fenobam and benzoxazolone

fenobam has been researched along with benzoxazolone* in 1 studies

Other Studies

1 other study(ies) available for fenobam and benzoxazolone

Article	Year
Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure. Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5 A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable pharmacokinetic properties and are active in an in vivo model of anxiety. Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzoxazoles; Drug Design; Drug Evaluation, Preclinical; Imidazoles; Models, Animal; Pharmacokinetics; Protein Binding; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Structure-Activity Relationship	2007

Article

Year

Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.

Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5

A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable pharmacokinetic properties and are active in an in vivo model of anxiety.

Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzoxazoles; Drug Design; Drug Evaluation, Preclinical; Imidazoles; Models, Animal; Pharmacokinetics; Protein Binding; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Structure-Activity Relationship

2007