Compounds > febuxostat
Page last updated: 2024-09-04

febuxostat and sildenafil citrate

febuxostat has been researched along with sildenafil citrate in 3 studies

Compound Research Comparison

Studies
(febuxostat)		Trials
(febuxostat)		Recent Studies (post-2010)
(febuxostat)		Studies
(sildenafil citrate)		Trials
(sildenafil citrate)		Recent Studies (post-2010) (sildenafil citrate)
8181337105,8629562,319

Protein Interaction Comparison

ProteinTaxonomyfebuxostat (IC50)sildenafil citrate (IC50)
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.0036

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Abd El-Raouf, OM; Gad, AM; Khalaf, MM; Khames, A1
Koziolek, M; Sager, M; Schapperer, E; Schick, P; Wegner, F; Weitschies, W; Wiedmann, M1

Other Studies

3 other study(ies) available for febuxostat and sildenafil citrate

ArticleYear
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Ameliorative effects of sildenafil and/or febuxostat on doxorubicin-induced nephrotoxicity in rats.
    European journal of pharmacology, 2017, Jun-15, Volume: 805

    Topics: Animals; Apoptosis; Caspase 3; Creatinine; Cytoprotection; Doxorubicin; Drug Interactions; Febuxostat; Gene Expression Regulation, Enzymologic; Glutathione; Kidney; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Tumor Necrosis Factor-alpha; Urea; Uric Acid

2017
Application of the GastroDuo as an in Vitro Dissolution Tool To Simulate the Gastric Emptying of the Postprandial Stomach.
    Molecular pharmaceutics, 2019, 11-04, Volume: 16, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Aged; Biological Availability; Drug Liberation; Febuxostat; Gastric Emptying; Humans; Kinetics; Male; Middle Aged; Postprandial Period; Sildenafil Citrate; Solubility; Stomach; Young Adult

2019