Xu, H | 1 |
| Chi, ZQ; Pélaprat, D; Roques, BP; Rostène, W; Vanhove, A; Wang, H | 1 |
| Mjanger, E; Yaksh, TL | 1 |
| Barnes, NM; Bunce, KT; Naylor, RJ; Rudd, JA | 1 |
| Chi, ZQ; Kopp, N; Pélaprat, D; Roques, BP; Rostène, W; Sarrieau, A; Vanhove, A; Wang, H | 1 |
| Stevens, CW; Yaksh, TL | 2 |
| Kitchen, I; Yeadon, M | 3 |
| Hill, RG; Hughes, J; Johnson, MA | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Rice, KC; Schoffelmeer, AN | 1 |
| Galzi, JL; Goeldner, M; Hirth, C; Ilien, B; Mejean, A | 1 |
| Burke, TR; Danks, JA; Jacobson, AE; Pert, CB; Rice, KC; Rothman, RB | 1 |
| Nahorski, SR; Traynor, JR | 1 |
| Atcheson, R; Lambert, DG; Rowbotham, DJ | 1 |
| Lambert, DG; Smart, D; Smith, G | 1 |
| Brine, GA; Carroll, FI; Ni, Q; Partilla, JS; Rothman, RB; Stark, PA; Xu, H | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
| Fitzgerald, LW; Teitler, M | 1 |
| Chan, KW; Duttory, A; Yoburn, BC | 1 |
| Bilsky, EJ; Hruby, VJ; Inturrisi, CE; Porreca, F; Sadée, W | 1 |
| Albrecht, E; Baeger, I; Berger, H; Fechner, K; Heinrich, N; Lorenz, D; Samovilova, N | 1 |
| Brine, GA; Carroll, FI; Chen, C; Lai, J; Liu-Chen, LY; Lu, YF; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Sadee, W; Xu, H | 1 |
| Schäfer, M; Stein, C; Zhou, L | 1 |
| Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB | 1 |
| Celver, JP; Chavkin, C; Kovoor, A; Wu, A | 1 |
| Akil, H; Lee, KO; Traynor, JR; Woods, JH | 1 |
| Akil, H; Bonner, G; Meng, F | 1 |
| Furuya, H; Nakayama, H; Nishimine, N; Ueno, S; Yoshikawa, M | 1 |
| Han, JS; Wang, XM; Wang, Y | 1 |
| Choi, BJ; Whang, KT | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Chen, J; Chen, LE; Chi, ZQ; Gao, C; Xu, XJ; Zhou, DH | 1 |
| Lalley, PM | 2 |
| Basbaum, AI; Taylor, BK | 1 |
| Hall, SF; Loh, HH; Mizoguchi, H; Nagase, H; Narita, M; Sora, I; Tseng, LF; Uhl, GR; Wu, HE | 1 |
| Kimura, N; Remmers, JE; Vasilakos, K; Wilson, RJ | 1 |
| Callado, LF; Dardonville, C; Fernandez-Fernandez, C; Gabilondo, AM; Gibbons, SL; Jagerovic, N; Meana, JJ; Ryan, GJ | 1 |
| Hara, N; Hashimoto, T; Kirihara, Y; Saito, Y; Tsuchiya, M; Yamada, K | 1 |
| Allen, JW; Horais, KA; Tozier, NA; Yaksh, TL | 1 |
| Ammon-Treiber, S; Höllt, V; Stolze, D | 1 |
| Bailey, C; Dewey, WL; Gabra, BH; Henderson, G; Hull, LC; Kelly, E; Llorente, J; Smith, FL | 1 |
| Ballanyi, K; Ruangkittisakul, A | 1 |
| Chu, J; Law, PY; Loh, HH; Zhang, Y; Zheng, H | 1 |
| Akbarali, HI; Dewey, WL; Maguma, HT | 1 |
| Giannopoulos, P; Papatheodoropoulos, C | 1 |
| Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C | 1 |
| Funk, GD; Greer, JJ; Hutchinson, MR; Ren, J; Rice, KC; Watkins, LR; Zhang, Y; Zwicker, JD | 1 |
| Connor, M; Knapman, A; Santiago, M | 1 |
| Cussac, D; Heusler, P; Tardif, S | 1 |
| Aicher, SA; Bobeck, EN; Hermes, SM; Ingram, SL; Morgan, MM | 1 |
| Asan, E; Brack, A; Hoffmann, C; Kieffer, BL; Kistner, K; Mambretti, EM; Massotte, D; Mayer, S; Reeh, PW; Rittner, HL | 1 |
| Abraham, AD; Burgeno, LM; Chavkin, C; Kuhar, JR; Land, BB; Ong, SE; Phillips, PEM; Reichard, KL; Schattauer, SS | 1 |
| Al-Madol, M; Khalefa, BI; Mousa, SA; Schäfer, M; Shakibaei, M; Shaqura, M; Tafelski, S | 1 |
| Kuo, A; Lam, AL; Li, T; Magiera, J; Ni, L; Qin, Y; Sekar, S; Shi, J; Shi, S; Smith, MT; Zhu, Z | 1 |
| Del Vecchio, G; Massaly, N; Meyer, J; Seitz, V; Stein, C | 1 |
| Barash, J; Cheng, C; Kofke, WA; Li, M; Liu, Q; Shen, Y; Sheng, Z; Xie, Z | 1 |
| Ambrosio, E; Caria, F; Castelli, MP; De Luca, MA; Di Chiara, G; Laus, A; Mostallino, R; Musa, A; Pintori, N; Poza, C; Tocco, G; Ucha, M | 1 |
70 other study(ies) available for fentanyl and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists.
Topics: | 2019 |
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2020 |
Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.
Topics: Analgesics; Animals; Cell Line; Fentanyl; Humans; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Rats; Rats, Long-Evans; Receptors, Opioid, delta | 2020 |
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
Topics: Analgesics, Opioid; Animals; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Rats, Sprague-Dawley; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Structure-Activity Relationship | 2021 |
Opioid agonists binding and responses in SH-SY5Y cells.
Topics: Alprostadil; Analgesics; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP Phosphohydrolases; Humans; Meperidine; Morphinans; Naloxone; Narcotics; Oxymorphone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1992 |
Effect of brain lesions on [3H]ohmefentanyl binding site densities in the rat striatum and substantia nigra.
Topics: Animals; Brain Injuries; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Male; Rats; Rats, Wistar; Receptors, Opioid; Substantia Nigra | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
RTI-4614-4: an analog of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; In Vitro Techniques; Kinetics; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
[3H]ohmefentanyl preferentially binds to mu-opioid receptors but also labels sigma-sites in rat brain sections.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding Sites; Brain; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Male; Molecular Sequence Data; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substrate Specificity; Tritium | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
The actions of fentanyl to inhibit drug-induced emesis.
Topics: Animals; Antiemetics; Apomorphine; Autoradiography; Brain Stem; Cisplatin; Copper; Copper Sulfate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fentanyl; Ferrets; Male; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Vomiting | 1991 |
Characterization and distribution of [3H]ohmefentanyl binding sites in the human brain.
Topics: Adult; Aged; Autoradiography; Basal Ganglia; Binding Sites; Binding, Competitive; Brain Chemistry; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fentanyl; Humans; In Vitro Techniques; Kinetics | 1991 |
Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Infusions, Parenteral; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Reference Values; Sufentanil | 1989 |
Magnitude of opioid dependence after continuous intrathecal infusion of mu- and delta-selective opioids in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders; Sufentanil; Time Factors | 1989 |
Binding characteristics of [D-Ala2-MePhe4-Glyol5] enkephalin and [D-Pen2,D-Pen5] enkephalin in rat brain: inhibition studies with fentanyl-like drugs.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Kinetics; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Comparison of the effects of calcium concentration on mu and kappa agonist actions in the guinea pig ileum.
Topics: Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Fentanyl isothiocyanate reveals the existence of physically associated mu- and delta-opioid receptors mediating inhibition of adenylate cyclase in rat neostriatum.
Topics: Adenylyl Cyclase Inhibitors; Animals; Caudate Nucleus; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; In Vitro Techniques; Isothiocyanates; Male; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Comparative binding of mu and delta selective ligands in whole brain and pons/medulla homogenates from rat: affinity profiles of fentanyl derivatives.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Male; Medulla Oblongata; Narcotic Antagonists; Pons; Rats; Rats, Inbred Strains | 1988 |
A mu-opioid receptor-filter assay. Rapid estimation of binding affinity of ligands and reversibility of long-lasting ligand-receptor complexes.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Filtration; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sufentanil | 1988 |
Differences in the characteristics of opioid receptor binding in the rat and marmoset.
Topics: Animals; Callitrichinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Male; Rats; Receptors, Opioid; Species Specificity | 1988 |
Tritiated-6-beta-fluoro-6-desoxy-oxymorphone: a highly selective ligand for the opiate mu receptor whose binding is characterized by low nonspecific binding.
Topics: Animals; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hydromorphone; Isothiocyanates; Kinetics; Oxymorphone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Tomography, Emission-Computed | 1984 |
Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.
Topics: Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Narcotics; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1995 |
Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells.
Topics: Atropine; Carbachol; Cell Differentiation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Humans; Morphine; Neuroblastoma; Norepinephrine; Potassium; Receptors, Muscarinic; Tumor Cells, Cultured | 1994 |
mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein.
Topics: Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Morphine; Narcotic Antagonists; Neuroblastoma; Pertussis Toxin; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Ligands; Molecular Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
Quantitative autoradiographic analysis of [3H]carfentanil binding to mu opiate receptors in the rat brain.
Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tissue Distribution; Tritium | 1993 |
Magnitude of tolerance to fentanyl is independent of mu-opioid receptor density.
Topics: Analgesics; Animals; Brain Chemistry; Cinnamates; Dose-Response Relationship, Drug; Down-Regulation; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Kinetics; Male; Mice; Morphine Derivatives; Narcotic Antagonists; Narcotics; Pain Measurement; Reaction Time; Receptors, Opioid, mu | 1997 |
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Dizocilpine Maleate; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Fentanyl; Isoquinolines; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Influence of continuous levels of fentanyl in rats on the mu-opioid receptor in the central nervous system.
Topics: Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guanosine Triphosphate; Male; Membranes; Rats; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord | 1997 |
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Topics: Affinity Labels; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fentanyl; Melphalan; Membrane Proteins; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; Stereoisomerism | 1998 |
Cholecystokinin inhibits peripheral opioid analgesia in inflamed tissue.
Topics: Analgesics, Opioid; Animals; Cholecystokinin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Fentanyl; Male; Naphthalenes; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Protein Kinase C; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1998 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; G-Protein-Coupled Receptor Kinase 3; G-Protein-Coupled Receptor Kinase 5; Humans; Kinetics; Morphine; Potassium Channels; Protein Serine-Threonine Kinases; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Opioid, mu; Sensitivity and Specificity; Xenopus laevis | 1998 |
Differential binding properties of oripavines at cloned mu- and delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Benzamides; Binding, Competitive; Buprenorphine; Cloning, Molecular; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfur Radioisotopes; Thebaine; Tritium; Tumor Cells, Cultured | 1999 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Novel quantitative reverse-transcribed polymerase chain reaction of mu opioid receptor mRNA level.
Topics: Analgesics, Opioid; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Gene Expression; PC12 Cells; Rats; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Taq Polymerase | 2001 |
Discrimination between peptide and non-peptide opioid agonists on the transcription of opioid receptors in two cell lines.
Topics: Benzamides; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Piperazines; Polymerase Chain Reaction; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger; Transcription, Genetic | 2001 |
Change of hyperexcitability of hippocampus by cyclosporin A and its modulatory action by fentanyl.
Topics: Analgesics, Opioid; Animals; Culture Techniques; Cyclosporine; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Fentanyl; Hippocampus; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2002 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Internalization and recycling of human mu opioid receptors expressed in Sf9 insect cells.
Topics: Analgesics, Opioid; Animals; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Humans; Hypertonic Solutions; Insecta; Microscopy, Confocal; Morphine; Naloxone; Narcotic Antagonists; Pertussis Toxin; Receptors, Cell Surface; Receptors, Opioid, mu; Transfection | 2003 |
Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances.
Topics: Action Potentials; Analgesics, Opioid; Animals; Cats; Decerebrate State; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Inhalation; Iontophoresis; Medulla Oblongata; Neurons; Phrenic Nerve; Proprioception; Receptors, Opioid, mu; Respiratory Center; Respiratory Insufficiency; Spinal Cord; Vagus Nerve | 2003 |
Systemic morphine-induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray.
Topics: Analgesics, Opioid; Animals; Drug Administration Routes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Medulla Oblongata; Microdialysis; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome; Wakefulness | 2003 |
Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Exons; Fentanyl; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Mice; Mice, Knockout; Morphine Derivatives; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2003 |
Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivity.
Topics: Action Potentials; Analgesics, Opioid; Analysis of Variance; Animals; Apnea; Carbon Dioxide; Cats; Decerebrate State; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Iontophoresis; Male; Medulla Oblongata; Neurons; Phrenic Nerve; Reaction Time; Receptors, Dopamine D1; Respiratory Insufficiency; Sensory Thresholds; Vagus Nerve | 2004 |
Ancient gill and lung oscillators may generate the respiratory rhythm of frogs and rats.
Topics: Action Potentials; Analysis of Variance; Animals; Biological Clocks; Brain Stem; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Gills; Hypercapnia; In Vitro Techniques; Larva; Lung; Male; Models, Biological; Naloxone; Narcotic Antagonists; Narcotics; Nerve Net; Periodicity; Photoplethysmography; Physical Conditioning, Animal; Ranidae; Rats; Rats, Wistar; Respiration; Respiratory Physiological Phenomena; Vagotomy | 2005 |
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites.
Topics: Analgesics, Opioid; Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Guanidine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoline Receptors; In Vitro Techniques; Indicators and Reagents; Male; Membranes; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Prefrontal Cortex; Reaction Time; Receptors, Drug; Receptors, Opioid, mu; Structure-Activity Relationship | 2006 |
Enhancement of morphine analgesic effect with induction of mu-opioid receptor endocytosis in rats.
Topics: Analgesics, Opioid; Animals; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Male; Morphine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2006 |
Opiate pharmacology of intrathecal granulomas.
Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Granuloma; Injections, Spinal; Male; Maximum Tolerated Dose; Methadone; Morphine; Spinal Cord | 2006 |
Differential effects of mu-opioid receptor agonists in a hippocampal hypoxia/hypoglycemia model.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Evoked Potentials; Fentanyl; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Meperidine; Rats; Rats, Wistar; Receptors, Opioid, mu; Reperfusion Injury | 2007 |
The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy.
Topics: Analgesics, Opioid; Animals; Brain; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; G-Protein-Coupled Receptor Kinases; In Vitro Techniques; Locus Coeruleus; Male; Meperidine; Mice; Mice, Inbred C57BL; Morphine; Neurons; Patch-Clamp Techniques; Protein Kinase C; Receptors, Opioid, mu | 2010 |
Methylxanthine reversal of opioid-evoked inspiratory depression via phosphodiesterase-4 blockade.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Caffeine; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; In Vitro Techniques; Interneurons; Nerve Net; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, mu; Respiratory Insufficiency; Respiratory Physiological Phenomena; Rolipram; Theophylline; Xanthines | 2010 |
Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Cell Line; Dendritic Spines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Mice; Morphine; Phosphorylation; Protein Kinase C-epsilon; Receptors, Opioid, mu; Signal Transduction | 2011 |
Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Colon; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Ileum; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Receptors, Opioid, mu | 2012 |
Effects of μ-opioid receptor modulation on the hippocampal network activity of sharp wave and ripples.
Topics: Analgesics, Opioid; Animals; CA1 Region, Hippocampal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Evoked Potentials; Fentanyl; In Vitro Techniques; Male; Morphine; Rats; Rats, Wistar; Receptors, Opioid, mu | 2013 |
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Fentanyl; Ganglia, Spinal; Humans; Hyperalgesia; Male; Membrane Potentials; Morphine; Mutagenesis, Site-Directed; Protein Binding; Rats; Receptors, Opioid, mu; Sensory Receptor Cells; Substance Withdrawal Syndrome; Tritium; TRPV Cation Channels | 2013 |
Glial TLR4 signaling does not contribute to opioid-induced depression of respiration.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Fentanyl; Male; Medulla Oblongata; Minocycline; Naloxone; Neuroglia; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Respiration; Respiratory Insufficiency; Signal Transduction; Toll-Like Receptor 4 | 2014 |
A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; beta-Endorphin; Buprenorphine; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genotype; Humans; Ion Channel Gating; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Phenotype; Phosphorylation; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; Signal Transduction; Time Factors; Transfection | 2015 |
Agonist stimulation at human μ opioid receptors in a [(35)S]GTPγS incorporation assay: observation of "bell-shaped" concentration-response relationships under conditions of strong receptor G protein coupling.
Topics: Animals; Cricetinae; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Gene Expression Regulation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Morphine; Naloxone; Receptors, Opioid, mu; Sodium | 2016 |
Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.
Topics: Analgesics, Opioid; Animals; Butadienes; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Fentanyl; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Nociceptive Pain; Periaqueductal Gray; Rats, Sprague-Dawley | 2016 |
Functional and structural characterization of axonal opioid receptors as targets for analgesia.
Topics: Amygdala; Analgesia; Animals; Antibodies, Monoclonal; Axons; Behavior, Animal; beta-Arrestins; Calcitonin Gene-Related Peptide; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Fentanyl; Gene Knock-In Techniques; Male; Membrane Potentials; Mice; Nociception; Potassium; Rats, Wistar; Receptors, Opioid, mu; Reproducibility of Results; Sciatic Nerve | 2016 |
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; GTP-Binding Protein alpha Subunits, Gi-Go; JNK Mitogen-Activated Protein Kinases; Mice; Morphine; NADPH Oxidases; Peroxiredoxin VI; Phosphorylation; Pyrrolidines; Reactive Oxygen Species; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2017 |
Accessibility of axonal G protein coupled mu-opioid receptors requires conceptual changes of axonal membrane targeting for pain modulation.
Topics: Analgesics, Opioid; Animals; Axons; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Freund's Adjuvant; Inflammation; Male; Naloxone; Narcotic Antagonists; Neuralgia; Rats, Wistar; Receptors, Opioid, mu; Sciatic Nerve | 2017 |
Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; HEK293 Cells; Humans; Narcotic Antagonists; Protein Binding; Receptors, Opioid | 2019 |
Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; HEK293 Cells; Histamine; Humans; Hydrogen-Ion Concentration; Ligands; Molecular Structure; Mutation; Naloxone; Receptors, Opioid, mu; Signal Transduction; Structure-Activity Relationship | 2019 |
Fentanyl induces autism-like behaviours in mice by hypermethylation of the glutamate receptor gene Grin2b.
Topics: Analgesics, Opioid; Animals; Autism Spectrum Disorder; Autistic Disorder; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Fentanyl; Glutamic Acid; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2022 |
Pharmacological characterization of novel synthetic opioids: Isotonitazene, metonitazene, and piperidylthiambutene as potent μ-opioid receptor agonists.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Morphine; Rats; Receptors, Opioid, mu | 2022 |