fenfluramine and n-methyl-3,4-methylenedioxyamphetamine

fenfluramine has been researched along with n-methyl-3,4-methylenedioxyamphetamine in 51 studies

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.92)18.7374
1990's23 (45.10)18.2507
2000's17 (33.33)29.6817
2010's9 (17.65)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Glennon, RA1
Azmitia, EC; Berger, UV; Gu, XF1
Culp, S; DeSouza, EB; Lehmann, J; Zaczek, R1
Black, CK; Schmidt, CJ; Taylor, VL1
Evans, SM; Johanson, CE; Zacny, JP1
Peroutka, SJ; Wagner, J1
Cabrera, T; Hamilton, ME; Hata, N; Lorens, SA1
Schechter, MD2
Cowen, PJ; Series, HG; Sharp, T1
Heller, A; Heller, B; Hoffmann, PC; Won, L1
Colado, MI; Green, AR; Murray, TK1
Rudnick, G; Schuldiner, S; Steiner-Mordoch, S; Wall, SC; Yelin, R1
Azmitia, EC; Kramer, K; Whitaker-Azmitia, PM1
Azmitia, EC; Leonardi, ET1
Miller, DB; O'Callaghan, JP1
Bennett, BA; Hollingsworth, CK; Wichems, CH1
Baker, LE; Makhay, MM1
Marona-Lewicka, D; Nichols, DE; Rhee, GS; Sprague, JE1
Colado, MI; Granados, R; Green, AR; Murray, TK; O'Shea, E1
Boone, KB; Brammer, GL; Grob, CS; Lutchmansingh, P; McCracken, JT; Pechnick, RN; Poland, RE; Zhao, JP1
Crespi, D; Gobbi, M; Mennini, T1
Naito, Y1
Ali, SF; Frederick, DL; Gillam, MP; Gossett, J; Paule, MG; Slikker, W1
Dafters, RI; Lynch, E1
Caccavari, R; Delsignore, R; Gerra, G; Giucastro, G; Maestri, D; Monica, C; Sartori, R; Zaimovic, A1
Brambilla, F; Delsignore, R; Ferri, M; Gerra, G; Marzocchi, GF; Neri, E; Timpano, M; Zaimovic, A; Zambelli, U1
Connor, TJ; Kelly, JP; Leonard, BE1
Baker, LE; Goodwin, AK1
Callahan, BT; Cord, BJ; Ricaurte, GA1
Biello, SM; Dafters, RI1
Delatte, MS; McCann, UD; Moerschbaecher, JM; Ricaurte, GA; Stevenson, MW; Winsauer, PJ; Yuan, J1
Hatzidimitriou, G; McCann, UD; Ricaurte, GA; Tsai, EH1
Becker, S; Daumann, J; Gouzoulis-Mayfrank, E; Pelz, S; Tuchtenhagen, F1
Callahan, BT; Cord, BJ; McCann, UD; Ricaurte, GA; Yuan, J1
Blough, B; Glennon, RA; Grande-Allen, KJ; Hufeisen, SJ; Roth, BL; Rothman, RB; Setola, V; Vesely, I1
Ali, SF; Bowyer, JF; Frederick, DL; Itzak, Y; Mayorga, AJ; Newport, GD; Paule, MG; Slikker, W; Young, JF1
Achat-Mendes, C; Ali, SF; Itzhak, Y1
Barnes, NM; Blakely, RD; Bunce, CM; Challa, A; Chamba, A; Drake-Lee, A; Drayson, MT; Dyer, MJ; Gordon, J; Holder, MJ; Meredith, EJ; Pilkington, G1
Hatzidimitriou, G; McCann, U; McLane, MW; Ricaurte, G; Tong, L; Xie, T; Yuan, J1
Bishop, C; Eskow, KL; Kuhn, DM; Park, JY; Taylor, JL; Walker, PD1
Bhattacharyya, S; Davar, J; Mikhailidis, DP; Schapira, AH1
Ayala, ME1
Condron, BG; Daubert, EA; Heffron, DS; Mandell, JW1
Brennan, KA; Colussi-Mas, J; Jones, K; Schenk, S1
Amos-Kroohs, R; Braun, AA; Grace, CE; Graham, DL; He, E; Schaefer, TL; Skelton, MR; Vorhees, CV; Williams, MT1
Lyvers, M1
Duffy, P; Gorman, I; Gormley, S; Harkin, A; Jennings-Murphy, C; Kelly, ME; Kerskens, CM; Rouine, J1
Banks, ML; Bauer, CT; Blough, BE; Negus, SS1
Banks, ML; Negus, SS1
Baker, LE; Berquist, MD1

Reviews

3 review(s) available for fenfluramine and n-methyl-3,4-methylenedioxyamphetamine

ArticleYear
Examination of developmental neurotoxicity by the use of tissue culture model systems.
    Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:5

    Topics: Appetite Depressants; Cell Line; Central Nervous System Stimulants; Culture Techniques; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Fenfluramine; Humans; Illicit Drugs; Mesencephalon; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; Serotonin; Serotonin Agents; Tumor Cells, Cultured

1995
[Neuroleptic malignant syndrome-dopamine-serotonin syndrome--the physiopathology, diagnosis, and therapy].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1997, Volume: 99, Issue:10

    Topics: Animals; Appetite Depressants; Dantrolene; Dopamine D2 Receptor Antagonists; Fenfluramine; Humans; Muscle Relaxants, Central; N-Methyl-3,4-methylenedioxyamphetamine; Neuroleptic Malignant Syndrome; Psychotropic Drugs; Serotonin; Serotonin Agents; Serotonin Antagonists; Syndrome

1997
Drug-induced fibrotic valvular heart disease.
    Lancet (London, England), 2009, Aug-15, Volume: 374, Issue:9689

    Topics: Antiparkinson Agents; Appetite Depressants; Cabergoline; Dexfenfluramine; Dopamine Agonists; Drug Monitoring; Ergolines; Ergotamine; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valves; Humans; Methysergide; Migraine Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Patient Selection; Pergolide; Receptors, Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Vasoconstrictor Agents

2009

Other Studies

48 other study(ies) available for fenfluramine and n-methyl-3,4-methylenedioxyamphetamine

ArticleYear
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
    Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7

    Topics: Animals; Central Nervous System Stimulants; Chemistry, Pharmaceutical; Dopamine; Drug Discovery; Hallucinogens; Humans; Illicit Drugs; Norepinephrine; Phenethylamines; Psychotropic Drugs; Receptors, Serotonin; Serotonin

2017
The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine.
    European journal of pharmacology, 1992, May-14, Volume: 215, Issue:2-3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Calcium; Cocaine; Fenfluramine; Fluoxetine; In Vitro Techniques; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; p-Chloroamphetamine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synaptosomes

1992
Regional distribution to recovery of 5-HT levels after administration of "atrophins" MDMA and D,L-fenfluramine. Stereospecificity and comparison with 5,7-dihydroxytryptamine.
    Annals of the New York Academy of Sciences, 1992, May-11, Volume: 648

    Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Atrophy; Brain; Cerebral Ventricles; Designer Drugs; Dopamine; Fenfluramine; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism

1992
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
    European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Fenfluramine; Hippocampus; Levodopa; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Nervous System Diseases; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Serotonin

1991
Three-choice discrimination among (+)-amphetamine, fenfluramine and saline in pigeons.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:4

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamine; Animals; Columbidae; Discrimination, Psychological; Female; Fenfluramine; Generalization, Stimulus; N-Methyl-3,4-methylenedioxyamphetamine; Sodium Chloride

1990
Neurochemistry and neurotoxicity of substituted amphetamines.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Designer Drugs; Fenfluramine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin

1990
Comparison of the behavioral and neurochemical effects of 5,7-DHT, MDMA and D,L-fenfluramine.
    NIDA research monograph, 1989, Volume: 95

    Topics: 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Amphetamines; Animals; Arousal; Behavior, Animal; Brain; Designer Drugs; Dihydroxytryptamines; Fenfluramine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin

1989
Discriminative profile of MDMA.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Apomorphine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Fenfluramine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Receptors, Dopamine; Receptors, Serotonin

1986
p-Chloroamphetamine (PCA), 3,4-methylenedioxy-methamphetamine (MDMA) and d-fenfluramine pretreatment attenuates d-fenfluramine-evoked release of 5-HT in vivo.
    Psychopharmacology, 1994, Volume: 116, Issue:4

    Topics: Amphetamines; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Dextroamphetamine; Fenfluramine; Hydroxyindoleacetic Acid; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; p-Chloroamphetamine; Potassium; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin

1994
5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine.
    British journal of pharmacology, 1993, Volume: 108, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Cerebral Cortex; Chlormethiazole; Dizocilpine Maleate; Fenfluramine; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; p-Chloroamphetamine; Rats; Serotonin

1993
Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters.
    Molecular pharmacology, 1993, Volume: 44, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood Platelets; Carrier Proteins; Cattle; Cell Membrane; Chromaffin Granules; Fenfluramine; Humans; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; p-Chloroamphetamine; Reserpine; Serotonin; Serotonin Plasma Membrane Transport Proteins

1993
In vitro release of [3H]5-hydroxytryptamine from fetal and maternal brain by drugs of abuse.
    Brain research. Developmental brain research, 1994, Mar-18, Volume: 78, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Brain Chemistry; Cocaine; Designer Drugs; Female; Fenfluramine; In Vitro Techniques; Maternal-Fetal Exchange; N-Methyl-3,4-methylenedioxyamphetamine; Potassium Chloride; Pregnancy; Rats; Rats, Sprague-Dawley; Serotonin; Substance-Related Disorders; Synaptosomes

1994
MDMA (ecstasy) inhibition of MAO type A and type B: comparisons with fenfluramine and fluoxetine (Prozac).
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1994, Volume: 10, Issue:4

    Topics: Animals; Binding, Competitive; Brain; Drug Interactions; Fenfluramine; Fluoxetine; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Phenethylamines; Rats; Rats, Sprague-Dawley; Serotonin

1994
The interactions of MK-801 with the amphetamine analogues D-methamphetamine (D-METH), 3,4-methylenedioxymethamphetamine (D-MDMA) or D-fenfluramine (D-FEN): neural damage and neural protection.
    Annals of the New York Academy of Sciences, 1993, May-28, Volume: 679

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biomarkers; Brain; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Female; Fenfluramine; Glial Fibrillary Acidic Protein; Hippocampus; Methamphetamine; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxins

1993
Release of serotonin induced by 3,4-methylenedioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further evidence for calcium-independent mechanisms of release.
    Brain research, 1995, Oct-09, Volume: 695, Issue:1

    Topics: Amphetamine; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Fenfluramine; N-Methyl-3,4-methylenedioxyamphetamine; Potassium Chloride; Raphe Nuclei; Rats; Serotonin

1995
Effects of (+)-fenfluramine on 3,4-methylenedioxymethamphetamine (MDMA) discrimination in rats.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:2

    Topics: Animals; Dextroamphetamine; Discrimination, Psychological; Dopamine Agents; Dose-Response Relationship, Drug; Fenfluramine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Serotonin Agents

1996
Reinforcing effects of certain serotonin-releasing amphetamine derivatives.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamines; Animals; Conditioning, Operant; Dopamine; Dopamine Antagonists; Fenfluramine; Indans; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Nucleus Accumbens; Rats; Reinforcement, Psychology; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Synaptic Transmission

1996
Serotonergic mediation of fenfluramine discriminative stimuli in fawn-hooded rats.
    Life sciences, 1997, Volume: 60, Issue:6

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Ibogaine; Male; Methoxydimethyltryptamines; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Quipazine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Receptor Agonists

1997
In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine.
    British journal of pharmacology, 1997, Volume: 121, Issue:5

    Topics: Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Fenfluramine; Free Radical Scavengers; Free Radicals; Hippocampus; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; p-Chloroamphetamine; Paroxetine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Agents

1997
Abnormal ACTH and prolactin responses to fenfluramine in rats exposed to single and multiple doses of MDMA.
    Psychopharmacology, 1997, Volume: 131, Issue:4

    Topics: Adrenocorticotropic Hormone; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Fenfluramine; Hallucinogens; Hippocampus; Hypothalamus; Male; N-Methyl-3,4-methylenedioxyamphetamine; Prolactin; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents

1997
Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine.
    British journal of pharmacology, 1997, Volume: 121, Issue:8

    Topics: Amphetamine; Animals; Calcium; Carrier Proteins; Dopamine; Fenfluramine; Male; Methiothepin; N-Methyl-3,4-methylenedioxyamphetamine; Neurotransmitter Uptake Inhibitors; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Serotonin

1997
Acute effects of dexfenfluramine (d-FEN) and methylenedioxymethamphetamine (MDMA) before and after short-course, high-dose treatment.
    Annals of the New York Academy of Sciences, 1998, May-30, Volume: 844

    Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Fenfluramine; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests; Serotonin; Time Factors

1998
Persistent loss of thermoregulation in the rat induced by 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") but not by fenfluramine.
    Psychopharmacology, 1998, Volume: 138, Issue:2

    Topics: Amphetamine; Animals; Body Temperature Regulation; Dopamine Agents; Female; Fenfluramine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Serotonin Agents

1998
Serotonergic function after (+/-)3,4-methylene-dioxymethamphetamine ('Ecstasy') in humans.
    International clinical psychopharmacology, 1998, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Affect; Aggression; Exploratory Behavior; Fenfluramine; Hallucinogens; Humans; Hydrocortisone; Male; N-Methyl-3,4-methylenedioxyamphetamine; Personality Assessment; Serotonin; Serotonin Agents

1998
Long-lasting effects of (+/-)3,4-methylenedioxymethamphetamine (ecstasy) on serotonin system function in humans.
    Biological psychiatry, 2000, Jan-15, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Exploratory Behavior; Fenfluramine; Hallucinogens; Hostility; Humans; Hydrocortisone; Male; N-Methyl-3,4-methylenedioxyamphetamine; Personality Inventory; Prolactin; Serotonin Receptor Agonists; Substance-Related Disorders

2000
An assessment of the acute effects of the serotonin releasers methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on immunity in rats.
    Immunopharmacology, 2000, Volume: 46, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Concanavalin A; Cytokines; Female; Fenfluramine; Immunity; Leukocyte Count; Lipopolysaccharides; Lymphocyte Activation; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin Agents

2000
A three-choice discrimination procedure dissociates the discriminative stimulus effects of d-amphetamine and (+/-)-MDMA in rats.
    Experimental and clinical psychopharmacology, 2000, Volume: 8, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Cues; Dextroamphetamine; Discrimination, Psychological; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fenfluramine; Lysergic Acid Diethylamide; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists

2000
Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamine.
    Synapse (New York, N.Y.), 2001, Volume: 40, Issue:2

    Topics: 5,7-Dihydroxytryptamine; Adrenergic Uptake Inhibitors; Animals; Axonal Transport; Axons; Desipramine; Fenfluramine; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neural Pathways; Neurotoxins; Pargyline; Proline; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Time Factors; Tritium

2001
MDMA and fenfluramine alter the response of the circadian clock to a serotonin agonist in vitro.
    Brain research, 2001, Nov-30, Volume: 920, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Circadian Rhythm; Drug Interactions; Electrophysiology; Fenfluramine; Hallucinogens; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists

2001
Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration.
    Psychopharmacology, 2002, Volume: 159, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Fenfluramine; GABA Modulators; Hydroxyindoleacetic Acid; Learning; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Reaction Time; Saimiri; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Triazolam

2002
Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine.
    Synapse (New York, N.Y.), 2002, Volume: 44, Issue:1

    Topics: Animals; Drug Administration Schedule; Drug Interactions; Fenfluramine; Hydrocortisone; Hypothalamus; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; Piperazines; Presynaptic Terminals; Prolactin; Raphe Nuclei; Reaction Time; Saimiri; Serotonin Agents

2002
Neuroendocrine abnormalities in recreational ecstasy (MDMA) users: is it ecstasy or cannabis?
    Biological psychiatry, 2002, May-01, Volume: 51, Issue:9

    Topics: Adrenergic Uptake Inhibitors; Adult; Analysis of Variance; Cannabis; Female; Fenfluramine; Humans; Illicit Drugs; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurosecretory Systems; Prolactin; Serotonin Agents; Time Factors

2002
Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Amphetamines; Animals; Antimetabolites; Biogenic Monoamines; Body Temperature; Carrier Proteins; Deoxyglucose; Energy Metabolism; Fenfluramine; Glucose; Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins

2002
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
    Molecular pharmacology, 2003, Volume: 63, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Cell Division; Cells, Cultured; COS Cells; Fenfluramine; Heart Valve Diseases; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Norfenfluramine; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Agents

2003
Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations.
    Neurotoxicology, 2003, Volume: 24, Issue:3

    Topics: Animals; Body Temperature; Carrier Proteins; Fenfluramine; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time

2003
Differential effects of amphetamines-induced neurotoxicity on appetitive and aversive Pavlovian conditioning in mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:6

    Topics: Amphetamines; Animals; Antimanic Agents; Appetitive Behavior; Avoidance Learning; Central Nervous System Stimulants; Conditioning, Classical; Dopamine; Fenfluramine; Hallucinogens; Lithium Chloride; Male; Methamphetamine; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Neurotoxicity Syndromes; Receptors, Serotonin; Reinforcement, Psychology; Reward; Serotonin

2005
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Burkitt Lymphoma; Cell Line, Tumor; Clomipramine; Fenfluramine; Fluoxetine; Humans; Lymphoma, B-Cell; N-Methyl-3,4-methylenedioxyamphetamine; Proto-Oncogene Proteins c-bcl-2; Psychotropic Drugs; Serotonin Plasma Membrane Transport Proteins

2005
Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:12

    Topics: 5,7-Dihydroxytryptamine; Animals; Axons; Brain; Down-Regulation; Fenfluramine; Immunohistochemistry; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Tryptophan Hydroxylase; Wallerian Degeneration

2006
MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation.
    The European journal of neuroscience, 2006, Volume: 23, Issue:10

    Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Fenfluramine; Levodopa; Male; N-Methyl-3,4-methylenedioxyamphetamine; Oxidopamine; Parkinsonian Disorders; Rats; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Antagonists; Serotonin Agents

2006
Brain serotonin, psychoactive drugs, and effects on reproduction.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:4

    Topics: Affect; Amphetamine-Related Disorders; Animals; Biological Clocks; Brain; Cognition Disorders; Depressive Disorder; Drug Interactions; Female; Fenfluramine; Fluoxetine; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Obesity; Psychotropic Drugs; Reproduction; Serotonin; Serotonin Receptor Agonists; Sexual Behavior, Animal; Substance-Related Disorders; Synaptic Transmission

2009
Serotonergic dystrophy induced by excess serotonin.
    Molecular and cellular neurosciences, 2010, Volume: 44, Issue:3

    Topics: Animals; Axons; Brain; Drosophila melanogaster; Fenfluramine; Male; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Serotonin; Serotonin Agents; Transgenes

2010
Tolerance to 3,4-methylenedioxymethamphetamine is associated with impaired serotonin release.
    Addiction biology, 2010, Volume: 15, Issue:3

    Topics: Amphetamines; Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Exploratory Behavior; Fenfluramine; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin Agents; Serotonin Receptor Agonists

2010
Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:5

    Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Body Weight; Central Nervous System Stimulants; Cold Temperature; Fenfluramine; Male; Maze Learning; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin Agents; Spatial Behavior; Swimming; Time Factors

2011
Commentary on Halpern et al. (2011): strengthening the case against functionally significant serotonergic neurotoxicity in human MDMA (ecstasy) users.
    Addiction (Abingdon, England), 2011, Volume: 106, Issue:4

    Topics: Fenfluramine; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Serotonin Agents; Young Adult

2011
Investigation of the mechanisms mediating MDMA "Ecstasy"-induced increases in cerebro-cortical perfusion determined by btASL MRI.
    Psychopharmacology, 2015, Volume: 232, Issue:9

    Topics: Animals; Brain; Cerebrovascular Circulation; Citalopram; Dopamine Antagonists; Fenclonine; Fenfluramine; Magnetic Resonance Imaging; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Spin Labels

2015
Role of 5-HT₂C receptors in effects of monoamine releasers on intracranial self-stimulation in rats.
    Psychopharmacology, 2015, Volume: 232, Issue:17

    Topics: Adrenergic Uptake Inhibitors; Aminopyridines; Animals; Benzeneacetamides; Biogenic Monoamines; Conditioning, Operant; Electrodes, Implanted; Fenfluramine; Indoles; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Opioid, kappa; Selective Serotonin Reuptake Inhibitors; Self Stimulation; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists

2015
Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs.
    Current topics in behavioral neurosciences, 2017, Volume: 32

    Topics: Amphetamine; Animals; Behavior, Animal; Dopamine Plasma Membrane Transport Proteins; Fenfluramine; Humans; Methamphetamine; Methylamines; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine Plasma Membrane Transport Proteins; Propiophenones; Psychotropic Drugs; Quantitative Structure-Activity Relationship; Rats; Self Administration; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Substance-Related Disorders

2017
Characterization of the discriminative stimulus effects of 3,4-methylenedioxypyrovalerone in male Sprague-Dawley rats.
    Behavioural pharmacology, 2017, Volume: 28, Issue:5

    Topics: Animals; Benzodioxoles; Cocaine; Dextroamphetamine; Discrimination Learning; Dopamine; Dopamine Agents; Fenfluramine; Lysergic Acid Diethylamide; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Synthetic Cathinone

2017