felbamate and valproic acid

felbamate has been researched along with valproic acid in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's26 (47.27)18.2507
2000's12 (21.82)29.6817
2010's14 (25.45)24.3611
2020's3 (5.45)2.80

Authors

AuthorsStudies
Bräuner-Osborne, H; Bruno, G; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Joppolo Di Ventimiglia, S; Madsen, U; Russo, E; Stensbøl, TB1
Bruno-Blanch, L; Gálvez, J; García-Domenech, R1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Ekins, S; Williams, AJ; Xu, JJ1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Bialer, M; Hen, N; Yagen, B1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bialer, M; Bibi, D; Mawasi, H1
Kelly, KM; Macdonald, RL1
Graves, NM; Leppik, IE; Perhach, JL; Remmel, RP; Shumaker, RC; Wagner, ML; Ward, DL1
Chandra, V; Loughlin, J; Ney, GC; Rai, K; Schaul, N1
Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG1
Jensen, PK1
Herranz Fernández, JL1
Chayasirisobhon, S; Faught, E; Harner, RN; Iragui-Madoz, VJ; Kanner, A; Kuzniecky, R; Ramsay, RE; Remler, MP; Sachdeo, RC; Sutula, TP1
Wilner, AN1
Banfield, CR; Dickinson, RG; Eadie, MJ; Franklin, ME; Glue, P; Hooper, WD; McIntyre, ME; McLaughlin, DB; Radwanski, E1
Bergen, DC; Hoeppner, TJ; Kanner, A; Ristanovic, RK; Waicosky, K1
Bourgeois, B1
Brillman, J; Cavalier, J; Cress, K; Duffy, JD; McConnell, H; Snyder, PJ; Valeriano, J; Weilburg, J1
Perucca, E; Pisani, F; Spina, E1
Herranz, JL1
Cox, S; Dusci, LJ; Kelley, MT; Walson, PD1
Chapman, DP; Giles, WH1
Banfield, CR; Glue, P; Levy, RH; Mather, GG; Perhach, JL; Racha, JK1
Pellock, JM1
Bazil, CW; Pedley, TA1
Boothe, DM1
Berlinghieri, MC; David, E; De Sarro, GB; Dominijanni, A; Elia, M; Gulletta, E; Musumeci, SA1
Anderson, GD1
Bassetti, MA; Marciani, MG; Mattia, D; Placidi, F; Romigi, A; Spanedda, F1
Flamini, R; Gaillard, WD; Kelley, K; Ko, D; Malow, B; Reeves-Tyer, P; Siegel, H; Stertz, B; Theodore, WH1
McCoy, GB; Yerby, MS1
Albani, F; Baruzzi, AA; Contin, M; Riva, R1
Glauser, TA1
Jagoda, A; Yoon, Y1
Meredith, TJ; Milstone, AP; Rengstorff, DS; Seger, DL1
Bachański, M; Jóźwiak, S; Karkowska, B; Kmieć, T; Kuczyński, D1
Rekling, JC1
Amat, G; Armijo, JA; Cuadrado, A1
Borowicz, KK; Czuczwar, SJ; Luszczki, JJ1
Pucci, V; Raggi, MA1
Dannhardt, G; Kiefer, W1
Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS1
Garraghty, PE; Orczyk, JJ1
Agrawal, M; Dhurandhar, Y; Panda, SP1
Battino, D; Bromley, R; Kochen, S; Meador, KJ; Pennell, PB; Thomas, SV; Tomson, T1
Schubert-Bast, S; Strzelczyk, A1

Reviews

20 review(s) available for felbamate and valproic acid

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Mechanisms of action of currently prescribed and newly developed antiepileptic drugs.
    Epilepsia, 1994, Volume: 35 Suppl 4

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drugs, Investigational; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Mice; Phenylcarbamates; Propylene Glycols; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Triazines; Valproic Acid

1994
[Contribution of new drugs to the better control of epilepsy].
    Anales espanoles de pediatria, 1993, Volume: 39 Suppl 55

    Topics: Aminocaproates; Anticonvulsants; Child; Delayed-Action Preparations; Epilepsy; Felbamate; Humans; Phenylcarbamates; Propylene Glycols; Valproic Acid; Vigabatrin

1993
Clinical use of drugs useful in the treatment of atonic seizures.
    Advances in neurology, 1995, Volume: 67

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Generalized; Felbamate; gamma-Aminobutyric Acid; Humans; Phenylcarbamates; Propylene Glycols; Seizures; Valproic Acid; Vigabatrin

1995
Clinically significant pharmacokinetic drug interactions with carbamazepine. An update.
    Clinical pharmacokinetics, 1996, Volume: 31, Issue:3

    Topics: Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents; Carbamazepine; Drug Interactions; Ethosuximide; Felbamate; Humans; Phenobarbital; Phenylcarbamates; Phenytoin; Primidone; Propylene Glycols; Valproic Acid

1996
[Advantages and disadvantages of new antiepileptic drugs].
    Revista de neurologia, 1996, Volume: 24, Issue:135

    Topics: Acetates; Adrenocorticotropic Hormone; Amines; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Phenylcarbamates; Propylene Glycols; Triazines; Valproic Acid; Vigabatrin

1996
Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances.
    Southern medical journal, 1997, Volume: 90, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Ketone Bodies; Lamotrigine; Phenylcarbamates; Phenytoin; Propylene Glycols; Triazines; Valproic Acid; Vigabatrin

1997
Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.
    Clinical pharmacokinetics, 1997, Volume: 33, Issue:3

    Topics: Anticonvulsants; Area Under Curve; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Epilepsy; Felbamate; Humans; In Vitro Techniques; Isoenzymes; Neuroprotective Agents; Phenylcarbamates; Phenytoin; Propylene Glycols; Valproic Acid

1997
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
    Journal of child neurology, 1997, Volume: 12 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Exanthema; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Treatment Outcome; Triazines; Valproic Acid; Vigabatrin

1997
Advances in the medical treatment of epilepsy.
    Annual review of medicine, 1998, Volume: 49

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approval; Drug Design; Drug Interactions; Drug Resistance; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Ketones; Lamotrigine; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Phenylcarbamates; Phenytoin; Prodrugs; Propylene Glycols; Tiagabine; Topiramate; Triazines; United States; Valproic Acid; Vigabatrin

1998
Anticonvulsant therapy in small animals.
    The Veterinary clinics of North America. Small animal practice, 1998, Volume: 28, Issue:2

    Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexanecarboxylic Acids; Diazepam; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Mephenytoin; Pentobarbital; Phenobarbital; Phenylcarbamates; Phenytoin; Primidone; Propylene Glycols; Seizures; Valproic Acid

1998
A mechanistic approach to antiepileptic drug interactions.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cyclohexanecarboxylic Acids; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Glucuronosyltransferase; Humans; Lamotrigine; Mixed Function Oxygenases; Nipecotic Acids; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin

1998
Idiosyncratic reactions: new methods of identifying high-risk patients.
    Epilepsia, 2000, Volume: 41 Suppl 8

    Topics: Anticonvulsants; Biomarkers; Drug Monitoring; Epilepsy; Epoxide Hydrolases; Felbamate; Free Radical Scavengers; Genetic Markers; Humans; Lamotrigine; Phenylcarbamates; Propylene Glycols; Risk Factors; Triazines; Valproic Acid

2000
New antiepileptic drugs and preparations.
    Emergency medicine clinics of North America, 2000, Volume: 18, Issue:4

    Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Diazepam; Drug Overdose; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Lamotrigine; Phenylcarbamates; Phenytoin; Propylene Glycols; Topiramate; Triazines; Valproic Acid

2000
Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography.
    Electrophoresis, 2005, Volume: 26, Issue:4-5

    Topics: Acetazolamide; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Felbamate; Humans; Hydantoins; Isoxazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Succinimides; Triazines; Valproic Acid; Vigabatrin; Zonisamide

2005
[New antiepileptics in development].
    Pharmazie in unserer Zeit, 2007, Volume: 36, Issue:4

    Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Felbamate; Humans; Levetiracetam; Phenylcarbamates; Piracetam; Propylene Glycols; Valproic Acid

2007
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
    Journal of critical care, 2016, Volume: 36

    Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide

2016
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
    Mitochondrion, 2022, Volume: 66

    Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; Lamotrigine; Mitophagy; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxcarbazepine; Parkinson Disease; Phenytoin; Seizures; Topiramate; Triazines; Ubiquitin-Protein Ligases; Valproic Acid

2022
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
    Epileptic disorders : international epilepsy journal with videotape, 2022, 12-01, Volume: 24, Issue:6

    Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Everolimus; Felbamate; Female; Fenfluramine; Gabapentin; Humans; Infant; Lacosamide; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenobarbital; Phenytoin; Prospective Studies; Tiagabine; Topiramate; Valproic Acid; Vigabatrin; Zonisamide

2022
Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies.
    CNS drugs, 2022, Volume: 36, Issue:10

    Topics: Autism Spectrum Disorder; Bromides; Cannabidiol; Clobazam; Cognition; Ethosuximide; Everolimus; Felbamate; Fenfluramine; Humans; Lacosamide; Lamotrigine; Levetiracetam; Pregabalin; Spasms, Infantile; Sulfides; Topiramate; Valproic Acid; Vigabatrin; Zinc Compounds; Zonisamide

2022

Trials

8 trial(s) available for felbamate and valproic acid

ArticleYear
The effect of felbamate on valproic acid disposition.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:5

    Topics: Adult; Cross-Over Studies; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Male; Phenylcarbamates; Propylene Glycols; Protein Binding; Valproic Acid

1994
Felbamate in the treatment of refractory partial-onset seizures.
    Epilepsia, 1993, Volume: 34 Suppl 7

    Topics: Adult; Anticonvulsants; Child; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Generalized; Felbamate; Humans; Phenylcarbamates; Placebos; Propylene Glycols; Research Design; Valproic Acid

1993
Felbamate monotherapy for partial-onset seizures: an active-control trial.
    Neurology, 1993, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Double-Blind Method; Epilepsies, Partial; Felbamate; Female; Humans; Male; Middle Aged; Phenylcarbamates; Propylene Glycols; Treatment Outcome; Valproic Acid

1993
Efficacy of felbamate monotherapy.
    Annals of neurology, 1993, Volume: 33, Issue:6

    Topics: Anticonvulsants; Epilepsies, Partial; Felbamate; Humans; Phenylcarbamates; Propylene Glycols; Research Design; Valproic Acid

1993
Effect of felbamate on valproic acid disposition in healthy volunteers: inhibition of beta-oxidation.
    Epilepsia, 1996, Volume: 37, Issue:1

    Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Felbamate; Humans; Male; Metabolic Clearance Rate; Oxidation-Reduction; Phenylcarbamates; Placebos; Propylene Glycols; Valproic Acid

1996
The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome.
    Epilepsy research, 1999, Volume: 34, Issue:2-3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; Epilepsy; Felbamate; Female; Humans; Incidence; Male; Phenylcarbamates; Propylene Glycols; Syndrome; Television; Valproic Acid

1999
Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Epilepsies, Partial; Felbamate; Female; Humans; Lamotrigine; Male; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Prospective Studies; Triazines; Valproic Acid

1999
[Gabitril as an additive drug in therapy of intractable epileptic seizures in children].
    Neurologia i neurochirurgia polska, 2000, Volume: 34 Suppl 7

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Generalized; Felbamate; Female; Follow-Up Studies; Humans; Lamotrigine; Male; Nipecotic Acids; Nitrazepam; Oxcarbazepine; Phenylcarbamates; Phenytoin; Propylene Glycols; Tiagabine; Triazines; Valproic Acid; Vigabatrin

2000

Other Studies

27 other study(ies) available for felbamate and valproic acid

ArticleYear
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Amino Acids, Acidic; Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Cerebral Cortex; CHO Cells; Cricetinae; Crystallography, X-Ray; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Heterocyclic Compounds, 2-Ring; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred DBA; Molecular Conformation; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism

2003
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship

2003
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
    Journal of medicinal chemistry, 2012, Mar-22, Volume: 55, Issue:6

    Topics: Animals; Anticonvulsants; Carbamates; Male; Mice; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Structure-Activity Relationship

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Design and comparative anticonvulsant activity assessment of CNS-active alkyl-carbamoyl imidazole derivatives.
    Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Carbamates; Electroshock; Imidazoles; Male; Mice; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship

2016
Thrombocytopenia in association with adjunctive felbamate use.
    Neurology, 1994, Volume: 44, Issue:5

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Felbamate; Humans; Male; Phenylcarbamates; Propylene Glycols; Thrombocytopenia; Valproic Acid

1994
Novel rat cardiac arrest model of posthypoxic myoclonus.
    Movement disorders : official journal of the Movement Disorder Society, 1994, Volume: 9, Issue:2

    Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies, Myoclonic; Felbamate; Heart Arrest; Hypoxia, Brain; Ischemic Attack, Transient; Male; Muscle Contraction; Myoclonus; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Valproic Acid

1994
Weight loss in patients taking felbamate.
    Clinical neuropharmacology, 1995, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Child; Epilepsy; Felbamate; Humans; Middle Aged; Phenylcarbamates; Propylene Glycols; Valproic Acid

1995
Neuropsychiatric side effects related to treatment with felbamate.
    The Journal of neuropsychiatry and clinical neurosciences, 1996,Summer, Volume: 8, Issue:3

    Topics: Adult; Anticonvulsants; Drug Interactions; Felbamate; Female; Humans; Male; Middle Aged; Phenylcarbamates; Propylene Glycols; Psychoses, Substance-Induced; Seizures; Valproic Acid

1996
Population pharmacokinetics of felbamate in children.
    Therapeutic drug monitoring, 1997, Volume: 19, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Felbamate; Humans; Infant; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Seizures; Valproic Acid

1997
Does antiepileptic therapy affect immune response?
    Journal of chemotherapy (Florence, Italy), 1998, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Cytokines; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lamotrigine; Male; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Receptors, Interleukin-2; Triazines; Valproic Acid

1998
Changes of the EEG paroxysmal pattern during felbamate therapy in Lennox-Gastaut syndrome: a case report.
    The International journal of neuroscience, 1998, Volume: 95, Issue:3-4

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Drug Therapy, Combination; Electroencephalography; Epilepsy; Felbamate; Female; Humans; Phenobarbital; Phenylcarbamates; Propylene Glycols; Syndrome; Valproic Acid

1998
Male infertility: possible association with valproate exposure.
    Epilepsia, 1999, Volume: 40, Issue:4

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Infertility, Male; Male; Phenylcarbamates; Propylene Glycols; Sperm Count; Valproic Acid

1999
Felbamate overdose complicated by massive crystalluria and acute renal failure.
    Journal of toxicology. Clinical toxicology, 2000, Volume: 38, Issue:6

    Topics: Acute Kidney Injury; Adult; Anticonvulsants; Chromatography, Gas; Crystallization; Drug Interactions; Drug Overdose; Felbamate; Female; Humans; Hydronephrosis; Phenylcarbamates; Poisoning; Propylene Glycols; Suicide, Attempted; Ultrasonography; Valproic Acid

2000
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
    Neuroscience letters, 2003, Jan-02, Volume: 335, Issue:3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid

2003
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
    Pharmacological research, 2003, Volume: 48, Issue:2

    Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid

2003
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
    Epilepsia, 2004, Volume: 45, Issue:10

    Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Felbamate; Female; Humans; Lethal Dose 50; Mice; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Phenylcarbamates; Propylene Glycols; Seizures; Valproic Acid

2004
The effects of felbamate on appetitive and aversive instrumental learning in adult rats.
    Epilepsy & behavior : E&B, 2018, Volume: 78

    Topics: Animals; Anticonvulsants; Appetitive Behavior; Avoidance Learning; Carbamazepine; Cognition; Conditioning, Operant; Felbamate; Female; Phenylcarbamates; Phenytoin; Propylene Glycols; Rats; Rats, Sprague-Dawley; Valproic Acid

2018