fenfluramine and norfenfluramine

fenfluramine has been researched along with norfenfluramine in 125 studies

Research

Studies (125)

Timeframe	Studies, this research(%)	All Research%
pre-1990	59 (47.20)	18.7374
1990's	42 (33.60)	18.2507
2000's	16 (12.80)	29.6817
2010's	4 (3.20)	24.3611
2020's	4 (3.20)	2.80

Authors

Authors	Studies
Beckett, AH	1
Kruk, ZL	1
Clemens, JA; Fuller, RW; Perry, KW	1
Brindley, DN; Pritchard, PH	1
Consolo, S; Forloni, GL; Garattini, S; Ladinsky, H; Tirelli, AS	1
Boulanger, M; Duhault, J; Malen, C; Schmitt, H; Voisin, C	1
Bowley, M; Brindley, DN	1
Broekkamp, CL; Van Rossum, JM; Weemaes, AJ	1
Bernier, JJ	1
Bizzi, A; Garattini, S; Morselli, PL; Tacconi, MT; Tognoni, G	1
Goudie, AJ	1
Campbell, DB; Ford, MJ; Innes, JA; Munro, JF; Stoddart, ME; Watson, ML	1
Fuller, RW; Hemrick, SK; Snoddy, HD	1
Macrae, SM	1
Campbell, DB; Hossain, M	1
Reuter, CJ	1
Hatleberg, SL; Killam, EK	1
Caccia, S; Jori, A	1
Blundell, JE; Campbell, DB	1
Farnebo, LO; Fuxe, K; Hamberger, B; Ogren, SO	1
Blundell, JE; Leshem, MB	1
Goudie, AJ; Taylor, M	1
Offermeier, J; Potgieter, B	1
Kirby, MJ; Turner, P	1
Galton, DJ; Kaye, JP; Tomlin, S	1
DeMeo, MD; Halper, J; Mann, JJ; McBride, PA; Shear, MK; Sweeney, JA	1
Cooper, TB; Gillon, D; Kindler, S; Lerer, B; Lichtenberg, P; Newman, ME; Shapira, B	1
Anelli, M; Caccia, S; Garattini, S; Sarati, S	1
Calev, A; Cooper, T; Gropp, C; Kindler, S; Lerer, B; Lichtenberg, P; Shapira, B	1
Anelli, M; Caccia, S; Ferrarese, A; Fracasso, C; Garattini, S	2
Bush, L; Gibb, JW; Hanson, GR; Singh, N	1
Appel, NM; Contrera, JF; Culp, S; De Souza, EB; Zaczek, R	1
Bizzi, A; Caccia, S; Codegoni, A; Fracasso, C; Frittoli, E; Guiso, G; Mennini, T; Padura, IM; Taddei, C; Uslenghi, A	1
Caccia, S; Fracasso, C; Garattini, S; Invernizzi, R; Samanin, R	1
Baker, GB; Coutts, RT; Dewhurst, WG; Hegadoren, KM	1
Cooper, TB; Johns, CA; Lemus, CZ; Lieberman, JA; Mayerhoff, DI; Novacenko, H; Pollack, S	1
Johnson, MP; Nichols, DE	1
Buchen, D; Fueg, A; Leibowitz, SF; Rogacki, N; Weiss, GF	1
Appel, NM; Battaglia, G; Contrera, JF; Culp, S; De Souza, EB; Zaczek, R	1
Schechter, MD	2
Kasper, S; Richter, P; Schmidt, R; Vieira, A	1
Dresse, A; Scuvée-Moreau, J	1
Carlton, J; Rowland, NE	1
Fuller, RW; Perry, KW; Snoddy, HD	1
De Luigi, A; De Simoni, MG; Fodritto, F; Garattini, S; Juraszczyk, Z	1
Barone, D; Bendotti, C; Caccia, S; Garattini, S; Mennini, T; Samanin, R	1
Ekman, G; Garle, M; Gillberg, C; Miranda-Linné, F; Wetterberg, L	1
Campbell, DB; Gordon, BH; Ings, RM; King, LJ; Richards, RP	1
Bertorelli, R; Consolo, S; Garattini, S; Invernizzi, R; Samanin, R	1
Caccia, S; Garattini, S; Mennini, T	1
Cooper, JK; Hubbard, JW; Midha, KK; Srinivas, NR	1
Boja, JW; Schechter, MD	1
Beeghly, JH; Kuperman, S; Perry, PJ; Tsai, LY; Wright, GJ	1
Gobbi, M; Mennini, T; Taddei, C	1
Caccia, S; Fracasso, C; Garattini, S; Guiso, G	1
Caccia, S; Fracasso, C; Garattini, S; Guiso, G; Spinelli, R	1
Grunewald, GL; Markovich, KM; Sall, DJ	1
Antelman, SM; Bartness, TJ; Rowland, NE	1
Lewis, DA; Sherman, BM	2
Caccia, S; Conforti, I; Duchier, J; Garattini, S	1
Cattabeni, F; Paoletti, R; Racagni, G	1
Goldberg, S; Hirsch, JA; Wurtman, RJ	1
Chalmers, SR; Douglas, JG; Frazer, I; Gough, J; Haslett, C; Munro, JF; Preston, PG	1
Fuller, RW; Perry, KW	1
Invernizzi, R; Kmieciak-Kolada, K; Samanin, R	1
Clemens, JA; Fuller, RW; Molloy, BB; Snoddy, HD	1
Aleotti, A; Bendotti, C; Borsini, F; Garattini, S; Samanin, R	1
Cheng, LK; Krebs, HA; Wright, GJ	1
Garattini, S; Samanin, R	1
Morris, RG; Reece, PA	1
Borroni, E; Ceci, A; Garattini, S; Mennini, T	1
Bareggi, SR; Boni, S; Bonini, LM; Magnoni, V; Zecca, L	1
Bendotti, C; Borsini, F; Garattini, S; Samanin, R; Zanini, MG	1
Caccia, S; Dagnino, G; Garattini, S; Guiso, G; Madonna, R; Zanini, MG	1
Wales, JK	1
Hoebel, BG; Parada, MA; Pothos, E; Puig de Parada, M	1
Rowland, NE	1
Barnfield, AM; Curzon, G; Gibson, EL; Oluyomi, AO	1
Dou, L; Duda, M; Stuting, HH; Zeng, JN	1
Bhargava, HN; Gray, NM; Lu, MC	1
Bertorelli, R; Consolo, S; Ladinsky, H; Russi, G; Zambelli, M	1
Curzon, G; Gibson, EL; Kennedy, AJ	1
Boutagy, J; Gross, AS; Phillips, AC; Shenfield, GM	1
Anelli, M; Caccia, S; Fracasso, C; Frittoli, E; Garattini, S; Giorcelli, P; Gobbi, M; Mennini, T; Taddei, C	1
Cooper, TB; Diehl, DJ; Malone, KM; Mann, JJ; Mintun, MA; Perel, J	1
Bergami, A; Caccia, S; Campbell, B; Fracasso, C; Garattini, S	1
Dacquet, C; Duhault, J; Millan, M; Ouvry, C; Spedding, M; Wurtman, R	1
Garattini, S	1
Bergami, A; Caccia, S; Cagnotto, A; Fracasso, C; Frittoli, E; Garattini, S; Gobbi, M; Mennini, T	1
Bowyer, JF; Clausing, P; Newport, GD; Rushing, LG	1
Clements, A; Cowen, PJ; Hawton, K; Sharpe, M	1
Anelli, M; Bergami, A; Caccia, S; Confalonieri, S; Fracasso, C; Garattini, S	1
Curzon, G; Datla, KP	1
Babb, SM; Christensen, JD; Cohen, BM; Renshaw, PF	1
Bowyer, JF; Clausing, P; Newport, GD	1
Collins, P; Hindmarsh, JG; Jenner, P; Rose, S	1
Cozzi, NV; Frescas, S; Huang, X; Marona-Lewicka, D; Nichols, DE	1
Donovan, AM; Halperin, JM; Newcorn, JH; Sharma, V	1
Abbaszade, I; Brown, BS; Burn, TC; Corjay, MH; Fitzgerald, LW; Hartig, PR; Hollis, GF; Hollis, JM; Largent, BL; Link, JR; Meunier, PC; Patterson, JP; Robertson, DW; Robichaud, AJ; Sun, JH; Valentine, PA	1
Anthenelli, RM; Maxwell, RA	1
Jagroop, IA; Mikhailidis, DP	1
Baumann, MH; Hufeisen, SJ; McBride, A; Rauser, L; Roth, BL; Rothman, RB; Savage, JE	1
Dourish, CT; Kennett, GA; Vickers, SP	1
Kaddoumi, A; Nakashima, K; Nakashima, MN	1
Baumann, MH; Clark, RD; Partilla, JS; Rothman, RB	1
Blough, B; Glennon, RA; Grande-Allen, KJ; Hufeisen, SJ; Roth, BL; Rothman, RB; Setola, V; Vesely, I	1
Dunlop, PC; Johnson, GJ; Leis, LA; Weir, EK	1
Fink, GD; Li, MW; Ni, W; Thakali, K; Watts, SW	1
Green, DJ; Robertson, K; Rokadia, S; Rowland, NE	1
Kaddoumi, A; Nakashima, K; Nakashima, MN; Wada, M	1
Miller, KJ	1
Halperin, JM; Kalmar, JH; Marks, DJ; Newcorn, JH; Schulz, KP; Sharma, V	1
Lim, DS; Welch, JT	1
Cooper, TB; Malone, KM; Mann, JJ; Oquendo, MA; Sher, L; Stanley, BH	1
Kaddoumi, A; Nakashima, K; Wada, M	1
Andréjak, M; Jeu, A; Jobic, Y; Maréchaux, S; Rusinaru, D; Tribouilloy, C	1
Bruneval, P; Etienne, Y; Frachon, I; Jobic, Y; Tribouilloy, C	1
Andréjak, M; Maréchaux, S; Peltier, M; Szymanski, C; Tribouilloy, C	1
Cabooter, D; Copmans, D; de Witte, PAM; Lagae, L; Li, J; Nelis, M; Sourbron, J	1
Boyd, B; Czerwiński, M; Limaye, PB; Martin, P; Muranjan, S; Ogilvie, BW; Smith, S	1
Bialer, M; Erenburg, N; Hamed, R; Perucca, E; Shaul, C	1
Göldner, V; Karst, U	1

Reviews

8 review(s) available for fenfluramine and norfenfluramine

Article	Year
Peripheral and metabolic effects of fenfluramine, 780SE, norfenfluramine and hydroxyethylnorfenfluramine--a review. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Adipose Tissue; Amphetamines; Animals; Autonomic Nervous System; Blood Pressure; Cats; Dogs; Fenfluramine; Glucose; Guinea Pigs; Humans; Lipid Metabolism; Muscles; Norfenfluramine; Obesity; Rabbits; Rats; Structure-Activity Relationship; Triglycerides	1975
A review of the CNS effects of fenfluramine, 780SE and norfenfluramine on animals and man. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Acetylcholine; Amphetamine; Analgesia; Animals; Behavior; Biogenic Amines; Body Temperature Regulation; Brain; Clomipramine; Depression; Drinking; Eating; Fenfluramine; Hormones; Humans; Indoles; Norfenfluramine; Sleep	1975
Tolerance to fenfluramine anorexia: fact or fiction? Appetite, 1986, Volume: 7 Suppl Topics: Animals; Behavior Therapy; Body Weight; Brain; Brain Chemistry; Drug Tolerance; Feeding Behavior; Female; Fenfluramine; Gastric Emptying; Hydroxyindoleacetic Acid; Intestines; Male; Norfenfluramine; Obesity; Rats; Rats, Inbred Strains; Self Stimulation; Serotonin; Stomach	1986
Biological actions of drugs affecting serotonin and eating. Obesity research, 1995, Volume: 3 Suppl 4 Topics: Animals; Appetite Depressants; Eating; Fenfluramine; Humans; Norfenfluramine; Serotonin; Serotonin Agents	1995
Serotonin 5-ht2c receptor agonists: potential for the treatment of obesity. Molecular interventions, 2005, Volume: 5, Issue:5 Topics: Animals; Fenfluramine; Humans; Norfenfluramine; Obesity; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists; Treatment Outcome	2005
[Benfluorex and valvular heart disease]. Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11 Topics: Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Cross-Sectional Studies; Echocardiography; Female; Fenfluramine; Follow-Up Studies; France; Heart Valves; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Norfenfluramine; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals	2011
Adverse effects of benfluorex on heart valves and pulmonary circulation. Pharmacoepidemiology and drug safety, 2014, Volume: 23, Issue:7 Topics: Echocardiography; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Hypertension, Pulmonary; Hypolipidemic Agents; Norfenfluramine; Pulmonary Circulation; Randomized Controlled Trials as Topic; Receptor, Serotonin, 5-HT2B	2014
In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. Pharmacology research & perspectives, 2022, Volume: 10, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Fenfluramine; Humans; Microsomes, Liver; Norfenfluramine; Rats	2022

Trials

10 trial(s) available for fenfluramine and norfenfluramine

Article	Year
Plasma fenfluramine levels, weight loss, and side effects. British medical journal, 1977, Nov-19, Volume: 2, Issue:6098 Topics: Adult; Aged; Body Weight; Female; Fenfluramine; Humans; Middle Aged; Norfenfluramine; Obesity	1977
Fenfluramine and methylcellulose in the treatment of obesity: the relationship between plasma drug concentrations and therapeutic efficacy. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Adolescent; Adult; Aged; Biological Availability; Clinical Trials as Topic; Diet, Reducing; Female; Fenfluramine; Humans; Male; Methylcellulose; Middle Aged; Norfenfluramine; Obesity	1975
Neuroendocrine and behavioral responses to challenge with the indirect serotonin agonist dl-fenfluramine in adults with obsessive-compulsive disorder. Biological psychiatry, 1992, Jan-01, Volume: 31, Issue:1 Topics: Adult; Age Factors; Behavior; Female; Fenfluramine; Humans; Male; Middle Aged; Neurosecretory Systems; Norfenfluramine; Obsessive-Compulsive Disorder; Prolactin; Psychiatric Status Rating Scales; Serotonin; Synaptic Transmission	1992
Hormone responses to fenfluramine and placebo challenge in endogenous depression. Psychiatry research, 1992, Volume: 43, Issue:2 Topics: Adult; Affective Disorders, Psychotic; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fenfluramine; Humans; Hydrocortisone; Male; Middle Aged; Norfenfluramine; Prolactin; Receptors, Serotonin; Serotonin; Weight Loss	1992
Fenfluramine treatment of twenty children with autism. Journal of autism and developmental disorders, 1989, Volume: 19, Issue:4 Topics: Autistic Disorder; Child; Child, Preschool; Double-Blind Method; Female; Fenfluramine; Humans; Infant; Intelligence; Male; Motor Activity; Norfenfluramine; Random Allocation; Serotonin	1989
Fenfluramine treatment of autism: relationship of treatment response to blood levels of fenfluramine and norfenfluramine. Journal of autism and developmental disorders, 1987, Volume: 17, Issue:4 Topics: Adolescent; Autistic Disorder; Biotransformation; Child; Clinical Trials as Topic; Double-Blind Method; Female; Fenfluramine; Humans; Male; Norfenfluramine; Psychological Tests; Random Allocation; Serotonin	1987
Long-term efficacy of fenfluramine in treatment of obesity. Lancet (London, England), 1983, Feb-19, Volume: 1, Issue:8321 Topics: Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Norfenfluramine; Obesity; Recurrence; Tablets; Time Factors	1983
Serotonergic stimulation of adrenocorticotropin secretion in man. The Journal of clinical endocrinology and metabolism, 1984, Volume: 58, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Cyproheptadine; Dose-Response Relationship, Drug; Fenfluramine; Humans; Hydrocortisone; Male; Norfenfluramine; Serotonin	1984
Cigarette smoking decreases the prolactin response to serotonergic stimulation in subgroups of alcoholics and controls. Alcoholism, clinical and experimental research, 2000, Volume: 24, Issue:7 Topics: Adolescent; Adult; Alcoholism; Analysis of Variance; Chi-Square Distribution; Fenfluramine; Humans; Male; Middle Aged; Norfenfluramine; Prolactin; Selective Serotonin Reuptake Inhibitors; Serotonin; Smoking; Substance-Related Disorders; Temperance	2000
Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:9 Topics: Adult; Aggression; Alcohol-Related Disorders; Depression; Emergency Services, Psychiatric; Female; Fenfluramine; Humans; Male; Middle Aged; Norfenfluramine; Prolactin; Retrospective Studies; Serotonin	2008

Other Studies

107 other study(ies) available for fenfluramine and norfenfluramine

Article	Year
Recent research on the basic factors involved in studies on the metabolism and distribution of anorectic drugs. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Appetite Depressants; Biological Availability; Diet; Fenfluramine; Humans; Hydrogen-Ion Concentration; Norfenfluramine	1975
The effects of intracerebral norfenfluramine on body temperature of the rat. The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:11 Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Fenfluramine; Injections, Intraventricular; Male; Norfenfluramine; Rats	1976
Elevation of 3, 4-dihydroxyphenylacetic acid concentrations in rat brain and stimulation of prolactin secretion by fenfluramine: evidence for antagonism at dopamine receptor sites. The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:8 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Fenfluramine; Male; Norfenfluramine; p-Chloroamphetamine; Phenylacetates; Prolactin; Rats; Receptors, Dopamine; Stimulation, Chemical; Time Factors	1976
Studies on the ethanol-induced changes in glycerolipid synthesis in rats and their partial reversal by N-(2-benzoyloxyethyl)norfenfluramine (benfluorex). The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:6 Topics: Animals; Breath Tests; Carbon Dioxide; Ethanol; Fenfluramine; Glucose; Glycerides; Lipids; Liver; Male; Norfenfluramine; Palmitates; Phosphatidic Acids; Rats; Time Factors	1977
Differential effects of the isomers of fenfluramine and norfenfluramine on rat striatal acetylcholine content. The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:10 Topics: Acetylcholine; Animals; Corpus Striatum; Fenfluramine; Mice; Norfenfluramine; Stereoisomerism	1979
Fenfluramine and 5-hydroxytryptamine. Part 2: Involvement of brain 5-hydroxytryptamine in the anorectic activity of fenfluramine. Arzneimittel-Forschung, 1975, Volume: 25, Issue:11 Topics: Amides; Animals; Appetite Depressants; Brain; Brain Chemistry; Clomipramine; Fenclonine; Fenfluramine; Hydroxyindoleacetic Acid; Male; Norfenfluramine; p-Chloroamphetamine; Rats; Serotonin; Telencephalon; Time Factors; Tyramine	1975
Effects of fenfluramine and related compounds on the synthesis of glycerolipids by rat liver. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Animals; Fenfluramine; Liver; Norfenfluramine; Phospholipids; Phosphoric Monoester Hydrolases; Rats; Triglycerides	1975
Does fenfluramine act via norfenfluramine? The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:2 Topics: Animals; Corpus Striatum; Depression, Chemical; Feeding Behavior; Fenfluramine; Injections; Male; Mesencephalon; Norfenfluramine; Rats	1975
[Letter: Inhibition of pancreatic lipase by 780 SE]. La Nouvelle presse medicale, 1975, Mar-29, Volume: 4, Issue:13 Topics: Benzoates; Binding, Competitive; Fatty Acids, Nonesterified; Fenfluramine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lipase; Norfenfluramine; Pancreas	1975
Distribution of fenfluramine in normal and obese mice. International journal of obesity, 1978, Volume: 2, Issue:1 Topics: Adipose Tissue; Animals; Aurothioglucose; Brain; Female; Fenfluramine; Mice; Norfenfluramine; Obesity	1978
Discriminative stimulus properties of fenfluramine in an operant task: an analysis of its cue function. Psychopharmacology, 1977, Jun-06, Volume: 53, Issue:1 Topics: Animals; Conditioning, Operant; Cues; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Female; Fenfluramine; Generalization, Psychological; Norfenfluramine; Rats; Reinforcement Schedule	1977
Effects of fenfluramine and norfenfluramine on brain serotonin metabolism in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1978, Volume: 157, Issue:2 Topics: Animals; Brain; Fenfluramine; Hydroxyindoleacetic Acid; Male; Norfenfluramine; Rats; Serotonin; Time Factors	1978
Electroencephalographic effects of fenfluramine and norfenfluramine in the baboon, Papio papio. Proceedings of the Western Pharmacology Society, 1975, Volume: 18 Topics: Animals; Anticonvulsants; Depression, Chemical; Electroencephalography; Fenfluramine; Haplorhini; Norfenfluramine; Papio	1975
Gas-liquid chromatographic determination of the optical isomers of fenfluramine and norfenfluramine in biological samples. Journal of chromatography, 1977, Nov-21, Volume: 144, Issue:1 Topics: Animals; Brain Chemistry; Chromatography, Gas; Chromatography, Liquid; Female; Fenfluramine; Isomerism; Norfenfluramine; Rats	1977
Proceedings: The relationship between fenfluramine and norfenfluramine blood levels and anoretic activity in the rat. British journal of pharmacology, 1975, Volume: 55, Issue:2 Topics: Animals; Appetite; Appetite Depressants; Fenfluramine; Half-Life; Male; Norfenfluramine; Rats	1975
On the in vivo and in vitro actions of fenfluramine and its derivatives on central monoamine neurons, especially 5-hydroxytryptamine neurons, and their relation to the anorectic activity of fenfluramine. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Animals; Behavior, Animal; Brain; Eating; Fenfluramine; Male; Neurons; Norfenfluramine; Rats; Serotonin	1975
Hypothalamic lesions and drug-induced anorexia. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Amphetamine; Animals; Appetite; Eating; Fenfluramine; Hypothalamus; Male; Norfenfluramine; Rats; Serotonin	1975
Comparisons between the behavioural and anorexic effects of 780SE and other phenylethylamines in the rat. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Amphetamines; Animals; Appetite; Behavior, Animal; Body Weight; Diethylpropion; Fenfluramine; Norfenfluramine; Rats	1975
Some effects of fenfluramine and its derivatives on the central catecholaminergic systems of mice. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Animals; Apomorphine; Clonidine; Fenfluramine; Male; Methyltyrosines; Mice; Motor Activity; Norfenfluramine; Pargyline; Reserpine	1975
Fenfluramine and norfenfluramine on glucose uptake into skeletal muscle. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Animals; Diaphragm; Female; Fenfluramine; Glucose; Glycogen; Insulin; Male; Muscles; Norfenfluramine; Rats	1975
The effect of fenfluramine and its derivatives on triglyceride secretion by the liver of the rabbit. Postgraduate medical journal, 1975, Volume: 51 Suppl 1 Topics: Animals; Fenfluramine; Liver; Male; Norfenfluramine; Protamines; Rabbits; Triglycerides	1975
Effect of escalating doses of d-fenfluramine on the content of indoles in brain. Neuropharmacology, 1992, Volume: 31, Issue:9 Topics: Animals; Brain Chemistry; Fenfluramine; Indoles; Male; Norfenfluramine; Rats; Rats, Inbred Strains	1992
Enhanced serotonergic responsivity following electroconvulsive therapy in patients with major depression. The British journal of psychiatry : the journal of mental science, 1992, Volume: 160 Topics: Depressive Disorder; Double-Blind Method; Electroconvulsive Therapy; Female; Fenfluramine; Humans; Male; Middle Aged; Norfenfluramine; Placebos; Prolactin; Randomized Controlled Trials as Topic; Serotonin; Stimulation, Chemical	1992
Single- and multiple-dose kinetics of d-fenfluramine in rats given anorectic and toxic doses. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:2 Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Fenfluramine; Injections, Subcutaneous; Male; Norfenfluramine; Rats; Rats, Inbred Strains	1992
Response of extrapyramidal and limbic neuropeptides to fenfluramine administration: comparison with methamphetamine. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:3 Topics: Animals; Corpus Striatum; Dopamine; Fenfluramine; Male; Methamphetamine; Neuropeptides; Neurotensin; Norfenfluramine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Substance P; Substantia Nigra	1991
Comparison of the effects of repeated oral versus subcutaneous fenfluramine administration on rat brain monoamine neurons: pharmacokinetic and dose-response data. Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:4 Topics: Administration, Oral; Animals; Biogenic Monoamines; Body Weight; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Fenfluramine; Injections, Subcutaneous; Male; Neurons; Norepinephrine; Norfenfluramine; Rats; Rats, Inbred Strains; Serotonin	1991
Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:5 Topics: Animals; Appetite Depressants; Brain; Fenfluramine; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitochondria; Norfenfluramine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Species Specificity; Synaptosomes; Tritium	1991
Effects of intracerebroventricular administration of d-fenfluramine and d-norfenfluramine, as a single injection or 2-hr infusion, on serotonin in brain: relationship to concentrations of drugs in brain. Neuropharmacology, 1991, Volume: 30, Issue:2 Topics: Animals; Brain Chemistry; Dopamine; Dose-Response Relationship, Drug; Fenfluramine; Injections, Intraventricular; Male; Norepinephrine; Norfenfluramine; Rats; Rats, Inbred Strains; Regression Analysis; Serotonin; Stereoisomerism	1991
Interactions of iprindole with fenfluramine metabolism in rat brain and liver. Journal of psychiatry & neuroscience : JPN, 1991, Volume: 16, Issue:1 Topics: Animals; Brain; Brain Chemistry; Chromatography, Gas; Drug Interactions; Fenfluramine; Iprindole; Liver; Norfenfluramine; Rats	1991
Hormonal response to fenfluramine challenges in clozapine-treated schizophrenic patients. Biological psychiatry, 1991, Apr-01, Volume: 29, Issue:7 Topics: Administration, Oral; Adult; Brain; Chronic Disease; Clozapine; Female; Fenfluramine; Humans; Male; Norfenfluramine; Prolactin; Schizophrenia; Schizophrenic Psychology; Serotonin Antagonists	1991
Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine. Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:1 Topics: Animals; Biogenic Monoamines; Fenfluramine; Frontal Lobe; Hippocampus; Male; Neurons; Norfenfluramine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism	1990
Impact of hypothalamic d-norfenfluramine and peripheral d-fenfluramine injection on macronutrient intake in the rat. Brain research bulletin, 1990, Volume: 25, Issue:6 Topics: Animals; Circadian Rhythm; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Eating; Fenfluramine; Male; Norfenfluramine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; Serotonin; Suprachiasmatic Nucleus	1990
Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:1 Topics: Animals; Body Weight; Brain; Catecholamines; Dose-Response Relationship, Drug; Fenfluramine; Male; Norfenfluramine; Rats; Rats, Inbred Strains; Serotonin; Time Factors	1990
Temporal differences in behavioral effect of fenfluramine and norfenfluramine. Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:3 Topics: Animals; Behavior, Animal; Discrimination Learning; Dose-Response Relationship, Drug; Fenfluramine; Injections, Intraperitoneal; Male; Norfenfluramine; Rats; Rats, Inbred Strains; Stereoisomerism	1990
Multiple hormone responses to stimulation with dl-fenfluramine in patients with major depression before and after antidepressive treatment. Pharmacopsychiatry, 1990, Volume: 23, Issue:2 Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Female; Fenfluramine; Growth Hormone; Hormones; Humans; Hydrocortisone; Male; Middle Aged; Norfenfluramine; Prolactin; Thyrotropin	1990
Influence of fenfluramine and norfenfluramine stereoisomers on the firing rate of central monoaminergic neurons in the rat. European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2 Topics: Animals; Cholinergic Fibers; Electrodes, Implanted; Electrophysiology; Fenfluramine; Infusions, Intravenous; Male; Neural Conduction; Norfenfluramine; Rats; Rats, Inbred Strains; Time Factors	1990
Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation. Life sciences, 1990, Volume: 47, Issue:1 Topics: Amphetamine; Analysis of Variance; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Fenfluramine; Food Deprivation; Male; Norfenfluramine; Rats; Rats, Inbred Strains; Satiation	1990
Metabolism of fenfluramine to norfenfluramine in guinea-pigs. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Animals; Brain Chemistry; Fenfluramine; Guinea Pigs; Hydroxyindoleacetic Acid; Male; Norfenfluramine; Serotonin	1988
Different effects of fenfluramine isomers and metabolites on extracellular 5-HIAA in nucleus accumbens and hippocampus of freely moving rats. European journal of pharmacology, 1988, Aug-24, Volume: 153, Issue:2-3 Topics: Animals; Extracellular Space; Fenfluramine; Hippocampus; Hydroxyindoleacetic Acid; Male; Motor Activity; Norfenfluramine; Nucleus Accumbens; Rats; Septal Nuclei; Serotonin; Stereoisomerism	1988
Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of D-fenfluramine in the rat. Neuropharmacology, 1989, Volume: 28, Issue:5 Topics: Animals; Appetite Depressants; Brain Chemistry; Eating; Fenfluramine; Histamine H2 Antagonists; Male; Metergoline; Norfenfluramine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Spiperone	1989
The measurement of d-fenfluramine and its metabolite, d-norfenfluramine in plasma and urine with an application of the method to pharmacokinetic studies. Xenobiotica; the fate of foreign compounds in biological systems, 1989, Volume: 19, Issue:5 Topics: Administration, Oral; Adult; Chromatography, Gas; Female; Fenfluramine; Humans; Male; Middle Aged; Norfenfluramine	1989
Effects of the l isomer of fenfluramine on dopamine mechanisms in rat brain: further studies. European journal of pharmacology, 1989, May-19, Volume: 164, Issue:2 Topics: Animals; Apomorphine; Brain Chemistry; Corpus Striatum; Dialysis; Dopamine; Dose-Response Relationship, Drug; Fenfluramine; Haloperidol; Homovanillic Acid; In Vitro Techniques; Male; Norfenfluramine; Rats; Stereoisomerism	1989
Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanisms. Psychopharmacology, 1985, Volume: 85, Issue:1 Topics: Animals; Appetite Depressants; Brain; Fenfluramine; In Vitro Techniques; Male; Nerve Endings; Norfenfluramine; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stereoisomerism; Synaptic Transmission	1985
Enantioselective gas chromatographic assay with electron-capture detection for dl-fenfluramine and dl-norfenfluramine in plasma. Journal of chromatography, 1988, Dec-09, Volume: 433 Topics: Chromatography, Gas; Fenfluramine; Humans; Male; Norfenfluramine; Reference Standards; Stereoisomerism	1988
Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation. Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:2 Topics: Animals; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Fenfluramine; Male; Norfenfluramine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Time Factors	1988
Different components of 3H-imipramine binding in rat brain membranes: relation to serotonin uptake sites. Life sciences, 1988, Volume: 42, Issue:5 Topics: Animals; Binding Sites; Brain; Cell Membrane; Fenfluramine; Imipramine; Male; Norfenfluramine; Piperidines; Rats; Serotonin; Serotonin Antagonists	1988
Disposition of D-fenfluramine in lean and obese rats. Appetite, 1988, Volume: 10, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Female; Fenfluramine; Half-Life; Kinetics; Microsomes, Liver; Norfenfluramine; Obesity; Proteins; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Rats, Zucker	1988
Disposition of (-)-fenfluramine and its active metabolite, (-)-norfenfluramine in rat: a single dose-proportionality study. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:5 Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Fenfluramine; Injections, Intravenous; Male; Norfenfluramine; Rats; Stereoisomerism; Tissue Distribution	1988
Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT) Journal of medicinal chemistry, 1987, Volume: 30, Issue:12 Topics: Amphetamines; Binding Sites; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Fenfluramine; Molecular Conformation; Norbornanes; Norfenfluramine; Phenylethanolamine N-Methyltransferase; Solubility; Structure-Activity Relationship	1987
Comparison of the effects of fenfluramine and other anorectic agents in different feeding and drinking paradigms in rats. Life sciences, 1985, Jun-17, Volume: 36, Issue:24 Topics: Animals; Appetite Depressants; Deoxyglucose; Drinking Behavior; Feeding Behavior; Fenfluramine; Food Deprivation; Injections, Intraperitoneal; Injections, Intraventricular; Male; Norfenfluramine; Pressure; Quipazine; Rats; Rats, Inbred Strains; Research Design; Stress, Physiological; Tail	1985
Serotonergic regulation of prolactin and growth hormone secretion in man. Acta endocrinologica, 1985, Volume: 110, Issue:2 Topics: Adult; Cyproheptadine; Dose-Response Relationship, Drug; Fenfluramine; Growth Hormone; Humans; Male; Norfenfluramine; Prolactin; Receptors, Serotonin	1985
Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given D- and DL-fenfluramine for 15 days. European journal of clinical pharmacology, 1985, Volume: 29, Issue:2 Topics: Adult; Female; Fenfluramine; Half-Life; Humans; Kinetics; Male; Norfenfluramine; Stereoisomerism	1985
A mass fragmentographic study of amphetamine and metabolites in rat brain. Journal of psychiatric research, 1974, Volume: 11 Topics: Amphetamine; Amphetamines; Animals; Brain; Brain Chemistry; Caudate Nucleus; Chromatography, Gas; Dextroamphetamine; Dopamine; Fenfluramine; Hypothalamus; In Vitro Techniques; Mass Spectrometry; Methamphetamine; Norfenfluramine; Phenylpropanolamine; Rats; Serotonin	1974
Effect of (+)- or (-)-enantiomers of fenfluramine or norfenfluramine on nutrient selection by rats. The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:1 Topics: Animals; Diet; Dietary Proteins; Fenfluramine; Food Preferences; Male; Norfenfluramine; Rats; Rats, Inbred Strains; Stereoisomerism	1982
Decreased accumulation of brain 5-hydroxytryptophan after decarboxylase inhibition in rats treated with fenfluramine, norfenfluramine or p-chloroamphetamine. The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:9 Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Brain; Carboxy-Lyases; Fenfluramine; Hydrazines; Male; Norfenfluramine; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Serotonin	1983
Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? British journal of pharmacology, 1982, Volume: 75, Issue:3 Topics: Animals; Brain; Drug Synergism; Female; Fenfluramine; Hydroxyindoleacetic Acid; In Vitro Techniques; Metergoline; Norfenfluramine; Rats; Receptors, Serotonin; Reserpine; Serotonin	1982
Effect of norfenfluramine and two structural analogues on brain 5-hydroxyindoles and serum prolactin in rats. The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:7 Topics: Animals; Brain; Fenfluramine; Hydroxyindoleacetic Acid; Indoles; Male; Norfenfluramine; Prolactin; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship	1982
D-Fenfluramine and D-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain. Pharmacological research communications, 1982, Volume: 14, Issue:7 Topics: Amidines; Animals; Brain; Brain Chemistry; Clomipramine; Depression, Chemical; Feeding Behavior; Female; Fenclonine; Fenfluramine; Metergoline; Norfenfluramine; Rats; Reserpine; Serotonin; Serotonin Antagonists	1982
Determination of fenfluramine and norfenfluramine in plasma using a nitrogen-sensitive detector. Journal of chromatography, 1984, Oct-12, Volume: 310, Issue:2 Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Dextroamphetamine; Fenfluramine; Humans; Norfenfluramine	1984
d-Fenfluramine and salbutamol: two drugs causing anorexia through different neurochemical mechanisms. International journal of obesity, 1984, Volume: 8 Suppl 1 Topics: Albuterol; Animals; Appetite; Appetite Depressants; Clomipramine; Dextroamphetamine; Eating; Feeding Behavior; Fenfluramine; Metergoline; Norfenfluramine; Rats; Serotonin; Serotonin Antagonists	1984
Improved gas-liquid chromatographic method for measuring fenfluramine and norfenfluramine in heparinised plasma. Journal of chromatography, 1983, Dec-09, Volume: 278, Issue:2 Topics: Amphetamine; Chromatography, Gas; Fenfluramine; Heparin; Humans; Methamphetamine; Norfenfluramine	1983
Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms. Journal of neurochemistry, 1983, Volume: 40, Issue:3 Topics: Animals; Brain; Dose-Response Relationship, Drug; Fenfluramine; Norfenfluramine; Rats; Reserpine; Serotonin; Synaptosomes	1983
[Activity of fenfluramine in obese subjects. Relation between dosage, plasma concentration of the drug and its effect on weight loss]. Minerva medica, 1982, Jun-08, Volume: 73, Issue:24 Topics: Adult; Aged; Body Weight; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Male; Middle Aged; Norfenfluramine; Obesity	1982
Effect of fenfluramine and norfenfluramine stereoisomers on stimulant effects of d-amphetamine and apomorphine in the rat. Pharmacological research communications, 1980, Volume: 12, Issue:6 Topics: Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Dextroamphetamine; Fenfluramine; Humans; Male; Motor Activity; Norfenfluramine; Rats; Stereoisomerism; Stereotyped Behavior	1980
Kinetics of fenfluramine isomers in the rat. European journal of drug metabolism and pharmacokinetics, 1981, Volume: 6, Issue:4 Topics: Animals; Dose-Response Relationship, Drug; Fenfluramine; Kinetics; Male; Norfenfluramine; Rats; Rats, Inbred Strains; Stereoisomerism	1981
The effect of fenfluramine on weight loss during restricted dietary regimes. International journal of obesity, 1980, Volume: 4, Issue:2 Topics: Body Weight; Female; Fenfluramine; Humans; Male; Norfenfluramine; Obesity	1980
The role of d-norfenfluramine in the indole-depleting effect of d-fenfluramine in the rat. European journal of pharmacology, 1993, Mar-16, Volume: 233, Issue:1 Topics: Animals; Brain; Brain Chemistry; Fenfluramine; Hydroxyindoleacetic Acid; Indoles; Injections, Intraperitoneal; Male; Norfenfluramine; Proadifen; Rats; Serotonin	1993
d-fenfluramine, but not d-norfenfluramine, uses calcium to increase extracellular serotonin. Life sciences, 1995, Volume: 56, Issue:22 Topics: Animals; Calcium; Extracellular Space; Fenfluramine; Hippocampus; Male; Microdialysis; Norfenfluramine; Rats; Rats, Sprague-Dawley; Serotonin; Verapamil	1995
Long-term administration of dexfenfluramine to genetically obese (ob/ob) and lean mice: body weight and brain serotonin changes. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:2 Topics: Animals; Blood Glucose; Body Weight; Brain Chemistry; Corticosterone; Dietary Fats; Female; Fenfluramine; Mice; Mice, Inbred C57BL; Mice, Obese; Norfenfluramine; Obesity; Paroxetine; Serotonin	1994
d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release. European journal of pharmacology, 1994, Oct-13, Volume: 264, Issue:1 Topics: Animals; Eating; Feeding and Eating Disorders; Fenclonine; Fenfluramine; Hypothalamus; Male; Microdialysis; Norfenfluramine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin	1994
New chiral high-performance liquid chromatographic methodology used for the pharmacokinetic evaluation of dexfenfluramine. Journal of chromatography. B, Biomedical applications, 1994, Apr-01, Volume: 654, Issue:2 Topics: Chromatography, High Pressure Liquid; Computers; Dinitrobenzenes; Fenfluramine; Humans; Indicators and Reagents; Isocyanates; Norfenfluramine; Quality Control; Spectrophotometry, Ultraviolet; Stereoisomerism	1994
Pharmacological evaluation of 2-amino-6(7)- and 9-amino-6-trifluoromethylbenzonorbornenes, the conformationally rigid analogues of norfenfluramine in mice. General pharmacology, 1993, Volume: 24, Issue:6 Topics: Amphetamine; Analgesics; Animals; Drug Synergism; Female; Fenfluramine; Mice; Mice, Inbred ICR; Molecular Conformation; Morphine; Motor Activity; Norbornanes; Norfenfluramine; Pain Measurement	1993
Serotonergic facilitation of acetylcholine release in vivo from rat dorsal hippocampus via serotonin 5-HT3 receptors. Journal of neurochemistry, 1994, Volume: 62, Issue:6 Topics: Acetylcholine; Animals; Citalopram; Denervation; Dose-Response Relationship, Drug; Female; Fenfluramine; Hippocampus; Microdialysis; Norfenfluramine; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists	1994
d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors. European journal of pharmacology, 1993, Sep-21, Volume: 242, Issue:1 Topics: Animals; Drug Interactions; Feeding and Eating Disorders; Fenclonine; Fenfluramine; Male; Norfenfluramine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists	1993
Determination of dexfenfluramine and nordexfenfluramine in urine by high-performance liquid chromatography using ultraviolet detection. Journal of chromatography, 1993, Nov-17, Volume: 621, Issue:1 Topics: Chromatography, High Pressure Liquid; Fenfluramine; Humans; Molecular Structure; Norfenfluramine; Reproducibility of Results; Spectrophotometry, Ultraviolet	1993
Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms. Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 347, Issue:3 Topics: Animals; Brain; Callithrix; Eating; Fenfluramine; In Vitro Techniques; Male; Norfenfluramine; Radioligand Assay; Receptors, Serotonin; Serotonin	1993
Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. The American journal of psychiatry, 1996, Volume: 153, Issue:2 Topics: Adult; Brain; Deoxyglucose; Depressive Disorder; Female; Fenfluramine; Fluorodeoxyglucose F18; Glucose; Hospitalization; Humans; Male; Norfenfluramine; Parietal Lobe; Prefrontal Cortex; Prolactin; Receptors, Serotonin; Serotonin; Serotonin Agents; Temporal Lobe; Tomography, Emission-Computed	1996
Oral kinetics of dexfenfluramine and dexnorfenfluramine in non-human primates. Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:10 Topics: Animals; Biotransformation; Chromatography, Gas; Fenfluramine; Half-Life; Macaca fascicularis; Macaca mulatta; Male; Norfenfluramine; Papio; Selective Serotonin Reuptake Inhibitors; Species Specificity	1995
Neural control of dieting. Nature, 1996, Apr-11, Volume: 380, Issue:6574 Topics: Animals; Appetite Depressants; Appetite Regulation; Diet, Reducing; Female; Fenfluramine; Humans; Norfenfluramine; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Satiety Response; Serotonin	1996
In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:6 Topics: Animals; Appetite Depressants; Brain; Brain Chemistry; Fenfluramine; In Vitro Techniques; Macaca fascicularis; Macaca mulatta; Male; Norfenfluramine; Rats; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Species Specificity	1996
Determination of D-fenfluramine, D-norfenfluramine and fluoxetine in plasma, brain tissue and brain microdialysate using high-performance liquid chromatography after precolumn derivatization with dansyl chloride. Journal of chromatography. B, Biomedical sciences and applications, 1997, May-09, Volume: 692, Issue:2 Topics: Animals; Brain; Chromatography, High Pressure Liquid; Dansyl Compounds; Fenfluramine; Fluoxetine; Indicators and Reagents; Microdialysis; Norfenfluramine; Rats; Reference Standards; Selective Serotonin Reuptake Inhibitors	1997
Increased brain serotonin function in men with chronic fatigue syndrome. BMJ (Clinical research ed.), 1997, Jul-19, Volume: 315, Issue:7101 Topics: Adult; Brain; Fatigue Syndrome, Chronic; Fenfluramine; Humans; Male; Norfenfluramine; Prolactin; Serotonin; Serotonin Agents	1997
Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine. Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:4 Topics: Administration, Oral; Animals; Appetite Depressants; Body Weight; Brain Chemistry; Catecholamines; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Hippocampus; Indoles; Male; Norfenfluramine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereoisomerism; Time Factors	1997
The effect of D-fenfluramine on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male and female rats. European journal of pharmacology, 1997, Aug-20, Volume: 333, Issue:1 Topics: Animals; Brain Chemistry; Female; Fenfluramine; Hydroxyindoleacetic Acid; Male; Norfenfluramine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sex Characteristics	1997
Quantitation of dexfenfluramine/d-norfenfluramine concentration in primate brain using 19F NMR spectroscopy. Magnetic resonance in medicine, 1998, Volume: 39, Issue:1 Topics: Animals; Appetite Depressants; Brain; Brain Chemistry; Disease Models, Animal; Female; Fenfluramine; Fluorine Radioisotopes; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Norfenfluramine; Sensitivity and Specificity; Signal Processing, Computer-Assisted	1998
Fenfluramine and norfenfluramine levels in brain microdialysate, brain tissue and plasma of rats administered doses of d-fenfluramine known to deplete 5-hydroxytryptamine levels in brain. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2 Topics: Animals; Body Temperature; Brain; Cerebral Cortex; Dialysis; Dose-Response Relationship, Drug; Fenfluramine; Hydroxyindoleacetic Acid; Male; Norfenfluramine; Rats; Rats, Sprague-Dawley; Serotonin	1998
The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain. Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:11-12 Topics: Animals; Body Weight; Brain Chemistry; Dose-Response Relationship, Drug; Eating; Fenfluramine; Hydroxyindoleacetic Acid; Male; Norfenfluramine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin	1997
Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential. Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:3 Topics: Animals; Appetite Depressants; Body Weight; Brain Chemistry; Discrimination, Psychological; Fenfluramine; In Vitro Techniques; Indans; Male; Nervous System Diseases; Neurotransmitter Uptake Inhibitors; Norfenfluramine; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Serotonin; Synaptosomes	1998
Thermal response to serotonergic challenge and aggression in attention deficit hyperactivity disorder children. Journal of child and adolescent psychopharmacology, 1999, Volume: 9, Issue:2 Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Body Temperature; Child; Fenfluramine; Humans; Male; Norfenfluramine; Serotonin	1999
Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. Molecular pharmacology, 2000, Volume: 57, Issue:1 Topics: Animals; Appetite Depressants; Cell Line; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Molecular Sequence Data; Norfenfluramine; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; RNA, Messenger; Serotonin Agents; Swine	2000
An investigation of the serotonergic effects of fenfluramine, dexfenfluramine and dexnorfenfluramine using platelets as neuronal models. Platelets, 2000, Volume: 11, Issue:3 Topics: Adult; Appetite Depressants; Blood Platelets; Cell Size; Dexfenfluramine; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Male; Middle Aged; Models, Biological; Neurons; Norfenfluramine; Phenethylamines; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists	2000
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation, 2000, Dec-05, Volume: 102, Issue:23 Topics: Dose-Response Relationship, Drug; Ergotamine; Fenfluramine; Heart Valve Diseases; Humans; Methylergonovine; Norfenfluramine; Receptors, Serotonin; Serotonin Antagonists	2000
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology, 2001, Volume: 41, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Eating; Fenfluramine; Male; Norfenfluramine; Rats; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists	2001
Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 2001, Nov-05, Volume: 763, Issue:1-2 Topics: Animals; Chromatography, High Pressure Liquid; Fenfluramine; Humans; Male; Norfenfluramine; Phentermine; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Stereoisomerism	2001
(+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3 Topics: Animals; Biogenic Monoamines; Fenfluramine; Male; Norepinephrine Plasma Membrane Transport Proteins; Norfenfluramine; Rats; Rats, Sprague-Dawley; Serotonin; Symporters; Tritium	2003
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Molecular pharmacology, 2003, Volume: 63, Issue:6 Topics: 3,4-Methylenedioxyamphetamine; Animals; Cell Division; Cells, Cultured; COS Cells; Fenfluramine; Heart Valve Diseases; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Norfenfluramine; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Agents	2003
The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:12 Topics: Appetite Depressants; Blood Platelets; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Humans; Hydrogen-Ion Concentration; Norfenfluramine; Phentermine; Reserpine; Secretory Vesicles; Selective Serotonin Reuptake Inhibitors; Serotonin	2003
The fenfluramine metabolite (+)-norfenfluramine is vasoactive. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:2 Topics: Animals; Aorta; Blood Pressure; Ergolines; Fenfluramine; In Vitro Techniques; Ketanserin; Male; Norfenfluramine; Prazosin; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Adrenergic, alpha; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Sympathectomy; Sympathetic Nervous System; Vasoconstriction	2004
Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine. Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:3 Topics: Animals; Anorexia; Brain; Fenfluramine; Mice; Mice, Inbred ICR; Norfenfluramine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Species Specificity	2004
Hair analysis for fenfluramine and norfenfluramine as biomarkers for N-nitrosofenfluramine ingestion. Forensic science international, 2004, Nov-10, Volume: 146, Issue:1 Topics: Animals; Appetite Depressants; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fenfluramine; Forensic Medicine; Hair; Humans; Molecular Structure; Norfenfluramine; Rats; Rats, Zucker; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Spectrometry, Fluorescence	2004
Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys. Journal of the American Academy of Child and Adolescent Psychiatry, 2006, Volume: 45, Issue:7 Topics: Adolescent; Adolescent Behavior; Adult; Aggression; Child; Child, Preschool; Conduct Disorder; Fenfluramine; Humans; Intelligence Tests; Male; Norfenfluramine; Predictive Value of Tests; Prolactin; Serotonin; Serotonin Agents	2006
The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21 Topics: Animals; Fenfluramine; Fluoxetine; Humans; Norfenfluramine; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors	2007
Pharmacokinetic properties of N-nitrosofenfluramine after its administration to rats. Biomedical chromatography : BMC, 2011, Volume: 25, Issue:5 Topics: Animals; Area Under Curve; Brain; Brain Chemistry; Calibration; Chromatography, High Pressure Liquid; Fenfluramine; Injections, Intraperitoneal; Kidney; Liver; Male; Norfenfluramine; Oxidation-Reduction; Rats; Rats, Wistar; Reproducibility of Results; Tissue Distribution	2011
[Letter on the article: "benfluorex and valvular heart disease"]. Presse medicale (Paris, France : 1983), 2012, Volume: 41, Issue:3 Pt 1 Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Humans; Male; Mitral Valve Insufficiency; Norfenfluramine	2012
Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochemical research, 2021, Volume: 46, Issue:9 Topics: Animals; Anticonvulsants; Epilepsies, Myoclonic; Fenfluramine; Head; Norfenfluramine; Stereoisomerism; Zebrafish	2021
Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia, 2023, Volume: 64, Issue:6 Topics: Animals; Brain; Fenfluramine; Mice; Norfenfluramine; Rats; Rodentia; Seizures	2023
Benfluorex metabolism complemented by electrochemistry-mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2023, Oct-25, Volume: 235 Topics: Diabetes Mellitus, Type 2; Electrochemistry; Fenfluramine; Humans; Norfenfluramine; Tandem Mass Spectrometry	2023