fenprostalene has been researched along with diethylene-glycol* in 1 studies
1 other study(ies) available for fenprostalene and diethylene-glycol
Article | Year |
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Degradation of fenprostalene in polyethylene glycol 400 solution.
The kinetics of degradation of fenprostalene (I) in polyethylene glycol 400 solution was examined using HPLC. The degradation of I at 80 degrees C was shown to depend on the presence of oxygen and a large number of polar products were produced, as evidenced by using 3H-labeled I. Evidence that autoxidation of the polyethylene glycol 400 was concurrent with degradation of I was found from a drop in the apparent pH. Antioxidants were very effective in retarding the rate of degradation in the presence of oxygen. Degradation of I in polyethylene glycol 400 appears to arise from a reaction between the drug and reactive peroxide intermediates formed through air-oxidation of polyethylene glycol 400. This is supported by the finding that I reacts exclusively by a slow transesterification reaction in diethylene glycol, a solvent that is stable to autoxidation. Topics: Chromatography, High Pressure Liquid; Drug Stability; Ethylene Glycols; Hydrolysis; Kinetics; Polyethylene Glycols; Prostaglandins F, Synthetic; Solutions; Solvents; Spectrophotometry, Ultraviolet | 1984 |