fenprostalene and diethylene-glycol

fenprostalene has been researched along with diethylene-glycol* in 1 studies

Other Studies

1 other study(ies) available for fenprostalene and diethylene-glycol

ArticleYear
Degradation of fenprostalene in polyethylene glycol 400 solution.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:10

    The kinetics of degradation of fenprostalene (I) in polyethylene glycol 400 solution was examined using HPLC. The degradation of I at 80 degrees C was shown to depend on the presence of oxygen and a large number of polar products were produced, as evidenced by using 3H-labeled I. Evidence that autoxidation of the polyethylene glycol 400 was concurrent with degradation of I was found from a drop in the apparent pH. Antioxidants were very effective in retarding the rate of degradation in the presence of oxygen. Degradation of I in polyethylene glycol 400 appears to arise from a reaction between the drug and reactive peroxide intermediates formed through air-oxidation of polyethylene glycol 400. This is supported by the finding that I reacts exclusively by a slow transesterification reaction in diethylene glycol, a solvent that is stable to autoxidation.

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Ethylene Glycols; Hydrolysis; Kinetics; Polyethylene Glycols; Prostaglandins F, Synthetic; Solutions; Solvents; Spectrophotometry, Ultraviolet

1984