Compounds > febuxostat
Page last updated: 2024-09-04

febuxostat and diclofenac

febuxostat has been researched along with diclofenac in 5 studies

Compound Research Comparison

Studies
(febuxostat)		Trials
(febuxostat)		Recent Studies (post-2010)
(febuxostat)		Studies
(diclofenac)		Trials
(diclofenac)		Recent Studies (post-2010) (diclofenac)
8181337108,8741,8743,616

Protein Interaction Comparison

ProteinTaxonomyfebuxostat (IC50)diclofenac (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)1.9
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.003
Prostaglandin G/H synthase 1Ovis aries (sheep)1.3376
Interleukin-8Homo sapiens (human)0.008
Prostaglandin G/H synthase 1Homo sapiens (human)0.0415
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.5
C-X-C chemokine receptor type 1Homo sapiens (human)0.012
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Homo sapiens (human)0.4165
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Ovis aries (sheep)1.6867
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.0502
Solute carrier family 22 member 6Homo sapiens (human)4
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.02

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Amin, OA; El-Kimary, EI; El-Yazbi, FA; Khamis, EF; Younis, SE1
Amin, OA; El-Kimary, EI; El-Yazbi, AF; El-Yazbi, FA; Elkhatib, MA; Khamis, EF; Younis, SE1
Cui, X; Geng, H; Jia, E; Jiang, Y; Li, B; Ma, W; Qiu, X; Wei, J; Xiao, M; Xiao, Y; Xie, J; Yao, X; Zhang, J; Zhang, Y; Zhong, L1
Abdel Moneim, AE; Daabees, HG; Elagawany, M; Rashad, AY; Rostom, SAF; Shahin, M1

Reviews

1 review(s) available for febuxostat and diclofenac

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for febuxostat and diclofenac

ArticleYear
Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial.
    Rheumatology (Oxford, England), 2021, 09-01, Volume: 60, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Single-Blind Method; Symptom Flare Up; Treatment Outcome; Uric Acid

2021

Other Studies

3 other study(ies) available for febuxostat and diclofenac

ArticleYear
HPTLC and Spectrophotometric Estimation of Febuxostat and Diclofenac Potassium in Their Combined Tablets.
    Journal of chromatographic science, 2016, Volume: 54, Issue:7

    Topics: Calibration; Chloroform; Chromatography, Thin Layer; Diclofenac; Febuxostat; Limit of Detection; Methanol; Reproducibility of Results; Solvents; Tablets

2016
A novel HPLC-DAD method for simultaneous determination of febuxostat and diclofenac in biological samples: pharmacokinetic outcomes.
    Bioanalysis, 2019, Volume: 11, Issue:1

    Topics: Adult; Animals; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Cross-Over Studies; Diclofenac; Febuxostat; Healthy Volunteers; Humans; Liquid-Liquid Extraction; Liver; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution

2019
Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs.
    Bioorganic chemistry, 2023, Volume: 135

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Esters; Febuxostat; Gout; Humans; Prodrugs; Uric Acid

2023